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Moumou M.,Laboratoire Of Chimie Biomoleculaire | Benharref A.,Laboratoire Of Chimie Biomoleculaire | Berraho M.,Laboratoire Of Chimie Biomoleculaire | El Ammari L.,Université Ibn Tofail | And 2 more authors.
Acta Crystallographica Section E: Structure Reports Online | Year: 2011

The title compound, C 15H 20O 4, was synthesized from 9-hy-droxy-parthenolide (9-hy-droxy-4,8-dimethyl-12-methyl-ene- 3,14-dioxatricyclo-[9.3.0.0 2,4]tetra-dec-7-en-13-one), which was isolated from the chloro-form extract of the aerial parts of Anvillea radiata. The seven-membered ring has a chair conformation, while the five-membered rings display twisted conformations. The dihedral angle between the seven-membered ring and the lactone ring is 21.69 (10)°. In the crystal, mol-ecules are linked into chains propagating along the c axis by inter-molecular O - H⋯O hydrogen bonds; an intra-molecular O - H⋯O link also occurs. © Moumou et al. 2011.


Loubidi M.,Laboratoire Of Chimie Biomoleculaire | Benharref A.,Laboratoire Of Chimie Biomoleculaire | El Ammari L.,Mohammed V University | Saadi M.,Mohammed V University | Berraho M.,Laboratoire Of Chimie Biomoleculaire
Acta Crystallographica Section E: Structure Reports Online | Year: 2014

The title compound, C25H33BrN2O 4, was synthesized from 9α-hydroxyparthenolide (9α-hydroxy-4,8-dimethyl-12-methylen-3,14-dioxa-tricyclo[9.3.0.0 2,4]tetradec-7-en-13-one), which was isolated from the chloroform extract of the aerial parts of Anvillea radiata. The molecule is built up from two fused five-and ten-membered rings with an additional epoxy ring system and a bromophenylpiperazine group as a substituent. The ten-membered ring adopts an approximate chair-chair-chair conformation, while the piperazine ring displays a chair conformation and the five-membered ring shows an envelope conformation with the C atom closest to the hydroxy group forming the flap. An intramolecular O-H..N hydrogen bond stabilizes the molecular conformation. The crystal packing features C-H..O hydrogen bonds, which link the molecules into zigzag chains running along the b-axis direction.

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