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Achour S.,Laboratoire Central dAnalyses Medicales | Achour S.,Université Ibn Tofail | Rhalem N.,Center Antipoison Et Of Pharmacovigilance Du Maroc | Rhalem N.,Université Ibn Tofail | And 6 more authors.
Therapie | Year: 2012

Peganum harmala L. is commonly used in traditional medicine in Morocco for its sedative and emmenagogue properties but expose to the risk of overdose and poisoning. The aim of our study was to analyze a series of 200 cases of poisoning collected in poison control and pharmacovigilance center of Morocco in order to describe the epidemiological, clinical, therapeutic features and outcome of patients and indicate the toxicity of this plant used primarily for therapeutic purposes. Methods. This retrospective study performed over a period of twenty four years from January 1984 to December 2008. Results. The mean age of patients was 24.4±16.8 years with a female predominance (167 women against 33 men). Therapeutic circumstance was found in 32.5%, followed by suicide (28.5%) and abortion (13.5%). The symptomatology was dominated by neurological, gastrointestinal and cardiovascular signs respectively 34.4%, 31.9 % and 15.8%. The evolution has been specified in 114 cases, 7 deaths have been deplored with a fatality rate of 6.2%. © 2012 Société Française de Pharmacologie et de Thérapeutique.


Achour S.,Laboratoire central danalyses medicales | Achour S.,Laboratoire Of Genetique Et Biomerie | Khattabi A.,Center Antipoison Et Of Pharmacovigilance Du Maroc | Rhalem N.,Center Antipoison Et Of Pharmacovigilance Du Maroc | And 5 more authors.
Sante Publique | Year: 2011

Objective: The purpose of this paper is to describe the epidemiological profile of acute pesticide poisoning in children (APP) treated by the Moroccan Poison Control Center (CAPM) and to analyze death cases in order to determine factors predictive of severity. Method: the study is based on a retrospective study of all cases of APP collected by the CAPM over a period of eighteen years (January 1990 to December 2008). Univariate analysis was performed to identify risk factors. Results: 2,672 cases of childhood poisoning by pesticide were collected. The mean age was 5.6 ± 4.57 years. The sex ratio was 1.12. The cause of poisoning was accidental in 87.1% of cases, followed by attempted suicide (12.1%). Organophosphates were the most frequent poison (50.7%), followed by alpha-chloralose (26.5%). The case fatality rate was 3.3%. Mortality was attributed to organophosphates in 30 cases, followed by inorganic derivatives (7 cases) and carbamates (6 cases). A univariate analysis comparing survivors and groups who died showed that rural origin (p = 0.04), voluntary circumstances (p = 0.001), and the type of chemical class of pesticide (p < 0.001) significantly influence fatal poisoning. Conclusion: Acute pesticide poisoning among children is a reality in Morocco. Preventive measures may be needed.


Touaoussa A.,Laboratoire Central dAnalyses Medicales | Youssi H.E.,Laboratoire Central dAnalyses Medicales | Hassani I.E.,Laboratoire Central dAnalyses Medicales | Hanouf D.,Laboratoire Central dAnalyses Medicales | And 3 more authors.
Annales de Biologie Clinique | Year: 2015

Disseminated intravascular coagulation (DIC) is a syndrome characterized by the systemic activation of blood coagulation. Its pathophysiological mechanisms are complex and dependent on the underlying pathology, making the clinical and biological expression of quite variable DIC. Among the various biological parameters disrupted, most are not specific, and none of them allows in itself to make the diagnosis. All this does not facilitate the task of the practitioner for diagnosis of overt DIC, much less that of the non-overt DIC, early stage whose treatment would improve the prognosis. These considerations have led to develop scores, combining several parameters depending on their availability in daily practice, as well as their diagnostic relevance. Of all the scores, the ISTH (International society of thrombosis and hemostasis) remains the most used.


Hassani M.A.,Laboratoire central danalyses medicales | Baba A.F.,Laboratoire central danalyses medicales | Alami M.,Laboratoire central danalyses medicales | Lahlou H.,Laboratoire central danalyses medicales
Cahiers Sante | Year: 2010

Laboratory diagnostic and prognostic factors: Multiple myeloma in Morocco Objectives: The purpose of this retrospective study was to clarify the factors for a laboratory diagnosis of multiple myeloma (Kahler's disease) and assess their prognostic value. Methods: The study of all 10 patients with multiple myeloma seen during 2009 in the department of internal medicine and the haematology laboratory of HASSAN II University Hospital Centre in Fez. Work-ups for all patients included hemograms, sedimentation speed, electrophoresis of serum and urinary proteins, myelograms, creatinemia, calcemia, ß2-microglobulin, LDH and CRP. Results: In this series, the average age of the patients was 59 years and the sex ratio 1.3 (men). The laboratory tests showed anemia below 12 g/dl in 80% of the cases, with IgG accounting for 50% of the cases. The median concentration of the monoclonal component was 28 g/l. The prognostic assessments showed an increase in ß2-microglobulins and creatinemia in one case. CRP was elevated in all patients. Conclusion: The results from this study are consistent with those from other series. Protein electrophoresis and myelography results are major diagnostic elements, because they make it possible to rule out a monoclonal gammopathy of undetermined significance, for which treatment differs completely from that for multiple myeloma. ß2-microglobulin and CRP are independent prognostic factors providing important information about survival.


