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Dahmane E.M.,Laboratoire Of Chimie Bio Organique Et Macromoleculaire Lcbm | Rhazi M.,Mohammed V University | Taourirte M.,Laboratoire Of Chimie Bio Organique Et Macromoleculaire Lcbm
Bulletin of the Korean Chemical Society | Year: 2013

Chitosan-based nanoparticles (CSNP) were prepared through ionic cross-linking and gelation of chitosan (CS) by tripolyphosphate (TPP). CS properties such as molecular weight, and preparation conditions were screened and the resulting nanoparticles were examined by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The obtained particles were consistently spherical with an overall diameter of approximately 107 ± 20 nm. They were successfully used as a carrier for Zidovudine, an anti-human immunodeficiency virus (HIV) which, to our knowledge, is novel. The encapsulation ability, loading capacity, and controlled release behavior for these CSNP was evaluated. Results indicated that their intrinsic properties were strongly affected by properties inherent to CS such as molecular weight, and by the preparation condition, such as cross-linking density, which depends on the concentration of the cross-linker. In vitro release tests for the entrapped zidovudine showed that the CNNP provided a continuous release that can last upwards 20 h.

El Montassir D.,Laboratoire Of Chimie Bio Organique Et Macromoleculaire Lcbm | Said E.,Laboratoire Of Chimie Bio Organique Et Macromoleculaire Lcbm | Gerald A.,Laboratoire dantibiologie | Hafida B.,Laboratoire Of Chimie Bio Organique Et Macromoleculaire Lcbm | Moha T.,Laboratoire Of Chimie Bio Organique Et Macromoleculaire Lcbm
Journal of Essential Oil-Bearing Plants | Year: 2010

This study was designed to investigate for the first time the essential oil of the leaves of wild growing Rosmarinus tournefortii De Noe endemic in Morocco in order to find new bioactive natural products. The essential oil obtained by hydrodistillation was characterized by capillary gas chromatography-mass spectrometry. Ten components, representing 70 % of the total oil, were identified, and unidentified compounds made up 21.6 % of the oil were also present. The oil was screened for antimicrobial activity against both Gram positive (Staphylococcus aureus, Enterococcus hirae) and Gram negative (Escherichia coli, Pseudomonas aeruginosa) bacteria and a pathogenic fungus Candida albicans. Except for P. aeruginosa, the oil had pronounced antibacterial and antifungal activities.

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