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Kyoto, Japan

Kyoto Prefectural University of Medicine is a public university in Kyoto, Kyoto, Japan. The predecessor of the school was founded in 1872, and it was chartered as a university in 1921. Wikipedia.

Ryang S.,Kyoto Prefectural University of Medicine
Journal of High Energy Physics | Year: 2011

We compute semiclassically the two-point correlator of the marginal vertex operators describing the rigid circular spinning string state with one large spin and one windining number in AdS5 and three large spins and three winding numbers in S5. The marginality condition and the conformal invariant expression for the two-point correlator obtained by using an appropriate vertex operator are shown to be associated with the diagonal and off-diagonal Virasoro constraints respectively. We evaluate semiclassically the three-point correlator of two heavy circular string vertex operators and one zero-momentum dilaton vertex operator and discuss its relation with the derivative of the dimension of the heavy circular string state with respect to the string tension. © SISSA 2011. Source

Ryang S.,Kyoto Prefectural University of Medicine
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics | Year: 2012

We consider an extremal three-point correlator of three heavy vertex operators for the circular winding string state with one large spin and one winding number in AdS 5 and one large spin and one winding number in S 5. We use a Schwarz-Christoffel transformation to compute semiclassically the extremal three-point correlator on a stationary string trajectory which is mapped to the complex plane with three punctures. It becomes a 4d conformal invariant three-point correlator on the boundary. We discuss the marginality condition of vertex operator. © 2012. Source

Fushiki S.,Kyoto Prefectural University of Medicine
Brain and Development | Year: 2013

On March 11, 2011, Japan was hit by the Great East Japan Earthquake followed by the Fukushima Daiichi Nuclear Disaster. Firstly, this review focuses on what happened after the accidents at the Three Mile Island nuclear power station in 1979 and the Chernobyl nuclear power plant in 1986, in terms of the effects of these incidents on health. The most critical issue when considering the effects of radiation on the health of children was the increase of thyroid cancer, as clearly demonstrated among people who were children or adolescence at the time of the Chernobyl accident. Therefore, in the early days after a nuclear accident, the primary concern should be efforts to prevent the exposure of children to radioactive iodine through inhalation and ingestion, because radioactive iodine preferentially accumulates in the thyroid. In the longer term, another concern is exposure to radionuclides with long half-lives, including cesium137 and cesium134, with physical half-lives of 30 and 2. years, respectively. Secondly, fetal radiation risks and radiobiological studies on low-level radiation are briefly reviewed, with reference to the effects upon the developing brain. A fetal dose of 100. mSv may increase the risk of an effect on brain development, especially neuronal migration, based upon the results of experiments with rodents. Finally, this review proposes that research on the health effects of low level radiation should be prioritized so that accurate information on the effects of radiation can be disseminated and prevent the prevalence of unnecessary fear lacking scientific justification. © 2012 The Japanese Society of Child Neurology. Source

Maruyama K.,Kyoto Prefectural University of Medicine
Investigative ophthalmology & visual science | Year: 2012

It has been shown previously that the presence in the cornea of antigen-presenting cells (APC), such as macrophages (MPS) and lymphangiogenesis, is a risk for corneal transplantation. We sought to determine whether the existence of lymphatic vessels in the non-inflamed cornea is associated with the presence of MPS. Flat mounts were prepared from corneas of untreated C57BL/6, CD11b(-/-), F4/80(-/-), and BALB/c mice, and after suture placement or corneal transplantation, observed by immunofluorescence for the presence of lymphatic vessels using LYVE-1 as a marker of lymphatic endothelium. Innate immune cells were detected in normal mouse corneas using CD11b, F4/80, CD40, as well as MHC-class II. Digital images of the flat mounts were taken using a spot image analysis system, and the area covered by lymphatic vessels was measured using NIH Image software. The number of spontaneous lymphatic vessels in C57BL/6 corneas was significantly greater than in BALB/c corneas (P = 0.03). There were more CD11b(+) (P < 0.01) and CD40(+), MHC-class II (+) cells in the C57BL/6 corneas than in BALB/c mouse corneas. MPS depletion via clodronate liposome in C57BL/6 mice led to fewer spontaneous lymphatic vessels and reduced inflammation-induced lymphangiogenesis relative to control mice. Mice deficient in CD11b or F4/80 had fewer spontaneous lymphatic vessels and less lymphangiogenesis than control C57BL/6 mice. C57BL/6 mouse corneas have more endogenous CD11b(+) cells and lymphatic vessels. The endogenous lymphatic vessels, along with pro-inflammatory MPS, account for the high risk of corneal graft rejection in C57BL/6 mice. CD11b(+) and F4/80(+) MPS appear to have an important role in of the formation of new lymphatic vessels. Source

Katsuyama M.,Kyoto Prefectural University of Medicine
Journal of Pharmacological Sciences | Year: 2010

NADPH oxidase is a superoxide (O2-)-generating enzyme first identified in phagocytes that shows bactericidal activities. It has been reported that O2- is also produced in an NADPHdependent manner in non-phagocytes. In the last decade, non-phagocyte-type NADPH oxidases have been identified, and the catalytic subunit NOX family has been found to be composed of five homologs, NOX1 to NOX5, and two related enzymes, DUOX1 and DUOX2. These NOX proteins have distinct features in dependency on other components for maximal enzymatic activity, tissue distribution, expressional regulation, and physiological functions. This review summarized the distinct characteristics of NOX family proteins, especially focusing on their functions and mechanisms of their expressional regulation. © 2010 The Japanese Pharmacological Society. Source

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