La Trobe University is an Australian public university with its flagship campus, the largest metropolitan campus in the country, located in Melbourne, Victoria. The University was established in 1964 following the assent of the La Trobe University Act by Victorian Parliament on 9 December of that year, becoming the third university in the State. While not sharing the architectural aesthetics of its sandstone peers, at its core La Trobe, as much as Monash, was 'among the last of the old universities in Australia.' In 2014 it was ranked in the top 100 universities under 50 in the Times Higher Education World University Rankings.La Trobe’s flagship campus is located in the Melbourne suburb of Bundoora with two other major campuses located in the regional Victorian city of Bendigo and in the twin border cities of Albury-Wodonga. The University also has two smaller regional campuses in Mildura and Shepparton, as well as three minor CBD campuses with two in Melbourne on Franklin Street and Collins Street, and one on York Street in Sydney.La Trobe offers undergraduate and postgraduate courses across its two colleges of Arts, Social Science and Commerce and Science, Health and Engineering . ASSC consists of the four schools of Business, Education, Humanities and Social science, and Law, while SHE consists of the nine schools of Allied Health, Applied Systems Biology, Cancer Medicine, Engineering and Mathematical science, Life science, Molecular science, Nursing and Midwifery, Psychology and Public Health and Rural Health.La Trobe is considered to be particularly strong in the area of arts and humanities; this was reflected in the 2014 QS World University Rankings where it was ranked in the top 200 international universities for Arts and Humanities. It was ranked 38th in the world in the fields of archaeology, ancient history and classics, while sociology, communication, media studies and linguistics all scored in the top 100. It was also ranked in the top 100 universities for arts and humanities in the 2014-15 Times Higher Education World University Rankings. La Trobe also features a strong MBA program which has been ranked in the top 200 Business Schools by QS Global Rankings since 2010. In 2014 the La Trobe MBA was ranked 14th in Asia, 4th in Australia and 2nd in Victoria by QS Global Rankings.In terms of research quality, the university exhibits strength in the areas of arts and humanities, and biological and biotechnical science. In 2012 La Trobe was ranked 3rd in Victoria in the Australian Research Council's Excellence in Research for Australia report.For most of its history La Trobe has been socially regarded as a bastion of left-wing and progressive thought within Australia, largely emanating from strong student activism at the university during the 1960s and 1970s. While not as prevalent as it was in the 20th century, it is a reputation that is still held to this day. Wikipedia.
News Article | May 2, 2017
Australia's La Trobe University has further strengthened its relationship with India by unveiling a number of new initiatives as part of La Trobe's 50th Anniversary Celebrations.
News Article | May 15, 2017
In the middle of the ‘70s, author A.S. Godfrey Lubulwa left Ssanda, a small village in Uganda where he was born. He ran away from the brutality of dictator Idi Amin and sought asylum as a refugee in Australia. In “Half a Refugee in Ssanda and Australia: 100 Poems” (published by Balboa Press AU), Lubulwa highlights life of a Ugandan refugee in Australia. The book is about memories of the old culture (Poems 1-20), confrontation with the new culture in Australia (Poems 21-32), marriage and starting a family (Poems 33-57), parenthood in a multi-cultural setting (Poems 58-80) and growing into old age (Poems 81-100). According to the author, “Half a Refugee in Ssanda and Australia: 100 Poems” is a celebration of successful refugee re-settlement. It is honest/ balanced about some of the struggles new migrants have faced, particularly those who come from non-European cultures. “Half a Refugee in Ssanda and Australia: 100 Poems” is not a whinge; not a political statement. It says that the journey from a small African village to a place like Australia can be done. It is a delicate journey for those involved but it has potential to enrich both the host community and the refugee. Through the poetry book, Lubulwa expresses and illustrates to readers a life between two cultures. “Half a Refugee in Ssanda and Australia: 