Time filter

Source Type

Morlieras J.,University Claude Bernard Lyon 1 | Chezal J.-M.,French Institute of Health and Medical Research | Chezal J.-M.,Clermont University | Chezal J.-M.,Center Jean Perrin | And 23 more authors.
Chemical Communications | Year: 2013

Ultrasmall gadolinium based particles have been functionalized with positively charged pyridinium quaternary ammonium and labelled with 111In. Evidence of their active targeting properties towards proteoglycans has been demonstrated in vivo after intravenous injection into rats opening thus a route to cancer imaging and therapy. This journal is © The Royal Society of Chemistry.


Morlieras J.,CNRS Laboratory of Physical Chemistry of Luminescent Materials | Chezal J.-M.,French Institute of Health and Medical Research | Chezal J.-M.,Clermont University | Chezal J.-M.,Center Jean Perrin | And 28 more authors.
Nanoscale | Year: 2013

Small Rigid Platforms (SRPs) are sub-5 nanometre gadolinium based nanoparticles that have been developed for multimodal imaging and theranostic applications. They are composed of a polysiloxane network surrounded by gadolinium chelates. A covalent coupling with quinoxaline derivatives has been performed. Such derivatives have proven their affinity for melanin frequently expressed in primary melanoma cases. Three different quinoxaline derivatives have been synthesised and coupled to the nanoparticles. The affinity of the grafted nanoparticles for melanin has then been shown in vitro by surface plasmon resonance on a homemade melanin grafted gold chip. © 2013 The Royal Society of Chemistry.

Loading Laboratoire Of Biochimie Et Biologie Moleculaire Et Service Of Medecine Nucleaire collaborators
Loading Laboratoire Of Biochimie Et Biologie Moleculaire Et Service Of Medecine Nucleaire collaborators