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Shameela S.,Sk University | Shamshad S.,Kvr Government Degree College | Indira Priyadarsini A.,Kvr Government Degree College | John Paul M.,P.A. College | Lakshmi Devi K.,Sk University
International Journal of Pharma and Bio Sciences | Year: 2015

Cardiovascular disease (CVD) or diseases of the circulatory system can be described as all diseases relating to the heart and blood vessels. The World Health Organization (WHO) estimates there will be about 20 million CVD deaths in 2015, accounting for 30 percent of all deaths worldwide. The present study was designed to evaluate the cardioprotective role of whole plant extract of Boerhaavia diffusa on isoproterenol induced myocardial infarction in wistar albino rats. The rats were divided into four groups of six animals each. Group I served as a normal control, Group II rats were administered isoproterenol (85mg/kg, i.p) at the end of experimental period on the45th and 46th days. Group III received an ethanolic extract of Boerhaavia diffusa 150mg/kg b.w for 45 days. Group IV rats were pretreated with Boerhaavia diffusa 150mg/kg b.w for a period of 45 days and received intraperitonial injection of isoproterenol (85 mg/kg, b.w) at the end of experimental period for 2 consecutive days. After the experimental period, blood was collected and serum was separated and used for the estimation of cholesterol, triglycerides, phospholipids, and lipoproteins and the assay lipid peroxidation and protein oxidation. The heart homogenate was used for the assay lipid profile, lipid peroxidation and protein oxidation. Isoproterenol induced rats showed a significant increase in the levels of triglycerides, total cholesterol and free fatty acids in both serum and heart homogenate. A rise in the levels of LDL, VLDL with a significant decrease in the level of HDL was also observed in the serum and heart tissues of isoproterenol treated rats. But the phospholipid content was found to be significantly increased in serum and decreased in heart tissue. The values of atherogenic index and C/P ratio were significantly increased in the ISPH treated group. The oral administration of ethanolic extract of Boerhaavia diffusa 150/kg b.w) to isoproterenol-induced rats daily for a period of 45 days proved the protective role of Boerhaavia diffusa. The levels of the biochemical parameters in the plant treated groups were nearly the same as that of the normal control. Source


Indira Priya Darsini A.,Kvr Government Degree College | Shamshad S.,Kvr Government Degree College | John Paul M.,P.A. College
International Journal of Pharma and Bio Sciences | Year: 2015

In the current research the Air Pollution Tolerance Index (APTI) of Nineteen plant species is found among which four plants are herbs, five are shrubs and remaining are trees. All these plants are growing in highly polluted areas of Hyderabad. The physiological and biochemical parameters, which are relative to leaf's water content(RWC), ascorbic acid content (AA), total leaf chlorophyll(TCH) and leaf extract PH were used to compute the APTI values. On the basis of APTI values, Acalypha indica, Euphorbia hirta, among herbs, Ricinus communis, Gossypium herbaceum among shrubs, Azadiricta indica, Ficus bengalensis showed tolerance, these plants serve as suitable sinks to survive the air pollution and the other plant species Vinca rosea, Calotropis gigantea, Pithecalobium dulce act as bio-indicators of air pollution stress as these are intolerant to the air pollution. Source


Darsini I.P.,Kvr Government Degree College | Shamshad S.,Kvr Government Degree College | John Paul M.,Prr Governmentdegreeecollege
International Journal of Pharma and Bio Sciences | Year: 2015

The use of plants as medicines predates written human history. Ethnobotany (the study of traditional human uses of plants) is recognized as an effective way to discover future medicines. In 2001, researchers identified 122 compounds used in modern medicine which were derived from "ethnomedical" plant sources; 80% of these have had an ethnomedical use identical or related to the current use of the active elements of the plant. The plant is a biosynthetic laboratory, not only for chemical compounds, but also a multitude of compounds like glycosides, alkaloids etc. These exert physiological and therapeutic effect. Plants can provide biologically active molecules and lead structures for the development of modified derivatives with enhanced activity and reduced toxicity. The small fraction of flowering plants that have so far been investigated have yielded about 120 therapeutic agents of known structure from about 90 species of plants. According to one estimate only 20% of the plant flora have been studied and 60%of synthetic medicines owe their origin to plants. The medicinal values of many plants have been established and published, but most of them are waiting to be explored till date. Therefore, there is every need to find their uses and to conduct pharmacological studies to discover their medicinal properties. Canna Indica (L.) is a spreading annual herb found throughout India but unfortunately it is one of the neglected plants. Hence, the present review aims to open new avenues for the improvement of medicinal use of Canna Indica for various ailments and to bring the anti-diabetic Medicinal plant to the scientists' notice, and raise awareness and add value to the resource. This review attempts to highlight the available literature on Canna Indica (L.) with respect to ethno botany, chemical constituents and summary of various pharmacologic activities. Source

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