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El Fal M.,Mohammed V University | Ramli Y.,Laboratoire National Of Controle Des Medicaments | Essassi E.M.,Mohammed V University | Saadi M.,Mohammed V University | El Ammari L.,Mohammed V University
Acta Crystallographica Section E: Structure Reports Online | Year: 2013

The pyrazolo[3,4-d]pyrimidine ring system of the title compound, C 12H10N4S, is essentially planar [maximum deviation = 0.025(1)Å for the C atom bearing the S atom] and almost perpendicular to the phenyl ring [dihedral angle = 71.42(6)°]. In the crystal, molecules are linked via pairs of N - H⋯N hydrogen bonds, forming inversion dimers. Source


Ramli Y.,Laboratoire National Of Controle Des Medicaments | Karrouchi K.,Mohammed V University | Essassi E.M.,Mohammed V University | Essassi E.M.,Institute of Nanomaterials and Nanotechnology | El Ammari L.,Mohammed V University
Acta Crystallographica Section E: Structure Reports Online | Year: 2013

The molecule of the title compound, C42H32N6O, is built up from one pyrazole ring linked to three phenyl rings and to an approximately planar [maximum deviation = 0.0455 (15) Å] quinoxaline system connected to a phenylbenzohydrazide group. The pyrazole ring assumes an envelope conformation, the C atom attached to the quinoxalin-3-yl ring system being the flap atom. The dihedral angle between the two phenyl rings of the phenylbenzohydrazide group is of 58.27 (9)°. The mean plane through the pyrazole ring is nearly perpendicular to the quinoxaline ring system and to the phenyl ring attached to the opposite side, forming dihedral angles of 82.58 (7) and 87.29 (9)°, respectively. An intramolecular C - H⋯O hydrogen bond is present. In the crystal, molecules are linked by pairs of N - H⋯N hydrogen bonds, forming inversion dimers, which are further connected by C - H⋯N hydrogen bonds into chains parallel to the b axis. Source


Doukkali Z.,Mohammed V University | Bouidida H.,Laboratoire National Of Controle Des Medicaments | Srifi A.,Sina | Taghzouti K.,Mohammed V University | And 2 more authors.
Phytotherapie | Year: 2015

An ethnobotanical study was conducted in Morocco in order to identify at the national level medicinal plants used in traditional Moroccan medicine in the treatment of anxiety. Seventy (70) herbalists were interviewed individually and each delivered the plants used to combat anxiety disorders. Sixty-seven (77) medicinal species spread over 43 families have been reported and identified. Statistical analysis of data from the ethnobotanical investigation has inventory twenty priority plants. The leaves are the most used part, usually in the form of infusion. Were also analyzed data on the profile of herbalists whose average age of between 35 and 55 years, 69% of them have agreed to discuss their profile, 79% have an experience of over a decade, 46% are graduate, 65% undergo continuous training, and 37 treat and care for their families only by plants. © 2015, Springer-Verlag France. Source


El Fal M.,Mohammed V University | Ramli Y.,Laboratoire National Of Controle Des Medicaments | Essassi E.M.,Mohammed V University | Saadi M.,Mohammed V University | El Ammari L.,Mohammed V University
Acta Crystallographica Section E: Structure Reports Online | Year: 2014

In the title compound, C8H8N4S, the pyrazolo[3,4-d]pyrimidine ring system is essentially planar, with a maximum deviation from the mean plane of 0.025(3)Å. The allyl group is disordered over two sites in a 0.512(6):0.488(6) ratio. In the crystal, molecules are linked by pairs of N-H⋯N hydrogen bonds, forming inversion dimers with an R 2 2(8) graph-set motif. Source


El Fal M.,Mohammed V University | Ramli Y.,Laboratoire National Of Controle Des Medicaments | Essassi E.M.,Mohammed V University | Saadi M.,Mohammed V University | El Ammari L.,Mohammed V University
Acta Crystallographica Section E: Structure Reports Online | Year: 2014

In the title compound, C7H8N4S, the methyl C atom is displaced by 1.232 (7) Å from the mean plane of the pyrazolo[3,4-d]pyrimidine ring system (r.m.s. deviation = 0.007 Å). The N - N - C - Cm (m = methyl) torsion angle is -60.3 (6)°. In the crystal, molecules are linked by N - S hydrogen bonds, generating [010] chains, which are reinforced by C - N interactions. The chains are cross-linked by weak C - S hydrogen bonds, generating (001) sheets. Source

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