Kyoto, Japan
Kyoto, Japan

Kyoto University , or Kyodai is a national university located in Kyoto, Japan. It is the second oldest Japanese university, one of the highest ranked universities in Asia and one of Japan's National Seven Universities. One of Asia’s leading research-oriented institutions, Kyoto University is famed for producing world-class researchers, including ten Nobel Prize laureates, two Fields medalists and one Gauss Prize. Wikipedia.


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Patent
Japan Tobacco Inc. and Kyoto University | Date: 2016-03-16

[PROBLEM] The problem to be solved by the invention is to provide a novel pharmaceutical use of a JAK inhibitor. [SOLUTION MEANS] A therapeutic or preventive agent for a skin disease selected from the group consisting of senile xerosis, asteatosis, eczema and contact dermatitis, containing a JAK inhibitor as an active ingredient. [EFFECT] The followings are found: a JAK inhibitor increases the expression amounts of filaggrin, loricrin, involucrin and -defensin 3 as skin barrier function-related proteins; a JAK inhibitor significantly increases NMF production in a Tape Stripping-treated mouse; and a JAK inhibitor significantly accelerates a reduction in TEWL in a dry skin mouse model, namely improves the skin barrier function. The JAK inhibitor can be used as an active ingredient of a therapeutic or preventive agent for skin diseases such as senile xerosis, asteatosis, eczema, contact dermatitis, ichthyosis vulgaris, Netherton syndrome, type B peeling skin syndrome, etc.


Patent
Kyoto University, Tokyo Medical, Dental University and Kagoshima University | Date: 2014-12-18

Provided is a pain-related compound, a pain-related pharmaceutical composition, and use of the same. Provided in one or more embodiments is a compound represented by Formula (I), a prodrug of the same, or a pharmaceutically permissible salt of any of the same.


A composition for producing a fiber, containing (A) a polymer compound containing a unit structure represented by the formula (1) and a unit structure represented by the formula (2), (B) a crosslinking agent, (C) an acid compound, and (D) a solvent wherein each symbol in the formulas (1) and (2) is as described in the DESCRIPTION.


Patent
Kyoto University | Date: 2016-08-24

A translational control method using an RNA-protein interaction motif is provided. The method comprises a step of introducing an mRNA having: a 5UTR regulation structure comprising: (1) a cap structure at the 5 terminus, (2) a spacer positioned on the 3 side of the cap structure, and (3) one or more RNA motifs positioned on the 3 side of the spacer, which comprises an RNA-protein interaction motif-derived nucleotide sequence or a variant thereof; and a nucleotide sequence encoding a target protein gene on the 3 side of the 5UTR regulation structure, into a cell in the presence of a protein specifically binding to the RNA motifs, wherein a translational level is decreased as the number of bases of the spacer decreases, and the translational level is decreased as the number of the RNA motifs increases.


Patent
Toyota Jidosha Kabushiki Kaisha and Kyoto University | Date: 2016-08-08

An object of the present invention is to provide a fluoride ion battery in which excess voltage at the time of charging is decreased. The present invention achieves the object by providing a fluoride ion battery comprising a cathode active material layer containing a cathode active material, an anode active material layer containing an anode active material, and an electrolyte layer formed between the cathode active material layer and the anode active material layer; wherein the anode active material is an alloy containing at least a Ce element and a Pb element.


Patent
Toyota Jidosha Kabushiki Kaisha and Kyoto University | Date: 2016-08-31

A main object of the present invention is to provide an anode current collector that is capable of inhibiting the reaction with liquid electrolyte. The present invention achieves the object by providing an anode current collector to be used for a fluoride ion battery; and the anode current collector being a simple substance of Fe, Mg, or Ti, or an alloy containing one or more of these metal elements.


Patent
Tanaka Kikinzoku Kogyo K.K. and Kyoto University | Date: 2014-01-30

The present invention provides an alloy for medical use including an AuPt alloy, in which the AuPt alloy has a Pt concentration of 24 mass % or more and less than 34 mass % with the balance being Au, and has at least a material structure in which a Pt-rich phase having a Pt concentration higher than that of an -phase is distributed in an -phase matrix, the Pt-rich phase has a Pt concentration that is 1.2 to 3.8 times the Pt concentration of the -phase, and the Pt-rich phase has an area ratio of 1 to 22% in any cross-section. This alloy is an artifact-free alloy material that exhibits excellent compatibility with a magnetic field environment such as an MRI and has magnetic susceptibility of 4 ppm with respect to magnetic susceptibility of water.


Conventionally, it has been impossible to output an image that allows for an easy and accurate diagnosis as to whether or not a malignant tumor is present and that allows for correctly indicating a part with a high or low grade of malignancy in the tumor. With an image processing apparatus that includes: a receiving unit configured to receive diffusion weighted images; a parameter acquisition unit configured to acquire parameters of two or more types for each of one or more units of processing that constitute the diffusion weighted images, by using the diffusion weighted images; a diagnostic image composition unit configured to acquire, for each of the one or more units of processing, a score that corresponds to the parameters of two or more types, by using the parameters of two or more types, and to compose a diagnostic image that is an image having, for each of the one or more units of processing, a pixel value that corresponds to the acquired score that corresponds to the unit of processing; and an output unit configured to output the diagnostic image, it is possible to output an image that allows for an easy and accurate diagnosis as to whether or not a malignant tumor is present and that allows for correctly indicating a part with a high or low grade of malignancy in the tumor.


Patent
Kyoto University and Kobe Digital Labo Inc. | Date: 2015-02-17

The invention aims to provide a relationship evaluation system capable of effectively evaluating a relationship of a node to a reference node in a relationship graph in which plural nodes are connected by links. A reference point node is selected based on selection information regarding the reference point node input from the selection information input unit. Based on the reference point node, a relationship graph becoming an evaluation target is extracted from the relationship graph database to create a virtual communication network based on the graph. In the virtual communication network, simulation is executed by sequentially propagating a virtual communication packet to adjacent nodes from a reference point node selected by the reference point node selection unit as propagation origin. The relationship of the node to the reference node is evaluated based on the content of the communication packet received at the node as a result of executing the simulation.


Patent
Denso Corporation and Kyoto University | Date: 2016-07-27

A proton conductor includes a coordination polymer having stoichiometrically metal ions, oxoanions, and proton coordinating molecules capable of undergoing protonation or deprotonation. The coordination polymer including coordination entities that are repeatedly coordinated to bond the coordination entities with one another. Each coordination entity is either a first coordination entity or a second coordination entity. The first coordination entity is one metal ion of the metal ions coordinated with either at least one oxoanion of the oxoanions or at least one proton coordinating molecule of the proton coordinating molecules. The second coordination entity is the metal ion coordinated with each of at least one oxoanion of the oxoanions and at least one proton coordinating molecule of the proton coordinating molecules. At least a part of the proton conductor is non-crystalline. The proton conductor has high ion conductivity at high temperature.


Patent
GS Yuasa International Ltd. and Kyoto University | Date: 2016-07-19

A storage battery includes a negative electrode including, as an active material, at least one of a metal capable of forming a dendrite and a metal compound thereof, a positive electrode, a separator, and an electrolyte containing an additive. In the storage battery, a concentration of the additive in the electrolyte in a region on a side of the negative electrode defined by the separator is higher than a concentration of the additive in a region on a side of the positive electrode.


Patent
GS Yuasa International Ltd. and Kyoto University | Date: 2016-07-19

An alkaline storage battery contains: a positive electrode; a negative electrode containing, as an active material, at least one of a metal capable of forming a dendrite and a metal compound thereof; and an alkaline electrolyte. The alkaline electrolyte contains a compound which is a chain saturated hydrocarbon at least partially having a hydrophilic functional group other than a hydroxyl group and having a molecular weight of 400 or more and less than 220000 in an amount of less than 15 g per 100 mL of the electrolyte.


Patent
Kyoto University, Toyota Jidosha Kabushiki Kaisha and Honda Corporation | Date: 2014-12-19

A secondary battery in which the difference between the voltage at the time of discharging and the voltage at the time of charging is small, ensuring good energy efficiency, and the charge/discharge life is long. Therefore, in order to attain the above-described object, a secondary battery containing a positive electrode, a negative electrode, and an electrolytic solution, wherein at least one of the positive electrode and the negative electrode contains, as the active material, at least one selected from the group consisting of a metal ion-containing fluoride, a metal oxide, a metal sulfide, a metal nitride, and a metal phosphide; the electrolytic solution contains an anion receptor; and the anion receptor forms a salt or a complex with an anion contained in the active material, thereby enabling the active material to dissolve in the electrolytic solution.


A novel genetic factor for rheumatoid arthritis is searched for and used as a diagnostic marker. A method of testing for rheumatoid arthritis, comprising detecting an autoantibody to myelin basic protein in a biological sample from a subject. A test kit for rheumatoid arthritis, comprising myelin basic protein. A diagnostic marker for rheumatoid arthritis, comprising an antibody to myelin basic protein. A method of judging the risk to develop rheumatoid arthritis, comprising identifying the single nucleotide polymorphism of a nucleotide present in the myelin basic protein gene of a subject or identifying the single nucleotide polymorphism of a nucleotide that is in linkage disequilibrium with the first mentioned nucleotide. A kit for judging the risk to develop rheumatoid arthritis, comprising nucleic acid probes and/or nucleic acid primers capable of detecting the single nucleotide polymorphism of a nucleotide present in the myelin basic protein gene of a subject or the single nucleotide polymorphism of a nucleotide that is in linkage disequilibrium with the first mentioned nucleotide. A method of screening for a substance effective as a prophylactic and/or therapeutic for rheumatoid arthritis, comprising adding a test substance to a myelin basic protein gene-expressing cell and then determining the expression level of the myelin basic protein gene or the gene product thereof.


An object of the present invention is to provide a technology of dispersing cellulose readily in a hydrophobic substance such as a resin by treating cellulose being a hydrophilic substance in a system that contains water as a main medium with a polymer dispersant, which has been developed for dispersing a fine and hydrophobic substance such as a pigment, in a simple and efficient manner without conducting surface modification of nanocellulose or other treatments. The object is solved by a process for producing a readily dispersible cellulose composition, the process including dissolving a polymer dispersant having a block copolymer structure having a resin-affinitive segment A and a cellulose-adsorptive segment B in a hydrophilic organic solvent solution, adding a surface active agent to the resultant solution, thereafter adding water to the resultant mixture to prepare an aqueous dispersion treatment agent containing the polymer dispersant, and adding the obtained aqueous dispersion treatment agent to cellulose in a water-containing state or in a dry state, thereby obtaining a readily dispersible cellulose composition. The object is also solved by a process for producing an aqueous dispersion treatment agent for use in the process for producing a readily dispersible cellulose composition, the readily dispersible cellulose composition, and a cellulose-dispersed resin composition using the readily dispersible cellulose composition.


Conventionally, it has been impossible to output an image that allows for an easy and accurate diagnosis as to whether or not a malignant tumor is present and that allows for correctly indicating a part with a high or low grade of malignancy in the tumor. With an image processing apparatus that includes: a receiving unit configured to receive diffusion weighted images; a parameter acquisition unit configured to acquire parameters of two or more types for each of one or more units of processing that constitute the diffusion weighted images, by using the diffusion weighted images; a diagnostic image composition unit configured to acquire, for each of the one or more units of processing, a score that corresponds to the parameters of two or more types, by using the parameters of two or more types, and to compose a diagnostic image that is an image having, for each of the one or more units of processing, a pixel value that corresponds to the acquired score that corresponds to the unit of processing; and an output unit configured to output the diagnostic image, it is possible to output an image that allows for an easy and accurate diagnosis as to whether or not a malignant tumor is present and that allows for correctly indicating a part with a high or low grade of malignancy in the tumor.


Patent
Kyoto University and ARKRAY Inc. | Date: 2017-01-04

Provided is a radioactive labeled compound that can detect a secondary mutation of an epidermal growth factor receptor and which is a compound represented by Formula (1) described below or a pharmaceutically acceptable salt thereof. In Formula (1), L_(1) is an alkanediyl group having 1 to 5 carbon atoms or an alkenediyl carbonyl group having 3 to 8 carbon atoms, R_(1) is a radioactive halogen atom, or 5- to 7-membered monocyclic nitrogen-containing heterocycloalkyl that may have one substituent, R_(2) is a 6- to 8-membered aryl group or nitrogen-containing heteroaryl group with one substituent, R_(1) or R_(2) contains a radioactive halogen atom or a radioactive carbon atom (^(11)C), and Y is -NH- or -O-.


The present invention provides a microfluidic device comprising at least one cell culture chamber, the or each chamber being connected to at least two openings, the device being configured to supply at least one physiologically active substance from at least one of the openings to the or each cell culture chamber in such a manner as to form a concentration gradient or concentration gradients in the or each chamber when cells and a hydrogel are introduced into the or each chamber to culture the cells in a 3D-gel medium.


Patent
Sumitomo Heavy Industries and Kyoto University | Date: 2017-03-01

Provided is a neutron capture therapy system which can improve a therapeutic efficacy. A neutron capture therapy system (1) in which a patient (S) is irradiated with a neutron beam (N) includes an irradiation chamber (3) which is surrounded by a shielding wall (W) blocking the neutron beam (N) from being radiated from the inside to the outside of the chamber and in which the patient (S) is arranged inside the chamber and is irradiated with the neutron beam (N), a neutron beam irradiation unit (8) that irradiates the inside of the irradiation chamber (3) with the neutron beam (N), a shielding door (D1) that closes a gate (3b) provided in the shielding wall (W), a medicine supply pump (17) that supplies a medicine to the patient (S), and a medicine supply tube (18) through which the medicine is introduced from the medicine supply pump (17) to the patient (S) arranged inside the irradiation chamber (3). The medicine supply pump (17) has a control unit (17a) which controls a supply quantity of the medicine and is arranged outside the irradiation chamber (3).


Patent
Kyoto University, Tohoku University and Ohki | Date: 2017-03-29

The present invention provides a method for preparing a graft material containing organ or tissue cells, the cells including cells having inhibited PHLDA3 expression.


Patent
Kyoto University | Date: 2017-01-25

An object display system for a relationship graph includes an object information reception unit (102) that receives object information from a terminal device, a node conversion unit (103) that converts the object information into a corresponding node and sets the node as a reference point node, a relationship graph extraction unit (104) that extracts a relationship graph containing the reference point node from a relationship graph database (20), a node relationship evaluation unit (105) that evaluates the relationship of each node to a reference point node by scores of two types of evaluation indexes, an object arrangement unit (106) that converts each node into a corresponding object and arranges each object converted from each node while making scores of two types of evaluation indexes by the node relationship evaluation unit (105) correspond to a two-dimensional coordinate, and an object output unit (107) that outputs each object to the terminal device.


Patent
Kyoto University, Tokyo Medical and Dental University | Date: 2017-02-01

A pharmaceutical composition for neovascular diseases, a pharmaceutical composition for inhibiting an angiogenic growth factor, and use of these pharmaceutical compositions are provided. In one or more embodiments, a pharmaceutical composition contains as an active ingredient a low molecular weight compound that is able to suppress the expression of the VEGF gene in cells or to reduce the production of VEGF protein from cells. In one or more embodiments, a pharmaceutical composition contains as an active ingredient a compound expressed by the following formula (I) or a prodrug thereof or pharmaceutically acceptable salts thereof


The method for producing a surface-modified base material according to the present invention includes a step of bringing a base material having a polar group present on a surface thereof into contact with a hydrosilane compound having a molecular structure A and having a Si-H group composed of a silicon atom of the molecular structure A and a hydrogen atom bonded to the silicon atom in the presence of a borane catalyst so as to allow a dehydrocondensation reaction to take place between the base material and the compound, thereby forming the base material surface-modified with the molecular structure A. This production method is capable of surface-modifying a base material at a lower temperature in a shorter time than conventional methods and allows a wide variety of options for the form, type, and application of the base material, the mode of the modification reaction, and the type of the molecular structure with which the base material is surface-modified.


