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Li X.-M.,French Institute of Health and Medical Research | Li X.-M.,University Paris - Sud | Mohammad-Djafari A.,University Paris - Sud | Dumitru M.,University Paris - Sud | And 12 more authors.
Cancer Research

Circadian timing of anticancer medications has improved treatment tolerability and efficacy several fold, yet with intersubject variability. Using three C57BL/6-based mouse strains of both sexes, we identified three chronotoxicity classes with distinct circadian toxicity patterns of irinotecan, a topoisomerase I inhibitor active against colorectal cancer. Liver and colon circadian 24-hour expression patterns of clock genes Rev-erba and Bmal1 best discriminated these chronotoxicity classes, among 27 transcriptional 24-hour time series, according to sparse linear discriminant analysis. An 8-hour phase advance was found both for Rev-erba and Bmal1 mRNA expressions and for irinotecan chronotoxicity in clock-altered Per2m/m mice. The application of a maximum-aposteriori Bayesian inference method identified a linear model based on Rev-erba and Bmal1 circadian expressions that accurately predicted for optimal irinotecan timing. The assessment of the Rev-erba and Bmal1 regulatory transcription loop in the molecular clock could critically improve the tolerability of chemotherapy through a mathematical model-based determination of host-specific optimal timing. © 2013 American Association for Cancer Research. Source

Cateau E.,Laboratoire Of Parasitologie Et Mycologie Medicale | Verdon J.,University of Poitiers | Fernandez B.,Laboratoire dAnatomie et Cytologie Pathologiques | Hechard Y.,University of Poitiers | And 2 more authors.
FEMS Microbiology Letters

Acinetobacter baumanii, which may be found in water, is an important emerging hospital-acquired pathogen. Free-living amoebae can be recovered from the same water networks, and it has been shown that these protozoa may support the growth of other bacteria. In this paper, we have studied potential relationships between A. baumanii and Acanthamoeba species. Two strains of A. baumanii isolated from hospital water were co-cultivated with the trophozoites or supernatants of two free-living amoebae strains: Acanthamoeba castellanii or Acanthamoeba culbertsoni. Firstly, the presence of the amoebae or their supernatants induced a major increase in A. baumanii growth, compared with controls. Secondly, A. baumanii affected only the viability of A. culbertsonii, with no effect on A. castellanii. Electron microscopy observations of the cultures investigating the bacterial location in the protozoa showed persistence of the bacteria within cyst wall even after 60 days of incubation. In our study, the survival and growth of A. baumanii could be favored by Acanthamoeba strains. Special attention should consequently be paid to the presence of free-living amoebae in hospital water systems, which can promote A. baumanii persistence. © 2011 Federation of European Microbiological Societies. Source

Morio F.,Nantes University Hospital Center | Morio F.,University of Nantes | Berre J.-Y.L.,Laboratoire Of Biologie | Dea G.-H.,Institute Pasteur Paris | And 5 more authors.
Medical Mycology

Black yeasts including Exophiala species are increasingly recognized as agents of human disease. In recent years, progress in molecular phylogeny and taxonomy of the genus Exophiala has led to the description of numerous novel species. The 'classical' but highly variable species Exophiala jeanselmei was split into a number of morphological siblings, which, however, were phylogenetically and clinically remote from each other. E. jeanselmei was restricted to an uncommon species causing subcutaneous infections. Hence only limited information is available on the segregants, among which is E. xenobiotica. We describe a case of an HIV-patient presenting with fungal arthritis and subcutaneous nodules caused by the latter species, which was identified by means of phenotypic and molecular methods. © 2012 ISHAM. Source

Cateau E.,Laboratoire Of Parasitologie Et Mycologie Medicale | Yacoub M.,Laboratoire dAnatomie et Cytologie Pathologiques | Tavilien C.,Center Hospitalier | Becq-Giraudon B.,Service des Maladies Infectieuses et Tropicales | Rodier M.-H.,Laboratoire Of Parasitologie Et Mycologie Medicale
Journal of Medical Microbiology

A woman was admitted to hospital with abdominal pain. A large kidney stone was recovered and a nephrectomy was performed. Histology revealed the unusual presence of multiple Enterobius vermicularis ova. However, no other parasitic element was recovered on further investigations. © 2010 SGM. Source

Cateau E.,Laboratoire Of Parasitologie Et Mycologie | Cateau E.,CNRS Ecobiological Interactions | Maisonneuve E.,CNRS Ecobiological Interactions | Peguilhan S.,Laboratoire Of Parasitologie Et Mycologie | And 4 more authors.
Research in Microbiology

Stenotrophomonas maltophilia, a bacteria involved in healthcare-associated infections, can be found in hospital water systems. Other microorganisms, such as Free Living amoebae (FLA), are also at times recovered in the same environment. Amongst these protozoa, many authors have reported the presence of Vermamoeba vermiformis. We show here that this amoeba enhances S. maltophilia growth and harbors the bacteria in amoebal-derived structures after 28 days in harsh conditions. These results highlight the fact that particular attention should be paid to the presence of FLA in hospital water systems, because of their potential implication in survival and growth of pathogenic bacterial species. © 2014 Institut Pasteur. Source

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