100 Poems” By A.S. Godfrey Lubulwa Softcover | 6 x 9in | 202 pages | ISBN 9781504307116 E-Book | 202 pages | ISBN 9781504307123 Available at Amazon and Barnes & Noble About the Author A.S. Godfrey Lubulwa was born in Ssanda village, Busiro County in Buganda, Uganda. He did his higher education at Makerere University, Kampala, Southampton University, U.K. and La Trobe University, Melbourne, Australia, where he obtained a doctorate in mathematical economics. He started off his career as an academic, teaching economics at Makerere University, Kampala. In the mid ‘70s, Lubulwa unwillingly left Uganda and sought asylum in Australia where he has lived since 1977, starting off as an academic at La Trobe University, Bundoora, Melbourne and in 1988 moving to Canberra where he worked for many years, in various government economic research bureaus, as a senior research economist and research manager. He has two children and now lives in Queanbeyan, where he spends most of his time writing poetry. Balboa Press Australia is a division of Hay House, Inc., a leading provider in publishing products that specialise in self-help and the mind, body and spirit genre. Through an alliance with indie book publishing leader Author Solutions, LLC, authors benefit from the leadership of Hay House Publishing and the speed-to-market advantages of the Author Solutions self-publishing model. For more information or to start publishing today, visit balboapress.com.au/ or call 1800 050 315. For the latest, follow @balboapress on Twitter and “Like” us at facebook.com/BalboaPress.
Monash University, La Trobe University, Peptides International Inc. and Baylor College of Medicine | Date: 2017-06-21
Novel analogues of the sea anemone Stichodactyla helianthus toxin ShK, and their use as, for example, therapeutic agents for treating autoimmune diseases are disclosed. The analogues comprise a ShK toxin polypeptide and an N-terminal extension comprising an amino acid sequence according to formula (I): wherein X-4 is D, E or other negatively-charged amino acid or derivative thereof, X-3 is E, I, L, S, V, W or a tryptophan derivative, X-2 is any amino acid, X-1 is any amino acid, a is absent or a first additional moiety, and b is absent or a second additional moiety.
La Trobe University | Date: 2016-08-15
The present disclosure provides proteins comprising antibody antigen binding domains that bind to Fn14 and uses thereof. The present disclosure also provides methods for treating wasting disorders, such as cachexia.
Ambrose R.L.,La Trobe University |
Mackenzie J.M.,La Trobe University
Journal of Virology | Year: 2013
West Nile virus strain Kunjin (WNVKUN) is an enveloped, positive-sense RNA virus within the virus family Flaviviridae. Many flaviviruses have been shown to manipulate multiple signaling pathways, including autophagic, innate immune, and stress responses, in order to benefit replication. In particular, we have demonstrated that WNVKUN regulates the unfolded protein response (UPR), skewing the downstream effectors toward chaperone expression and Xbp-1 activation while preventing PERKmediated translation attenuation and C/EBP homologous protein (CHOP) upregulation. WNVKUN-regulated UPR signaling can then be hijacked in order to affect type I interferon (IFN) responses, preventing IFN-mediated STAT1 phosphorylation and nuclear translocation. To extend our previous observations, we aimed to investigate the contribution of ATF6- and IRE1-mediated signaling during WNVKUN replication and how the two sensors contribute to the inhibition of IFN signaling. ATF6-deficient cells infected with WNVKUN showed decreased protein and virion production. These cells also demonstrated increased eIF2α phosphorylation and CHOP transcription, absent in infected matched control cells. Thus, we propose that in the absence of ATF6, WNVKUN is incapable of manipulating the PERK-mediated response to infection. In contrast, infection of IRE1-/- knockout cells showed no discernible differences compared to IRE1+/+ cells. However, both ATF6 and IRE1 were required for WNVKUN-induced inhibition of STAT1 phosphorylation. We suggest that the combination of abhorrent UPR signaling, promotion of cell death, and increased innate immune responses contributes to the replication defects in ATF6-deficient cells, thus demonstrating the dual importance of ATF6 in maintaining cell viability and modulating immune responses during WNVKUN infection. © 2013, American Society for Microbiology.