An object of the present invention is to provide a high-performance polymer dispersant that can be applied to cellulose being a hydrophilic substance, and another object of the present invention is to provide a technology for practical application of obtaining a cellulose-dispersed resin composition that realizes stable dispersion of cellulose in a simpler manner and in an environmentally conscious manner that never uses a large amount of organic solvents when the polymer dispersant for cellulose is applied to cellulose and disperses the cellulose in a thermoplastic resin. These objects are achieved by providing a polymer dispersant for cellulose, being a polymer compound including a block copolymer structure having a resin-affinitive segment A and a cellulose-adsorptive segment B, the polymer compound synthesized by a reversible chain transfer catalyzed polymerization (RTCP) method not using any of a heavy metal, a nitroxide compound, and a sulfur-based compound, using an organic iodine compound as an initiation compound, and using a phosphorus compound, a nitrogen compound, an oxygen compound, or a carbon compound as a catalyst.


Patent
Kyoto University | Date: 2017-02-01

An object of the present invention is to provide a medium that comprises fewer protein components and enables the maintenance of pluripotent stem cells in an undifferentiated state. The culture medium for pluripotent stem cells comprises a GSK3 inhibitor (A) and a DYRK inhibitor (B).


Patent
Kuraray Co. and Kyoto University | Date: 2017-01-04

The present invention provides a device for producing a large number of uniform spheroids by an easy method. The spheroid-producing device (1) at least includes a first surface (11), a second surface (12), and a plurality of wall surfaces (13). The second surface (12) faces the first surface (11). The respective wall surfaces (13) constitute a plurality of holes penetrating through the first surface and the second surface. In addition, an equivalent diameter of inscribed circles of openings in the first surface (11) is greater than an equivalent diameter of inscribed circles of openings in the second surface (12).


The present invention provides a method for inducing cardiac differentiation of a pluripotent stem cell, which comprises the steps of (1) culturing a pluripotent stem cell in a medium containing a WNT signaling activator and a PCK activator and (2) culturing the cell after the step (1) in a medium containing a WNT signaling inhibitor, a Src inhibitor, and an EGFR inhibitor.


Patent
Kyoto University and ARKRAY Inc. | Date: 2017-01-04

Provided is a radioactive labeled compound that can detect a secondary mutation of an epidermal growth factor receptor and which is a compound represented by Formula (1) or a pharmaceutically acceptable salt thereof. In Formula (1), R_(1) is a group represented by Formula (a), (b) or (c), R_(2) is a group represented by Formula (d) or (e), and Y is -NH- or -O-.


Patent
Kyoto University | Date: 2017-01-25

An object of the present invention is to provide a novel method for sorting cardiomyocytes. Another object of the present invention is to provide a method for producing high-purity cardiomyocytes and a kit used therefor. The present invention provides a method for sorting cardiomyocytes, comprising a step of introducing miRNA-responsive mRNA into a cell group, wherein the miRNA-responsive mRNA consists of a sequence comprising the following (i) and (ii):(i) a nucleic acid specifically recognized by miRNA specifically expressed in cardiomyocytes, and(ii) a nucleic acid corresponding to the coding region of a gene, wherein translation of (ii) the nucleic acid corresponding to the coding region of a gene into protein is regulated by the nucleic acid sequence in (i) above, thereby achieving the aforementioned objects.


Provided is a method for generating pancreatic bud cells, having the step of culturing PDX1^(+)/NKX6.1^(-) cells in a medium containing KGF, EGF and a BMP inhibitor. The culturing step may be performed in suspension cultures or in adherent cultures. When the cells are cultured in adherent cultures, the cells may be cultured in a medium further containing a ROCK inhibitor or a nonmuscle myosin II inhibitor.


Patent
Kyoto University | Date: 2017-02-15

The present invention relates to a method for screening an inhibitor of ATP11C or CDC50A, comprising determining (a) exposure of phosphatidylserine on cell surface, (b) engulfment of cells by macrophages, or (c) cleavage of ATP11C by caspase. The present invention also relates to a method for inducing engulfment of cells by macrophages, comprising inhibiting ATP11C or CDC50A.


Patent
Kyoto University | Date: 2017-01-04

An object of the present invention is to provide a novel porous coordination polymer having superhydrophobicity. The present invention relates to a porous coordination polymer comprising:a divalent or trivalent metal ion; andan organic ligand represented by the following formula (1) :^(1), X^(2), and X^(3) are the same or different, and each represent CO_(2)^(-), CS_(2)^(-), PO_(3)^(2-), PO_(4)^(2-), AsO_(3)^(2-), AsO_(4)^(2-), SO_(3)^(-), SO_(4)^(-), SeO_(3)^(-), SeO_(4)^(-), TeO_(3)^(-), or TeO_(4)^(-); andR^(1), R^(2), R^(3), R^(4), R^(5), R^(6), R^(7), R^(8), R^(9), R^(10), R^(11), and R^(12) are the same or different, and each represent hydrogen or C_(1-20) alkyl;the metal ion and the organic ligand being alternately linked by a coordinate bond.


Yamada M.,Tokyo Gakugei University | Akasaka T.,University of Tsukuba | Nagase S.,Kyoto University
Chemical Reviews | Year: 2013

Carbenes are unquestionably powerful intermediates to functionalize fullerenes. Various carbene precursors are useful for reactions. The availability of widely diverse carbene precursors enriches the fullerene chemistry. Both electrophilic and nucleophilic carbenes are applicable reagents, giving the corresponding fullerene derivatives. The reaction mechanisms depend on the precursors and reaction conditions applied. A typical carbene reaction involves addition to a π bond of olefins, which is also the case for a π bond of fullerenes. It is also important to note that carbenes exhibit diverse reactivity. Singlet carbenes possess both electrophilic and nucleophilic character, whereas triplet carbenes show diradical reactivity. Dihalocarbene, because it is among the simplest and most representative carbene species, is widely used in synthetic chemistry. Diazo compounds are useful carbene transfer reagents to fullerenes.


Fujii K.,Kyoto University | Tokunaga Y.,Nippon Telegraph and Telephone
Physical Review Letters | Year: 2010

We propose a scalable way to construct a 3D cluster state for fault-tolerant topological one-way computation (TOWC) even if the entangling two-qubit gates succeed with a small probability. It is shown that fault-tolerant TOWC can be performed with the success probability of the two-qubit gate such as 0.5 (0.1) provided that the unheralded error probability of the two-qubit gate is less than 0.040% (0.016%). Furthermore, the resource usage is considerably suppressed compared to the conventional fault-tolerant schemes with probabilistic two-qubit gates. © 2010 The American Physical Society.


Patent
Kyoto University and Hamamatsu Photonics K K | Date: 2011-06-21

A semiconductor surface light-emitting element of this invention is provided with a photonic crystal layer 6 obtained by periodically forming a plurality of holes H in a basic layer 6A comprised of a first compound semiconductor of the zinc blende structure and growing embedded regions 6B comprised of a second compound semiconductor of the zinc blende structure, in the holes H, and an active layer 4 to supply light to the photonic crystal layer 6, in which a principal surface of the basic layer 6A is a (001) plane and in which side faces of each hole H have at least three different {100} facets.


Patent
Kyoto University and NEC Corp | Date: 2012-06-13

Provided is a nonvolatile magnetic device that is capable of realizing low power consumption by performing writing with a voltage and is also excellent in retention characteristics. The nonvolatile magnetic device includes a nonvolatile magnetic element. The nonvolatile magnetic element includes: a first free layer made of a ferromagnetic substance; a first insulating layer made of an insulator, the first insulating layer being provided to be connected to the first free layer; a charged layer provided adjacent to the first insulating layer; a second insulating layer made of an insulator, the second insulating layer being provided adjacent to the charged layer; and an injection layer provided adjacent to the second insulating layer. The charged layer is smaller in electric resistivity than both of the first insulating layer and the second insulating layer. The injection layer is smaller in electric resistivity than the second insulating layer.


Patent
University of Tokyo, Kyoto University and OK Laboratory Co. | Date: 2013-09-12

Provided is a chemical analysis device to analyze a chemical composition of a sample, including a main body including a laser light source, a chemical analysis unit, and a housing; an optical head that is arranged to be faced to the sample; and a pressureproof-feedthrough-equipped fiber that is extended from the housing to the optical head to guide laser light emitted from the laser light source to the optical head. The housing houses the laser light source and the chemical analysis unit as having a pressure-resistant function. The optical head includes a mirror system that causes the sample to be irradiated with laser light outgoing from the pressureproof-feedthrough-equipped fiber and to cause plasma emission light occurring at the sample owing to irradiation with the laser light to reenter to the pressureproof-feedthrough-equipped fiber. The chemical analysis unit performs spectroscopic analysis on the plasma emission light that reentered to the pressureproof-feedthrough-equipped fiber.


Patent
Hamamatsu Photonics K K and Kyoto University | Date: 2012-02-29

The present edge-emitting semiconductor layer element includes two-dimensional photonic crystals 4 formed in a semiconductor layer, and when one direction of a contact region of an electrode 8 is provided as a length direction (X-direction) and a direction perpendicular to both of the length direction and a thickness direction of a substrate is provided as a width direction (Y-direction), the two-dimensional photonic crystals 4 are, when viewed from a direction (Z-axis) perpendicular to the substrate, located in a region containing the electrode contact region and wider in the width direction than the contact region, and have a refractive index periodic structure in which the refractive index satisfies a Braggs diffraction condition while periodically changing at every interval along the one direction (X-axis).


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: SPA.2013.2.1-01 | Award Amount: 3.22M | Year: 2013

GENIUS is designed to boost the impact of the next European breakthrough in astrophysics, the Gaia astrometric mission. Gaia is an ESA Cornerstone mission scheduled for launch in October 2013 and aims at producing the most accurate and complete 3D map of the Milky Way to date. A pan-European consortium named DPAC is working on the implementation of the Gaia data processing, of which the final result will be a catalogue and data archive containing more than one billion objects. The archive system containing the data products will be located at the European Space Astronomy Centre (ESAC) and will serve as the basis for the scientific exploitation of the Gaia data. The design, implementation, and operation of this archive are a task that ESA has opened up to participation from the European scientific community. GENIUS is aimed at significantly contributing to this development based on the following principles: an archive design driven by the needs of the user community; provision of exploitation tools to maximize the scientific return; ensuring the quality of the archive contents and the interoperability with existing and future astronomical archives (ESAC, ESO, ...); cooperation with the only other two astrometric missions in the world, nanoJASMINE and JASMINE (Japan); and last but not least, the archive will facilitate outreach and academic activities to foster the public interest in science in general and astronomy in particular. GENIUS fits seamlessly into existing Gaia activities, exploiting the synergies with ongoing developments. Its members actively participate in these ongoing tasks and provide an in-depth knowledge of the mission as well as expertise in key development areas. Furthermore, GENIUS has the support of DPAC, several Gaia national communities in the EU member states, and will establish cooperation with the Japanese astrometric missions already mentioned.


Patent
Kyoto University and Sumitomo Electric Industries | Date: 2011-11-07

A separator (3) of a molten salt battery is impregnated with a molten salt that serves as the electrolyte. The molten salt contains, as cations, at least one kind of ions selected from among quaternary ammonium ions, imidazolium ions, imidazolinium ions, pyridinium ions, pyrrolidinium ions, piperidinium ions, morpholinium ions, phosphonium ions, piperazinium ions and sulfonium ions in addition to sodium ions. These cations do not have adverse effects on a positive electrode (1). In addition, the melting point of the molten salt, which contains sodium ions and the above-mentioned cations, is significantly lower than the operating temperature of sodium-sulfur batteries, said operating temperature being 280-360 DEG C. Consequently, the molten salt battery is capable of operating at lower temperatures than sodium-sulfur batteries.


Patent
Sumitomo Electric Industries and Kyoto University | Date: 2013-08-12

As a molten salt composition lacking a clear melting point and including a molten salt that can be suitably used as an electrolytic solution of a secondary battery, there is provided a molten salt composition including a mixture of two or more kinds of molten salts which can be used as an electrolytic solution of a secondary battery. Particularly, provided is a molten salt composition comprising two kinds of molten salts each having cations with ion diameters different from each other, composition ratio being set to a composition ratio within a range in which the molten salt composition lacks a melting point. Also provided is a secondary battery including the molten salt composition as an electrolytic solution, which can maintains an available state even when the temperature becomes low without rapidly becoming unavailable.


Patent
Kyoto University and Sumitomo Electric Industries | Date: 2012-05-09

An optical tomography device 1 is provided as one capable of obtaining tomographic information of a measuring object with higher accuracy. In the optical tomography device 1, numerical apertures of reception fibers 12, 13 are different from each other. Therefore, the device has a configuration wherein the reception fibers 12, 13 receive two kinds of respective light beams with different solid angle distributions, whereby the device can also obtain angular information, in addition to intensity information of light emerging from a measuring object 100. As a result, the accuracy is enhanced for an analysis about the tomographic information of the measuring object.


Patent
Kyoto University and Hamamatsu Photonics K K | Date: 2012-11-07

A semiconductor light emitting element includes an electrode 8, an active layer 3, a photonic crystal layer 4, and an electrode 9. Conductivity types between the active layer 3 and the electrode 8 and between the active layer 3 and the electrode 9 differ from each other. The electrode 8, the active layer 3, the photonic crystal layer 4, and the electrode 9 are stacked along the X-axis. The X-axis passes through a central part 8a2 of the opening 8a when viewed from the axis line direction of the X-axis. The end 9e1 of the electrode 9 and the end 8e1 of the opening 8a substantially coincide with each other when viewed from the axis line direction of the X-axis.


Patent
Sumitomo Electric Industries and Kyoto University | Date: 2014-03-19

An optical tomography device 1 is provided as one capable of obtaining tomographic information of a measuring object with higher accuracy. In the optical tomography device 1, numerical apertures of receiving fibers 12, 13 are different from each other. Therefore, the device has a configuration wherein the receiving fibers 12, 13 receive two kinds of respective light beams with different solid angle distributions, whereby the device can also obtain angular information, in addition to intensity information of light emerging from a measuring object 100. As a result, the accuracy is enhanced for an analysis about the tomographic information of the measuring object. Elected figure is Fig. 1.


Patent
Sumitomo Electric Industries and Kyoto University | Date: 2016-05-11

A molten salt battery comprising a battery case, a positive electrode, a separator, a negative electrode and a molten salt as an electrolyte, the positive electrode, the negative electrode and the separator being impregnated with the molten salt, wherein:the molten salt contains an anion having a chemical structure represented by a following formula (1):as cations, Na ion and K ion;the molten salt is a mixed salt between NaFSA in which the cation is Na ion and the anion is FSA ion, and KFSA in which the cation is K ion and the anion is FSA ion, FSA ion being bis(fluorosulfonyl)amide ion; andthe positive electrode contains, as active material, a metal oxide represented by a composition formula: Na_(x)M1_(y)M2_(1-y)O_(2), wherein M1 is Fe or Ni, M2 is Mn or Ti, x is a number satisfying 0 < x 1 and y is a number satisfying 0 < y < 1,characterised in that:the battery case is provided with an elastic body; and when the positive electrode or the negative electrode is expanded or shrunk due to charge and discharge, the change in the volume of the positive electrode or the negative electrode is absorbed by expansion and contraction of the elastic body.


