Kyoto University , or Kyodai is a national university located in Kyoto, Japan. It is the second oldest Japanese university, one of the highest ranked universities in Asia and one of Japan's National Seven Universities. One of Asia’s leading research-oriented institutions, Kyoto University is famed for producing world-class researchers, including ten Nobel Prize laureates, two Fields medalists and one Gauss Prize. Wikipedia.
Ohno H.,Kyoto University
Chemical Reviews | Year: 2014
A number of new and useful methodologies for the synthesis of vinylaziridines and ethynylaziridines have been developed. Vinylaziridines can be generally synthesized in two steps, with the vinyl group being constructed following formation of the aziridine ring. The addition of a nitrene equivalent to a conjugated diene is a traditional method for direct synthesis of aziridines. Reagent-controlled asymmetric induction for the synthesis of vinylaziridines was reported in 2000, where the reaction of oximes with a chloroallyl phosphonic diamide anion derived led to formation of cis-N-alkoxy-2-alkenylaziridines in a enantiomerically pure form. The strained aziridine ring at the reactive allylic/propargylic position provides efficient levels of reactivity toward a range of transformations, including stereoselective nucleophilic ring opening reactions, as well as rearrangement and cycloaddition reactions to yield a variety of nitrogen-containing molecules. Source
Iwai K.,Kyoto University
Trends in Cell Biology | Year: 2012
Nuclear factor-kappa B (NF-κB) is a transcription factor involved in a wide variety of phenomena including inflammation, immune responses, and cell survival. Abnormal activation of NF-κB occurs in many pathological conditions, such as allergic and auto-inflammatory diseases and malignancies. As a result, the signal-induced NF-κB activation pathway has been extensively studied and revealed to be regulated by ubiquitination. Several types of polyubiquitin chains exist and the type of chain seems to impact how ubiquitinated proteins are regulated. Recently, different types of polyubiquitin chains, including linear (M1) and K11 chains, have been implicated in NF-κB activation. This review discusses existing evidence of the differential roles played by various ubiquitin chains, particularly K63, M1, and K11 chains, in NF-κB activation. © 2012 Elsevier Ltd. Source
Takada S.,Kyoto University
Current Opinion in Structural Biology | Year: 2012
Recently, we saw a dramatic increase in the number of researches that rely on coarse-grained (CG) simulations for large biomolecules. Here, first, we briefly describe recently developed and used CG models for proteins and nucleic acids. Balance between structure-based and physico-chemical terms is a key issue. We also discuss the multiscale algorithms used to derive CG parameters. Next, we comment on the dynamics used in CG simulations with an emphasis on the importance of hydrodynamic interactions. We then discuss the pros and cons of CG simulations. Finally, we overview recent exciting applications of CG simulations. Publicly available tools and software for CG simulations are also summarized. © 2012 Elsevier Ltd. Source
Toyota Jidosha Kabushiki Kaisha and Kyoto University | Date: 2015-07-31
An object of the present invention is to provide a liquid electrolyte for a fluoride ion battery with improved fluoride ion stability. By providing a liquid electrolyte for a fluoride ion battery comprising a fluoride salt and a diol compound in which one or two ether bonds are disposed between two OH groups, the present invention achieves the aforementioned object.
ARKRAY Inc. and Kyoto University | Date: 2015-03-30
A precursor of molecular probe for imaging of pancreatic islets is provided. A polypeptide represented by any one of the following formulae (1) to (4), or a polypeptide having a homology with the foregoing polypeptide.