KVG Dental College and Hospital
KVG Dental College and Hospital
Alyousef A.A.,King Saud University |
Divakar D.D.,King Saud University |
Divakar D.D.,KVG Dental College and Hospital |
Muzaheed,University of Dammam
Microbial Pathogenesis | Year: 2017
Although periodontal diseases are caused by some of the specific pathogens, most of the tissue damage is caused by the host reaction to disease and not actually by the infections. Therefore, host modulatory therapy (HMT) has advanced benefit for the treatment of periodontitis, which works basically by reducing tissue destruction and regeneration in periodontium by altering the critical aspects of host response regulation and up regulating defensive regenerative responses. The present study was conducted with the goal to test an innovative therapeutic option using chemically modified tetracycline in patients affected with generalized, moderate and severe chronic periodontitis. We assumed that CMT might have the potential to provoke an assessable clinical result and pharmacologically impede the level inflammatory flow. CMT (incyclinide) treated group had significantly higher CAL (clinical attachment) values than Placebo Control suggesting an improved CAL in CMT treatment. Host modulation therapy width incyclinide can be as an adjunct to conventional nonsurgical therapies without antimicrobial resistance. Progress was noticed in the clinical parameters but not the serum CRP level in our study establishing the role of CMTs in controlling chronic periodontitis. Also CMT treatment indicates its role in anti-inflammatory process as it inhibited IL-12 and TNF alpha but IL-10 level was not affected. However, more randomized placebo-controlled clinical trials with large sample size are required in order to authenticate the usage of CMTs in chronic periodontitis treatment. Based on this understanding, exploration of the novel, low-cost synthetic inhibitors that can be used as potential therapeutic agents, has been tested. © 2017 Elsevier Ltd
Rai H.K.,KVG Dental College and Hospital |
Pai S.M.,KVG Dental College and Hospital |
Dayakar A.,KVG Dental College and Hospital |
Supriya H.,KVG Dental College and Hospital
Journal of Oral and Maxillofacial Pathology | Year: 2017
Odontogenic tumors comprise an unusual group of lesions of the jaw and present diverse histological patterns. Derived from the primordial tooth-forming tissues, they represent a heterogeneous group of lesions that range from hamartomas to benign and malignant neoplasms of variable aggressiveness. Sporadic case reports and diverse complex histogenetic source also defy categorization of odontogenic tumors. Many can be diagnosed accurately based on the distinctive clinical, radiological and histopathological presentation. Considerable variations in the clinicopathological presentation of odontogenic tumors can be confusing, increasing the chance of misdiagnosis. An interesting case of adenoid ameloblastoma reported in a 55-year-old male patient in the mandible, presenting with a diverse and intriguing histopathology, is discussed here. © 2017 Journal of Oral and Maxillofacial Pathology | Published by Wolters Kluwer - Medknow.
Rai H.C.,KVG Dental College and Hospital |
Ahmed J.,Manipal University India
Asian Pacific Journal of Cancer Prevention | Year: 2016
Background: Oral squamous cell carcinoma (OSCC), the most common malignancy of the oral cavity, shows geographical variation with respect to the age, sex, site and habits of the population. The histolopathologic grade of the tumor is closely related to its tissue of origin. This study was conducted to establish the prevalence of OSCC in relation to patient sex, age, habits and sites of lesions. Materials and Methods: A total of 130 cases of histopathologically diagnosed OSCC were selected for the study, out of which 66, 38 and 26 were well (WD), moderately (MD)and poorly differentiated (PD), respectively. Sections were stained with haematoxylin and eosin and graded according to a modified Borders's system. Then statistically analyzed different grades of OSCC for correlations with other variables. Results: In our study the majority cases of OSCC were found in the 5th to 7th decades of life, males acconting for 53%. The most common site was the buccal mucosa and most cases had habit of tobacco use either in the form of chewing or smoking or both. When the different grades of OSCC were compared with different sites a statistically significant value was observed (P=0.029). Conclusions: The incidence of high grade PD is very much less in female patients but in males such lesions were common. In our location population the buccal mucosa is the most common site due to the tobbaco habits of the patients and majority cases of the buccal mucosa are WD whereas in tongue, floor of the mouth and palate PD are common.