Spencer M.J.S.,RMIT University |
Spencer M.J.S.,La Trobe University
Progress in Materials Science | Year: 2012
Gas sensor devices have traditionally comprised thin films of metal oxides, with tin oxide, zinc oxide and indium oxide being some of the most common materials employed. With the recent discovery of novel metal oxide nanostructures, sensors comprising nano-arrays or single nanostructures have shown improved performance over the thin films. The improved response of the nanostructures to different gases has been primarily attributed to the highly single crystalline surfaces as well as large surface area of the nanostructures. In this paper the properties of clean and defected quasi one-dimensional ZnO nanostructures, including hexagonal and triangular nanowires, nanotubes and facetted nanotubes are reviewed. The adsorption of atoms and molecules on the ZnO nanostructures are also reviewed and the findings are compared to studies examining similar reactions on nanostructured metal oxide surfaces for sensing purposes. While both experimental and theoretical approaches have been employed to examine gas sensor reactions, this review focuses on studies that employ electronic structure calculations, which primarily concentrate on using density functional theory. Computational studies have been useful in elucidating the reaction mechanism, binding strength, charge transfer as well as other electronic and structural properties of the nanomaterials and the gas-sensor interaction. Despite these studies there are still significant areas of research that need to be pursued that will assist in the link between theoretical and experimental findings, as well as advancing the current chemical and physical understanding of these novel materials. A summary and outlook for future directions of this exciting area of research is also provided. © 2011 Elsevier Ltd. All rights reserved.
McDonald S.J.,La Trobe University
The Cochrane database of systematic reviews | Year: 2013
Policies for timing of cord clamping vary, with early cord clamping generally carried out in the first 60 seconds after birth, whereas later cord clamping usually involves clamping the umbilical cord more than one minute after the birth or when cord pulsation has ceased. The benefits and potential harms of each policy are debated. To determine the effects of early cord clamping compared with late cord clamping after birth on maternal and neonatal outcomes We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (13 February 2013). Randomised controlled trials comparing early and late cord clamping. Two review authors independently assessed trial eligibility and quality and extracted data. We included 15 trials involving a total of 3911 women and infant pairs. We judged the trials to have an overall moderate risk of bias. Maternal outcomes: No studies in this review reported on maternal death or on severe maternal morbidity. There were no significant differences between early versus late cord clamping groups for the primary outcome of severe postpartum haemorrhage (risk ratio (RR) 1.04, 95% confidence interval (CI) 0.65 to 1.65; five trials with data for 2066 women with a late clamping event rate (LCER) of ~3.5%, I(2) 0%) or for postpartum haemorrhage of 500 mL or more (RR 1.17 95% CI 0.94 to 1.44; five trials, 2260 women with a LCER of ~12%, I(2) 0%). There were no significant differences between subgroups depending on the use of uterotonic drugs. Mean blood loss was reported in only two trials with data for 1345 women, with no significant differences seen between groups; or for maternal haemoglobin values (mean difference (MD) -0.12 g/dL; 95% CI -0.30 to 0.06, I(2) 0%) at 24 to 72 hours after the birth in three trials. Neonatal outcomes: There were no significant differences between early and late clamping for the primary outcome of neonatal mortality (RR 0.37, 95% CI 0.04 to 3.41, two trials, 381 infants with a LCER of ~1%), or for most other neonatal morbidity outcomes, such as Apgar score less than seven at five minutes or admission to the special care nursery or neonatal intensive care unit. Mean birthweight was significantly higher in the late, compared with early, cord clamping (101 g increase 95% CI 45 to 157, random-effects model, 12 trials, 3139 infants, I(2) 62%). Fewer infants in the early cord clamping group required phototherapy for jaundice than in the late cord clamping group (RR 0.62, 95% CI 0.41 to 0.96, data from seven trials, 2324 infants with a LCER of 4.36%, I(2) 0%). Haemoglobin concentration in infants at 24 to 48 hours was significantly lower in the early cord clamping group (MD -1.49 g/dL, 95% CI -1.78 to -1.21; 884 infants, I(2) 59%). This difference in haemoglobin concentration was not seen at subsequent assessments. However, improvement in iron stores appeared to persist, with infants in the early cord clamping over twice as likely to be iron deficient at three to six months compared with infants whose cord clamping was delayed (RR 2.65 95% CI 1.04 to 6.73, five trials, 1152 infants, I(2) 82%). In the only trial to report longer-term neurodevelopmental outcomes so far, no overall differences between early and late clamping were seen for Ages and Stages Questionnaire scores. A more liberal approach to delaying clamping of the umbilical cord in healthy term infants appears to be warranted, particularly in light of growing evidence that delayed cord clamping increases early haemoglobin concentrations and iron stores in infants. Delayed cord clamping is likely to be beneficial as long as access to treatment for jaundice requiring phototherapy is available.