Patent
Hamamatsu Photonics K K and Kyoto University | Date: 2015-02-04

The present invention relates to a cell evaluation method comprising evaluating a cell differentiation degree based on a cell thickness.


Patent
Sumitomo Electric Industries and Kyoto University | Date: 2014-06-10

From a first image indicating an intensity distribution of radiation from a subject 5 in a first wavelength region and a second image indicating an intensity distribution of radiation from the subject in a second wavelength region, a surgical microscope system 1 obtains image data of a third image indicating a position of a target substance. Output data obtained by superposing the image data of the third image onto form image data further includes information indicating the target substance in addition to the image indicating the surface form of the subject 5. Therefore, the position of the target substance existing on the inside of a tissue can be grasped non-invasively by referring to the output data.


Patent
Kyoto University and Sumitomo Electric Industries | Date: 2012-05-30

An induction heating apparatus includes a rotor having a rotation shaft, and a stator having a heating portion disposed at a distance from the rotor. A coil that generates magnetic flux in a direction of the heating portion is provided in the rotor. The heating portion is formed of a composite material of a magnetic material and a conductive material, and has a structure in which a magnetic material portion and a conductive material portion are combined. When the coil is in a position opposed to the heating portion, a cross-sectional area of the magnetic material portion is smaller than an area of linkage of magnetic flux generated by the coil in the heating portion, and the conductive material portion is disposed to surround a periphery of the magnetic material portion. A flow passage in which the heating medium circulates is provided in the heating portion.


Patent
Sumitomo Electric Industries and Kyoto University | Date: 2014-01-08

The molten salt used as an electrolyte of a molten salt battery is a mixed salt between a salt in which the anion is an ion represented by [R1-SO_(2)-N-SO_(2)-R_(2)]- such as FSA ion and the cation is Na ion, and a salt in which the cation is an alkali metal ion other than Na ion or an alkaline earth metal ion. The active material of a positive electrode 1 is a metal oxide represented by Na_(x)M1_(y)M2_(1-y)O_(2) (wherein M1 is Fe or Ni, M2 is Mn or Ti, 0 < x 1 and 0 < y < 1). The active material of the positive electrode 1 is, for example, Na_(2/13)Fe_(1/3)Mn_(2/3)O_(2). The molten salt battery operates at a low temperature, whereby time required for increasing the temperature of the battery to the operation temperature is reduced. The molten salt battery also has improved safety because the electrolyte is nonvolatile and nonflammable.


Patent
Hamamatsu Photonics K K and Kyoto University | Date: 2012-08-31

When an end-face-emitting photonic crystal laser element 10 is seen in an X axis, one end of an upper electrode E2 overlaps a laser light exit surface SF, the upper electrode E2 and an opposite end face SB are separated from each other, the upper electrode E2 is separated from both lateral end faces SR, SL, and one end of an active layer 3B overlaps the laser light exit surface SF.


Patent
Canon Kabushiki Kaisha, Kyoto University, Tokyo Institute of Technology, Tokyo University of Science, Yamanashi University, Japan National Institute of Advanced Industrial Science, Technology and Sophia University | Date: 2013-08-05

Provided is a piezoelectric material excellent in piezoelectricity. The piezoelectric material includes a perovskite-type complex oxide represented by the following General Formula (1). A(Zn_(x)Ti_((1-x)))_(y)M_((1-y))O_(3)(1) wherein A represents at least one kind of element containing at least a Bi element and selected from a trivalent metal element; M represents at least one kind of element of Fe, Al, Sc, Mn, Y, Ga, and Yb; x represents a numerical value satisfying 0.4x0.6; and y represents a numerical value satisfying 0.1y0.9.


Patent
Kyoto University and Sumitomo Electric Industries | Date: 2012-02-22

The molten salt used as an electrolyte of a molten salt battery is a mixed salt between a salt in which the anion is an ion represented by [R1-SO_(2)NSO_(2)R_(2)] such as FSA ion and the cation is Na ion, and a salt in which the cation is an alkali metal ion other than Na ion or an alkaline earth metal ion. The active material of a positive electrode 1 is a metal oxide represented by Na_(x)M1_(y)M2_(1-y)O_(2 )(wherein M1 is Fe or Ni, M2 is Mn or Ti, 0


Provided is a solid electrolyte made of yttrium-doped barium zirconate having hydrogen ion conductivity, a doped amount of yttrium being 15 mol% to 20 mol%, and a rate of increase in lattice constant at 100C to 1000C with respect to temperature changes being substantially constant. Also provided is a method for manufacturing the solid electrolyte. This solid electrolyte can be formed as a thin film, and a solid electrolyte laminate can be obtained by laminating electrode layers on this solid electrolyte. This solid electrolyte can be applied to an intermediate temperature operating fuel cell.


Patent
Kyoto University and Hamamatsu Photonics K K | Date: 2014-11-10

A surface emitting laser element capable of emitting a main beam and a sub-beam, and a monitoring light detection element capable of detecting a light intensity of the sub-beam are included, the surface emitting laser element is a PCSEL, the main beam and the sub-beam are emitted in an upward direction of the surface emitting laser element and are inclined to each other at a predetermined angle, and respective changes in a peak light intensity of the main beam and a peak light intensity of the sub-beam with respect to a value of a driving current of the surface emitting laser element are correlated with each other. Therefore, if an output of the monitoring light detection element indicating the peak light intensity of the sub-beam is used, the peak light intensity of the main beam can be estimated.


Patent
Sumitomo Electric Industries and Kyoto University | Date: 2013-10-09

A separator (3) of a molten salt battery is impregnated with a molten salt that serves as the electrolyte. The molten salt contains, as cations, at least one kind of ions selected from among quaternary ammonium ions, imidazolium ions, imidazolinium ions, pyridinium ions, pyrrolidinium ions, piperidinium ions, morpholinium ions, phosphonium ions, piperazinium ions and sulfonium ions in addition to sodium ions. These cations do not have adverse effects on a positive electrode (1). In addition, the melting point of the molten salt, which contains sodium ions and the above-mentioned cations, is significantly lower than the operating temperature of sodium-sulfur batteries, said operating temperature being 280-360 DEG C. Consequently, the molten salt battery is capable of operating at lower temperatures than sodium-sulfur batteries.


Patent
Kyoto University and Hamamatsu Photonics K K | Date: 2014-03-07

In a laser device, a different refractive index region 6B of a photonic crystal layer is arranged at a lattice point position of a square lattice. In the case where a plane shape of the different refractive index regions 6B is a nearly isosceles right triangle, two sides forming a right angle extend along longitudinal and horizontal lateral lines of the square lattice. A direction parallel to or vertical to an oblique side of the triangle and a direction of polarization in the periodic polarization inversion structure of a nonlinear optical crystal NL are the same.


Patent
Kyoto University and Hamamatsu Photonics K K | Date: 2014-02-27

A semiconductor laser element is realized with high beam quality (index M^(2)<1). A diffraction grating 6ba of a diffraction grating layer 6 extends along a principal surface 2a and is provided on a p-side surface 6a of the diffraction grating layer 6; the refractive index of the diffraction grating layer 6 periodically varies in directions extending along the principal surface 2a, in the diffraction grating 6ba; the diffraction grating 6ba has a plurality of holes 6b; the plurality of holes 6b are provided in the p-side surface 6a and arranged in translational symmetry along a square lattice R3; the plurality of holes 6b each have the same size and shape; each hole 6b corresponds to a lattice point of the diffraction grating 6ba and is of a triangular prism shape; a shape of a bottom face 6c of the hole 6b is an approximate right triangle.


Patent
Kyoto University and Hamamatsu Photonics K K | Date: 2014-05-14

The present invention discloses a method for evaluating vitality of a plant including (a) a step of measuring a delayed luminescence of a leaf of each plant of a group of plants subject to evaluation to obtain data of delayed luminescence amount, and (b) a step of processing data of a plurality of delayed luminescence amounts thus obtained to evaluate a plant exhibiting a delayed luminescence amount not less than a preset upper limit threshold as an individual of poor growth or evaluate a plant exhibiting a delayed luminescence amount not more than a preset lower limit threshold as an individual of good growth, and a measurement system and an evaluation system used for the method.


Patent
Sumitomo Electric Industries and Kyoto University | Date: 2014-02-21

A molten salt battery is provided which includes a positive electrode including a positive-electrode active material represented by the general formula: A_(n(1x))M^(1)_(nx)Fe_(1y)M^(2)_(y)P_(2)O_(7 )(wherein n is 1 or 2, 0x0.5, 0y0.5, A is an alkali metal element, M^(1 )is an element other than the element A, M^(2 )is an element other than Fe), a negative electrode including a negative-electrode active material, a separator interposed between the positive electrode and the negative electrode, and a molten salt electrolyte. The molten salt electrolyte contains 90% by mass or more of an ionic liquid containing a salt of the element A.


Patent
Sumitomo Electric Industries and Kyoto University | Date: 2015-02-04

Provided is a solid electrolyte laminate comprising a solid electrolyte layer having proton conductivity and a cathode electrode layer laminated on one side of the solid electrolyte layer and made of lanthanum strontium cobalt oxide (LSC). Also provided is a method for manufacturing the solid electrolyte. This solid electrolyte laminate can further comprise an anode electrode layer made of nickel-yttrium doped barium zirconate (Ni-BZY). This solid electrolyte laminate is suitable for a fuel cell operating in an intermediate temperature range less than or equal to 600C.


Patent
Sumitomo Electric Industries and Kyoto University | Date: 2013-03-26

Provided is a solid electrolyte laminate comprising a solid electrolyte layer having proton conductivity and a cathode electrode layer laminated on one side of the solid electrolyte layer and made of lanthanum strontium cobalt oxide (LSC). Also provided is a method for manufacturing the solid electrolyte. This solid electrolyte laminate can further comprise an anode electrode layer made of nickel-yttrium doped barium zirconate (NiBZY). This solid electrolyte laminate is suitable for a fuel cell operating in an intermediate temperature range less than or equal to 600 C.


Provided is a solid electrolyte made of yttrium-doped barium zirconate having hydrogen ion conductivity, a doped amount of yttrium being 15 mol % to 20 mol %, and a rate of increase in lattice constant at 100 C. to 1000 C. with respect to temperature changes being substantially constant. Also provided is a method for manufacturing the solid electrolyte. This solid electrolyte can be formed as a thin film, and a solid electrolyte laminate can be obtained by laminating electrode layers on this solid electrolyte. This solid electrolyte can be applied to an intermediate temperature operating fuel cell.


Patent
Kyoto University and Hamamatsu Photonics K K | Date: 2014-10-17

The present invention relates to a cell assessment method characterized in including an acquisition step of acquiring an optical path length image of a small cell clump, an extraction step of extracting a cell nucleus region within the acquired optical path length image, a comparison step of comparing an optical path length of an inside and an optical path length of an outside of the extracted cell nucleus region, and an assessment step of assessing whether or not a cell is a stem cell based on the comparison results.


Patent
Sumitomo Electric Industries, Kyoto University and Keio University | Date: 2012-03-21

The present invention relates to a blood vessel wall analyzing apparatus provided with a structure enabling accurate measurement of plaque components in a blood vessel wall in a state that reduces the burden on a patient. In the blood vessel wall analyzing apparatus (1), measurement light is illuminated onto a measured portion within a blood vessel such as a carotid artery (C) from a light illuminating unit (30) provided outside the blood vessel, while light from the measured portion is detected in a light receiving unit (40) provided outside the blood vessel. Thus, since the status of the blood vessel wall can be analyzed without inserting an apparatus involved in measurement into the blood vessel, the burden on the patient is reduced during measurement. In addition, as a result of carrying out measurement using near infrared light (a light component in the wavelength range of 780 nm to 2750 nm) that exhibits characteristics that differ according to the compositions of substances such as plaque adhered within the blood vessel, analyses can be carried out that distinguish compositions such as plaque using an analyzing apparatus provided outside the blood vessel.


Patent
Sumitomo Electric Industries and Kyoto University | Date: 2012-08-08

A battery (1) including a positive electrode (4), a negative electrode (3) mainly composed of sodium, and an electrolyte provided between the positive electrode (4) and the negative electrode (3), the electrolyte being molten salt containing anions expressed with chemical formula (I) below and cations of metal,^(1) and R^(2) in the chemical formula (I) above independently representing fluorine atom or fluoroalkyl group, the cations of metal containing at least one of at least one type of cations of alkali metal and at least one type of cations of alkaline-earth metal, as well as an energy system including the battery (1) are provided.


To realize a transmission function of power line communication by a further simplified and cost-effective circuit configuration, in a PLC modem installed in an electric appliance such as a household electrical appliance. A semiconductor switching element Sx that is present on an electric circuit connected to a power line is driven by a modulator unit (12). The modulator unit (12) controls ON/OFF operations of the semiconductor switching element Sx, to thereby cause a communication signal of a modulated rectangular wave to be output to the power line for a prescribed period.


Patent
Sumitomo Electric Industries and Kyoto University | Date: 2012-03-21

The present invention relates to a blood vessel inner wall analyzing apparatus provided with a structure for more accurately analyzing components of substances adhered to the inner walls of blood vessels. A blood vessel inner wall analyzing apparatus (1) is provided with illuminating means, detecting means and analyzing means. The illuminating means illuminates a light component in a measurement wavelength range of 1957 nm to 2713 nm onto a measured position from an end surface (30b) of a light illuminating fiber (30) inserted into a carotid artery (C). The detecting means receives a light component from a measured position through an end surface (40a) of a light receiving fiber (40) within the carotid artery (C). The light component to be detected is a light component in a detection wavelength range which extends 15 nm on both short and long sides of the selected center wavelength, with each one or more center wavelengths being selected from a wavelength group comprised of specific wavelengths respectively in the measurement wavelength range. The analyzing means analyzes for the presence or absence of substances differing from blood by using intensity information on the detected light component.


Patent
Sumitomo Electric Industries and Kyoto University | Date: 2014-06-24

A wind power generating system includes: a wind mill, an induction rotating machine coupled to a rotating shaft of the wind mill; a power converting device that supplies exciting current to the induction rotating machine; a heat medium circulating structure that circulates a heat medium that receives heat generated by the induction rotating machine; a heat accumulator that accumulates heat of the heat medium; a thermal power generator that converts, into electric power, the heat of the heat medium accumulated in the heat accumulator; and an armature control unit that controls the exciting current in accordance with electric power demand of an electric power system. The armature control unit performs one or both of power generation mode control in which the induction rotating machine is operated as a power generator and heat generation mode control in which the induction rotating machine is operated as a heat generator.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2009.8.0 | Award Amount: 3.78M | Year: 2010

In this project we set up an interdisciplinary consortium of computer scientists, physicists, economists and policy makers to deal with the problem of understanding and forecasting systemic risk and global financial instabilities. By leveraging on expertise in the various disciplines, we want to provide a novel integrated and network-oriented approach to the issue. On one hand, we will offer a theoretical framework to measure systemic risk in global financial market and financial networks. On the other hand, we will deliver an ICT collaborative platform for monitoring systemic fragility and the propagation of financial distress across institutions and markets around the world. Experts will be able to evaluate algorithms and models to forecast financial crises as well as visualise interactively possible future scenarios.


