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Mochizuki Y.,Shiga University of Medical Science | Saito Y.,Shiga University of Medical Science | Tanaka T.,Shiga University of Medical Science | Nitta N.,Shiga University of Medical Science | And 5 more authors.
Journal of Gastrointestinal Cancer | Year: 2012

We report a case of a patient with esophageal squamous cell carcinoma who presented with obstruction of the esophagus. On endoscopy, a central ulcerating lesion was found spreading to the anterior wall of the middle esophagus. Four courses of chemoradiation therapy successfully produced a complete response for 3 years. A recurrence occurred which consisted of a morphologically flat lesion that occupied the entire circumference of the esophagus. Endoscopic submucosal dissection removed all lesions en bloc. To prevent a post-procedure mucosal defect of the circumference of the esophagus, biodegradable polyl- lactic acid monofilaments esophageal stents were placed on the same day. One month later, the patient reported a feeling of obstruction. An endoscopic examination revealed food stuck in the stents, this was removed, and balloon dilatation provided good passage which has been maintained for 7 months. © Springer Science+Business Media, LLC 2011. Source


Yamane H.,Kyoto Institute of Technology | Momii S.,Kyoto Institute of Technology | Yagi S.-I.,Kyoto Medical Planning Co. | Wataoka I.,Kyoto Institute of Technology | Suzuki N.,Kaneka Corporation
Advanced Materials Research | Year: 2014

Synthetic mica organically treated with alkylamines was added to poly(3-hydroxybutyrate-co-3hydroxyhexanoate) (PHBH), one of the bacterial co-polyesters. Mica dispersing in PHBH acted as a crosslinking point of PHBH chains and increased the melt viscosity of PHBH significantly. The melt spinnability of PHBH was greatly improved by the addition of mica and the crystallization of PHBH in the spinline was highly promoted. WAXD spectra showed that the as-spun fibers of PHBH/MICA contain both highly oriented a- and b-forms of PHBH crystal. Further the SAXS revealed that the mica dispersing in the PHBH fiber oriented with its surface parallel to the fiber axis. The crystalline orientation of PHBH, orientation of mica, and the formation of b-form all improve the mechanical property of PHBH fibers. © (2014) Trans Tech Publications, Switzerland. Source


Nishio S.,Shiga Medical Center for Adults | Kosuga K.,Shiga Medical Center for Adults | Igaki K.,Kyoto Medical Planning Co. | Okada M.,Shiga Medical Center for Adults | And 19 more authors.
Circulation | Year: 2012

Background-The purpose of this study was to evaluate the long-term safety of the Igaki-Tamai stent, the first-in-human fully biodegradable coronary stent made of poly-l-lactic acid. Methods and Results-Between September 1998 and April 2000, 50 patients with 63 lesions were treated electively with 84 Igaki-Tamai stents. Overall clinical follow-up (>10 years) of major adverse cardiac events and rates of scaffold thrombosis was analyzed together with the results of angiography and intravascular ultrasound. Major adverse cardiac events included all-cause death, nonfatal myocardial infarction, and target lesion revascularization/target vessel revascularization. During the overall clinical follow-up period (121±17 months), 2 patients were lost to follow-up. There were 1 cardiac death, 6 noncardiac deaths, and 4 myocardial infarctions. Survival rates free of all-cause death, cardiac death, and major adverse cardiac events at 10 years were 87%, 98%, and 50%, respectively. The cumulative rates of target lesion revascularization (target vessel revascularization) were 16% (16%) at 1 year, 18% (22%) at 5 years, and 28% (38%) at 10 years. Two definite scaffold thromboses (1 subacute, 1 very late) were recorded. The latter case was related to a sirolimus-eluting stent, which was implanted for a lesion proximal to an Igaki-Tamai stent. From the analysis of intravascular ultrasound data, the stent struts mostly disappeared within 3 years. The external elastic membrane area and stent area did not change. Conclusion-Acceptable major adverse cardiac events and scaffold thrombosis rates without stent recoil and vessel remodeling suggested the long-term safety of the Igaki-Tamai stent. © 2012 American Heart Association, Inc. Source


Patent
Kyoto Medical Planning Co. | Date: 2012-02-17

An object is to surely hold a stent formed of a biodegradable polymer and shape memorized to an expanded size having a diameter larger than an inner diameter of a vessel on a balloon in contracted state. A stent apparatus comprises a stent formed of a biodegradable polymer material using polylactic acid having a shape memory property as a tubular shape and shape memorized to a size capable of scaffolding a vessel from the inside when implanted in the vessel; and a stent holding member formed of a biodegradable polymer material for covering the outer surface of the stent to hold the stent in a contracted state that is smaller in diameter than the shape memorized size, wherein a stent detecting member is attached to the stent and a part of the stent holding member is fixed to the stent detecting member.


Patent
Kyoto Medical Planning Co. | Date: 2010-09-09

Present invention is a medical catheter apparatus used for implanting a vascular stent into a vessel of a living body comprising a catheter (

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