Sacco Luigi Sacco Hospital

Milano, Italy

Sacco Luigi Sacco Hospital

Milano, Italy
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Truffi M.,University of Milan | Colombo M.,University of Milan Bicocca | Penaranda-Avila J.,University of Milan Bicocca | Sorrentino L.,University of Milan | And 10 more authors.
Nanomedicine | Year: 2017

Aim: We investigate MAdCAM-1 as a reliable target to detect active bowel inflammation for selective noninvasive nanodiagnostics. Materials & methods: We coupled anti-MAdCAM-1 antibodies to manganese oxide nanoparticles, and analyzed nanoconjugate biodistribution and safety in murine model of inflammatory bowel disease by imaging and histology. Results: Nanoparticles were stable and nontoxic. Upon administration in colitic mice, anti-MAdCAM-1 functionalized nanoparticles preferentially localized in the inflamed bowel, whereas untargeted nanoparticles were more rapidly washed out. Nanoparticles did not induce lesions in nontarget organs. Conclusion: Anti-MAdCAM-1 functionalized nanoparticles detected active bowel inflammation foci, accurately following MAdCAM-1 expression pattern. These nanoconjugates could be a promising noninvasive imaging system for an early and accurate follow-up in patients affected by acute colitis. © 2017 Future Medicine Ltd.

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