Kise H.,Kuwana East Medical Center |
Aoyama S.,Aoyama Clinic
Nishinihon Journal of Urology | Year: 2016
A 31-year-old woman visited our clinic with the complaints of urge incontinence, pollakisuria, leg edema and pain, with a history of surgery for spinal cord lipoma. The patient had previously visited another hospital and had been diagnosed with detrusor sphincter dyssynergia, low compliance bladder and detrusor overactivity. She had taken solifenacin and urapidil for 3 months, because she did not wish to perform clean intermittent self-catheterization. Five years after she stopped going to the hospital, she visited our clinic. We prescribed solifenacin and Gosha-jinki-gan and processed aconite root. One month later, another Kampo herbal medicine, Kakkon-to, was added for leg pain. Four months after the start of treatment, the overactive bladder symptom score (OABSS) had improved from 11 to 3, and most of her symptoms had disappeared.
Kise H.,Kuwana East Medical Center |
Tachino H.,Kuwana East Medical Center |
Hotta Y.,Kuwana East Medical Center
Nishinihon Journal of Urology | Year: 2016
A 36-year-old woman was admitted to our hospital with the complaints of acute left lower abdominal pain and nausea. She had Swyer-James syndrome, asthma and had been delivered of two babies by Caesarean section. Computerized tomography showed left hydronephrosis and an obstruction of the left ureter with ureteral herniation into the left sciatic foramen. We placed a ureteral stent, and the ureterosciatic hernia was relieved and the ureter was linearized. After placement of the stent, the patient's symptoms improved completely. Three months after the stenting, the stent was removed. The patient has not had any relapse for more than one year.
Okano H.,Suzuka General Hospital |
Takahashi M.,Jichi Medical University |
Isono Y.,Suzuka General Hospital |
Tanaka H.,Suzuka General Hospital |
And 10 more authors.
Hepatology Research | Year: 2014
Aim: To characterize hepatitis E in Mie prefecture and to investigate whether raw pig liver sold as food in Mie is contaminated with hepatitis E virus (HEV) strains similar to those recovered from patients. Methods: Seventeen patients with sporadic acute hepatitis E treated from 2004 to 2012 were studied. A total of 243 packages of raw pig liver from regional grocery stores were tested for the presence of HEV RNA. The partial genomic sequences of human and swine HEV isolates were determined and subjected to the phylogenetic analyses. Results: The HEV isolates recovered from the 17 patients segregated into genotype 3 (n=15) and genotype 4 (n=2), and 15 genotype 3 isolates further segregated into 3e (n=11) and 3b (n=4). Pig liver specimens from 12 (4.9%) of the 243 packages had detectable HEV RNA. All 12 swine HEV isolates were grouped into genotype 3 (3a or 3b). Although no 3e strains were isolated from pig liver specimens, two 3b swine strains were 99.5-100% identical to two HEV strains recovered from hepatitis patients, within 412-nt partial sequences. Conclusion: The 3e HEV was prevalent among hepatitis E patients. HEV RNA was detected in approximately 5% of pig liver sold as food. The presence of identical HEV strains between hepatitis patients and pig liver indicated that pigs play an important role as reservoirs for HEV in humans in Mie. Further studies are needed to clarify the source of 3e HEV in the animal and environmental reservoirs. © 2013 The Japan Society of Hepatology.
Usui D.,Shizuoka Institute of Epilepsy and Neurological Disorders |
Shimada S.,Tokyo Women's Medical University |
Shimojima K.,Tokyo Women's Medical University |
Sugawara M.,Tokyo Women's Medical University |
And 6 more authors.
American Journal of Medical Genetics, Part A | Year: 2013
Duplications of the 2q33 region are rare; to date, only 13 patients have been reported to have this chromosomal abnormality. The reported duplications are of varying size, and the patients shared developmental delay and minor dysmorphic findings. In this study, we identified a duplication of 2q32.1-q33.3 in a patient with psychomotor developmental delay, epilepsy, and autistic behavior. The duplicated region of this patient was reciprocal to the 2q32-q33 deletion syndrome. Chromosomal microarray testing confirmed the 19.5Mb of duplication that includes over 100 genes, some of which could have functional relevance to the neurological features of this patient. The SATB homeobox 2 gene (SATB2)-the primary gene responsible for the 2q32-q33 deletion syndrome-may be one of them, because of its expression in the cortical projection neurons of the developing brain. The duplication of the potassium channel tetramerisation domain-containing 18 gene (KCTD18) and the ADAM metallopeptidase domain 23 gene (ADAM23) may also contribute to the phenotype. FISH analysis confirmed a tandem configuration of the duplicated segments. This result is in agreement with our previous study, in which we observed that duplicated segments as interstitial duplications are generally inserted in the tandem configuration. © 2012 Wiley Periodicals, Inc.
