Laboratoire National Of Controle Des Medicaments

Rabat, Morocco

Laboratoire National Of Controle Des Medicaments

Rabat, Morocco
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Mejri A.,Tunis el Manar University | Fliss O.,Tunis el Manar University | Fliss O.,Laboratoire National Of Controle Des Medicaments | Alouani K.,Tunis el Manar University
Journal of Electroanalytical Chemistry | Year: 2017

The synthesis of a new neutral bidentate ligand, bis(tetraethylselenophosphoramidoyl)methylamine, MeN[P(Se)(NEt2)2]2 (L1), was reported. A new cyclodiphosphazane ligand, [MeNP(Se)(NEt2)]2 (L2), was also isolated from the reaction mixture as a minor product. The title ligands were characterized by spectroscopic and electrochemical investigations. The electrochemical studies reveal that L1 is able to bind various heavy metallic cations (M2 +: Zn2 +, Cd2 +, Pb2 +, Hg2 + and Fe2 +) forming very stable complexes. The addition of each cation led to important oxidation potential shifts up to 1070 mV. However, the ligand L2 exhibited no sensitivity for any of the reported cations. In addition, DFT/B3LYP theoretical study was carried out and that unlike to the cyclic ligand L2, L1 is potentially able to chelate metal ions. © 2017 Elsevier B.V.


Bouyarmane H.,Mohammed V University | El Hanbali I.,Mohammed V University | El Hanbali I.,CNRS Laboratory of Condensed Matter Chemistry, Paris | El Karbane M.,Laboratoire National Of Controle Des Medicaments | And 6 more authors.
Journal of Hazardous Materials | Year: 2015

The retention of four antibiotics, ciprofloxacin, ofloxacin, amoxicillin and sulfamethoxazole by a natural phosphate rock (francolite) was studied and compared with a converted hydroxyapatite powder. The maximum sorption capacities were found to correlate with the molecular weight of the molecules. The mechanisms of sorption depended mostly on the charge of the antibiotic whereas the kinetics of the process was sensitive to their hydrophobic/hydrophilic character. The two materials showed slightly distinct affinities for the various antibiotics but exhibited similar maximum sorption capacities despite different specific surface areas. This was mainly attributed to the more pronounced hydrophobic character of the francolite phase constituting the natural phosphate. These data enlighten that the retention properties of these mineral phases depend on a complex interplay between the inter-molecular and molecule-solid interactions. These findings are relevant to understand better the contribution of calcium phosphates in the fate and retention of antibiotics in soils. © 2015 Elsevier B.V.


PubMed | Laboratoire National Of Controle Des Medicaments, Mohammed V University, CNRS Laboratory of Condensed Matter Chemistry, Paris and CNRS Chemistry Laboratory
Type: | Journal: Journal of hazardous materials | Year: 2015

The retention of four antibiotics, ciprofloxacin, ofloxacin, amoxicillin and sulfamethoxazole by a natural phosphate rock (francolite) was studied and compared with a converted hydroxyapatite powder. The maximum sorption capacities were found to correlate with the molecular weight of the molecules. The mechanisms of sorption depended mostly on the charge of the antibiotic whereas the kinetics of the process was sensitive to their hydrophobic/hydrophilic character. The two materials showed slightly distinct affinities for the various antibiotics but exhibited similar maximum sorption capacities despite different specific surface areas. This was mainly attributed to the more pronounced hydrophobic character of the francolite phase constituting the natural phosphate. These data enlighten that the retention properties of these mineral phases depend on a complex interplay between the inter-molecular and molecule-solid interactions. These findings are relevant to understand better the contribution of calcium phosphates in the fate and retention of antibiotics in soils.


PubMed | Institute Superieur Des Professions Infirmieres Et Techniques Of Sante, University Sidi Mohammed Ben Abdellah and Laboratoire National Of Controle Des Medicaments
Type: Journal Article | Journal: Annales pharmaceutiques francaises | Year: 2016

We propose in this work an efficient way to evaluate the measurement of uncertainty at the end of the development step of an analytical method, since this assessment provides an indication of the performance of the optimization process.The estimation of the uncertainty is done through a robustness test by applying a Placquett-Burman design, investigating six parameters influencing the simultaneous chromatographic assay of five water-soluble vitamins. The estimated effects of the variation of each parameter are translated into standard uncertainty value at each concentration level.The values obtained of the relative uncertainty do not exceed the acceptance limit of 5%, showing that the procedure development was well done. In addition, a statistical comparison conducted to compare standard uncertainty after the development stage and those of the validation step indicates that the estimated uncertainty are equivalent.The results obtained show clearly the performance and capacity of the chromatographic method to simultaneously assay the five vitamins and suitability for use in routine application.


