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Shiokawa M.,Kyoto University | Kodama Y.,Kyoto University | Yoshimura K.,Kyoto University | Kawanami C.,Red Cross | And 22 more authors.
American Journal of Gastroenterology | Year: 2013

OBJECTIVES:Although simultaneous occurrences of autoimmune pancreatitis (AIP) and cancer are occasionally observed, it remains largely unknown whether cancer and AIP occur independently or these disorders are interrelated. The aim of this study was to examine the relationship between AIP and cancer.METHODS:We conducted a multicenter, retrospective cohort study. One hundred and eight patients who met the Asian diagnostic criteria for AIP were included in the study. We calculated the proportion, standardized incidence ratio (SIR), relative risk, and time course of cancer development in patients with AIP. We also analyzed the clinicopathological characteristics of AIP patients with cancer in comparison with those without cancer.RESULTS:Of the 108 AIP patients, 18 cancers were found in 15 patients (13.9%) during the median follow-up period of 3.3 years. The SIR of cancer was 2.7 (95% confidence interval (CI) 1.4-3.9), which was stratified into the first year (6.1 (95% CI 2.3-9.9)) and subsequent years (1.5 (95% CI 0.3-2.8)) after AIP diagnosis. Relative risk of cancer among AIP patients at the time of AIP diagnosis was 4.9 (95% CI 1.7-14.9). In six of eight patients whose cancer lesions could be assessed before corticosteroid therapy for AIP, abundant IgG4-positive plasma cell infiltration was observed in the cancer stroma. These six patients experienced no AIP relapse after successful cancer treatment.CONCLUSIONS:Patients with AIP are at high risk of having various cancers. The highest risk for cancer in the first year after AIP diagnosis and absence of AIP relapse after successful treatment of the coexisting cancers suggest that AIP may develop as a paraneoplastic syndrome in some patients. © 2013 by the American College of Gastroenterology.

PubMed | Osaka University, Kyoto Industrial Health Association, Japan National Cardiovascular Center Research Institute, Kyoto Prefectural University of Medicine and 2 more.
Type: | Journal: Scientific reports | Year: 2016

Cerebral microbleeds (CMBs) are an important risk factor for stroke and dementia. We have shown that the collagen binding surface Cnm protein expressed on cnm-positive Streptococcus mutans is involved in the development of CMBs. However, whether the collagen binding activity of cnm-positive S. mutans is related to the nature of the CMBs or to cognitive impairment is unclear. Two-hundred seventy nine community residents (70.0 years) were examined for the presence or absence of cnm-positive S. mutans in the saliva by PCR and collagen binding activity, CMBs, and cognitive function were evaluated. Cnm-positive S. mutans was detected more often among subjects with CMBs (p<0.01) than those without. The risk of CMBs was significantly higher (odds ratio=14.3) in the group with S. mutans expressing collagen binding activity, as compared to the group without that finding. Deep CMBs were more frequent (67%) and cognitive function was lower among subjects with cnm-positive S. mutans expressing collagen binding activity. This work supports the role of oral health in stroke and dementia and proposes a molecular mechanism for the interaction.

PubMed | Kyoto Industrial Health Association, Kyoto Prefectural University of Medicine and Nara University
Type: Journal Article | Journal: BMC neurology | Year: 2016

Recent research suggests that several pathogenetic factors, including aging, genetics, inflammation, dyslipidemia, diabetes, and infectious diseases, influence cognitive decline (CD) risk. However, no definitive candidate causes have been identified. The present study evaluated whether certain serum parameters predict CD.A total of 151 participants were assessed for CD using the Mini-Mental State Examination (MMSE), and 34 participants were identified as showing CD.Among CD predictive risk factors, Helicobacter pylori seropositivity was significantly predictive of CD risk, more so than classical risk factors, including white matter lesions and arterial stiffness [adjusted odds ratio (OR)=4.786, 95% confidence interval (CI)=1.710-13.39]. A multivariate analysis indicated that the albumin to globulin (A/G) ratio was the only factor that significantly lowered CD risk (OR=0.092, 95% CI=0.010-0.887). A/G ratio also was positively correlated with MMSE scores and negatively correlated with disruption of homeostatic factors (i.e., non-high-density lipoprotein, hemoglobin A1c, and high-sensitive C-reactive protein).The current study results suggest that the A/G ratio is related to cognitive decline and may reflect homeostatic alterations.