Patent
Hamamatsu Photonics K K and Kyoto University | Date: 2015-08-12

The present invention relates to a cell evaluation method comprising evaluating a cell differentiation degree based on a cell thickness.


Patent
Kyoto University and Sumitomo Electric Industries | Date: 2012-08-08

An element recovery method and an element recovery apparatus are provided by which an element containing a high-purity rare earth element can be recovered at low cost. The element recovery method includes the steps of: preparing molten salt containing a rare earth element; and controlling electric potentials in a pair of electrode members at prescribed values while keeping the pair of electrode members in contact with the molten salt, thereby depositing the rare earth element existing in the molten salt on one of the pair of electrode members. In this way, as compared with the conventional wet separation method, an element such as a rare earth element that is to be recovered can be directly recovered from the molten salt in which the element is dissolved, so that the steps of the recovery method can be simplified and reduced in cost.


Grant
Agency: GTR | Branch: EPSRC | Program: | Phase: Training Grant | Award Amount: 3.99M | Year: 2014

The Scottish Doctoral Training Centre in Condensed Matter Physics, known as the CM-DTC, is an EPSRC-funded Centre for Doctoral Training (CDT) addressing the broad field of Condensed Matter Physics (CMP). CMP is a core discipline that underpins many other areas of science, and is one of the Priority Areas for this CDT call. Renewal funding for the CM-DTC will allow five more annual cohorts of PhD students to be recruited, trained and released onto the market. They will be highly educated professionals with a knowledge of the field, in depth and in breadth, that will equip them for future leadership in a variety of academic and industrial careers. Condensed Matter Physics research impacts on many other fields of science including engineering, biophysics, photonics, chemistry, and materials science. It is a significant engine for innovation and drives new technologies. Recent examples include the use of liquid crystals for displays including flat-screen and 3D television, and the use of solid-state or polymeric LEDs for power-saving high-illumination lighting systems. Future examples may involve harnessing the potential of graphene (the worlds thinnest and strongest sheet-like material), or the creation of exotic low-temperature materials whose properties may enable the design of radically new types of (quantum) computer with which to solve some of the hardest problems of mathematics. The UKs continued ability to deliver transformative technologies of this character requires highly trained CMP researchers such as those the Centre will produce. The proposed training approach is built on a strong framework of taught lecture courses, with core components and a wide choice of electives. This spans the first two years so that PhD research begins alongside the coursework from the outset. It is complemented by hands-on training in areas such as computer-intensive physics and instrument building (including workshop skills and 3D printing). Some lecture courses are delivered in residential schools but most are videoconferenced live, using the well-established infrastructure of SUPA (the Scottish Universities Physics Alliance). Students meet face to face frequently, often for more than one day, at cohort-building events that emphasise teamwork in science, outreach, transferable skills and careers training. National demand for our graduates is demonstrated by the large number of companies and organisations who have chosen to be formally affiliated with our CDT as Industrial Associates. The range of sectors spanned by these Associates is notable. Some, such as e2v and Oxford Instruments, are scientific consultancies and manufacturers of scientific equipment, whom one would expect to be among our core stakeholders. Less obviously, the list also represents scientific publishers, software houses, companies small and large from the energy sector, large multinationals such as Solvay-Rhodia and Siemens, and finance and patent law firms. This demonstrates a key attraction of our graduates: their high levels of core skills, and a hands-on approach to problem solving. These impart a discipline-hopping ability which more focussed training for specific sectors can complement, but not replace. This breadth is prized by employers in a fast-changing environment where years of vocational training can sometimes be undermined very rapidly by unexpected innovation in an apparently unrelated sector. As the UK builds its technological future by funding new CDTs across a range of priority areas, it is vital to include some that focus on core discipline skills, specifically Condensed Matter Physics, rather than the interdisciplinary or semi-vocational training that features in many other CDTs. As well as complementing those important activities today, our highly trained PhD graduates will be equipped to lay the foundations for the research fields (and perhaps some of the industrial sectors) of tomorrow.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: HEALTH-2009-2.1.1-1 | Award Amount: 13.70M | Year: 2010

Genetic studies in model organisms and humans, including human genome-wide association studies, have pinpointed genomic regions that contribute susceptibility to common disease. However, to date, these data have provided limited insights into the genes, molecular pathways and mechanisms underlying disease pathophysiology. The EU FP6 Euratools consortium has been a remarkable success that established significant research collaborations, expertise and infrastructure in the EU, making a major contribution to the rat focus issue of Nature Genetics (Volume 40, May 2008), which featured six papers from the consortium. These successes underpin the current project in which we will use state-of-the-art and emerging large-scale technologies and advanced computation in an expanded multi-disciplinary approach to identify gene networks and genomic mechanisms underlying common diseases. We will use the rat as a model system to identify the major functional pathways underlying human inflammatory, cardiovascular and metabolic, and behavioral disorders. Our consortium brings together world class investigators who will use next-generation sequencing technologies to generate genomic, transcriptomic and epigenomic datasets. To this, we will add cutting-edge, quantitative metabonomic and proteomic datasets to give significant depth of coverage, at multiple levels, across pathophysiological phenotypes. These datasets will be gathered, annotated and integrated in relational and dynamic models that will be used in comparative analyses to understand human gene function at the level of the molecule, cell, tissue and organism. These studies will lead to new insights into disease mechanisms, through an integrative, cross-disciplinary approach to understanding large-scale functional genomic datasets in rats and humans.


Irie M.,Rikkyo University | Fukaminato T.,Hokkaido University | Matsuda K.,Kyoto University | Kobatake S.,Osaka City University
Chemical Reviews | Year: 2014

Chemical bond rearrangement during the phototransformation induces electronic as well as geometrical structure changes of the molecules. The molecular structure changes can be applied to various photonic devices. The electronic structure changes can be applied to optical memory media and various photoswitching devices. On the other hand, the geometrical structure changes can be applied to light-driven actuators and others. The photochromic diarylethene was serendipitously discovered during the course of study on photoresponsive polymers a quarter of a century ago. Various types of polymers having photoisomerizable chromophores, such as spiropyran, azobenzene, or stilbene, in the side or main chains, have been prepared in an attempt to change their conformation by photoirradiation.


Lutz J.-F.,Charles Sadron Institute | Ouchi M.,Kyoto University | Liu D.R.,Howard Hughes Medical Institute | Sawamoto M.,Kyoto University
Science | Year: 2013

Sequence-controlled polymers are macromolecules in which monomer units of different chemical nature are arranged in an ordered fashion. The most prominent examples are biological and have been studied and used primarily by molecular biologists and biochemists. However, recent progress in protein- and DNA-based nanotechnologies has shown the relevance of sequence-controlled polymers to nonbiological applications, including data storage, nanoelectronics, and catalysis. In addition, synthetic polymer chemistry has provided interesting routes for preparing nonnatural sequence-controlled polymers. Although these synthetic macromolecules do not yet compare in functional scope with their natural counterparts, they open up opportunities for controlling the structure, self-assembly, and macroscopic properties of polymer materials.


Kanehisa M.,Kyoto University | Goto S.,Kyoto University | Sato Y.,Fujitsu Limited | Kawashima M.,Fujitsu Limited | And 2 more authors.
Nucleic Acids Research | Year: 2014

In the hierarchy of data, information and knowledge, computational methods play a major role in the initial processing of data to extract information, but they alone become less effective to compile knowledge from information. The Kyoto Encyclopedia of Genes and Genomes (KEGG) resource (http://www.kegg.jp/ or http://www.genome.jp/kegg/) has been developed as a reference knowledge base to assist this latter process. In particular, the KEGG pathway maps are widely used for biological interpretation of genome sequences and other high-throughput data. The link from genomes to pathways is made through the KEGG Orthology system, a collection of manually defined ortholog groups identified by K numbers. To better automate this interpretation process the KEGG modules defined by Boolean expressions of K numbers have been expanded and improved. Once genes in a genome are annotated with K numbers, the KEGG modules can be computationally evaluated revealing metabolic capacities and other phenotypic features. The reaction modules, which represent chemical units of reactions, have been used to analyze design principles of metabolic networks and also to improve the definition of K numbers and associated annotations. For translational bioinformatics, the KEGG MEDICUS resource has been developed by integrating drug labels (package inserts) used in society. © 2013 The Author(s). Published by Oxford University Press.


Matsuoka M.,Kyoto University | Jeang K.-T.,National Institute of Allergy and Infectious Diseases
Oncogene | Year: 2011

The human T-cell leukemia virus type 1 (HTLV-1) was the first retrovirus discovered to be causative of a human cancer, adult T-cell leukemia. The transforming entity of HTLV-1 has been attributed to the virally-encoded oncoprotein, Tax. Unlike the v-onc proteins encoded by other oncogenic animal retroviruses that transform cells, Tax does not originate from a c-onc counterpart. In this article, we review progress in our understanding of HTLV-1 infectivity, cellular transformation, anti-sense transcription and therapy, 30 years after the original discovery of this virus. © 2011 Macmillan Publishers Limited All rights reserved.


Strober W.,National Institute of Allergy and Infectious Diseases | Watanabe T.,Kyoto University
Mucosal Immunology | Year: 2011

Nucleotide-binding oligomerization domain 2 (NOD2) is an intracellular sensor for small peptides derived from the bacterial cell wall component, peptidoglycan. Recent studies have uncovered unexpected functions of NOD2 in innate immune responses such as induction of type I interferon and facilitation of autophagy; moreover, they have disclosed extensive cross-talk between NOD2 and Toll-like receptors, which has an indispensable role both in host defense against microbial infection and in the development of autoimmunity. Of particular interest, polymorphisms of CARD15 encoding NOD2 are associated with Crohn's disease and other autoimmune states such as graft vs. host disease. In this review, we summarize recent findings regarding normal functions of NOD2 and discuss the mechanisms by which NOD2 polymorphisms associated with Crohn's disease lead to intestinal inflammation. © 2011 Society for Mucosal Immunology.


Puri S.,University of California at San Francisco | Akiyama H.,Kyoto University | Hebrok M.,University of California at San Francisco
Genes and Development | Year: 2013

Precise functioning of the pancreatic β cell is paramount to whole-body glucose homeostasis, and β-cell dysfunction contributes significantly to diabetes mellitus. Using transgenic mouse models, we demonstrate that deletion of the von Hippel-Lindau (Vhlh) gene (encoding an E3 ubiquitin ligase implicated in, among other functions, oxygen sensing in pancreatic β cells) is deleterious to canonical β-cell gene expression. This triggers erroneous expression of factors normally active in progenitor cells, including effectors of the Notch, Wnt, and Hedgehog signaling cascades. Significantly, an up-regulation of the transcription factor Sox9, normally excluded from functional β cells, occurs upon deletion of Vhlh. Sox9 plays important roles during pancreas development but does not have a described role in the adult β cell. β-Cell-specific ectopic expression of Sox9 results in diabetes mellitus from similar perturbations in β-cell identity. These findings reveal that assaults on the β cell that impact the differentiation state of the cell have clear implications toward our understanding of diabetes mellitus. © 2013 Puri et al.


Patent
Nippon Oil Corporation, Osaka Municipal Technical Research Institute and Kyoto University | Date: 2013-11-27

The present invention provides a fullerene derivative having an electron donating group adjacent to the fullerene nucleus, represented by formula (I) which exhibits a high LUMO energy and a high open circuit voltage based thereon and which is highly compatible with polymers and excellent in charge mobility and charge separation ability:_(60) or C_(70), Donor-Sub represents a substituent having at least one electron donating substituent atom located at a position apart from the fullerene nucleus by two bonds, R is hydrogen, Donor-Sub, an alkyl, cycloalkyl, alkoxy, alkoxy-substituted alkyl, alkoxy-substituted alkoxy, alkylthio-substituted alkoxy, alkylthio, alkylthio-substituted alkylthio, or alkoxy-substituted alkylthio group, having a total carbon atoms of 1 or more and 20 or fewer, or a benzyl or phenyl group, and n is an integer of 1 to 10.


Patent
Nippon Steel & Sumitomo Metal Corporation and Kyoto University | Date: 2015-09-09

An object of the present invention is to provide a porous polymer metal complex which can be used as a gas adsorbent and contains two or more types of similar ligands. A porous polymer metal complex is provided expressed by [CuX]_(n)(1) (in the Formula, X represents two or more types of isophthalic acid ions selected from the group consisting of isophthalic acid ions and isophthalic acid ions having a substituent at position 5, at least an amount of one type of X is 5 mol% to 95 mol% of the total number of moles of X, and n represents an assembly number of constituent units expressed by Clip and is not particularly limited.).


Patent
Kyoto University and Nippon Oil Corporation | Date: 2013-11-08

An organic semiconductor represented by the following formula (1). wherein Ar and Ar are or are not the same as each other and each of them is independently a cyclic compound having a conjugated structure; R and R are or are not the same as each other and each of them is independently one of a straight chain alkyl group, branched alkyl group, straight chain alkoxy group, branched alkoxy group, hydrogen, and halogen; R is one of a straight chain alkyl group, branched alkyl group, straight chain alkoxy group, branched alkoxy group, hydrogen, and halogen; x, y, and z are multiples of 0.5, and xz, yz; and n is a constant of 1 to 1000.


Patent
Oriental Yeast Co. and Kyoto University | Date: 2011-01-19

For efficient proliferation of pluripotent stem cells in a system free from any animal-derived material such as feeder cells or serum, the present invention provides a method for proliferation of pluripotent stem cells, which comprises culturing the pluripotent stem cells in a medium free from both feeder cells and serum in a system containing laminin-5.


Patent
Kyoto University and Kabushiki Kaisha Topcon | Date: 2015-01-07

Technology that is capable of providing objective data for center management while considering reduction of examination time in ophthalmology is provided. A fundus observation apparatus of an embodiment comprises an optical system, image forming part, specifying part, association information generating part and evaluation information generating part. The optical system divides light from a light source into signal light and reference light, generates interference light by superposing the signal light having traveled by way of an eye fundus and the reference light having traveled by way of a reference optical path, and detects the interference light. The image forming part forms a cross sectional image of the eye fundus based on detection results of the interference light. The specifying part analyzes the cross sectional image to specify an abnormal region located in the vicinity of central fovea of the eye fundus. The association information generating part calculates the distance between the central fovea and the abnormal region and generates association information in which the direction of the abnormal region relative to the central fovea and the distance are associated with each other. The evaluation information generating part generates evaluation information for evaluating the state of the eye fundus based on the association information.


Patent
Mitsubishi Group and Kyoto University | Date: 2014-02-28

A therapy planning device includes: a condition acquiring unit configured to acquire therapy conditions including a position of an affected area, a necessary dose for the affected area, and a threshold dose for an area other than the affected area; a first planning unit configured to plan a first irradiation of irradiating a first irradiation field including the entire affected area to radiation; and a second planning unit configured to make a therapy plan satisfying the therapy conditions in combination of the first irradiation planned by the first planning unit and irradiation of an irradiation field including only part of the affected area.


A radiotherapy equipment control device acquires reference position information for a specific location at a reference time. Furthermore, representative point reference position information is generated from reference position information for a plurality of markers at the reference time, and relative position information up to the reference position information for the specific location is generated. Moreover, representative point position information at another time is generated from the position information for a plurality of markers in a subject at the other time, which differs from the reference time. In addition, position information for the specific location at the other time is generated from the representative point position information and the relative position information. In this case, representative point reference position information and representative position information are generated on the basis of the position information and reference position information for the plurality of markers, said information having been weighted by weighting factors.


