Kyorin University is a private university located in the western part of Tokyo, Japan. Its two campuses are in Mitaka and Hachiō-ji, Tokyo. It was established in 1970. The predecessor of the school, Mitaka Shinkawa Hospital, was founded in 1953 by Shinyu Matsuda. Wikipedia.
News Article | February 17, 2017
DUBLIN - Feb. 17, 2017 - Medtronic plc (NYSE: MDT) today announced Japan regulatory approval for the world's smallest pacemaker, the Micra(TM) Transcatheter Pacing System (TPS). Japan's Pharmaceuticals and Medical Device Agency (PMDA) granted approval for Micra based on positive data from the Medtronic Micra TPS Global Clinical Trial, which enrolled 744 patients and evaluated the safety and efficacy of the device through a single-arm, multi-center study at 56 centers in 19 countries, including Japan. Approved by the U.S. Food and Drug Administration (FDA) in April 2016 for patients who need a single-chamber pacemaker, the Micra TPS is the first and only leadless pacemaker approved for use in the United States. Micra was recently named at the top of US News & World Report's list of "2016's Biggest Achievements in Medicine." It is approved for both 1.5 and 3 Tesla full-body magnetic resonance imaging (MRI) scans. "The development of a leadless pacemaker which can be implanted with a less invasive procedure has been eagerly awaited by physicians and patients in Japan," said Kyoko Soejima, M.D., professor of cardiovascular internal medicine at Kyorin University. "The safety and efficacy of the Micra TPS has been confirmed in my hospital as well as in other hospitals across the world that took part in the Micra TPS Global Clinical Trial." Comparable in size to a large vitamin, the Micra TPS is less than one-tenth the size of traditional pacemakers, yet delivers the most advanced pacing technology to patients via a minimally-invasive approach. During the implant procedure, it is attached to the heart with small tines and delivers electrical impulses that pace the heart through an electrode at the end of the device. Unlike traditional pacemakers, the Micra TPS does not require leads or a surgical "pocket" under the skin, so potential sources of complications related to such leads and pocket are eliminated - as are any visible signs of the device. "Medtronic is excited to be the first to offer a miniaturized, leadless pacemaker to patients in Japan," said John Liddicoat, M.D., senior vice president, Medtronic, and president of the Cardiac Rhythm and Heart Failure division. "We look forward to working with Japan's Ministry of Health, Labor and Welfare to gain reimbursement for Micra so patients can gain access to this innovative technology as quickly as possible." The Micra design incorporates a retrieval feature which can be enabled when possible; however, the device is designed to be left in the body. For patients who need more than one device, the miniaturized Micra TPS can be permanently turned off, allowing it to remain in the body so a new device can be implanted without risk of electrical interaction. Preliminary results from the Medtronic Micra TPS Global Clinical Trial, published in the New England Journal of Medicine, showed the Micra TPS was successfully implanted in 99.2 percent of patients and that the system met its safety and effectiveness endpoints with wide margins. In August 2016, new long-term data presented in a late-breaking clinical trial at the European Society of Cardiology congress continued to reinforce these results, demonstrating consistent and sustained outcomes from early performance through 12-month follow-up. In collaboration with leading clinicians, researchers and scientists worldwide, Medtronic offers the broadest range of innovative medical technology for the interventional and surgical treatment of cardiovascular disease and cardiac arrhythmias. The company strives to offer products and services of the highest quality that deliver clinical and economic value to healthcare consumers and providers around the world. Medtronic plc (www.medtronic.com), headquartered in Dublin, Ireland, is among the world's largest medical technology, services and solutions companies - alleviating pain, restoring health and extending life for millions of people around the world. Medtronic employs more than 88,000 people worldwide, serving physicians, hospitals and patients in approximately 160 countries. The company is focused on collaborating with stakeholders around the world to take healthcare Further, Together. Any forward-looking statements are subject to risks and uncertainties such as those described in Medtronic's periodic reports on file with the Securities and Exchange Commission. Actual results may differ materially from anticipated results.
Shishido-Hara Y.,Kyorin University |
Shishido-Hara Y.,Tokyo Metropolitan Institute for Neuroscience
Acta Neuropathologica | Year: 2010
Progressive multifocal leukoencephalopathy is a fatal viral-induced demyelinating disease that was once rare but has become more prevalent today. Over the past decades, much has been learned about the disease from molecular study of the etiological agent of the disease, JC virus. Recently, promyelocytic leukemia nuclear bodies (PML-NBs), punctuate structures for important nuclear functions in eukaryotic cells, were identified as an intranuclear target of JC virus infection. Neuropathologically, JC virus-infected glial cells display diffuse amphophilic viral inclusions by hematoxylin-eosin staining (full inclusions), a diagnostic hallmark of this disease. Recent results using immunohistochemistry, however, revealed the presence of punctate viral inclusions preferentially located along the inner nuclear periphery (dot-shaped inclusions). Dot-shaped inclusions reflect the accumulation of viral progeny at PML-NBs, which may be disrupted after viral replication. Structural changes to PML-NBs have been reported for a variety of human diseases, including cancers and neurodegenerative disorders. Thus, PML-NBs may provide clues to the further pathogenesis of JC virus-induced demyelinating disease. Here, we review what we have learned since the disease entity establishment, including a look at recent progress in understanding the relationship between JC virus, etiology and PML-NBs. © 2010 Springer-Verlag.
