Kyoto University , or Kyodai is a national university located in Kyoto, Japan. It is the second oldest Japanese university, one of the highest ranked universities in Asia and one of Japan's National Seven Universities. One of Asia’s leading research-oriented institutions, Kyoto University is famed for producing world-class researchers, including ten Nobel Prize laureates, two Fields medalists and one Gauss Prize. Wikipedia.
Japan Tobacco Inc. and Kyoto University | Date: 2016-03-16
[PROBLEM] The problem to be solved by the invention is to provide a novel pharmaceutical use of a JAK inhibitor. [SOLUTION MEANS] A therapeutic or preventive agent for a skin disease selected from the group consisting of senile xerosis, asteatosis, eczema and contact dermatitis, containing a JAK inhibitor as an active ingredient. [EFFECT] The followings are found: a JAK inhibitor increases the expression amounts of filaggrin, loricrin, involucrin and -defensin 3 as skin barrier function-related proteins; a JAK inhibitor significantly increases NMF production in a Tape Stripping-treated mouse; and a JAK inhibitor significantly accelerates a reduction in TEWL in a dry skin mouse model, namely improves the skin barrier function. The JAK inhibitor can be used as an active ingredient of a therapeutic or preventive agent for skin diseases such as senile xerosis, asteatosis, eczema, contact dermatitis, ichthyosis vulgaris, Netherton syndrome, type B peeling skin syndrome, etc.
Kyoto University | Date: 2016-08-24
A translational control method using an RNA-protein interaction motif is provided. The method comprises a step of introducing an mRNA having: a 5UTR regulation structure comprising: (1) a cap structure at the 5 terminus, (2) a spacer positioned on the 3 side of the cap structure, and (3) one or more RNA motifs positioned on the 3 side of the spacer, which comprises an RNA-protein interaction motif-derived nucleotide sequence or a variant thereof; and a nucleotide sequence encoding a target protein gene on the 3 side of the 5UTR regulation structure, into a cell in the presence of a protein specifically binding to the RNA motifs, wherein a translational level is decreased as the number of bases of the spacer decreases, and the translational level is decreased as the number of the RNA motifs increases.
Panasonic and Kyoto University | Date: 2016-10-11
An electrolytic: solution for electrochemical devices includes: a salt consisting of a bifluoride anion and a cation.; a compound containing boron; and an organic solvent.
Kyoto University | Date: 2017-04-26
In an information terminal processing device 1 of a first user, after selection of a content on a prescribed experience by the first user, content identification information is output to an information terminal device 3 of a second user B, and various information thereof is transmitted to a server device 3. In an information terminal device 2 of a second user B, after the content identification information is input, a unique key corresponding to the content identification information is generated, information on the input date and time and/or the input location of the content identification information is transmitted to the server device 3. In the server device 3, after collating unique keys, the input date and time and/or the input location of the content identification information are defined as a shared date and time and/or a shared location of the content, and the shared experience information is constructed to make a database thereof.
Nihon Medi Physics Co., Kyoto University and National Hospital Organization | Date: 2017-05-03
Provided is a compound represented by general formula (1) or a salt thereof as well as a medicine containing the compound or the salt. (In the formula, R_(1) represents a hydrogen atom or CO_(2)R_(a); R_(2) represents a hydrogen atom, a halogen atom, or CO_(2)R_(a); R_(3) represents a hydrogen atom or a C1-10 hydroxyalkyl group; R_(4) represents a hydrogen atom, a hydroxy group, or a C1-10 alkoxy group; R_(5) represents a C1-5 chain alkyl group in which the hydrogen atoms are optionally substituted with halogen atoms, a C3-5 cyclic alkyl group in which the hydrogen atoms are optionally substituted with halogen atoms, a C1-5 hydroxyalkyl group, or an o-, p-, or m-halobenzyl group; A represents CH or a nitrogen atom; X_(1) and X_(3) independently represent hydrogen atoms or halogen atoms; X_(2) represents a hydrogen atom, a halogen atom, or a nitrile group; at least one of X_(1), X_(2), and X_(3) represents a halogen atom; and R_(a) independently represents a C1-10 alkyl group.)
Kyoto University | Date: 2017-05-17
The present invention relates to a method for determining prognosis of cancer in a subject, which comprises the step of detecting phosphorylation of a tyrosine residue at position 2681 of TRIO in a sample obtained from the subject.
Kyoto University and Thyas Co. | Date: 2017-05-24
Provided is a method for inducing T cells for a cell-based immunotherapy, comprising the steps of:(1) providing Rag 1 and/or Rag2 gene knockout human pluripotent stem cells bearing genes encoding a T cell receptor specific for a desired antigen, and(2) inducing T cells from the pluripotent stem cells of step (1). Further provided are a cell-based immunotherapy method that uses the T cells for the cell-based immunotherapy and an iPS cell bank for the cell-based immunotherapy.
Kyoto University | Date: 2017-05-24
A method for extracting differentiated cells from a cell population comprising undifferentiated cells after induction of the differentiation of pluripotent stem cells. A method for extracting differentiated cells from a cell population, comprising the following steps: (1) a step of introducing, into a cell population, mRNA comprising a marker gene operably linked to the target sequence of miRNA specifically expressed in pluripotent stem cells; and (2) a step of extracting cells in which the marker gene has been translated.
Kyoto University | Date: 2017-01-04
The present invention provides a process for thermal crosslinking of polymers of intrinsic microporosity (PIMs) by heat treatment of PIMs under controlled oxygen concentration.
Kyoto University | Date: 2017-05-31
An RNA and protein delivery system utilizing an RNA-protein complex having a higher-order structure, and an RNA-protein complex having a novel higher-order structure.