Mathew P.,Annamalai University |
Austin R.D.,Annamalai University |
Varghese S.S.,Mar Baselious Dental College and Hospital |
Kumar M.,KVG Dental College and Hospital
Journal of Clinical and Diagnostic Research | Year: 2014
Background: Oral Squamous cell carcinoma (OSCC) is often preceded by potentially malignant disorders like oral submucous fibrosis (OSMF). The rate of transformation of OSMF to OSCC ranges from 3 to 19%. OSMF is etiologically related to chewing of areca nut (betel nut), a habit prevalent among the population groups in south-east Asia. Along with alkaloids, the high copper content in areca nut plays an important role in the pathogenesis of OSMF. The increased prevalence of OSMF in the last two decades or so corresponds with the increased processing and commercialization of areca nut products. Aim: The aim of the study was to estimate and compare the copper content of raw areca nuts in three different stages of maturity, and commercial areca nut products. Materials and Methods: Raw areca nut samples of three different maturities were obtained from four plantations in Sullia, Karnataka, India and commercial areca nut products were obtained from local shops in Chidambaram, Tamil Nadu, India. The samples were grounded and subjected to Atomic Absorption Spectrometry (AAS) for copper analysis. Results: There was statistically significant difference in copper content in raw areca nuts of all three maturities (p<0.05) and was highest in the exfoliated mature nuts. Importantly copper level was significantly higher in the commercial products compared to raw areca nuts of different degrees of maturity (p<0.05). Conclusions: The copper levels in commercial products are significantly higher than that of raw areca nuts in all three stages of maturity. The increase in copper content on processing and post commercialization can be related to the increasing prevalence of OSMF.
Dayakar M.M.,KVG Dental College and Hospital |
Akbar S.M.,KVG Dental College and Hospital
Saudi Journal of Anaesthesia | Year: 2016
Aim: To study the efficacy of a noninjectable anesthetic gel with a thermosetting agent in the reduction of pain during scaling and root planing (SRP) in untreated chronic periodontitis patients. Materials and Methods: This study is a randomized, double-masked, split-mouth, placebo-controlled trial. Thirty patients were enrolled who underwent SRP in a split-mouth (right side/left side) manner. Before commencement of SRP, both quadrants on each side were isolated and had a randomized gel (either placebo or test gel) placed in the periodontal pockets for 30 s. The pain was measured using numerical rating scale (NRS) and verbal rating scale (VRS). Results: The median NRS pain score for the patients treated with the anesthetic test gel was 1 (range: 0-4) as opposed to 5 (range: 3-7) in the placebo treated patients. The mean rank of pain score using NRS in test gel was 16.18 as compared to 44.82 in placebo treated sites. Hence, significant reduction in pain was found in test gel as compared to placebo using NRS (P < 0.001). The VRS showed that the majority of patients reported no pain or mild pain with a median of 1 as compared to placebo treated sites with a median of 2 suggestive of moderate pain. Conclusions: The NRS and VRS pain scores showed that the side treated with anesthetic gel was statistically more effective than the placebo in reducing pain during SRP. © 2016 Saudi Journal of Anesthesia.
Shaila M.,K V G Dental College and Hospital |
Shetty P.,A B Shetty Memorial Institute of Dental science |
Madonna Decruz A.,AB Shetty Memorial Institute of Dental science |
Pai P.,KVG Dental College and Hospital
Journal of Clinical and Diagnostic Research | Year: 2013
Introduction: Oral squamous cell carcinoma is one of the leading causes of mortality in India. The screening and the early detection of the premalignant and malignant lesions are the only means for controlling the disease. General dental practitioners can play a great role in this direction. The objective of the present study was to assess the self-reported knowledge, attitude, as well as the practices concerning the early detection of oral cancer among the dentists of Dakshina Kannada, Karnataka, India. Materials and Methods: About 200 clinicians (BDS/MDS) were randomly selected for an 18 itemed questionnaire survey. The aspects which were enquired into were the usage of exfoliative cytology in their clinical practice, the recent attempts which are made by dentists at updating their knowledge on oral cancer, their practical approaches towards the screening for oral premalignant diseases, etc. Results: Over 98% of the dentists reported to have not performed exfoliative cytology in their clinics. However, 85% had attended education programs on oral cancer. About 72% felt the need to be trained and they welcomed the suggestion of conducting practical workshops in this direction. 29.5% conducted biopsies when they encountered suspicious looking lesions, but only 13% counseled such patients for the habit cessation. 86% felt the need for Oral Pathology consultants in their clinics. Conclusion: This pilot survey identified an existing gap in the knowledge and practices among physicians and dentists and this emphasises the need to increase the numbers of oral cancer detection workshops which are held among the professional groups.
