Eastern Ukrainian National University

Luts’k, Ukraine

Eastern Ukrainian National University

Luts’k, Ukraine
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Ukrainets I.V.,National Pharmaceutical University | Mospanova E.V.,Eastern Ukrainian National University | Davidenko A.A.,Vinnitsa National Medical University
Pharmaceutical Chemistry Journal | Year: 2014

With the aim of identifying new biologically active substances with antihypoxic actions, the methyl ester of 4-hydroxy-6,7-dimethoxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid was reacted with dialkylaminoalkylamines for the targeted synthesis of a series of corresponding N-R-amides, obtained as hydrochlorides with good solubility in water. Primary pharmacological screening demonstrated structural-biological relationships of importance for future testing. As essentially nontoxic substances, several of the resulting amides showed high antihypoxic effects. One of these compounds, 3-(morpholin-4-yl)-propylamide 4-hydroxy-6,7-dimethoxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid hydrochloride, is suitable for further pharmacological testing as a potential antioxidant. © 2014, Springer Science+Business Media New York.


Reshak A.H.,University of West Bohemia | Reshak A.H.,University Malaysia Perlis | Reshak A.H.,University of South Bohemia | Tan S.T.,National University of Malaysia | And 6 more authors.
International Journal of Electrochemical Science | Year: 2014

ZnO nanorods with controlled-surface density have been successfully obtained by simply varying the concentration of the growth solution. It was found that the variation in the growth solution concentration may vary the surface density of the ZnO nanorods arrays grown on the surface. The lowest concentration produces the lowest nanorods surface density. The photoinduced second harmonic generation was studied for the nanosecond Er:glass lasers at wavelength 1540 nm and induced by bicolour treatment at 1540/770 nm wavelengths. The nonlinear dependence on the Ag NP presence was observed. And it s was substantially higher than for the pure ZnO nanoparticles. © 2014 The Authors.

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