Patent
Mitsubishi Group and Kyoto University | Date: 2016-04-13

A radiograph analysis device is configured to detect a marker area from a radiograph obtained by imaging a specimen in whichh a marker is embedded, and the radiograph analysis device includes a brightness relation information acquisition unit configured to acquire brightness relation information generated based on information related to a quantity of radiation and showing a relation between a brightness of the marker area and a brightness of a reference portion assumed to be a portion other than the marker, a reference brightness acquisition unit configured to acquire the brightness of the reference portion, and a marker area detection unit configured to detect the marker area based on the brightness relation information acquired by the brightness relation information acquisition unit and the brightness of the reference portion acquired by the reference brightness acquisition unit.


Patent
Kyowa Medex Co. and Kyoto University | Date: 2016-05-18

The present invention provides a method for measuring glycated hemoglobin in a sample, which comprises directly oxidizing glycated hemoglobin in a sample, and then measuring a substance produced or consumed by the oxidation; and a method for measuring glycated hemoglobin in a sample, which comprises directly oxidizing glycated hemoglobin in a sample using an enzyme, and then measuring a substance produced or consumed by the oxidation. A method for measuring glycated hemoglobin of the present invention is useful for diagnosing lifestyle-related disease such as diabetes mellitus.


Patent
Nippon Oil Corporation and Kyoto University | Date: 2014-03-19

An organic semiconductor represented by the following formula (1).


Patent
Mitsubishi Group and Kyoto University | Date: 2013-02-27

This treatment planning device calculates position information for specific locations for a plurality of times corresponding to a time course on the basis of the positions of markers positioned in the vicinity of the specific locations, and generates a three-dimensional range for the specific locations for each of the plurality of times. In addition, the treatment planning device generates representative range information, which represents a range that includes the entire three-dimensional ranges for the specific locations for each of the plurality of times, tracks the position information for the specific locations for each of the plurality of times, and calculates the amount of radiation to be emitted in the range for the specific locations represented by representative range information when radiation is emitted for a prescribed time period in the range for the specific locations represented by the representative range information.


Patent
Kyoto University and Nippon Steel & Sumitomo Metal Corporation | Date: 2013-10-31

An object of the present invention is to provide a porous polymer metal complex which can be used as a gas adsorbent and contains two or more types of similar ligands. A porous polymer metal complex is provided expressed by [CuX]_(n)(1) (in the Formula, X represents two or more types of isophthalic acid ions selected from the group consisting of isophthalic acid ions and isophthalic acid ions having a substituent at position 5, at least an amount of one type of X is 5 mol % to 95 mol % of the total number of moles of X, and n represents an assembly number of constituent units expressed by CuX and is not particularly limited).


Patent
Mitsubishi Group and Kyoto University | Date: 2012-09-26

A radiotherapy device controller includes: a visual line calculator configured to calculate a visual line based on a position on a transmissive image imaged using a radiation penetrating a subject, a specific part of the subject being shown at the position; a position calculator configured to calculate a position of the specific part based on a position of a trajectory of the specific part and a position of the visual line; and an emitter configured to control a radiation emitter that emits a therapeutic radiation, so that the therapeutic radiation penetrates at the position of the specific part.


Patent
Kyoto University, Yokogawa Electric Corporation and Fujifilm Co. | Date: 2011-01-12

The present invention provides a fluid distribution device for uniformly distributing and outputting a fluid, which is supplied to an input flow channel, into at least three output flow channels, comprising a plurality of branch flow channels, at least three fluid bifurcation portions, and at least one fluid converging portion, wherein the fluid distribution device is configured to correspond to a pressure drop compartment connection model composed of a fluid balance equation and a pressure balance equation. Furthermore, the present invention provides a micro plant using the fluid distribution device, a method of designing the fluid distribution device and a method of detecting blockage of flow channels of the fluid distribution device.


Patent
Kyoto University and Kabushiki Kaisha Topcon | Date: 2013-01-21

In a fundus observation apparatus, an optical system detects interference light generated by superposing signal light having traveled by way of an eye fundus and reference light having traveled by way of a reference optical path. An image forming part forms a cross sectional image based on detection results of the interference light. A specifying part analyzes the cross sectional image to specify an abnormal region located in the vicinity of central fovea of the eye fundus. The association information generating part calculates the distance between the central fovea and the abnormal region and generates association information in which the direction of the abnormal region relative to the central fovea and the distance are associated with each other. The evaluation information generating part generates evaluation information for evaluating the state of the eye fundus based on the association information.


Patent
Kyowa Medex Co. and Kyoto University | Date: 2016-05-18

The present invention provides a protein comprising an amino acid sequence in which arginine at position 61 of a protein comprising the amino acid sequence represented by SEQ ID NO: 1 is substituted to an amino acid selected from the group consisting of glycine, alanine, valine, leucine, serine, threonine, proline, cysteine, methionine, asparagine, glutamine, and aspartic acid; and a method for measuring a glycated hemoglobin in a sample, wherein the method comprises reacting a glycated hemoglobin in a sample with a protease to produce a glycated hexapeptide, then reacting the produced glycated hexapeptide with the aforementioned protein, and measuring a substance produced or consumed by the reaction.


Patent
Kyoto University and Mitsubishi Group | Date: 2014-05-19

A radiograph analysis device is configured to detect a marker area from a radiograph obtained by imaging a specimen in which a marker is embedded, and the radiograph analysis device includes a brightness relation information acquisition unit configured to acquire brightness relation information generated based on information related to a quantity of radiation and showing a relation between a brightness of the marker area and a brightness of a reference portion assumed to be a portion other than the marker, a reference brightness acquisition unit configured to acquire the brightness of the reference portion, and a marker area detection unit configured to detect the marker area based on the brightness relation information acquired by the brightness relation information acquisition unit and the brightness of the reference portion acquired by the reference brightness acquisition unit.


Patent
Kyowa Medex Co. and Kyoto University | Date: 2014-07-07

The present invention provides a method for measuring glycated hemoglobin in a sample, which comprises directly oxidizing glycated hemoglobin in a sample, and then measuring a substance produced or consumed by the oxidation; and a method for measuring glycated hemoglobin in a sample, which comprises directly oxidizing glycated hemoglobin in a sample using an enzyme, and then measuring a substance produced or consumed by the oxidation. A method for measuring glycated hemoglobin of the present invention is useful for diagnosing lifestyle-related disease such as diabetes mellitus.


Patent
Mitsubishi Group and Kyoto University | Date: 2015-11-25

A therapy planning device includes: a condition acquiring unit configured to acquire therapy conditions including a position of an affected area, a necessary dose for the affected area, and a threshold dose for an area other than the affected area; a first planning unit configured to plan a first irradiation of irradiating a first irradiation field including the entire affected area to radiation; and a second planning unit configured to make a therapy plan satisfying the therapy conditions in combination of the first irradiation planned by the first planning unit and irradiation of an irradiation field including only part of the affected area.


Patent
Mitsubishi Group and Kyoto University | Date: 2015-01-07

This treatment planning device calculates position information for specific locations for a plurality of times corresponding to a time course on the basis of the positions of markers positioned in the vicinity of the specific locations, and generates a three-dimensional range for the specific locations for each of the plurality of times. In addition, the treatment planning device generates representative range information, which represents a range that includes the entire three-dimensional ranges for the specific locations for each of the plurality of times when the position information for the specific locations for each of the plurality of times is regarded as the same reference point. Furthermore, the treatment planning device tracks the position information for the specific locations for each of the plurality of times, and calculates the amount of radiation to be emitted in the range for the specific locations represented by representative range information when radiation is emitted for a prescribed time period in the range for the specific locations represented by the representative range information.


Patent
Nippon Oil Corporation, Kyoto University and Osaka Municipal Technical Research Institute | Date: 2012-01-17

The present invention provides a fullerene derivative having an electron donating group adjacent to the fullerene nucleus, represented by formula (I) which exhibits a high LUMO energy and a high open circuit voltage based thereon and which is highly compatible with polymers and excellent in charge mobility and charge separation ability: wherein the encircled FL represents fullerene C_(60 )or C_(70), Donor-Sub represents a substituent having at least one electron donating substituent atom located at a position apart from the fullerene nucleus by two bonds, R is hydrogen, Donor-Sub, an alkyl, cycloalkyl, alkoxy, alkoxy-substituted alkyl, alkoxy-substituted alkoxy, alkylthio-substituted alkoxy, alkylthio, alkylthio-substituted alkylthio, or alkoxy-substituted alkylthio group, having a total carbon atoms of 1 or more and 20 or fewer, or a benzyl or phenyl group, and n is an integer of 1 to 10.


Patent
Kyoto University and Mitsubishi Group | Date: 2016-11-09

In an X-ray CT apparatus 1 and an X-ray CT method, an image reconstruction unit uses, as projection data, a ratio _(1)/_(2) between the number of transmitted X-rays within a predetermined energy range _(1) that is smaller than the K-absorption edge of an object to be inspected, and the number of transmitted X-rays within a predetermined energy range _(2) that is greater than the K-absorption edge of said object to the inspected, performs convolution of said projection of said projection data and a predetermined reconstruction function, and generates a CT image of said subject through back projection of the convolution result.


A radiotherapy equipment control device (2) acquires reference position information for a specific location (61) at a reference time. Furthermore, representative point reference position information is generated from reference position information for a plurality of markers at the reference time, and relative position information up to the reference position information for the specific location, which uses the representative point reference position information as a base point, is generated. Moreover, representative point position information at another time is generated from the position information for a plurality of markers (62) in a subject at the other time, which differs from the reference time. In addition, position information for the specific location at the other time is generated from the representative point position information and the relative position information. In this case, representative point reference position information and representative position information are generated on the basis of the position information and reference position information for the plurality of markers, said information having been weighted by weighting factors.


Patent
Kyowa Medex Co. and Kyoto University | Date: 2014-07-07

The present invention provides a protein comprising an amino acid sequence in which arginine at position 61 of a protein comprising the amino acid sequence represented by SEQ ID NO: 1 is substituted to an amino acid selected from the group consisting of glycine, alanine, valine, leucine, serine, threonine, proline, cysteine, methionine, asparagine, glutamine, and aspartic acid; and a method for measuring a glycated hemoglobin in a sample, wherein the method comprises reacting a glycated hemoglobin in a sample with a protease to produce a glycated hexapeptide, then reacting the produced glycated hexapeptide with the aforementioned protein, and measuring a substance produced or consumed by the reaction.


Camera S.,University of Lisbon | Nishizawa A.,Kyoto University
Physical Review Letters | Year: 2013

We show how future gravitational-wave detectors would be able to discriminate between the concordance Λ cold dark matter cosmological model and up-to-date competing alternatives, e.g., dynamical dark energy (DE) models or modified gravity (MG) theories. Our method consists of using the weak-lensing magnification effect that affects a standard-siren signal because of its traveling through the Universe's large scale structure. As a demonstration, we present constraints on DE and MG from proposed gravitational-wave detectors, namely Einstein Telescope and DECI-Hertz Interferometer Gravitational-Wave Observatory and Big-Bang Observer. © 2013 American Physical Society.


Morrison S.F.,Oregon Health And Science University | Nakamura K.,Kyoto University
Frontiers in Bioscience | Year: 2011

Central neural circuits orchestrate a homeostatic repertoire to maintain body temperature during environmental temperature challenges and to alter body temperature during the inflammatory response. This review summarizes the functional organization of the neural pathways through which cutaneous thermal receptors alter thermoregulatory effectors: the cutaneous circulation for heat loss, the brown adipose tissue, skeletal muscle and heart for thermogenesis and species-dependent mechanisms (sweating, panting and saliva spreading) for evaporative heat loss. These effectors are regulated by parallel but distinct, effector-specific neural pathways that share a common peripheral thermal sensory input. The thermal afferent circuits include cutaneous thermal receptors, spinal dorsal horn neurons and lateral parabrachial nucleus neurons projecting to the preoptic area to influence warm-sensitive, inhibitory output neurons which control thermogenesis-promoting neurons in the dorsomedial hypothalamus that project to premotor neurons in the rostral ventromedial medulla, including the raphe pallidus, that descend to provide the excitation necessary to drive thermogenic thermal effectors. A distinct population of warmsensitive preoptic neurons controls heat loss through an inhibitory input to raphe pallidus neurons controlling cutaneous vasoconstriction.


Nakamura K.,Kyoto University | Morrison S.F.,Oregon Health And Science University
Journal of Physiology | Year: 2011

Shivering is an involuntary somatic motor response that occurs in skeletal muscles to produce heat during exposure to cold environments or during the development of fever. This study describes the brain circuitry mechanism that produces shivering. The reception of either cutaneous cool-sensory signals or pyrogenic signals by neurons in the preoptic area, a thermoregulatory and febrile centre, leads to activation of descending excitatory signalling through hypothalamic and medullary sites to drive shivering. Intriguingly, this central command pathway for shivering parallels that for sympathetically regulated non-shivering thermogenesis in brown adipose tissue. The present results promote our understanding of the brain mechanisms for thermal homeostasis that orchestrate the regulation of the somatic and autonomic motor systems to meet the critical demand for regulation of the body and brain temperatures. Abstract Shivering is a remarkable somatomotor thermogenic response that is controlled by brain mechanisms. We recorded EMGs in anaesthetized rats to elucidate the central neural circuitry for shivering and identified several brain regions whose thermoregulatory neurons comprise the efferent pathway driving shivering responses to skin cooling and pyrogenic stimulation. We simultaneously monitored parameters from sympathetic effectors: brown adipose tissue (BAT) temperature for non-shivering thermogenesis and arterial pressure and heart rate for cardiovascular responses. Acute skin cooling consistently increased EMG, BAT temperature and heart rate and these responses were eliminated by inhibition of neurons in the median preoptic nucleus (MnPO) with nanoinjection of muscimol. Stimulation of the MnPO evoked shivering, BAT thermogenesis and tachycardia, which were all reversed by antagonizing GABA A receptors in the medial preoptic area (MPO). Inhibition of neurons in the dorsomedial hypothalamus (DMH) or rostral raphe pallidus nucleus (rRPa) with muscimol or activation of 5-HT 1A receptors in the rRPa with 8-OH-DPAT eliminated the shivering, BAT thermogenic, tachycardic and pressor responses evoked by skin cooling or by nanoinjection of prostaglandin (PG) E 2, a pyrogenic mediator, into the MPO. These data are summarized with a schematic model in which the shivering as well as the sympathetic responses for cold defence and fever are driven by descending excitatory signalling through the DMH and the rRPa, which is under a tonic inhibitory control from a local circuit in the preoptic area. These results provide the interesting notion that, under the demand for increasing levels of heat production, parallel central efferent pathways control the somatic and sympathetic motor systems to drive thermogenesis. © 2011 The Authors. Journal compilation © 2011 The Physiological Society.


Patent
Japan Science, Technology Agency, Kyoto University and Nippoh Chemicals Co. | Date: 2011-05-11

A method of the present invention, for producing an aromatic iodine compound, includes the step of causing an iodizing agent, and an aromatic compound whose nucleus has one or more substituent groups and two or more hydrogen atoms, to react with each other under the presence of a certain ether compound. This realizes such a method of producing an aromatic iodine compound that position selectivity in iodizing reaction of an aromatic compound is improved.