PubMed | KVG Dental College and Hospital
Type: Journal Article | Journal: Asian Pacific journal of cancer prevention : APJCP | Year: 2016
Oral squamous cell carcinoma (OSCC), the most common malignancy of the oral cavity, shows geographical variation with respect to the age, sex, site and habits of the population. The histolopathologic grade of the tumor is closely related to its tissue of origin. This study was conducted to establish the prevalence of OSCC in relation to patient sex, age, habits and sites of lesions.A total of 130 cases of histopathologically diagnosed OSCC were selected for the study, out of which 66, 38 and 26 were well (WD), moderately (MD)and poorly differentiated (PD), respectively. Sections were stained with haematoxylin and eosin and graded according to a modified Borderss system. Then statistically analyzed different grades of OSCC for correlations with other variables.In our study the majority cases of OSCC were found in the 5th to 7th decades of life, males acconting for 53%. The most common site was the buccal mucosa and most cases had habit of tobacco use either in the form of chewing or smoking or both. When the different grades of OSCC were compared with different sites a statistically significant value was observed (P=0.029).The incidence of high grade PD is very much less in female patients but in males such lesions were common. In our location population the buccal mucosa is the most common site due to the tobbaco habits of the patients and majority cases of the buccal mucosa are WD whereas in tongue, floor of the mouth and palate PD are common.
PubMed | University of Kuala Lumpur, King Saud University, Malabar Dental College and Research Center and KVG Dental College and Hospital
Type: | Journal: BMJ case reports | Year: 2016
Pagets disease is a metabolic disorder of bone caused due to defect in the remodelling process and is very common in western countries but is very rare in Asians and Africans. It was first described by a British scientist Sir James Paget in 1877. It can be monostotic or polyostotic depending on the number of bones involved. It most commonly affects older people of more than 50years. Disease involvement can be symptomatic or asymptomatic depending on the extent of the disease process. Diagnosis of Pagets disease can be made by raised serum alkaline phosphatase levels, radiological examination and by radioisotope bone scans.
PubMed | KVG Dental College and Hospital and Sri Hasanamba Dental College and Hospital
Type: Journal Article | Journal: Journal of clinical and experimental dentistry | Year: 2016
The prevalence of apical periodontitis in diabetes mellitus patients is high. The altered immunity in diabetes affects the healing process of periapical tissue. Single visit endodontic treatment has shown to increase the periapical healing rate with better patient compliance. Hence the present study aims at evaluating the clinical and radiographic healing outcome of single visit endodontic treatment, in type 2 diabetes mellitus patients with periapical disease.Eighty patients with periapical disease were divided into 2 groups of 40 each: Group I, Control subjects and Group II, Type 2 diabetics. Glycosylated hemoglobin levels were assessed preoperatively and at follow up intervals in diabetics. Pre-operative assessment of periapical status was done using CPDR (Clinical periapical diagnosis of root), QLDR (Qualitative radiographic diagnosis of tooth) and QTDR (Quantitative radiographic diagnosis of tooth) criteria. Postoperative healing was evaluated following single-visit endodontic treatment by Strindberg criteria.Group 2 subjects had chronic and exacerbating lesions with significantly larger lesions (Type 2 diabetics had chronic and larger sized lesions when compared to control subjects. The periapical lesions in patients with poor diabetic control showed failure. The clinical and radiographic healing outcome of single visit endodontic therapy was delayed in diabetic patients.
PubMed | Ministry of Health and Al Farabi College for Medicine, King Saud University, Al Farabi College for Medicine, Ministry of Health and KVG Dental College and Hospital
Type: Journal Article | Journal: Saudi journal of biological sciences | Year: 2016
To compare the angular changes of the third molars relative to the occlusal plane and to the second molar long axis in extraction group and compare these changes with a non extraction group.The study included pre and post treatment panoramic radiograph records of 90 subjects treated by first premolar extractions and 90 subjects who had been treated with non extraction orthodontic therapy (The analyzed data to assess the changes in the third molar angulation from pretreatment to post treatment did not vary significantly in both the groups (Extraction of premolars did not demonstrate considerable changes on the angulation of the third molars. The factors other than premolar extractions may influence the angulation of the third molars.