Kyorin University is a private university located in the western part of Tokyo, Japan. Its two campuses are in Mitaka and Hachiō-ji, Tokyo. It was established in 1970. The predecessor of the school, Mitaka Shinkawa Hospital, was founded in 1953 by Shinyu Matsuda. Wikipedia.
Nagane M.,Kyorin University
Japanese Journal of Cancer and Chemotherapy | Year: 2014
Glioblastoma (GBM) is the most malignant and frequent primary brain tumor. The current standard of care consists of maximum safe resection and radiotherapy with concomitant and subsequent temozolomide (TMZ) treatment. With this treatment plan, the prognosis of patients with GBM remains dismal, with a 5-year survival rate of <10%; thus development of effective, novel therapies is needed. Bevacizumab (Bev, Avastin®) is a humanized monoclonal antibody against vascular endothelial growth factor (VEGF), one of the major potent angiogenic factors for the growth of human cancers, including GBM. Bev has been shown to effectively shrink enhancing lesions of recurrent GBM and decrease symptom burden and brain edema. These positive results led to its approval for malignant glioma treatment in June 2013 in Japan. Two double-blind, placebo-controlled, randomized phase III studies of Bev in newly diagnosed GBM were conducted to verify its efficacy as a first-line therapy used in combination with TMZ. The results, which were reported at the American Society for Clinical Oncology (ASCO) meeting in June 2013, failed to show an increase in overall survival, despite prolongation in progression-free survival. These results led to many unsolved issues regarding the use of Bev for the treatment of GBM. We discuss these problems in this paper and highlight our institutional experience with Bev monotherapy for recurrent high-grade gliomas.
Sakurai H.,Kyorin University
Current Opinion in Nephrology and Hypertension | Year: 2013
PURPOSE OF REVIEW: Recent advances in genome technology have provided us with a list of molecules affecting urate handling in humans, many of which are unlikely to be identified through traditional physiological approach alone. Although this article is focused on urate, this can be viewed as a successful model of genomics-physiology collaboration. RECENT FINDINGS: URATv1/GLUT9 (SLC2A9) is shown to play a critical role in urate reabsorption at the proximal tubule, probably more prominent than its partner URAT1 (SLC22A12). The major site of action of ABCG2 (ABCG2), an influential urate secretion transporter, has been shown to be the intestine rather than the kidney proximal tubule. Accordingly, hypofunction of ABCG2 leads to increased fractional excretion of urate, a finding traditionally interpreted as overproduction hyperuricemia. Some SLC17 family members secrete urate in the kidney or intestine. OAT2 (SLC22A7) may take up urate from blood to the proximal tubular cell. In addition, how a common single-nucleotide polymorphisms in ABCG2 affects its function has been elucidated. SUMMARY: A finer grained picture of urate handling in the human body is now emerging, which will help choosing novel targets for urate-lowering therapy.
Shishido-Hara Y.,Kyorin University |
Shishido-Hara Y.,Tokyo Metropolitan Institute for Neuroscience
Acta Neuropathologica | Year: 2010
Progressive multifocal leukoencephalopathy is a fatal viral-induced demyelinating disease that was once rare but has become more prevalent today. Over the past decades, much has been learned about the disease from molecular study of the etiological agent of the disease, JC virus. Recently, promyelocytic leukemia nuclear bodies (PML-NBs), punctuate structures for important nuclear functions in eukaryotic cells, were identified as an intranuclear target of JC virus infection. Neuropathologically, JC virus-infected glial cells display diffuse amphophilic viral inclusions by hematoxylin-eosin staining (full inclusions), a diagnostic hallmark of this disease. Recent results using immunohistochemistry, however, revealed the presence of punctate viral inclusions preferentially located along the inner nuclear periphery (dot-shaped inclusions). Dot-shaped inclusions reflect the accumulation of viral progeny at PML-NBs, which may be disrupted after viral replication. Structural changes to PML-NBs have been reported for a variety of human diseases, including cancers and neurodegenerative disorders. Thus, PML-NBs may provide clues to the further pathogenesis of JC virus-induced demyelinating disease. Here, we review what we have learned since the disease entity establishment, including a look at recent progress in understanding the relationship between JC virus, etiology and PML-NBs. © 2010 Springer-Verlag.
Tohyama M.,Kyorin University
Physical Review C - Nuclear Physics | Year: 2015
The ground state of O16 is calculated by using a time-dependent density-matrix approach derived from a new truncation scheme of the Bogoliubov-Born-Green-Kirkwood-Yvon hierarchy for reduced density matrices, where a three-body density matrix is approximated by an antisymmetrized product of two-body density matrices. The new scheme is compared with a simpler truncation scheme previously used for the calculation of the ground state of O16 where the three-body density matrix is neglected and only two-particle-two-hole elements of the two-body density matrix are considered. It is shown that the results obtained from the two truncation schemes agree well with the exact solution. © 2015 American Physical Society.
Tohyama M.,Kyorin University
Journal of the Physical Society of Japan | Year: 2012
We study collective excitations of a quantum dot consisting of two electrons using a time-dependent density-matrix approach. The advantages of the density-matrix approach are that one- and two-body observables are directly calculated using one- and two-body density matrices and that it has a clear relation to the time-dependent Hartree-Fock theory. Some low-lying spin modes associated with intrinsic transitions of a deformed configuration are predicted. © 2012 The Physical Society of Japan.