Sakurai H.,Kyorin University
Current Opinion in Nephrology and Hypertension | Year: 2013
PURPOSE OF REVIEW: Recent advances in genome technology have provided us with a list of molecules affecting urate handling in humans, many of which are unlikely to be identified through traditional physiological approach alone. Although this article is focused on urate, this can be viewed as a successful model of genomics-physiology collaboration. RECENT FINDINGS: URATv1/GLUT9 (SLC2A9) is shown to play a critical role in urate reabsorption at the proximal tubule, probably more prominent than its partner URAT1 (SLC22A12). The major site of action of ABCG2 (ABCG2), an influential urate secretion transporter, has been shown to be the intestine rather than the kidney proximal tubule. Accordingly, hypofunction of ABCG2 leads to increased fractional excretion of urate, a finding traditionally interpreted as overproduction hyperuricemia. Some SLC17 family members secrete urate in the kidney or intestine. OAT2 (SLC22A7) may take up urate from blood to the proximal tubular cell. In addition, how a common single-nucleotide polymorphisms in ABCG2 affects its function has been elucidated. SUMMARY: A finer grained picture of urate handling in the human body is now emerging, which will help choosing novel targets for urate-lowering therapy.
Takizawa H.,Kyorin University
Korean Journal of Internal Medicine | Year: 2011
The incidence of allergic diseases in most industrialized countries has increased. Although the exact mechanisms behind this rapid increase in prevalence remain uncertain, a variety of air pollutants have been attracting attention as one causative factor. Epidemiological and toxicological research suggests a causative relationship between air pollution and the increased incidence of asthma, allergic rhinitis, and other allergic disorders. These include ozone, nitrogen dioxide and, especially particulate matter, produced by traffic-related and industrial activities. Strong epidemiological evidence supports a relationship between air pollution and the exacerbation of asthma and other respiratory diseases. Recent studies have suggested that air pollutants play a role in the development of asthma and allergies. Researchers have elucidated the mechanisms whereby these pollutants induce adverse effects; they appear to affect the balance between antioxidant pathways and airway inflammation. Gene polymorphisms involved in antioxidant pathways can modify responses to air pollution exposure. While the characterization and monitoring of pollutant components currently dictates pollution control policies, it will be necessary to identify susceptible subpopulations to target therapy/prevention of pollution-induced respiratory diseases. © 2011 The Korean Association of Internal Medicine.
Nagane M.,Kyorin University
Japanese Journal of Cancer and Chemotherapy | Year: 2014
Glioblastoma (GBM) is the most malignant and frequent primary brain tumor. The current standard of care consists of maximum safe resection and radiotherapy with concomitant and subsequent temozolomide (TMZ) treatment. With this treatment plan, the prognosis of patients with GBM remains dismal, with a 5-year survival rate of <10%; thus development of effective, novel therapies is needed. Bevacizumab (Bev, Avastin®) is a humanized monoclonal antibody against vascular endothelial growth factor (VEGF), one of the major potent angiogenic factors for the growth of human cancers, including GBM. Bev has been shown to effectively shrink enhancing lesions of recurrent GBM and decrease symptom burden and brain edema. These positive results led to its approval for malignant glioma treatment in June 2013 in Japan. Two double-blind, placebo-controlled, randomized phase III studies of Bev in newly diagnosed GBM were conducted to verify its efficacy as a first-line therapy used in combination with TMZ. The results, which were reported at the American Society for Clinical Oncology (ASCO) meeting in June 2013, failed to show an increase in overall survival, despite prolongation in progression-free survival. These results led to many unsolved issues regarding the use of Bev for the treatment of GBM. We discuss these problems in this paper and highlight our institutional experience with Bev monotherapy for recurrent high-grade gliomas.
Tohyama M.,Kyorin University
Physical Review C - Nuclear Physics | Year: 2015
The ground state of O16 is calculated by using a time-dependent density-matrix approach derived from a new truncation scheme of the Bogoliubov-Born-Green-Kirkwood-Yvon hierarchy for reduced density matrices, where a three-body density matrix is approximated by an antisymmetrized product of two-body density matrices. The new scheme is compared with a simpler truncation scheme previously used for the calculation of the ground state of O16 where the three-body density matrix is neglected and only two-particle-two-hole elements of the two-body density matrix are considered. It is shown that the results obtained from the two truncation schemes agree well with the exact solution. © 2015 American Physical Society.