Patent
ROHM Semiconductor and Kyoto University | Date: 2011-09-02

The present invention intends to provide a surface-emitting laser light source using a two-dimensional photonic crystal in which the efficiency of extracting light in a direction perpendicular to the surface is high. In a laser light source provided with a two-dimensional photonic crystal layer created from a plate-shaped matrix body in which a large number of holes are periodically arranged and an active layer arranged on one side of the two-dimensional photonic crystal layer, the holes are created to be columnar with a predetermined cross-sectional shape such as a circular shape, and the main axis of each of the columnar holes is tilted to a surface of the matrix body. When provided with this two-dimensional photonic crystal layer, the surface-emitting laser source using a two-dimensional photonic crystal has a Q_() value (i.e. a Q value in a direction perpendicular to the surface) of several thousands, which is suitable for an oscillation of laser light, and the efficiency of extracting light is high in the direction perpendicular to the surface.


Patent
Shimadzu Corporation and Kyoto University | Date: 2014-04-30

Provided is a polymeric micelle pharmaceutical preparation that can increase the ratio of contrast at tumor site to background contrast in a short period of time after administration of a lactosome and can suppress the ABC phenomenon so that the lactosome can be administered more than once within a short span. A branched-type amphiphilic block polymer comprising: a multi-branched hydrophilic block comprising sarcosine; and a hydrophobic block comprising polylactic acid. The branched-type amphiphilic block polymer, wherein the number of branches of the hydrophilic block is 3. A molecular assembly comprising the branched-type amphiphilic block polymer. The molecular assembly further comprising a linear type amphiphilic block polymer.


Patent
Kyoto University and ROHM Semiconductor | Date: 2015-07-23

A two-dimensional photonic crystal laser according to the present invention includes a two-dimensional photonic crystal layer 15 having a base body made of Al_()Ga_(1-)As (0<<1) or (Al_()Ga_(1-))_()In_(1-)P (0<=<1, 0<<1) with modified refractive index areas (air holes) 151 periodically arranged therein and an epitaxial growth layer 16 created on the two-dimensional photonic crystal layer 15 by an epitaxial method. Since Al_()Ga_(1-)As and (Al_()Ga_(1-))_()In_(1-)P are solid even at high temperatures, the air holes 151 will not be deformed in the process of creating the epitaxial growth layer 16, so that the performance of the two-dimensional photonic crystal layer 15 as a resonator can be maintained at high levels.


Patent
Kyoto University and Nihon Medi Physics Co. | Date: 2011-02-24

The present invention is a compound represented by the following formula (1) or a salt thereof. Furthermore, the present invention is an imaging agent used for imaging a tau protein, the imaging agent containing a compound represented by the formula (1) below or a salt thereof. In the formula (1), R^(3 )is a radioactive iodine.


Patent
Kyoto University, Aquafairy Corporation and ROHM Semiconductor | Date: 2014-12-26

A hydrogen production method and hydrogen production system using the reaction of water and aluminum, the hydrogen production method and system being capable of continuously generating hydrogen for a long period of time without causing a decrease in the total amount of hydrogen generation. A hydrogen generation system according to one embodiment of the present invention includes aluminum sheet placed in a container and calcium hydroxide contained in the same container. In the hydrogen production system having the previously described configuration, water is poured in the container to dissolve the calcium hydroxide so that an aqueous solution is prepared, and the aluminum sheet is immersed in this aqueous solution. As a result, the hydrogen generation reaction begins, generating hydrogen gas. The amount, rate and duration of the generation of hydrogen gas can be controlled by adjusting the area and thickness of the aluminum sheet.


Patent
ROHM Semiconductor and Kyoto University | Date: 2011-07-28

A two-dimensional photonic crystal laser according to the present invention includes a two-dimensional photonic crystal layer 15 having a base body made of Al_()Ga_(1-)As (0<<1) or (Al_()Ga_(1-))_()In_(1-)P (0<=<1, 0<<1) with modified refractive index areas (air holes) 151 periodically arranged therein and an epitaxial growth layer 16 created on the two-dimensional photonic crystal layer 15 by an epitaxial method. Since Al_()Ga_(1-)As and (Al_()Ga_(1-))_()In_(1-)P are solid even at high temperatures, the air holes 151 will not be deformed in the process of creating the epitaxial growth layer 16, so that the performance of the two-dimensional photonic crystal layer 15 as a resonator can be maintained at high levels.


Patent
Kyoto University and Nihon Medi Physics Co. | Date: 2014-07-02

It is intended to provide a radioactive compound represented by the following general formula (1) or a salt thereof that has higher selectivity for CYP11B2 than that for CYP11B1, exhibits highly selective accumulation in the adrenal gland compared with blood and organs adjacent to the adrenal gland, and permits commercial supply.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2009.4.2 | Award Amount: 3.30M | Year: 2010

In 21stC Europe, many cultural, ethnic and religious groups must live and work together. This is not always a smooth process; cultural differences can lead to social stresses and sometimes outright conflict. Thus education in cultural awareness and understanding has a very significant role. This is an educational domain in which attitudes and behaviours count much more than knowledge alone, and where developing empathy is a key pedagogical mechanism. Experiential approaches using role-play and case-studies have been shown to be highly effective, but can be difficult and expensive to organise. eCUTE will develop innovative technologically-enhanced learning approaches in cultural awareness and understanding that will help with these problems, based on virtual world simulations with intelligent interactive graphical characters embodying models of culturally-specific behaviour and interaction in scenarios developed via a user-centred design process. It will target two contrasting learner types-late primary-age children (9-11) and young adults (18-25) .\nWe will: a) Develop pedagogical approaches to education in cultural understanding grounded in psychological and educational theory; b) Create believable cultural learning scenarios based on theoretical approaches that connect with the experiences of the target learner groups c) Establish an operational parameterisation of theoretically derived cultural behaviour and use it to create synthetic cultures and characters that behave as if they live within such cultures; d) Develop expressive behaviour for synthetic characters that is culturally appropriate; e)Create two cultural Virtual Learning Environments (VLEs), one for late-primary children and the other for young adults based on virtual dramas using synthetic characters with culturally-specific interaction behaviour; f)Evaluate the created systems with stakeholder, teacher and learner groups, demonstrating their learning efficacy.


Patent
Kyoto University and Daito Chemix Corporation | Date: 2011-09-30

The present invention provides agents effective to treat eye diseases, pharmaceutical compositions comprising them, methods for preparing pharmaceuticals for treatment of eye diseases comprising using the agents, use of the agents in manufacture of pharmaceuticals for treatment of eye diseases and methods for treating eye diseases comprising administering the agents or the pharmaceutical compositions. The eye diseases treated by the present invention include particularly glaucoma, especially normal tension glaucoma, or retinitis pigmentosa. The present invention provides the compound of formula (I) wherein R is as defined in the description.


Patent
Daito Chemix Corporation and Kyoto University | Date: 2013-06-05

The present invention provides compounds which can regulate VCP activity. The present invention provides the compound of formula (I)or oxides, esters, prodrugs, pharmaceutically acceptable salts or solvates thereof. The compounds can regulate VCP activity, and thus are useful for treating VCP-mediated diseases such as neurodegenerative diseases.


Patent
Daito Chemix Corporation and Kyoto University | Date: 2013-08-07

The present invention provides agents effective to treat eye diseases, pharmaceutical compositions comprising them, methods for preparing pharmaceuticals for treatment of eye diseases comprising using the agents, use of the agents in manufacture of pharmaceuticals for treatment of eye diseases and methods for treating eye diseases comprising administering the agents or the pharmaceutical compositions. The eye diseases treated by the present invention include particularly glaucoma, especially normal tension glaucoma, or retinitis pigmentosa. The present invention provides the compound of formula (I)


Patent
Kyoto University and Shimadzu Corporation | Date: 2014-01-08

[Abstract] [Problem] To provide a novel fluorescent nanoparticle imaging probe having a switching function (a function to quench a fluorescent dye in a blood component and emit fluorescence in a tumor or an inflamed site to be imaged). [Solution] A fluorescent nanoparticle probe comprising: a molecular assembly composed of an amphiphilic block polymer having a hydrophilic block chain and a hydrophobic block chain; and a fluorescent dye encapsulated in the assembly, wherein (a) the hydrophilic block chain comprises, as an essential hydrophilic structural unit, a unit selected from a sarcosine unit and an alkylene oxide unit, (b) the hydrophobic block chain comprises, as an essential hydrophobic structural unit, a unit selected from the group consisting of an amino acid unit and a hydroxylic acid unit, and (c) the fluorescent dye is a polylactic acid-bound cyanine compound comprising: a fluorescent group represented by the formula (I):[ChemicalFig.1


Patent
Nihon Medi Physics Co. and Kyoto University | Date: 2013-12-19

It is intended to provide a radioactive compound that has higher selectivity for CYP11B2 than that for CYP11B1, exhibits highly selective accumulation in the adrenal gland compared with blood and organs adjacent to the adrenal gland, and permits commercial supply. The present invention provides a radioactive quinolinone derivative represented by the predetermined general formula or a salt thereof.


Patent
ROHM Semiconductor and Kyoto University | Date: 2012-08-10

A photonic crystal surface emission laser includes an active layer, and a photonic crystal layer made of a plate-shaped slab provided with modified refractive index area having a refractive index different from that of the slab, the modified refractive index areas being arranged on each of the lattice points of a first rhombic-like lattice and a second rhombic-like lattice in which both diagonals are mutually parallel and only one diagonal is of a different length, wherein a_(x1), a_(x2), a_(y), and n satisfy the following inequality:


Patent
ROHM Semiconductor and Kyoto University | Date: 2015-09-21

In a gate driver for driving a first transistor, the gate driver includes first, second and third push-pull circuits, in each of the push-pull circuits, two transistors are connected in series, an output terminal of the first push-pull circuit is connected to the gate of the first transistor, an output terminal of the second push-pull circuit is connected to the gate of a second transistor included in the first push-pull circuit and an output terminal of the third push-pull circuit is connected to the gate of a third transistor included in the first push-pull circuit.


Patent
Shimadzu Corporation and Kyoto University | Date: 2015-07-15

The present invention provides a molecular assembly whose retention time in a target site is adjusted depending on the kind or purpose of a labeling agent or drug encapsulated therein, and a molecular assembly that can suppress the ABC phenomenon and that can be administered more than once within a short span. A molecular assembly comprising: a branched-type amphiphilic block polymer A comprising a branched hydrophilic block comprising sarcosine and a hydrophobic block comprising a polylactic acid chain; and a functional substance F comprising a functional site and a polylactic acid chain, wherein the polylactic acid chain constituting the hydrophobic block of the amphiphilic block polymer A comprises L-lactic acid units, and the polylactic acid chain contained in the functional substance F comprises D-lactic acid units, or the Polylactic acid chain constituting the hydrophobic block of the amphiphilic block polymer A comprises D-lactic acid units, and the polylactic acid chain contained in the functional substance F comprises L-lactic acid units.


Patent
Shimadzu Corporation and Kyoto University | Date: 2013-07-03

The present invention provides a novel fluorescent nanoparticle imaging probe having a switching function (a function to quench a fluorescent dye during nanoparticle preparation, and emit fluorescence during imaging). A switching fluorescent nanoparticle probe comprising: a molecular assembly composed of an amphiphilic block polymer having a hydrophilic block chain and a hydrophobic block chain; and a fluorescent dye encapsulated in the molecular assembly, wherein (a) the hydrophilic block chain comprises, as an essential hydrophilic structural unit, a unit selected from a sarcosine unit and an alkylene oxide unit, (b) the hydrophobic block chain comprises, as an essential hydrophobic structural unit, a unit selected from the group consisting of an amino acid unit and a hydroxylic acid unit, and (c) the fluorescent dye is a cyanine compound represented by the formula (I):


Patent
Asahi Glass Co. and Kyoto University | Date: 2013-05-10

A glass emitting white light in itself, and a light-emitting element and a light-emitting device covered with the glass as stated above are provided. The white light-emitting glass is a glass emitting fluorescence at a region having a wavelength of 380 nm to 750 nm by excitation light with a wavelength of 240 nm to 405 nm, not containing crystal, and containing SnO_(x )(where x=1 to 2, typically x=1 or 2), P_(2)O_(5), and MnO_(y )(where y=1 to 2, typically y=1 or 2). The light-emitting element and the light-emitting device are made up by covering a main surface of a semiconductor light-emitting element with the glass as stated above.


Patent
Shimadzu Corporation, Waseda University and Kyoto University | Date: 2011-07-08

A well has a pair of side surfaces, and one of the side surfaces is in contact with a compartment of a first channel with a gas-permeable membrane being interposed therebetween and the other side surface is in contact with a compartment of a second channel with a gas-permeable membrane being interposed therebetween. The well is filled with a liquid cell culture medium, and in such a state, a high-concentration gas and a low-concentration gas, which are different in the concentration of a specific component from each other, are allowed to flow through the first and second channels, respectively, to form a concentration distribution of the specific component in the well.


Patent
ROHM Semiconductor and Kyoto University | Date: 2013-02-27

Provided is a two-dimensional photonic crystal surface emitting laser having an active layer for generating light of a predetermined wavelength range by an injection of electric current and a two-dimensional photonic crystal layer provided on one side of the active layer, the layer having a plate-shaped base member in which modified refractive index areas whose refractive index differs from that of the base member are arranged.


Patent
Kyoto University and Shimadzu Corporation | Date: 2012-08-16

A cell sorter including a well that has a microspace filled with a liquid and having a typical length of 1 mm or less, and that has a bottom surface made of a light-permeable material allowing optical observation of an interior of the microspace; a matrix provided on the bottom surface in the well; a bone fragment placed on the matrix in the well; and osteoclasts placed between the matrix and the bone fragment.


Patent
Nihon Medi Physics Co. and Kyoto University | Date: 2013-01-09

The present invention is a compound represented by the following formula (1) or a salt thereof. Furthermore, the present invention is an imaging agent used for imaging a tau protein, the imaging agent containing a compound represented by the formula (1) below or a salt thereof. In the formula (1), R^(3) is a radioactive iodine.


Patent
Shimadzu Corporation and Kyoto University | Date: 2012-01-11

A method for synthesizing [^(18)F]SFB is disclosed, which comprises using a microreactor including a substrate having one channel formed therein so as to have a cross-sectional width of 1 mm or less and a cross-sectional depth of 1 mm or less, the channel being connected to a raw material injection port and a first reagent injection port at one end thereof, and connected to a second reagent injection port at a position far from the one end thereof, and connected to a third reagent injection port at a position far from the second reagent injection port in a direction toward another end thereof, and connected to a liquid discharge port at the other end thereof; and continuously performing a three-step reaction by allowing a reaction solution to flow through the channel serving as a reaction channel from the one end to the other end thereof without taking out the reaction solution from anywhere between the one end and the other end of the channel.


Patent
Shimadzu Corporation and Kyoto University | Date: 2014-06-25

The present invention provides a therapeutic system that is widely applicable to general solid cancers, can achieve both a reduction in side effects of cancer therapy and suppression of cancer recurrence and metastasis, and requires no expensive drug such as an antibody; and a nanoparticle for internal radiation therapy. A system for internal radiation therapy of a vascular lesion site comprising: a device comprising a means for acquiring image data showing a position of a vascular lesion site, and a means for positioning a needle, which should be punctured into the vascular lesion site, at the vascular lesion site based on the image data; and a nanoparticle comprising an amphiphilic block polymer comprising a hydrophilic block having a sarcosine unit and a hydrophobic block having a lactic acid unit, and a substance labeled with a -ray emitting nuclide. The nanoparticle for internal radiation therapy.


Patent
Kyoto University and Nihon Medi Physics Co. | Date: 2014-03-26

Provided is a compound effective as a diagnostic imaging probe targeting amyloid and an agent for Alzheimers disease diagnosis including the compound.


