Calabasas, CA, United States

Time filter

Source Type

Comppositions directed to the purification of deoxycholic acid and its salts are provided. A first composition consists of deoxycholic acid or a salt thereof and a mixture of one or more C1-3-alcohols and methylene chloride. A second composition consists of deoxycholic acid or a salt thereof and a mixture of one or more C1-3-alcohols and deionized water.


Patent
Johns Hopkins University and Kythera Biopharmaceuticals | Date: 2015-10-30

Compositions and method for augmenting tissue after delivery to localized area. The compositions include a hydrogel and a dermal filler. The hydrogel can polymerize and/or crosslink upon a first trigger event. The dermal filler can also optionally crosslink upon a second trigger event.


Patent
Kythera Biopharmaceuticals | Date: 2014-11-04

Synthetic methods for preparing deoxycholic acid and intermediates thereof, high purity synthetic deoxycholic acid, compositions and methods of use are provided. Also, provided are processes for the synthesis of 12-keto or 12--hydroxysteroids from -9,11-ene, 11-keto or 11-hydroxy--steroids. This inversion is also directed to novel compounds prepared during the synthesis. This invention is also directed to the synthesis of deoxycholic acid starting from hydrocortisone.


Patent
Kythera Biopharmaceuticals | Date: 2016-04-06

Synthesis of deoxycholic acid (DCA)


Patent
Kythera Biopharmaceuticals | Date: 2014-02-07

The present application is directed to an aqueous pharmaceutical formulation comprising less than about 5% w/v sodium deoxycholate maintained at a pH sufficient to substantially inhibit precipitation of the sodium deoxycholate. Also disclosed herein, are methods for inhibiting precipitation of sodium deoxycholate in an aqueous solution comprising less than about 5% w/v of sodium deoxycholate, said method comprising maintaining pH of the solution of from at least about 8.0 to about 8.5.


Patent
Kythera Biopharmaceuticals | Date: 2015-06-05

Bile acids and related compositions and methods of synthesis and use. More specifically, deoxycholic acid and related compositions, said compositions being free of all moieties of animal origin and free of pyrogenic moieties.


Patent
Kythera Biopharmaceuticals | Date: 2014-05-28

The present application is directed to an aqueous pharmaceutical composition comprising from about 0.4% w/v to less than about 2% w/v of a salt of deoxycholic acid, wherein the composition is maintained at a pH from about 8.1 to about 8.5 such that the composition is stabilized against precipitation. Also disclosed herein, are methods for stabilizing an aqueous pharmaceutical composition comprising from about 0.4% w/v to less than about 2% w/v of a salt of deoxycholic acid against precipitation, said method comprising maintaining pH of the solution from about 8.1 to about 8.5.


Compositions of deoxycholic acid (DCA) containing a steroidal DCA precursor or by-product containing a 12.beta.-hydroxy group (in particular 12.beta.-DCA) and their use in a cosmetic method of non-surgical removal of undesirable fat deposits.


Patent
Kythera Biopharmaceuticals | Date: 2015-04-24

Synthetic methods for preparing deoxycholic acid and intermediates thereof are provided.


Patent
Kythera Biopharmaceuticals | Date: 2015-08-20

Bile acids and related compositions and methods of synthesis and use. More specifically, deoxycholic acid and related compositions, said compositions being free of all moieties of animal origin and free of pyro-genic moieties.

Loading Kythera Biopharmaceuticals collaborators
Loading Kythera Biopharmaceuticals collaborators