Kyushu Cancer Center Hospital

Fukuoka-shi, Japan

Kyushu Cancer Center Hospital

Fukuoka-shi, Japan
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Kikuchi A.,Teikyo University | Hasegawa D.,St Lukes International Hospital | Ohtsuka Y.,Hyogo Medical College | Hamamoto K.,Red Cross | And 4 more authors.
British Journal of Haematology | Year: 2012

We report the outcome of 16 children with refractory anaemia with excess of blasts (RAEB; n = 4) and RAEB in transformation (RAEB-T; n = 12) following induction therapy with etoposide, cytarabine and mitoxantrone (ECM) prior to haematopoietic stem cell transplantation (HSCT). The median observation period was 77 months (range 5-123). Complete remission rate was 81% following induction; no toxic deaths occurred. Eight-year event-free survival and overall survival was 50% and 56%, respectively. None of the three patients with a complex karyotype survived, suggesting karyotype is a crucial prognostic factor for survival. This study indicates the safety and high remission rate of ECM and high survival rates after HSCT for paediatric RAEB and RAEB-T. © 2012 Blackwell Publishing Ltd.

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