Vaux D.L.,La Trobe University
Biochimica et Biophysica Acta - Molecular Cell Research | Year: 2011
When cells kill themselves, they usually do so by activating mechanisms that have evolved specifically for that purpose. These mechanisms, which are broadly conserved throughout the metazoa, involve two processes: activation in the cytosol of latent cysteine proteases (termed caspases), and disruption of mitochondrial functions. These processes are linked in a number of different ways. While active caspases can cleave proteins in the mitochondrial outer membrane, and cleave and thereby activate certain pro-apoptotic members of the Bcl-2 family, proteins released from the mitochondria can trigger caspase activation and antagonise IAP family proteins. This review will focus on the pro-apoptotic molecules that are released from the mitochondria of cells endeavouring to kill themselves. This article is part of a Special Issue entitled Mitochondria: the deadly organelle. © 2010 Elsevier B.V.
Cumming G.,La Trobe University
Psychological Science | Year: 2014
We need to make substantial changes to how we conduct research. First, in response to heightened concern that our published research literature is incomplete and untrustworthy, we need new requirements to ensure research integrity. These include prespecification of studies whenever possible, avoidance of selection and other inappropriate data-analytic practices, complete reporting, and encouragement of replication. Second, in response to renewed recognition of the severe flaws of null-hypothesis significance testing (NHST), we need to shift from reliance on NHST to estimation and other preferred techniques. The new statistics refers to recommended practices, including estimation based on effect sizes, confidence intervals, and meta-analysis. The techniques are not new, but adopting them widely would be new for many researchers, as well as highly beneficial. This article explains why the new statistics are important and offers guidance for their use. It describes an eight-step new-statistics strategy for research with integrity, which starts with formulation of research questions in estimation terms, has no place for NHST, and is aimed at building a cumulative quantitative discipline. © The Author(s) 2013.
Barbaro J.,La Trobe University
Autism : the international journal of research and practice | Year: 2013
The Social Attention and Communication Study involved the successful implementation of developmental surveillance of the early markers of autism spectrum disorders in a community-based setting. The objective in the current study was to determine the most discriminating and predictive markers of autism spectrum disorders used in the Social Attention and Communication Study at 12, 18 and 24 months of age, so that these could be used to identify children with autism spectrum disorders with greater accuracy. The percentage of 'yes/no' responses for each behavioural marker was compared between children with autistic disorder (n = 39), autism spectrum disorder (n = 50) and developmental and/or language delay (n = 20) from 12 to 24 months, with a logistic regression also conducted at 24 months. Across all ages, the recurring key markers of both autistic disorder and autism spectrum disorder were deficits in eye contact and pointing, and from 18 months, deficits in showing became an important marker. In combination, these behaviours, along with pretend play, were found to be the best group of predictors for a best estimate diagnostic classification of autistic disorder/autism spectrum disorder at 24 months. It is argued that the identified markers should be monitored repeatedly during the second year of life by community health-care professionals.