Ikeda M.,Kyoto Industrial Health Association | Watanabe T.,Kyoto Industrial Health Association | Ohashi F.,Miyagi University of Education | Shimbo S.,Kyoto Women's University
Biological Trace Element Research | Year: 2010

This study was initiated to examine if variations in the concentrations of cadmium (Cd) and lead (Pb) in water environment may affect metal levels in local foods and body burden oflocal residents in non-polluted areas in Japan. Two nationwide databases have been made available on concentrations of Cd in locally harvested brown rice and of Cd and Pb in sediments in local river beds. These data were combined with published data on metal concentrations in polished rice, food duplicates, and blood and urine from the residents. Cd in river sediments correlated significantly with those in brown rice, food duplicates, blood, and urine. Cd in food duplicates correlated with Cd in rice. In contrast, Pb concentrations in the river sediments either did not correlate or correlated only weakly with Pb in biological materials or food duplicates. Possible implication of the different behavior between Cd and Pb regarding the intensity of correlation was discussed with reference to the different routes ofexposure to the elements. In conclusions, the Cd body burden on local residents in Japan is significantly influenced by Cd levels in water in the general environment, whereas waterborne Pb did not show clear correlation with the Pb body burden. ©Humana Press Inc. 2009.

Koizumi N.,George Mason University | Ohashi F.,Kyoto Industrial Health Association | Ikeda M.,Kyoto Industrial Health Association
International Archives of Occupational and Environmental Health | Year: 2010

Objectives Cadmium is a ubiquitous hazardous element with nephro-toxicity after long-term exposure. The present study was initiated to examine possible effects of dietary cadmium (Cd) intake on health of local residents across Japan. For this purpose, Cd in locally harvested brown rice (Cd-BR) was taken as the parameter of Cd exposure, and two measures of mortality, i.e., standardized mortality ratio (SMR) and age-adjusted renal insufficiency mortality rate (AARIMR) were employed as parameters of over-all health effects including effects on kidney. Methods Japan consists of 47 prefectures. Data on Cd in 37,250 brown rice samples harvested in 1997-1998 in the 47 prefectures were made available from the Ministry of Agriculture, Forestry and Fisheries, Japan. SMR and AARIMR data (for the year 2000) by two genders in the 47 prefectures were cited from publications of the Ministry of Health, Labour and Welfare, Japan. Possible correlation of Cd in brown rice (Cd-BR) with SMR and AARIMR was examined by Poisson regression analysis. Results The geometric mean (GM) Cd-BR for Japan as a whole was 0.040 mg/kg with a geometric standard deviation (GSD) of 2.72. Prefectural GM values varied from a low of\0.01 mg/kg to a high of 0.089 mg/kg. Nevertheless, SMR (in a range of 89.9-119.5 for men and 87.1-111.7 for women) did not correlatewithCd-BRsignificantly.AARIMR (in a range of 5.3-11.9 and 3.2-8.4 for men and women, respectively) tended to decrease as a function of increasing Cd-BR both in men and women, although the correlation was insignificant in both genders. Conclusions No evidence was obtained in the present analysis to suggest that either mortality as a whole or the mortality due to renal failure is affected by dietary intake of Cd in rice. © Springer-Verlag 2009.

Moon C.-S.,Catholic University of Pusan | Lee C.K.,Busan Paik Hospital | Hong Y.S.,Dong - A University | Ikeda M.,Kyoto Industrial Health Association
Asia Pacific Journal of Clinical Nutrition | Year: 2014

This survey was initiated to examine possible coastal-inland differences in cadmium (Cd) burden in general Korean populations. In total, 268 healthy non-smoking middle-aged women (30 to 49 years; 88 residents in 8 coastal areas and 180 residents in 15 inland areas) participated in the study. They offered peripheral blood and spot urine samples so that cadmium in blood (Cd-B) and urine (Cd-U) were taken as exposure markers. Determination of Cd-B and Cd-U was carried out by graphite furnace atomic absorption spectrophotometry. With regard to Cd burden, geometric means for the coastal and inland residents were 1.70 and 1.72 μg/L for Cd-B, 1.54 and 1.00 μg/L for Cd-U as observed (Cd-U), 2.59 and 1.81 μg/g creatinine for Cd-U as corrected for creatinine (Cd-Ucr), respectively. Cd-U and Cd-Ucr were higher in the coastal areas than in inland areas. Reasons for higher Cd-U in the coastal areas than in the inland areas were are discussed in relation to major sources of Cd in daily life of the residents. Attention was paid to consumption of fish and shellfish in the coastal areas as major sources of dietary Cd intake. This study shows that Cd burdens were higher in coastal areas than in inland areas in Korea.

