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Kitakyushu, Japan

Kyushu Nutrition Welfare University is a private university in Kitakyushu, Fukuoka, Japan, established in 2001. Wikipedia.

Kakoi C.,National Institute of Fitness and Sports in Kanoya | Udo H.,Kyushu University | Matsukawa T.,Mikakuto Co. | Ohnuki K.,Kyushu Nutrition Welfare University
Biomedical Research (Japan) | Year: 2012

The present study examined the effects of enzymatically hydrolyzed collagen peptides on the level of hippocampal neurogenesis and emotional behavior in adult mice. For this purpose, two kinds of enzymatically hydrolyzed collagen peptides, the lower or higher molecular weight peptides (LP: below 2,000, HP: about 30,000) were administered orally to C57BL/6 mice for 4 weeks. As a result, the density of proliferating cells in subgranular zone of hippocampus showed a 1.2-fold increase in LP mice as compared with HP mice. Additionally, LP mice spent less time in closed arms than HP mice in elevated plus maze test to examine anxiety-related behavior. These results suggest that oral administration of the lower molecular weight peptides derived from collagen enhanced the hippocampal neurogenesis and exerted emotional behavior in adult mice. Source

Ohmine S.,Kyushu Rehabilitation College | Kimura Y.,Kyushu Nutrition Welfare University | Saeki S.,University of Occupational and Environmental Health Japan | Hachisuka K.,University of Occupational and Environmental Health Japan
Prosthetics and Orthotics International | Year: 2012

Background: There were no recent reports of community-based surveys on the incidence, level and causes of amputation in Japan.Objectives: To identify any changes in the incidence, level, causes of amputation and gender distribution.Study Design: A community-based survey.Methods: The subjects were Kitakyushu-citizens amputated between 2001 and 2005 and selected based on medical certificates for the physically disabled person's certificate.Results: The incidence of amputation (/100,000 population per year) was 6.9 overall, 1.4 for upper limbs and 5.8 for lower limbs. The average age at amputation was 63.5 ± 20.1 years and the male:female ratio was 1.9:1. The most frequent levels of amputations were partial hand amputation (84.4%) for upper limbs, and transtibial amputation (42.3%) and transfemoral amputation (36.8%) for lower limbs. The major causes were injuries (54.3%) for upper limbs, and peripheral vascular disorder (49.0%) and diabetes mellitus with peripheral circulatory complications (28.6%) for lower limbs.Conclusions: The incidence of amputation was 6.9 overall, 1.4 for upper limbs and 5.8 for lower limbs, and the male:female ratio was 1.9:1. In comparison to a previous survey the percentages of amputation due to peripheral circulatory disorders and injuries increased and decreased, respectively, and the rate of female amputations increased.Clinical relevanceThis study provides useful data about change of the recent epidemiology of amputation in Kitakyushu, Japan. These data are essential to perform clinical practices in amputation rehabilitation, including prescription of prosthesis, general fatigue for aged amputees, and complication of peripheral circulatory disorders. © The International Society for Prosthetics and Orthotics 2012. Source

Kita T.,Kyushu Nutrition Welfare University | Asanuma M.,Okayama University of Science | Miyazaki I.,Okayama University of Science | Takeshima M.,Okayama University of Science | Takeshima M.,Ehime University
Journal of Pharmacological Sciences | Year: 2014

The specific toxicity to dopaminergic neurons of psychostimulants and neurotoxins has been extensively studied in vivo and in vitro, and findings have been used to establish animal models of amphetamine psychosis or Parkinson's disease. The multiple mechanisms of neurotoxicity operating in these disorders are known to involve oxidative stress or neuroinflammation, producing the characteristic behavioral and neuropathlogical changes arising from injured dopaminergic neurons and glial cells. A number of studies have shown that glia-targeting antioxidants play important roles in protecting against the neurotoxicity caused by psychostimulants or neurotoxins. Phytochemicals, which are non-nutritive plant chemicals, protect dopaminergic neurons and glial cells from damage caused by psychostimulants or neurotoxins. The objective of this review was to evaluate the involvement of glial cells in dopaminergic neuron-specific toxicity and to explore the neuroprotective activity of phytochemicals in terms of anti-inflammatory and antioxidant action. © The Japanese Pharmacological Society. Source

Ando S.,Fukuoka University | Mitsuyasu K.,Fukuoka University | Soeda Y.,Fukuoka University | Hidaka M.,Fukuoka University | And 5 more authors.
Journal of Peptide Science | Year: 2010

A series of Trp and Arg analogs of antibacterial indolicidin (Ind) was synthesized and the antimicrobial and hemolytic activities were investigated. [L9]Ind, [L11]Ind, [K8,L9]Ind and [K6,8,L9]Ind showed desirable characteristics, exhibiting negligible hemolytic activity while keeping strong antibacterial activity. The results indicated that the Trp residue at position 11 essentially contributes to both activities and one can not be exchanged for the other, whereas the Trp residues at positions 4 and 9 play important roles in antimicrobial and hemolytic activities, respectively. The Trp residues at positions 6 and 8 play no important roles in biological activities. We then found that the retro analog of Ind showed higher antibacterial activity than Ind against both Gram-positive and Gram-negative bacteria but remarkably lower hemolytic activity than that of Ind. Copyright © 2010 European Peptide Society and John Wiley & Sons, Ltd. Source

Watanabe T.,University of Shizuoka | Ohnuki K.,Kyushu Nutrition Welfare University | Kobata K.,Josai University
Expert Opinion on Drug Metabolism and Toxicology | Year: 2011

Introduction: Capsinoids are nonpungent compounds that are found in almost all pungent peppers and are abundant in the sweet pepper cultivar CH-19 Sweet. Since the discovery of capsinoids 13 years ago, various physiological effects of these compounds - especially reduction of visceral fat - have been observed both in rodents and humans. Recently, capsules containing capsinoids have become commercially available and comprehensive studies have been performed on the metabolism and toxicity of capsinoids. Areas covered: This article reviews all the literature from 1998 to date providing details on the nature and physiological effects of capsinoids. In addition to this, the article also looks at their metabolism as well as their acute and chronic toxicity including their genotoxicity and teratology. Expert opinion: Capsinoids are the most promising compounds among all known transient receptor potential vanilloid 1 agonists. The physiological activities of capsinoids are similar to those of capsaicin, the most pungent food component of red pepper, but appear to be much safer to use as a therapeutic compound. That said, there is still a need for further research into the capsinoid mechanism of action before it can be green-lighted for therapeutic use. © 2011 Informa UK, Ltd. Source

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