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Nandigāma, India

Chinnam S.,Sri Venkateswara University | Potturi C.,Sri Rama Engineering College | Maddila S.,University of KwaZulu - Natal | Muttana V.B.R.,Sri Venkateswara University | And 2 more authors.
Der Pharma Chemica | Year: 2013

A facile method has been developed for the synthesis of novel α-aminophosphonates 5a-j by the one-pot three component reaction of equimolar quantities of 4-amino-N-2-thiazolyl-benzenesulfonamide (Sulfathiazole) (1), dimethyl phosphite (2) and various aldehydes (4a-j) in dry toluene at reflux conditions via Kabachinik-Fields reaction in high yields (70-80%) without use of any catalyst. Their chemical structures were established by IR, 1H, 13C, 31P-NMR, mass spectral studies and elemental analyses. All the title compounds exhibited promising antibacterial and antifungal activities. Source


Ravi Kumar K.,KVR College | Suresh N.,KVR College | Venkateswarlu C.,KVR College | Sampath C.,iversity | Ramababu C.,Acharya Nagarjuna University
Der Pharma Chemica | Year: 2012

A facile and an efficient method has been developed for the synthesis of novel α-aminophosphonates (4a-j) by the one-pot, three-component reaction of equimolar quantities of 2-Amino-6-Nitrobenzothiazole (1), dimethyl phosphite (2) and various aldehydes (3a-j) in dry toluene at reflux conditions via Kabachinik-Fields reaction in high yields (70-80%) without any catalyst. Their chemical structures were established by IR, 1H, 13C, 31P-NMR, mass spectral studies and elemental analyses. Source

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