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Stojanovski D.,La Trobe Institute for Molecular Science | Bohnert M.,Albert Ludwigs University of Freiburg | Pfanner N.,Albert Ludwigs University of Freiburg | van der Laan M.,Albert Ludwigs University of Freiburg
Cold Spring Harbor Perspectives in Biology | Year: 2012

A protein's function is intimately linked to its correct subcellular location, yet the machinery required for protein synthesis is predominately cytosolic. Howproteins are trafficked through the confines of the cell and integrated into the appropriate cellular compartments has puzzled and intrigued researchers for decades. Indeed, studies exploring this premise revealed elaborate cellular protein translocation and sorting systems, which ensure that all proteins are shuttled to the appropriate cellular destination, where they fulfill their specific functions. This holds true for mitochondria, where sophisticated molecular machines serve to recognize incoming precursor proteins and integrate them into the functional framework of the organelle. We summarize the recent progress in our understanding of mitochondrial protein sorting and the machineries and mechanisms that mediate and regulate this highly dynamic cellular process essential for survival of virtually all eukaryotic cells. © 2012 Cold Spring Harbor Laboratory Press. Source


Vaux D.L.,Walter and Eliza Hall Institute | Vaux D.L.,La Trobe Institute for Molecular Science
BioEssays | Year: 2011

According to the somatic mutation theory (SMT), cancer begins with a genetic change in a single cell that passes it on to its progeny, thereby generating a clone of malignant cells. It is strongly supported by observations of leukemias that bear specific chromosome translocations, such as Burkitt's lymphoma, in which a translocation activates the c-myc gene, and chronic myeloid leukemia (CML), in which the Philadelphia chromosome causes production of the BCR-ABL oncoprotein. Although the SMT has been modified and extended to encompass tumor suppressor genes, epigenetic inheritance, and tumor progression through accumulation of further mutations, perhaps the strongest validation comes from the successful treatment of certain malignancies with drugs that directly target the product of the mutant gene. © 2011 WILEY Periodicals, Inc. Source


Richards A.F.,La Trobe Institute for Molecular Science | Beavers C.M.,Lawrence Berkeley National Laboratory
Dalton Transactions | Year: 2012

A cationic, pentanuclear aluminium phosphonate cage, [L4Al 5Cl6(THF)6]Cl, 1, supported by (phthalimidomethyl) phosphonate, (L), has been synthesized and characterized. This polynuclear cage features the phosphonate ligand in an unusual coordination mode, supporting five aluminium atoms in two different environments. In comparison, the aqueous reaction of LH2 with In(ClO4) 3 afforded [{(LH)In(H2O)}(H2O) 2(ClO4)]n, 2, an indium(iii) phosphonate coordination polymer, that has been crystallographically characterized. Reactions of the corresponding phosphonate ester, diethyl (phthalimidomethyl) phosphonate, (L′), with GaI3 and InCl3 afforded the simple coordination complexes, [L′·GaI3], 3, and [L′·InCl3(THF)], 4. © 2013 The Royal Society of Chemistry. Source


Beavers C.M.,Lawrence Berkeley National Laboratory | Prosverin A.V.,Texas A&M University | Cashion J.D.,Monash University | Dunbar K.R.,Texas A&M University | Richards A.F.,La Trobe Institute for Molecular Science
Inorganic Chemistry | Year: 2013

The reaction of 2-pyridylphosphonic acid (LH2) with iron(II) perchlorate and iron(III) nitrate afforded an interconnected, double-layered, cationic iron cage, [{Fe36L44(H2O) 48}]20+ (1a), the largest interconnected, polynuclear ferric cage reported to date. Magnetic studies on 1a revealed antiferromagnetic coupling between the spins on adjacent FeIII ions. © 2013 American Chemical Society. Source


Gregori M.,CSIC - Institute of Marine Research | Roura A.,La Trobe Institute for Molecular Science | Abollo E.,Centro Tecnologico El Mar | Gonzalez A.F.,CSIC - Institute of Marine Research | Pascual S.,CSIC - Institute of Marine Research
Journal of Natural History | Year: 2015

The euphausiid Nyctiphanes couchii and an unidentified mysid have been found, for the first time, with third-stage larvae (L3) of the Anisakis simplex complex in the mesozooplanktonic community of the coastal upwelling system in Galicia (NW Spain). Parasite larvae were molecularly identified using the internal transcribed spacer (ITS) region. The prevalence of these parasites in the euphausiid population was 0.0019%. The existence of parasites in a variety of mesozooplankton organisms suggests that the transmission routes of A. simplex sensu stricto and A. pegrefii are wider than expected. The results suggest that these two Anisakis species are not specific to their intermediate hosts. Finally, the recruitment of A. simplex complex may be affected by oceanography, differing under upwelling or downwelling conditions. © 2014 Taylor & Francis. Source

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