El Fal M.,Mohammed V University | Ramli Y.,Laboratoire National Of Controle Des Medicaments | Essassi E.M.,Mohammed V University | Saadi M.,Mohammed V University | El Ammari L.,Mohammed V University
Acta Crystallographica Section E: Structure Reports Online | Year: 2013

The pyrazolo[3,4-d]pyrimidine ring system of the title compound, C 12H10N4S, is essentially planar [maximum deviation = 0.025(1)Å for the C atom bearing the S atom] and almost perpendicular to the phenyl ring [dihedral angle = 71.42(6)°]. In the crystal, molecules are linked via pairs of N - H⋯N hydrogen bonds, forming inversion dimers.


Ramli Y.,Laboratoire National Of Controle Des Medicaments | Moussaif A.,Center National dEtudes Scientifiques et Techniques dEnergie Nucleaire | Karrouchi K.,Mohammed V University | Essassi E.M.,Mohammed V University
Journal of Chemistry | Year: 2014

Quinoxalinone and its derivatives are used in organic synthesis for building natural and designed synthetic compounds and they have been frequently utilized as suitable skeletons for the design of biologically active compound. This review covers updated information on the most active quinoxalinone derivatives that have been reported to show considerable pharmacological actions such as antimicrobial, anti-inflammatory, antidiabetic, antiviral, antitumor, and antitubercular activity. It can act as an important tool for chemists to develop newer quinoxalinone derivatives that may prove to be better agents in terms of efficacy and safety. © 2014 Youssef Ramli et al.


Bouyarmane H.,Mohammed V University | Asri S.E.,Mohammed V University | Rami A.,Laboratoire National Of Controle Des Medicaments | Roux C.,UPMC P6 | And 4 more authors.
Journal of Hazardous Materials | Year: 2010

A natural phosphate rock and two synthetic mesoporous hydroxyapatites were evaluated for the removal of pyridine and phenol from aqueous solutions. Experiments performed by the batch method showed that the sorption process occurs by a first order reaction for both pyridine and phenol. In contrast, the Freundlich model was able to describe sorption isotherms for phenol but not for pyridine. In parallel, the three apatites exhibit similar pyridine sorption capacities whereas phenol loading was in agreement with their respective specific surface area. This was attributed to the strong interaction arising between pyridine and apatite surface that hinders further inter-particular diffusion. This study suggests that, despite its low specific surface area, natural phosphate rock may be used as an efficient sorbent material for specific organic pollutants, with comparable efficiency and lower processing costs than some activated carbons. © 2010 Elsevier B.V.


El Fal M.,Mohammed V University | Ramli Y.,Laboratoire National Of Controle Des Medicaments | Essassi E.M.,Mohammed V University | Saadi M.,Mohammed V University | El Ammari L.,Mohammed V University
Acta Crystallographica Section E: Structure Reports Online | Year: 2014

In the title compound, C8H8N4S, the pyrazolo[3,4-d]pyrimidine ring system is essentially planar, with a maximum deviation from the mean plane of 0.025(3)Å. The allyl group is disordered over two sites in a 0.512(6):0.488(6) ratio. In the crystal, molecules are linked by pairs of N-H⋯N hydrogen bonds, forming inversion dimers with an R 2 2(8) graph-set motif.


El Fal M.,Mohammed V University | Ramli Y.,Laboratoire National Of Controle Des Medicaments | Essassi E.M.,Mohammed V University | Saadi M.,Mohammed V University | El Ammari L.,Mohammed V University
Acta Crystallographica Section E: Structure Reports Online | Year: 2014

In the title compound, C7H8N4S, the methyl C atom is displaced by 1.232 (7) Å from the mean plane of the pyrazolo[3,4-d]pyrimidine ring system (r.m.s. deviation = 0.007 Å). The N - N - C - Cm (m = methyl) torsion angle is -60.3 (6)°. In the crystal, molecules are linked by N - S hydrogen bonds, generating [010] chains, which are reinforced by C - N interactions. The chains are cross-linked by weak C - S hydrogen bonds, generating (001) sheets.


PubMed | Laboratoire National Of Controle Des Medicaments and Mohammed V University
Type: Journal Article | Journal: Acta crystallographica. Section E, Structure reports online | Year: 2014

In the title compound, C7H8N4S, the methyl C atom is displaced by 1.232(7) from the mean plane of the pyrazolo-[3,4-d]pyrimidine ring system (r.m.s. deviation = 0.007). The N-N-C-Cm (m = meth-yl) torsion angle is -60.3(6). In the crystal, mol-ecules are linked by N-HS hydrogen bonds, generating [010] chains, which are reinforced by C-HN inter-actions. The chains are cross-linked by weak C-HS hydrogen bonds, generating (001) sheets.

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