Patent
Sumitomo Heavy Industries and Kyoto University | Date: 2015-02-11

In a collimator 6 according to the present invention, an irradiation field F is accurately set with respect to an affected area T by making a plurality of leaf plates 13B be slidable along a left-right direction X. Further, by making separate leaf plates 15 of the leaf plates 13B be slidable in an irradiation direction Y as well, it is possible to bring the separate leaf plates 15 close to the body surface of a patient P so as to conform to the outer shape of an irradiation site. A gap between the collimator 6 and the patient P is narrowed thereby, whereby dispersion of neutrons is suppressed. As a result, a neutron dose which is irradiated to the affected area T per hour is secured, and thus irradiation time is shortened.


The present invention provides a molecular assembly which is less likely to accumulate in tissue other than cancer tissue, is highly safe for a living body, and can be prepared by a simple and safe method and whose particle size can be easily controlled. The present invention provides a molecular imaging system and a molecular probe useful for the system, and a drug delivery system and a molecular probe useful for the system. The present invention provides a method for preparing molecular assembly, by which the particle size of molecular assembly having a signal group or a drug can be arbitrarily controlled in order to allow the molecular assembly to effectively accumulate in cancer tissue by utilizing EPR effect. A molecular assembly comprising: an amphiphilic block polymer A comprising a hydrophilic block chain and a hydrophobic block chain having 10 or more lactic acid units; a hydrophobic polymer A2 having at least 10 or more lactic acid units; and/or a labeled polymer B comprising at least 10 or more lactic acid units and a labeling group.


Patent
Tokyo Women's Medical University and Kyoto University | Date: 2014-02-05

The present invention provides a method for producing a myocardial sheet using a group of cells derived from embryonic stem cells. This method is characterized by mixing Flk/KDR positive cells, cardiomyocytes, endothelial cells, and mural cells, all derived from embryonic stem cells, and culturing the mixed cells. Furthermore, the myocardial sheet can be used as a therapeutic agent for heart diseases since VEGF is released from the sheet.


Patent
Kyoto University and ROHM Semiconductor | Date: 2013-11-20

There is provided solution testing equipment which can detect an output variation of a THz oscillation device using a THz wave (h) by contacting a liquid or cells on an RTD oscillation device, and can reduce the size and weight thereof. The solution testing equipment includes: a THz oscillation device configured to radiate the THz wave I_(s); a THz detection device configured to receive the THz wave I_(s); and a solution as a test object disposed on the THz oscillation device, in which the solution is tested on the basis of output characteristics of the terahertz wave varying in response to a relative permittivity of the solution.


Patent
Shimadzu Corporation and Kyoto University | Date: 2016-02-27

Provided is a polymeric micelle pharmaceutical preparation that can increase the ratio of contrast at tumor site to background contrast in a short period of time after administration of a lactosome and can suppress the ABC phenomenon so that the lactosome can be administered more than once within a short span. A branched-type amphiphilic block polymer comprising: a multi-branched hydrophilic block comprising sarcosine; and a hydrophobic block comprising polylactic acid. The branched-type amphiphilic block polymer, wherein the number of branches of the hydrophilic block is 3. A molecular assembly comprising the branched-type amphiphilic block polymer. The molecular assembly further comprising a linear type amphiphilic block polymer.


Patent
Nihon Medi Physics Co. and Kyoto University | Date: 2013-08-26

Provided is a compound effective as a diagnostic imaging probe targeting amyloid and an agent for Alzheimers disease diagnosis including the compound.


Konoplya R.A.,Kyoto University | Konoplya R.A.,University of Tübingen | Zhidenko A.,University of Sao Paulo | Zhidenko A.,Federal University of ABC
Reviews of Modern Physics | Year: 2011

Perturbations of black holes, initially considered in the context of possible observations of astrophysical effects, have been studied for the past 10 years in string theory, brane-world models, and quantum gravity. Through the famous gauge/gravity duality, proper oscillations of perturbed black holes, called quasinormal modes, allow for the description of the hydrodynamic regime in the dual finite temperature field theory at strong coupling, which can be used to predict the behavior of quark-gluon plasmas in the nonperturbative regime. On the other hand, the brane-world scenarios assume the existence of extra dimensions in nature, so that multidimensional black holes can be formed in a laboratory experiment. All this stimulated active research in the field of perturbations of higher-dimensional black holes and branes during recent years. In this review recent achievements on various aspects of black hole perturbations are discussed such as decoupling of variables in the perturbation equations, quasinormal modes (with special emphasis on various numerical and analytical methods of calculations), late-time tails, gravitational stability, anti-de Sitter/conformal field theory interpretation of quasinormal modes, and holographic superconductors. We also touch on state-of-the-art observational possibilities for detecting quasinormal modes of black holes. © 2011 American Physical Society.


Tanaka M.,Japan National Astronomical Observatory | Hotokezaka K.,Kyoto University
Astrophysical Journal | Year: 2013

Mergers of binary neutron stars (NSs) are among the most promising gravitational wave (GW) sources. Next generation GW detectors are expected to detect signals from NS mergers within about 200 Mpc. The detection of electromagnetic wave (EM) counterparts is crucial to understanding the nature of GW sources. Among the possible EM emission from the NS merger, emission powered by radioactive r-process nuclei is one of the best targets for follow-up observations. However, predictions so far have not taken into account detailed r-process element abundances in the ejecta. We perform for the first time radiative transfer simulations of the NS merger ejecta including all the r-process elements from Ga to U. We show that the opacity of the NS merger ejecta is about κ = 10 cm2 g-1, which is higher than that of Fe-rich Type Ia supernova ejecta by a factor of ∼100. As a result, the emission is fainter and lasts longer than previously expected. The spectra are almost featureless due to the high expansion velocity and bound-bound transitions of many different r-process elements. We demonstrate that the emission is brighter for a higher mass ratio of the two NSs and a softer equation of state adopted in the merger simulations. Because of the red color of the emission, follow-up observations in red optical and near-infrared (NIR) wavelengths will be the most efficient. At 200 Mpc, the expected brightness of the emission is i = 22-25 AB mag, z = 21-23 AB mag, and 21-24 AB mag in the NIR JHK bands. Thus, observations with wide-field 4 m- and 8 m-class optical telescopes and wide-field NIR space telescopes are necessary. We also argue that the emission powered by radioactive energy can be detected in the afterglow of nearby short gamma-ray bursts. © 2013. The American Astronomical Society. All rights reserved..


Hyeon-Deuk K.,Kyoto University | Prezhdo O.V.,University of Rochester
ACS Nano | Year: 2012

Multiple exciton generation and recombination (MEG and MER) dynamics in semiconductor quantum dots (QDs) are simulated using ab initio time-dependent density functional theory in combination with nonadiabatic molecular dynamics. The approach differs from other MEG and MER theories because it provides atomistic description, employs time-domain representation, allows for various dynamical regimes, and includes electron-phonon interactions. MEG rapidly accelerates with energy, reflecting strong energy dependence of double exciton (DE) density of states. At early times, MEG is Gaussian rather than exponential. Exponential dynamics, assumed in rate theories, starts at a later time and becomes more important in larger QDs. Phonon-assisted MEG is observed at energies below the purely electronic threshold, particularly in the presence of high-frequency ligand vibrations. Coupling to phonons is essential for MER since higher-energy DEs must relax to recombine into single excitons (SEs), and SEs formed during MERs must lose some of their energy to avoid recreating DEs. MER simulated starting from a DE is significantly slower than MER involving an optical excitation of a SE, followed by MEG and then MER. The latter time scale agrees with experiment, emphasizing the importance of quantum-mechanical superpositions of many DEs for efficient MER. The detailed description of the interplay between MEG and MER coupled to phonons provides important insights into the excited state dynamics of semiconductor QDs and nanoscale materials in general. © 2012 American Chemical Society.


Hyeon-Deuk K.,Kyoto University | Prezhdo O.V.,University of Rochester
Nano Letters | Year: 2011

We developed time-domain ab initio simulation of Auger phenomena, including multiple exciton generation (MEG) and recombination (MER). It is the first approach describing phonon-assisted processes and early dynamics. MEG starts below the electronic threshold, strongly accelerating with energy. Ligands are particularly important to phonon-assisted MEG, which therefore can be probed with infrared spectroscopy. Short-time Gaussian component gives 5-10% of MEG, justifying rate theories that assume exponential dynamics. MER is preceded by electron-phonon relaxation to low energies. © 2011 American Chemical Society.


Patent
Tohoku University and Kyoto University | Date: 2012-06-27

The present invention relates to a sheet for corneal transplants comprising corneal endothelial cells on a gelatin hydrogel, which is obtainable by seeding and culturing corneal endothelial cells on a gelatin hydrogel coated with collagen. The sheet of the present invention is extremely useful as a sheet for corneal transplants not only for its biocompatibility and biodegradability, but also for its high transparency.


Patent
Kyocera Corporation and Kyoto University | Date: 2013-03-19

A porous coordination polymer-ionic liquid composite according to the present invention includes an insulating structure composed of a porous coordination polymer, and an ionic liquid retained inside pores of the porous coordination polymer. The porous coordination polymer preferably has a main chain containing a typical metal element.


Patent
Kyoto University and Nihon Kohden | Date: 2013-12-18

A lifesaving support apparatus includes: a sensor section which is adapted to be attachable to a patient, and which is configured to acquire information of blood flow of the patient; a determining section which, based on the information of blood flow, is configured to determine whether or not a use of an automatic external defibrillator is necessary; and an outputting section which is configured to notify a rescuer of information which is determined by the determining section.


Patent
Kyoto University and Canon Kabushiki Kaisha | Date: 2011-02-28

Provided are a piezoelectric thin film having good piezoelectricity in which a rhombohedral structure and a tetragonal structure are mixed, and a piezoelectric element using the piezoelectric thin film. The piezoelectric thin film includes a perovskite type metal oxide, in which the perovskite type metal oxide is a mixed crystal system of at least a rhombohedral structure and a tetragonal structure, and a ratio between an a-axis lattice parameter and a c-axis lattice parameter of the tetragonal structure satisfies 1.15c/a1.30. The piezoelectric element includes on a substrate: the above-mentioned piezoelectric thin film; and a pair of electrodes provided in contact with the piezoelectric thin film.


Patent
Murata Manufacturing Co. and Kyoto University | Date: 2015-01-14

A discharge plasma machining device that includes punches as a pressing unit for applying a pressure with respect to a machined item, a direct current pulse current generator as a pulse current applying unit for applying a pulse current with respect to the machined item, a spectroscope as a detection unit for detecting a spectrum of light of plasma generated by application of a pulse current, and a control unit for controlling a pulse current in accordance with a detection result of the detection unit.


Patent
Tokuyama Corporation, Tohoku University, Kyoto University and University of Tokyo | Date: 2012-02-08

[Problems to be Solved] It is an object of the present invention to provide a novel radiographic image detector which can detect radiation, such as hard X-rays or -rays, with high sensitivity and which is excellent in position resolution and count rate characteristic. [Means to Solve the Problems] A radiographic image detector comprises a combination of a scintillator, such as a lanthanum fluoride crystal containing neodymium, for converting incident radiation into ultraviolet rays; and a gas multiplication ultraviolet image detector for converting ultraviolet rays into electrons, amplifying such electrons by use of a gas electron avalanche phenomenon, and detecting the electrons. The radiographic image detector is characterized in that the gas multiplication ultraviolet image detector is basically constituted by a photoelectric conversion substance, such as cesium iodide or cesium telluride, for converting ultraviolet rays into electrons; a gas electron multiplier for amplifying electrons by use of the gas electron avalanche phenomenon; and a pixel electrode having an amplification function and a detection function.


Patent
Kyoto University and Takeda Pharmaceutical | Date: 2011-01-19

The present invention provides a metastin derivative represented by the formula (I):


Patent
Canon Kabushiki Kaisha, Japan National Institute of Advanced Industrial Science, Technology and Kyoto University | Date: 2012-12-07

Provided are a bismuth-based piezoelectric material whose insulation property is improved while its performance as a piezoelectric body is not impaired and a piezoelectric device using the piezoelectric material. The piezoelectric material includes a perovskite-type metal oxide represented by the following general formula (1): Bi_(x)(Fe_(1-y)Co_(y))O_(3)(1) where 0.95x1.25 and 0y0.30, and a root mean square roughness Rq (nm) of a surface of the piezoelectric material satisfies a relationship of 0


Patent
Nihon Kohden and Kyoto University | Date: 2014-07-02

A lifesaving support apparatus includes: a sensor section which is adapted to be attachable to a patient, and which is configured to acquire information of blood flow of the patient; a determining section which, based on the information of blood flow, is configured to determine whether or not a use of an automatic external defibrillator is necessary; and an outputting section which is configured to notify a rescuer of information which is determined by the determining section.


Patent
Kyoto University and Canon Kabushiki Kaisha | Date: 2014-04-25

Provided are a thermal expansion suppressing member having negative thermal expansion properties and a metal-based anti-thermally-expansive member having small thermal expansion. More specifically, provided are a thermal expansion suppressing member, including at least an oxide represented by the following general formula (1), and an anti-thermally-expansive member, including a metal having a positive linear expansion coefficient at 20 C., and a solid body including at least an oxide represented by the following general formula (1), the metal and solid being joined to each other: (Bi_(1-x)M_(x))NiO_(3 )(1) where M represents at least one metal selected from the group consisting of La, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu, Y, and In; and x represents a numerical value of 0.02x0.15.


Patent
Canon Kabushiki Kaisha and Kyoto University | Date: 2012-02-15

Provided are a thermal expansion suppressing member having negative thermal expansion properties and a metal-based anti-thermally-expansive member having small thermal expansion. More specifically, provided are a thermal expansion suppressing member, including at least an oxide represented by the following general formula (1), and an anti-thermally-expansive member, including a metal having a positive linear expansion coefficient at 20C, and a solid body including at least an oxide represented by the following general formula (1), the metal and solid being joined to each other: (Bi_(1-x)M_(x))NiO_(3) (1) where M represents at least one metal selected from the group consisting of La, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu, Y, and In; and x represents a numerical value of 0.02x0.15.


Patent
Kyoto University and Canon Kabushiki Kaisha | Date: 2014-01-10

Provided are resin-based and metal-based anti-thermally-expansive members each having small thermal expansion. More specifically, provided are an anti-thermally-expansive resin and an anti-thermally-expansive metal, each including a resin or a metal having a positive linear expansion coefficient at 20 C. and a solid particle dispersed in the resin or metal, in which the solid particle includes at least an oxide represented by the following general formula (1): (Bi_(1-x)M_(x))NiO_(3 )(1), where M represents at least one metal selected from the group consisting of La, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu, Y, and In; and x represents a numerical value of 0.02x0.15.


Patent
Kyoto University and Japan Chemical Engineering & Machinery Co. | Date: 2011-05-18

[PROBLEMS] The present invention provides a microwave radiating device which treats a radiated material by microwave irradiation; and further provides a method of producing glycocomponent from plant material. [MEANS FOR SOLVING PROBLEMS] The microwave radiating device of the present invention is equipped with irradiating means which has microwave radiating source, and containers which accept radiated material inside. Further, the container of the device has supply means which provides radiated material to container, and discharge means which discharges radiated material from container, and microwave receiving section which makes microwave that irradiated from radiating means, penetrate into the container through the medium of dielectric material. Further, there is provided at least one layer that is composed of non-dielectric material, between the atmosphere of the inner side and the outer side of the container. Yet, irradiating means and the above container are connected in removable mode.


