Furukawa T.A.,Nagoya City University |
Kawakami N.,University of Tokyo |
Kadota M.,Nagoya City University |
Sasaki M.,Naruto University of Education |
And 8 more authors.
PLoS ONE | Year: 2012
Background: Subthreshold depression is highly prevalent in the general population and causes great loss to society especially in the form of reduced productivity while at work (presenteeism). We developed a highly-structured manualized eight-session cognitive-behavioral program with a focus on subthreshold depression in the workplace and to be administered via telephone by trained psychotherapists (tCBT). Methods: We conducted a parallel-group, non-blinded randomized controlled trial of tCBT in addition to the pre-existing Employee Assistance Program (EAP) versus EAP alone among workers with subthreshold depression at a large manufacturing company in Japan. The primary outcomes were depression severity as measured with Beck Depression Inventory-II (BDI-II) and presenteeism as measured with World Health Organization Health and Work Productivity Questionnaire (HPQ). In the course of the trial the follow-up period was shortened in order to increase acceptability of the study. Results: The planned sample size was 108 per arm but the trial was stopped early due to low accrual. Altogether 118 subjects were randomized to tCBT+EAP (n = 58) and to EAP alone (n = 60). The BDI-II scores fell from the mean of 17.3 at baseline to 11.0 in the intervention group and to 15.7 in the control group after 4 months (p&0.001, Effect size = 0.69, 95%CI: 0.32 to 1.05). However, there was no statistically significant decrease in absolute and relative presenteeism (p = 0.44, ES = 0.15, -0.21 to 0.52, and p = 0.50, ES = 0.02, -0.34 to 0.39, respectively). Conclusion: Remote CBT, including tCBT, may provide easy access to quality-assured effective psychotherapy for people in the work force who present with subthreshold depression. Further studies are needed to evaluate the effectiveness of this approach in longer terms. The study was funded by Sekisui Chemicals Co. Ltd. Trial Registration: ClinicalTrials.gov
Nagano M.,Kyoto Bunkyo University |
Adachi M.,Okayama University |
Kakoi C.,National Institute of Fitness and Sports in Kanoya |
Kumagai S.,Kyushu University
Japanese Journal of Physical Fitness and Sports Medicine | Year: 2015
Very few studies have reported an independent association of the physical activityrelated indices with the psychological stress reaction. The present study therefore investigated the association of fitness and screentime as one of the indices of sedentary behavior with the four types of psychological stress reactions and the number of days absent from school for 249 children at a local public school and a metropolitan private school while considering confounding factors. No significant difference was observed in the fitness level of both schools; however, the rate of obesity, the screentime and the level of all psychological stress reactions were significantly worse in the public school. Further, significant differences and trends among the groups classified by fitness level were recognized in the rates of participation in after school activities, feeling of powerlessness and days of absence per year. In addition, the odds ratio of the screentime for depressive and anxiety symptoms was 1.004 (95%CI: 1.000-1.007, p=0.039), while the odds of the fitness level for high feeling of powerlessness and more than five days of absence were 1.582 (95%CI: 1.045-2.396, p=0.030) and 1.434 (95%CI: 1.045-2.396, p=0.015), respectively, after adjusting for the school type, differences in lifestyle and participation in after school activities. In conclusion, the fitness level and the screentime were associated with high psychological stress reactions and the days of absence, independent of the above-mentioned adjusting factors among the children in the present study. Prospective and interventional studies to verify these results are needed.
PubMed | Red Cross, Kyoto Bunkyo University, University of Tokyo and National Health Research Institute
Type: | Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences | Year: 2015
Fatty acids and related metabolites, comprising several hundreds of molecular species, are an important target in disease metabolomics, as they are involved in various mammalian pathologies and physiologies. Selected reaction monitoring (SRM) analysis, which is capable of monitoring hundreds of compounds in a single run, has been widely used for comprehensive quantification. However, it is difficult to monitor a large number of compounds with different ionization polarity, as polarity switching requires a sub-second period per cycle in classical mass spectrometers. In the present study, we developed and evaluated a comprehensive quantification method for eicosanoids and related compounds by using LC/MS with high-speed continuous ionization polarity switching. The new method employs a fast (30ms/cycle) continuous ionization polarity switching, and differentiates 137 targets either by chromatography or by SRM transition. Polarity switching did not affect the lower limits of quantification, which ranged similarly from 0.5 to 200pg on column. Lipid extracts from mouse tissues were analyzed by this method, and 65 targets were quantitatively detected in the brain, including 6 compounds analyzed in the positive ion mode. We demonstrated that a fast continuous ionization polarity switching enables the quantification of a wide variety of lipid mediator species without compromising the sensitivity and reliability.
