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Kwansei Gakuin University , colloquially abbreviated to Kangaku , is a non-denominational Christian private and coeducational university located in Nishinomiya, Sanda, Osaka City, and Tokyo, Japan. Chartered in 1932, it is the 13th institution with university status in Kansai region, the 23rd-oldest outside of Greater Tokyo, and the 46th-oldest in the country. Kwansei Gakuin University is one of oldest and leading private universities in Japan. It has relatively strong network of alumni in Kansai region and has produced a number of CEOs in Japanese companies and politicians. Wikipedia.

Igata T.,Kwansei Gakuin University
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2015

The existence of stable bound orbits of test particles is one of the most characteristic properties in black hole spacetimes. In higher-dimensional black holes, due to the dependence of gravity on the spacetime dimensions, there is no stable bound orbit balanced by Newtonian gravitational monopole force and centrifugal force, although this balance occurs in the four-dimensional Kerr black hole. In this paper, however, the existence of stable bound orbits of massive and massless particles is shown in six-dimensional singly spinning Myers-Perry black holes with a value of the spin parameter larger than a critical value. The innermost stable bound orbits and the outermost stable bound orbits are found on the rotational axis. © 2015 American Physical Society.

The role of p120-catenin in the function of classical cadherins is still enigmatic despite various studies. To elucidate its role, we examined the effect of p120-catenin on the N-cadherin-mediated localization of junctional proteins in epithelial cells in this study. Cadherin-deficient MIA PaCa-2 epithelial cells did not show linear localization of tight junction proteins ZO-1 and occludin. When N-cadherin was expressed in these cells, however, the resultant transfectant cells revealed strong cell adhesion activity and linear localization of ZO-1, occludin, and N-cadherin in the lateral membrane. When the p120-catenin-binding site of N-cadherin was disrupted, the linear localization of ZO-1 and occludin disappeared, and the mutant N-cadherin became localized more diffusely in the transfectant, although the cell adhesion activity did not change much. Knockdown of p120-catenin also resulted in the very weak localization of ZO-1 and occludin. A similar effect of p120-catenin on the localization of junctional proteins was obtained under more dynamic conditions in a wound healing assay. Moreover, p120-catenin was essential for the regulation of centrosome orientation in this healing assay. Taken together, the present data indicate that p120-catenin is essential for N-cadherin-mediated formation of proper junctional structures and thereby the establishment of the cell polarity. Similar results were obtained when E-cadherin mutants comparable to those of N-cadherin were used, suggesting that p120-catenin plays the same role in the function of other classical cadherins.

Imaoka S.,Kwansei Gakuin University
International Review of Cell and Molecular Biology | Year: 2011

Protein disulfide isomerase (PDI) is a folding assistant in the endoplasmic reticulum (ER) of eukaryotic cells. PDI has multiple roles, acting as a chaperone, a binding partner of other proteins, and a hormone reservoir as well as a disulfide isomerase in the formation of disulfide bonds. PDI only interacts covalently with the cysteines of its substrates, but also binds a variety of peptides/proteins and small chemical ligands such as thyroid hormone. Oxidative stress and nitrosative stress can cause damage to chaperones, protein misfolding, and neurodegenerative disease, by affecting the functional integrity of PDI. There are 20 putative PDI-family members in the ER of human cells, but their functional differentiation is far from complete. This review discusses recent advances in our understanding of the mammalian PDI family of enzymes and focuses on their functional properties and interaction with substrates and small chemical ligands. © 2011 Elsevier Inc.

Ozaki Y.,Kwansei Gakuin University
Analytical Sciences | Year: 2012

The purpose of this review article is to outline recent progress in near-infrared (NIR) spectroscopy. Some particular emphasis is put on the delineation of its versatility in analytical chemistry. NIR spectroscopy is versatile in many aspects. For example, it is electronic spectroscopy as well as vibrational spectroscopy. It is also all-round in applications from basic to practical applications. NIR spectroscopy can be applied to various kinds of materials, bulk materials, thin or thick polymers, tablets, human bodies, and so on. It is particularly powerful in non-invasive, non-destructive, and in situ analysis. In this review, the principles and advantages of NIR spectroscopy are described first, and then its applications to various fields, including polymer science, on-line monitoring, inorganic material research, medical diagnosis, and NIR imaging are introduced. © The Japan Society for Analytical Chemistry.

The article seeks to explicate a link between energy and long-term economic growth and development. While in many ways intuitive, attempts at sketching theoretical frameworks explicating this link have been few and simplistic, typically limited to technology and economics. This article emphasizes the importance of politics as well, fostering a symbiosis between the dominant industries of a historical epoch and the energy system that enabled them to flourish. The framework combines Joseph Schumpeter and Mancur Olson, emphasizing 1) the importance of structural economic change for long-term growth and development and 2) vested interests. The framework yields one theoretical proposition: In order to rise, states must prevent vested interests from blocking structural change. States that are unable to do this will get locked into yesterday's technologies, industries and energy systems, effectively consigning themselves to stagnation and decline. A brief empirical section provides historical data from 6 historical epochs (including present-day renewables) over a period of 250 years to demonstrate the usefulness of the approach. While no exhaustive test, the data suggests that countries that have prevented vested interests from blocking change have been far more successful in fostering a symbiosis between energy and industry than those countries that have not. © 2009 Elsevier Ltd. All rights reserved.

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