Khabbal Y.,Laboratoire central dAnalyses medicales | Alami L.,Service de la Pharmacie centrale | Nejjari C.,Laboratoire Depidemiologie Et Of Sante Publique
Eastern Mediterranean Health Journal | Year: 2012

In an effort to improve patient safety, Hassan II hospital in Fez introduced a pharmacovigilance system for notification of adverse drug reactions as a priority objective. The implementation of pharmacovigilance activities actually began in June 2007 but it was in 2009 after the inauguration of the new complex that the system became properly operational. This report outlines the activities carried out to develop and implement this system, including informing and training the health professionals, and the results obtained after its introduction. From 2007 to 2009, fewer than 100 cases of adverse drug reactions were reported. Up to June 2011, however, 520 reports of adverse drug reactions were recorded. The classes of drugs most implicated in adverse events were: cancer drugs (26%), anti-inflammatory drugs and antibiotics (each 15%), analgesics (12%), iodinated contrast agents (6%), and anticoagulants and corticosteroids (5%). The main adverse events were dermatological and 27% of reports came from the internal medicine department, followed by hepatogastroenterology (25%). Of the 520 cases reported, 46% were severe.


PubMed | Laboratoire central danalyses medicales
Type: Journal Article | Journal: Annales de biologie clinique | Year: 2015

Disseminated intravascular coagulation (DIC) is a syndrome characterized by the systemic activation of blood coagulation. Its pathophysiological mechanisms are complex and dependent on the underlying pathology, making the clinical and biological expression of quite variable DIC. Among the various biological parameters disrupted, most are not specific, and none of them allows in itself to make the diagnosis. All this does not facilitate the task of the practitioner for diagnosis of overt DIC, much less that of the non-overt DIC, early stage whose treatment would improve the prognosis. These considerations have led to develop scores, combining several parameters depending on their availability in daily practice, as well as their diagnostic relevance. Of all the scores, the ISTH (International society of thrombosis and hemostasis) remains the most used.


PubMed | Laboratoire central danalyses medicales
Type: Journal Article | Journal: Sante publique (Vandoeuvre-les-Nancy, France) | Year: 2011

The purpose of this paper is to describe the epidemiological profile of acute pesticide poisoning in children (APP) treated by the Moroccan Poison Control Center (CAPM) and to analyze death cases in order to determine factors predictive of severity.the study is based on a retrospective study of all cases of APP collected by the CAPM over a period of eighteen years (January 1990 to December 2008). Univariate analysis was performed to identify risk factors.2,672 cases of childhood poisoning by pesticide were collected. The mean age was 5.6 4.57 years. The sex ratio was 1.12. The cause of poisoning was accidental in 87.1% of cases, followed by attempted suicide (12.1%). Organophosphates were the most frequent poison (50.7%), followed by alpha-chloralose (26.5%). The case fatality rate was 3.3%. Mortality was attributed to organophosphates in 30cases, followed by inorganic derivatives (7 cases) and carbamates (6 cases). A univariate analysis comparing survivors and groups who died showed that rural origin (p = 0.04), voluntary circumstances (p = 0.001), and the type of chemical class of pesticide (p < 0.001) significantly influence fatal poisoning.Acute pesticide poisoning among children is a reality in Morocco. Preventive measures may be needed.


PubMed | Laboratoire central dAnalyses medicales
Type: Journal Article | Journal: Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit | Year: 2012

In an effort to improve patient safety, Hassan II hospital in Fez introduced a pharmacovigilance system for notification of adverse drug reactions as a priority objective. The implementation of pharmacovigilance activities actually began in June 2007 but it was in 2009 after the inauguration of the new complex that the system became properly operational. This report outlines the activities carried out to develop and implement this system, including informing and training the health professionals, and the results obtained after its introduction. From 2007 to 2009, fewer than 100 cases of adverse drug reactions were reported. Up to June 2011, however, 520 reports of adverse drug reactions were recorded. The classes of drugs most implicated in adverse events were: cancer drugs (26%), anti-inflammatory drugs and antibiotics (each 15%), analgesics (12%), iodinated contrast agents (6%), and anticoagulants and corticosteroids (5%). The main adverse events were dermatological and 27% of reports came from the internal medicine department, followed by hepatogastroenterology (25%). Of the 520 cases reported, 46% were severe.


PubMed | Laboratoire Central dAnalyses Medicales
Type: Journal Article | Journal: Therapie | Year: 2012

Peganum harmala L. is commonly used in traditional medicine in Morocco for its sedative and emmenagogue properties but expose to the risk of overdose and poisoning. The aim of our study was to analyze a series of 200 cases of poisoning collected in poison control and pharmacovigilance center of Morocco in order to describe the epidemiological, clinical, therapeutic features and outcome of patients and indicate the toxicity of this plant used primarily for therapeutic purposes.This retrospective study performed over a period of twenty four years from January 1984 to December 2008.The mean age of patients was 24.416.8 years with a female predominance (167 women against 33 men). Therapeutic circumstance was found in 32.5%, followed by suicide (28.5%) and abortion (13.5%). The symptomatology was dominated by neurological, gastrointestinal and cardiovascular signs respectively 34.4%, 31.9 % and 15.8%. The evolution has been specified in 114 cases, 7 deaths have been deplored with a fatality rate of 6.2%.

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