Ubukata S.,Kyoto University |
Ubukata S.,Kobe University |
Miyata J.,Kyoto University |
Yoshizumi M.,Kyoto University |
And 15 more authors.
Journal of Psychiatric Research | Year: 2013
Subjective quality of life (QOL) has been recognized as an important consideration in schizophrenia. Several symptoms and neurocognitive functions were shown to be correlated with subjective QOL; however its determinants are not well understood. In this study, we investigated the association between brain structural abnormalities and subjective QOL in patients with schizophrenia. Forty-five schizophrenia patients and 48 age, sex, and education-matched healthy participants underwent magnetic resonance imaging (MRI), and the Schizophrenia Quality of Life Scale (SQLS) was used to rate subjective QOL. We performed voxel-based morphometry (VBM) to investigate regional brain alterations. Relative to normal controls, schizophrenia patients exhibited gray matter reductions mainly in the frontal and temporal regions. Worse psychosocial subscale of SQLS was associated with gray matter (GM) reduction in the right dorsolateral prefrontal cortex (DLPFC), and worse motivation/energy subscale was associated with gray matter reduction in the left superior frontal sulcus, left parahippocampal gyrus, and the left inferior temporal gyrus. The correlation between DLPFC GM volume and psychosocial subscale of SQLS disappeared after controlling for severity of psychopathology, while the other correlations remained significant when controlled by demographic and clinical variables. Combining imaging techniques with psychosocial methods would help to elucidate those factors that are associated with QOL. © 2013 Elsevier Ltd.
Nagano M.,Kyoto Bunkyo University |
Shimizu K.,Kyushu University |
Kondo R.,Kyushu University |
Hayashi C.,Kyushu University |
And 3 more authors.
Biomedical Research | Year: 2010
Hericium erinaceus, a well known edible mashroom, has numerous biological activities. Especially hericenones and erinacines isolated from its fruiting body stimulate nerve growth factor (NGF) synthesis, which expects H. erinaceus to have some effects on brain functions and autonomic nervous system. Herein, we investigated the clinical effects of H. erinaceus on menopause, depression, sleep quality and indefinite complaints, using the Kupperman Menopausal Index (KMI), the Center for Epidemiologic Studies Depression Scale (CES-D), the Pittsburgh Sleep Quality Index (PSQI), and the Indefinite Complaints Index (ICI). Thirty females were randomly assigned to either the H. erinaceus (HE) group or the placebo group and took HE cookies or placebo cookies for 4 weeks. Each of the CES-D and the ICI score after the HE intake was significantly lower than that before. In two terms of the ICI, "insentive" and "palpitation", each of the mean score of the HE group was significantly lower than the placebo group. "Concentration", "irritating" and "anxious" tended to be lower than the placebo group. Our results show that HE intake has the possibility to reduce depression and anxiety and these results suggest a different mechanism from NGF-enhancing action of H. erinaceus.
Ninomiya K.,Hokkaido University |
Ohno M.,Kyoto University |
Kataoka N.,Kyoto Bunkyo University
Genes to Cells | Year: 2016
Localization of mRNA in neuronal cells is a critical process for spatiotemporal regulation of gene expression. Cytoplasmic localization of mRNA is often conferred by transport elements in 3' untranslated region (UTR). Activity-regulated cytoskeleton-associated protein (arc) mRNA is one of the localizing mRNAs in neuronal cells, and its localization is mediated by dendritic targeting element (DTE). As arc mRNA has introns in its 3' UTR, it was thought that arc mRNA is a natural target of nonsense-mediated mRNA decay (NMD). Here, we show that DTE in human arc 3' UTR has destabilizing activity of RNA independent of NMD pathway. DTE alone was able to cause instability of the reporter mRNA and this degradation was dependent on translation. Our results indicate that DTE has dual activity in mRNA transport and degradation, which suggests the novel spatiotemporal regulation mechanism of activity-dependent degradation of the mRNA. © 2016 Molecular Biology Society of Japan and John Wiley & Sons Australia, Ltd.