Kawai T.,Osaka Occupational Health Service Center | Mitsuyoshi K.,Osaka Occupational Health Service Center | Ikeda M.,Kyoto Industrial Health Association
Journal of Occupational Health | Year: 2015

Objectives: The aim of this study was to examine the applicability of urinalysis for unmetabolized solvent to biomonitor 1,2-dichloropropane (1,2-DCP) exposure. Methods: Thirty three male printers exposed to 1,2-DCP and 5 nonexposed male controls participated in the study. The 8-hr average levels of exposure to 1,2-DCP in air and 1,2-DCP in the end-of-shift urine samples were measured with capillary FID-GC. Results: The geometric mean (the maximum) concentrations was 7.1 ppm (23.1 ppm) for 1,2-DCP in air, and the level in urine (without correction for urine density) was 77 μ g/l (247 μ g/l). A regression analysis showed a correlation coefficient of 0.909 (p<0.01). No 1,2-DCP was detected in the urine samples from nonexposed subjects. Conclusions: The high correlation and low background (essentially zero) showed that urinalysis for unmetabolized 1,2-DCP is a promising tool for biomonitoring of occupational exposure to this carcinogenic solvent at lower levels (e.g. <1 ppm). © 2015. Japan Society for Occupational Health.

Kawai T.,Osaka Occupational Health Service Center | Takeuchi A.,Osaka Occupational Health Service Center | Ikeda M.,Kyoto Industrial Health Association
Journal of Occupational Health | Year: 2015

Comparison of the exposure-excretion relationship between men and women exposed to organic solvents: Toshio KAWAI, et al. Osaka Occupational Health Service Center-Objectives: The present study was initiated to examine if application of the same biological occupational exposure limits (BOELs) for organic solvents is applicable across the sexes. Methods: A survey was conducted in 69 micro-scale enterprises in a furniture-producing industrial park. In practice, 211 men and 52 women participated in the survey. They worked in a series of production process, and were exposed to solvent vapor mixtures. The exposure intensities were monitored with two types of diffusive samplers, one with carbon cloth (for solvents in general) and the other with water (for methyl alcohol) as adsorbents. Solvents in the adsorbents and head-space air from urine samples were analyzed with capillary FID-GC. The measured values were subjected to linear regression analysis followed by statistical evaluation for possible sex-related differences in slopes. Results: Essentially no significant difference was detected between men and women in regression line parameters including slopes. Possible differences in the cases of acetone and toluene were discussed and excluded. Conclusions: With the exceptions for acetone and toluene, the present study did not detect any clear differences between men and women. In examinations of past reports, no support for the observed differences was found. The present findings deserve further study so that a solid conclusion can be formed.

Iwami O.,Iwami Neurological Clinic | Ikeda M.,Kyoto Industrial Health Association
Environmental Health and Preventive Medicine | Year: 2013

Objectives: Many traditionally established medical interventions are not examined with randomized trials especially in emergency medicine. We researched what is the scientific basis of the measurement of the causal effect in these interventions and proposed another trial to measure causal effects. Methods: We deduced steady state trials from the counterfactual model and used Bayesian approaches to estimate causal effects statistically. Results: When the state of the observed person is fairly steady before an exposure, the ratio of the after-period to the before-period of the exposure is sufficiently small, and changes are obtained in relatively short time, it is possible to postulate that the state of the counterfactual person to be compared is almost equal to the state of the real person before the exposure. Bayesian approaches show that the causal effect of the exposure is estimated even in only one-person steady state trials, when large changes are observed. Conclusions: Steady state trials are valid methods to measure causal effects and can measure causal effects even in one-person trials. When we can measure the causal effect of interventions with steady state trials, these interventions should be regarded as scientific without use of randomized trials. © 2012 The Author(s).

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