Tohyama M.,Kyorin University
Journal of the Physical Society of Japan | Year: 2012
We study collective excitations of a quantum dot consisting of two electrons using a time-dependent density-matrix approach. The advantages of the density-matrix approach are that one- and two-body observables are directly calculated using one- and two-body density matrices and that it has a clear relation to the time-dependent Hartree-Fock theory. Some low-lying spin modes associated with intrinsic transitions of a deformed configuration are predicted. © 2012 The Physical Society of Japan.
Inoue M.,Kyorin University
Developments in Ophthalmology | Year: 2014
A wide-angle viewing system offers a panoramic view of the surgical field and also improves the safety and efficacy of the vitreoretinal surgical procedure. Surgeons can easily observe the fundus in almost the whole area and evaluate the retinal pathologies through the panoramic view even in eyes with small pupils, corneal opacity, or eyes implanted with multifocal intraocular lens or toric intraocular lens. Recent wide-angle viewing systems consist of two types: contact lens and non-contact lens. The benefit of the contact lens type is better resolution and contrast of the fundus image compared to the non-contact lens type. The contact lens is directly attached to the cornea and the aberration and the reflection from the corneal surface are canceled. However, the eye position needs to be fixed and surgical procedures that rotate the eye should be avoided because incomplete attachment of the contact lens causes decreased visibility of the fundus image. The benefit of the non-contact lens type is that the viewing angle can be changed by moving the front lens up and down to adjust the distance between the cornea and the front lens. The surgical procedures are more flexible and the eye can be rotated. Dehydration of the corneal surface decreases the visibility of the fundus image and the corneal surface needs to be covered with viscoelastic material to avoid dehydration. Condensation of the front lens also decreases the visibility of fundus. Understanding the optical characteristics of the wide-angle viewing system is the key to a successful vitreoretinal surgery. © 2014 S. Karger AG, Basel.
Tohyama M.,Kyorin University
Physical Review C - Nuclear Physics | Year: 2013
The effects of the correlations in the ground state of 16O on the octupole and dipole excitations are studied using the extended random phase approximation (ERPA) derived from the time-dependent density-matrix theory. It is found that the ground-state correlation effects are significant, especially in the octupole excitation. It is shown that the first 3- state calculated in the random phase approximation (RPA) is shifted upward when the self-energy contributions are included in particle-hole pairs. The coupling to the two-particle-two-hole states plays a role in shifting the first 3- state down to the right position. It is also found that the dipole strength is fragmented due to the partial occupation of the single-particle states and that the peak position of the giant dipole resonance calculated in ERPA is little changed from that in RPA due to the above-mentioned competing effects: the increase in particle-hole energy and the coupling to two-particle-two-hole configurations. © 2013 American Physical Society.
Sakurai T.,Kyorin University
The British journal of nutrition | Year: 2013
Recently, the ability of polyphenols to reduce the risk of dementia and Alzheimer's disease (AD) has attracted a great deal of interest. In the present study, we investigated the attenuating effects of oligomerised lychee fruit-derived polyphenol (OLFP, also called Oligonol) on early cognitive impairment. Male senescence-accelerated mouse prone 8 (SAMP8) mice (4 months old) were given OLFP (100 mg/kg per d) for 2 months, and then conditioned fear memory testing was conducted. Contextual fear memory, which is considered hippocampus-dependent memory, was significantly impaired in SAMP8 mice compared with non-senescence-accelerated mice. OLFP attenuated cognitive impairment in SAMP8 mice. Moreover, the results of real-time PCR analysis that followed DNA array analysis in the hippocampus revealed that, compared with SAMP8 mice, the mRNA expression of Wolfram syndrome 1 (Wfs1) was significantly higher in SAMP8 mice administered with OLFP. Wfs1 reportedly helps to protect against endoplasmic reticulum (ER) stress, which is thought to be one of the causes for AD. The expression of Wfs1 was significantly up-regulated in NG108-15 neuronal cells by the treatment with OLFP, and the up-regulation was inhibited by the treatment of the cells with a c-Jun N-terminal kinase-specific inhibitor rather than with an extracellular signal-regulated kinase inhibitor. Moreover, OLFP significantly attenuated the tunicamycin-induced expression of the ER stress marker BiP (immunoglobulin heavy chain-binding protein) in the cells. These results suggest that OLFP has an attenuating effect on early cognitive impairment in SAMP8 mice, and diminishes ER stress in neuronal cells.