Kawamoto N.,Kyoto Bunkyo University
Journal of the Japan Research Association for Textile End-Uses | Year: 2011
To clear the features of apparel colors preferred by young people, an experiment was done for 275 college students, i.e., 164 females and 111 male students. In the experiment, every subject classified 25 colors, which correspond to gross classification in "The Color Code for Investigation" published by Japan Color Research Institute, into three categories: usually preferred colors, occasionally preferred colors, and disliked colors. By using the data of the present experiment, the differences between preference colors of female and those of male subjects were considered. Furthermore, the present (2008-2009) data was compared to the previous (2005-2006) data obtained in the similar way, and the changes in the three years were considered. Female subjects usually preferred beige, brown, and gray range, and occasionally preferred pink, yellow, and lavender more than male subjects, and their differences were statistically significant. By using cluster analysis, the subjects were classified into three groups. It was seen that a group who especially prefers pink range was in female subjects, and a group who especially prefers blue range was in male subjects. The number of occasionally preferred colors in the present research decreased compared to that of the previous research in three years before. Preferences to intermediate hues significantly decreased. On the contrary, preferences to neutral colors and unique hues were considerably stable. © 2011 Jpn.Res.Assn.Text.End-Uses.
Sasamoto A.,Kyoto University |
Miyata J.,Kyoto University |
Kubota M.,Kyoto University |
Hirao K.,Kyoto University |
And 10 more authors.
Schizophrenia Bulletin | Year: 2014
Previous neuroimaging studies have revealed that both gray matter (GM) and white matter (WM) are altered in several morphological aspects in schizophrenia patients. Although several studies reported associations between GM and WM alterations in restricted regions, the existence of a global association between GM and WM pathologies is unknown. Considering the wide distribution of GM morphological changes and the profound genetic background of WM abnormalities, it would be natural to postulate a global association between pathologies of GM and WM in schizophrenia. In this investigation, we studied 35 schizophrenia patients and 35 healthy control subjects using T1-weighted magnetic resonance imaging and diffusion tensor imaging (DTI) and investigated the association between GM thickness and WM fractional anisotropy (FA) as a proxy of pathology in each tissue. To investigate cortical thickness, surface-based analysis was used. The mean cortical thickness for the whole brain was computed for each hemisphere, and group comparisons were performed. For DTI data, mean FA for the whole brain was calculated, and group comparisons were performed. Subsequently, the correlation between mean cortical thickness and mean FA was investigated. Results showed that the mean cortical thickness was significantly thinner, and the mean FA was significantly lower in schizophrenia patients. Only in the patient group the mean cortical thickness and mean FA showed significant positive correlations in both hemispheres. This correlation remained significant even after controlling for demographic and clinical variables. Thus, our results indicate that the GM and WM pathologies of schizophrenia are intertwined at the global level. © 2013 The Author. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved.
Kawamoto N.,Kyoto Bunkyo University
Journal of the Japan Research Association for Textile End-Uses | Year: 2015
The author has investigated color distribution features in the cover of female fashion magazines. Using nine features derived from the image data of the cover, cluster analysis was performed to classify the magazines. In terms of the features of the cover, the female fashion magazines were found to be clearly distinguished from those of the other genres. It was also found that each female fashion magazine had distinctive cover depending on the fashion type of the magazine. Furthermore, factor analysis was performed to summarize the image features, and four factors, "average saturation", "average lightness and fineness", "multi-hue", and "tone contrast", were obtained. Scores for "average lightness and fineness" factor and "multi-hue" factor were high for most teen's magazines. Scores for "multi-hue" factor were significantly low for most mode magazines, and scores for "tone contrast" factor were high for most street fashion magazines. The female fashion magazines were distinguished clearly in terms of the average saturation and the average lightness of the cover, but there was no little difference for average hue. The covers of most female fashion magazines had similar average hue ranging from red to orange. ©2015 Jpn. Res.Assn.Text.End-Uses.
Takada M.,Mie University |
Shima S.,Kyoto Bunkyo University
Industrial Health | Year: 2010
The present study reviews the literature on suicide prevention programs conducted in the workplace and other settings, namely school, the community, medical facilities, jail, and the army, by conducting an electronic literature search of all articles published between 1967 and November 2007. From a total of 256 articles identified, various contents of suicide prevention programs were determined, and in 34 studies, the effect of programs was evaluated. A review of the literature reveals that the common contents of suicide prevention programs in the workplace and other settings are education and training of individuals, development of a support network, cooperation from internal and external resources, as well as education and training of managers and staff. Although the characteristic contents of suicide prevention programs at the workplace aimed at improving personnel management and health care, screening and care for high-risk individuals, as well as improvement of building structures, were not described. Although a reduction in undesirable attitudes and an increase in mental health knowledge and coping skills in the workplace are in agreement with findings in other settings, suicide rate, suicide-associated behavior, and depression, which were assessed in other settings, were not evaluated in the three studies targeting the workplace.