Patent
Kyoto University and Kyocera Corporation | Date: 2015-03-04

A porous coordination polymer-ionic liquid composite according to the present invention includes an insulating structure composed of a porous coordination polymer, and an ionic liquid retained inside pores of the porous coordination polymer. The porous coordination polymer preferably has a main chain containing a typical metal element.


Patent
Kyoto University and Canon Kabushiki Kaisha | Date: 2011-08-08

Provided are resin-based and metal-based anti-thermally-expansive members each having small thermal expansion. More specifically, provided are an anti-thermally-expansive resin and an anti-thermally-expansive metal, each including a resin or a metal having a positive linear expansion coefficient at 20 C. and a solid particle dispersed in the resin or metal, in which the solid particle includes at least an oxide represented by the following general formula (1): (Bi_(1-x)M_(x))NiO_(3 )(1), where M represents at least one metal selected from the group consisting of La, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu, Y, and In; and x represents a numerical value of 0.02x0.15.


Patent
Kyoto University and Canon Kabushiki Kaisha | Date: 2011-08-08

Provided are a thermal expansion suppressing member having negative thermal expansion properties and a metal-based anti-thermally-expansive member having small thermal expansion. More specifically, provided are a thermal expansion suppressing member, including at least an oxide represented by the following general formula (1), and an anti-thermally-expansive member, including a metal having a positive linear expansion coefficient at 20 C., and a solid body including at least an oxide represented by the following general formula (1), the metal and solid being joined to each other: (Bi_(1-x)M_(x))NiO_(3 )(1) where M represents at least one metal selected from the group consisting of La, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu, Y, and In; and x represents a numerical value of 0.02x0.15.


Gatto R.,University of Geneva | Ruggieri M.,Kyoto University
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2011

We perform a model study of deconfinement and chiral symmetry restoration in a strong magnetic background. We use a Nambu-Jona-Lasinio model with the Polyakov loop, taking into account a possible dependence of the coupling on the Polyakov-loop expectation value, as suggested by the recent literature. Our main result is that, within this model, the deconfinement and chiral crossovers of QCD in strong magnetic field are entangled even at the largest value of eB considered here, namely eB=30mπ2 (that is, B≈6×1015 T). The amount of split that we measure is, at this value of eB, of the order of 2%. We also study briefly the role of the 8-quark term on the entanglement of the two crossovers. We then compare the phase diagram of this model with previous results, as well as with available lattice data. © 2011 American Physical Society.


Gatto R.,University of Geneva | Ruggieri M.,Kyoto University
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2010

We evaluate the dressed Polyakov loop for hot quark matter in strong magnetic field. To compute the finite temperature effective potential, we use the Polyakov extended Nambu-Jona-Lasinio model with eight-quark interactions taken into account. The bare quark mass is adjusted in order to reproduce the physical value of the vacuum pion mass. Our results show that the dressed Polyakov loop is very sensitive to the strength of the magnetic field, and it is capable to capture both the deconfinement crossover and the chiral crossover. Additionally, we self-consistently compute the phase diagram of the model. We find a tiny split of the two aforementioned crossovers as the strength of the magnetic field is increased. Concretely, for the largest value of magnetic field investigated here, eB=19mπ2, the split is of the order of 10%. A qualitative comparison with other effective models and recent lattice results is also performed. © 2010 The American Physical Society.


Patent
Kyoto University, Kyoto Prefectural University, Kaken Co. and Koken Co. | Date: 2013-08-21

Provided is a pharmaceutical composition, including a drug and a collagen, in which the composition is satisfactory in handleability and has sustained-release property. The sustained-release pharmaceutical composition includes: a drug; a collagen; and at least one kind of sugar selected frommonosaccharides, disaccharides, trisaccharides, and tetrasaccharides. The inventors of the present invention have found that the in vivo administration of a collagen solution containing a sugar results in the gelation of a collagen. Based on this finding, the inventors have found that a composition containing a drug, a collagen, and a sugar can control the release rate of the drug, and such composition can be used as a sustained-release pharmaceutical composition.


Patent
Sharp Kabushiki Kaisha and Kyoto University | Date: 2012-11-14

A solar cell (1) of the present invention includes a photoelectric conversion layer (2) and a photonic crystal provided inside the photoelectric conversion layer (2) in order to have a photonic band gap. The photonic crystal has defects (31) in order to provide a defect level in the photonic band gap. Q_(V) which is a Q value representing a magnitude of a resonance effect yielded by coupling between the photonic crystal and an outside is substantially equal to Q_() which is a Q value representing a magnitude of a resonance effect yielded by a medium of the photoelectric conversion layer (2).


Patent
Sumitomo Osaka Cement and Kyoto University | Date: 2013-11-27

Provided is an organic-inorganic composite having two or more kinds of light emission sites. When the organic-inorganic composite is caused to emit light, each of emission colors in each of light emission sites is independently maintained as a emission color that is shown when each of the light emission sites is independently caused to emit light.


Patent
Sharp Kabushiki Kaisha and Kyoto University | Date: 2012-11-14

A photoelectric transducer (10) including: a semiconductor layer (13); and a photonic crystal (21) formed inside the semiconductor layer, the photonic crystal being formed by providing nanorods (19) inside the semiconductor layer, each of the nanorods having a refractive index lower than that of a medium of the semiconductor layer, the nanorods being provided two-dimensionally and periodically at a pitch of not less than /4 nor more than , where is a wavelength of a peak of resonance caused by the photonic crystal, the photoelectric transducer satisfying the following formula: where Qv is (a) a Q value which indicates a magnitude of an effect of resonance caused by coupling between the photonic crystal and an external world and (b) in proportion to a reciprocal of a coefficient _(V) indicating a strength of the coupling between the photonic crystal and the external world, and Qa is (a) a Q value which indicates a magnitude of an effect of resonance caused by the medium of the semiconductor layer and (b) in proportion to a reciprocal of a coefficient a of light absorption by the medium of the semiconductor layer. This allows an increase in light absorption ratio of a photoelectric transducer including a photonic crystal structure.


Patent
Kyoto University, Mitsubishi Rayon Co. and Sanyo | Date: 2011-01-18

To provide a method for producing a conductive film with excellent transparency and conductivity by a simple method suitable for large-area production. A method for producing a conductive film comprising a step of placing a template (B), having openings in a mesh structure running from the side that is to contact a substrate (A) through to the back side, on the surface of the substrate (A), and spreading a dispersion (D) of conductive particles (P) on the surface of the substrate (A) on which the template (B) has been placed, and drying it, thereby forming a mesh-like structure (C) of the conductive particles (P) near the points of contact between the substrate (A) and the template (B), and then removing the template (B) from the substrate (A) to form a mesh-like structure (C) of the conductive particles (P) on the surface of the substrate (A).


Patent
Sharp Kabushiki Kaisha and Kyoto University | Date: 2012-11-14

A photoelectric conversion element (1) of the present invention includes: a photoelectric conversion layer (2); and a photonic crystal provided inside the photoelectric conversion layer (2) to provide a photonic band gap, the photonic crystal being designed such that nanorods (30) whose refraction index is smaller than that of a medium of the photoelectric conversion layer (2) are provided periodically inside the photoelectric conversion layer (2), and there are provided defects (31) to provide a defect level in the photonic band gap, when a wavelength of a resonance peak corresponding to the defect level is , the nanorods (30) are provided two-dimensionally with a pitch of not less than /7 and not more than /2, and a coefficient _(v) indicative of strength of coupling between the photonic crystal and the outside is substantially equal to a coefficient a of absorption of light by the photoelectric conversion layer (2).


Patent
MItsubishi Electric, Kyoto University and Kochi University | Date: 2013-04-17

In a film formation method, a mist of a solution is sprayed onto a substrate to form a film on the substrate. A film formation is then suspended. The substrate is then exposed to plasma.


Patent
MItsubishi Electric and Kyoto University | Date: 2015-10-28

A method for forming a metal oxide film, the method including: forming a source solution containing metal into a mist, heating a substrate, supplying the source solution formed into a mist onto a first main surface of the substrate through a first supply path, and supplying hydrogen peroxide through a second path different from the first supply path onto the first main surface of the substrate, where the method further includes, in the following order, preliminarily preparing data showing a relationship among a molar ratio of an amount of the hydrogen peroxide to an amount of the zinc in the source solution, a carrier concentration of the metal oxide film, and a mobility of the metal oxide film, determining an amount of the hydrogen peroxide supplied with the data, and supplying the determined amount of the hydrogen peroxide through the second path onto the first main surface of the substrate.


To provide a technology that solves the above-mentioned problems, and is directly applicable to eukaryotic algal cells with cell-wall, the technology enabling gene transfer and transformation to be performed with high efficiency and good reproducibility irrespective of species of algae. Also provided is a method of transferring an exogenous gene into a eukaryotic algal cell, the method comprising performing electroporation using multiple square-wave pulses to the solution containing a cell of a green alga with cell-wall, and a nucleic acid molecule by the following three steps: applying a square-wave electric pulse (first electric pulse) with a high voltage for a short period of time under the condition that its total electric energy falls within a predetermined range; then applying a square-wave electric pulse (second electric pulse) with a low voltage for a long period of time two or more times; and then applying a square-wave electric pulse (third electric pulse) that is opposite in polarity to the second electric pulse, with a low voltage for a long period of time, two or more times.


A method of manufacturing a composite composition, having: bonding a dispersant to the surfaces of inorganic oxide particles to provide dispersibility in a hydrophobic solvent to the inorganic oxide particles, and then dispersing the inorganic oxide particles in a hydrophobic solvent; substituting the dispersant bonded to the surfaces of the inorganic oxide particles with a surface modifier, which is a polydimethylsiloxane-skeleton polymer having one functional group at one terminal end, in the hydrophobic solvent in which the organic oxide particles are dispersed to bond the functional group of the polydimethylsiloxane-skeleton polymer to the surfaces of the inorganic oxide particles; and conjugating a silicone resin and the inorganic oxide particles obtained in the previous step, wherein the surface thereof is modified by bonding the polydimethylsiloxane-skeleton polymer having one functional group at one terminal end thereof, to obtain a composite composition.


Patent
Kyoto University, Koken Co., Kaken Co. and Kyoto Prefectural University | Date: 2011-10-14

Provided is a pharmaceutical composition, including a drug and a collagen, in which the composition is satisfactory in handleability and has sustained-release property. The sustained-release pharmaceutical composition includes: a drug; a collagen; and at least one kind of sugar selected from monosaccharides, disaccharides, trisaccharides, and tetrasaccharides. The inventors of the present invention have found that the in vivo administration of a collagen solution containing a sugar results in the gelation of a collagen. Based on this finding, the inventors have found that a composition containing a drug, a collagen, and a sugar can control the release rate of the drug, and such composition can be used as a sustained-release pharmaceutical composition.


Patent
MItsubishi Electric, Kyoto University and Kochi University | Date: 2013-07-11

A method for manufacturing solar cell includes the following. A solution containing aluminum elements is misted. The misted solution is sprayed onto the main surface of a p-type silicon substrate in the atmosphere, to thereby form an aluminum oxide film. Then, a solar cell is produced using the p-type silicon substrate including the aluminum oxide film formed thereon.


Patent
Sharp Kabushiki Kaisha, Kyoto University and Keio University | Date: 2011-12-21

A storage system (300) comprising a semiconductor storage device (100) and a data reading device (300). The semiconductor storage device includes a substrate (102) and a plurality of storage cells (120) sealed in a film (120). Each of the storage cells includes a non-volatile storage unit, an electric power generation unit (50) for receiving energy in a non-contact fashion, and a transmitting unit (80) for transmitting the stored data by radio. The data reading device includes an energy supply unit (20) for supplying energy to the semiconductor storage device, a plurality of receiving units positioned at locations corresponding to the plurality of storage cells respectively, a data row assigned to each of the non-volatile storage units according to the address thereof, and a circuit for outputting, as a series of data row, the data respectively received in parallel by said plurality of receiving units.


Patent
Kyoto University and Sumitomo Osaka Cement | Date: 2012-01-18

Provided is an organic-inorganic composite having two or more kinds of light emission sites. When the organic-inorganic composite is caused to emit light, each of emission colors in each of light emission sites is independently maintained as a emission color that is shown when each of the light emission sites is independently caused to emit light.


Patent
Sumitomo Osaka Cement and Kyoto University | Date: 2012-12-12

An organic-inorganic composite of the present invention includes metal oxide particles and an organic polymer compound including a monomer containing organic ligands and a vinyl-based monomer having organic ligands which are bonded to a polymer chain through covalent bonds and the organic polymer compound is bonded to the metal oxide particles by the organic ligands forming a complex with metal atoms on the surface of the metal oxide particles. According to the organic-inorganic composite, the metal oxide particles and the organic polymer compound containing the organic ligands can be chemically bonded, therefore, light emission characteristics such as light emission intensity or stabilization of light emission wavelength can be improved, and transparency and mechanical characteristics such as thermal stability or hardness can also be improved.


A method of manufacturing a composite composition, having: bonding a dispersant to the surfaces of inorganic oxide particles to provide dispersibility in a hydrophobic solvent to the inorganic oxide particles, and then dispersing the inorganic oxide particles in a hydrophobic solvent; substituting the dispersant bonded to the surfaces of the inorganic oxide particles with a surface modifier, which is a polydimethylsiloxane-skeleton polymer having one functional group at one terminal end, in the hydrophobic solvent in which the organic oxide particles are dispersed to bond the functional group of the polydimethylsiloxane-skeleton polymer to the surfaces of the inorganic oxide particles; and conjugating a silicone resin and the inorganic oxide particles obtained in the previous step, wherein the surface thereof is modified by bonding the polydimethylsiloxane-skeleton polymer having one functional group at one terminal end thereof, to obtain a composite composition.


Akamatsu Y.,Nagoya University | Yamamoto N.,Kyoto University | Yamamoto N.,University of Maryland University College
Physical Review Letters | Year: 2013

We study the collective modes in relativistic electromagnetic or quark-gluon plasmas with an asymmetry between left- and right-handed chiral fermions, based on the recently formulated kinetic theory with Berry curvature corrections. We find that there exists an unstable mode, signaling the presence of a plasma instability. We argue the fate of this "chiral plasma instability" including the effect of collisions, and briefly discuss its relevance in heavy ion collisions and compact stars. © 2013 American Physical Society.


Nakao H.,Kyoto University | Nakao H.,Japan Science and Technology Agency | Mikhailov A.S.,Fritz Haber Institute of the Max Planck Society
Nature Physics | Year: 2010

Turing instability in activator-inhibitor systems provides a paradigm of non-equilibrium self-organization; it has been extensively investigated for biological and chemical processes. Turing instability should also be possible in networks, and general mathematical methods for its treatment have been formulated previously. However, only examples of regular lattices and small networks were explicitly considered. Here we study Turing patterns in large random networks, which reveal striking differences from the classical behaviour. The initial linear instability leads to spontaneous differentiation of the network nodes into activator-rich and activator-poor groups. The emerging Turing patterns become furthermore strongly reshaped at the subsequent nonlinear stage. Multiple coexisting stationary states and hysteresis effects are observed. This peculiar behaviour can be understood in the framework of a mean-field theory. Our results offer a new perspective on self-organization phenomena in systems organized as complex networks. Potential applications include ecological metapopulations, synthetic ecosystems, cellular networks of early biological morphogenesis, and networks of coupled chemical nanoreactors. © 2010 Macmillan Publishers Limited. All rights reserved.

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