Kojima M.,Komono Kosei Hospital |
Okubo S.,Kuwana East Medical Center |
Mizubayashi R.,Yokkaichi Diabetes Clinic |
Isaka N.,Murase Hospital |
And 13 more authors.
Nephrology Dialysis Transplantation | Year: 2013
Background. A thiazide diuretic used in combination with benazepril is superior to amlodipine plus benazepril in reducing albuminuria in hypertensive patients with diabetes. However, calcium channel blockers have diverse characteristics. Thus, we investigated whether combining an angiotensin receptor blocker with either azelnidipine or a thiazide diuretic produced similar reductions in albuminuria in hypertensive diabetic patients for the same levels of blood pressure achieved. Methods. Hypertensive patients with type 2 diabetes and albuminuria (30-600 mg/g creatinine) under antihypertensive treatment (mean age 67.0 ± 7.6 years) were instructed to stop all antihypertensive treatment and take a combination of olmesartan (20 mg/day) and amlodipine (5 mg/day) for 3 months (run-in period). Then, patients were randomly assigned to receive either olmesartan plus azelnidipine (16 mg/day; n = 71) or olmesartan plus trichlormethiazide (1 mg/day; n = 72) for an additional 6 months. The primary end point was urinary excretion of albumin at 6 months after randomization. Results. At the time of randomization, urinary albumin was 116.0 and 107.8 mg/g creatinine (geometric mean) in the azelnidipine and diuretic arms, respectively, and was reduced to a similar extent [79.8 (95% confidence interval 66.4-96.0) and 89.7 (74.6-107.7) mg/g creatinine, respectively, after adjustment for baseline values]. Blood pressure did not differ between the two groups throughout the study period. Conclusions. Azelnidipine is equally effective as a thiazide diuretic in reducing urinary albumin when used in combination with olmesartan. © The Author 2013.
Fukumoto Y.,Tohoku University |
Yamada N.,Mie University |
Matsubara H.,National Hospital Organization Okayama Medical Center |
Mizoguchi M.,Kurume University |
And 15 more authors.
Circulation Journal | Year: 2013
Background: We have previously demonstrated that long-term inhibition of Rho-kinase ameliorates pulmonary arterial hypertension (PAH) in animal models. In the present study, we examined the clinical effects of mid-term oral treatment with an extended release formulation of AT-877 (fasudil hydrochloride), a specific Rho-kinase inhibitor (AT-877ER) on PAH. Methods and Results: 23 PAH patients were treated with either placebo (10/2 females/males, 51±16 years, idio-pathic PAH (IPAH) in 6, PAH associated with connective tissue disease (CTD-PAH) in 3, PAH with congenital heart disease (CHD-PAH) in 2, and portal PAH in 1) or AT-877ER (6/5 females/males, 47±14 years, IPAH in 2, CTD-PAH in 5, and CHD-PAH in 4); 3 patients were excluded. We performed a 6-min walk test and right heart catheterization in the remaining 20 patients, before and 3 months after the treatment (placebo n=11, AT-877ER n=9). Although there were no significant differences between the 2 groups for the 6-min walk distance, pulmonary hemodynamics tended to be improved in the AT-877ER group, especially the prevalence of improved cardiac index from baseline, which was significantly higher in the AT-877ER than in the placebo group. In the AT-877ER group, serum levels of hy-droxyfasudil, an active metabolite of AT-877ER tended to correlate with improvements in the cardiac index and mean pulmonary artery pressure. Conclusions: Mid-term treatment with oral AT-877ER showed additional improvement in pulmonary hemodynam-ics in patients with PAH.
Hayase S.,U.S. National Institutes of Health |
Hayase S.,Fukushima Medical University |
Sasaki Y.,U.S. National Institutes of Health |
Sasaki Y.,Kuwana East Medical Center |
And 17 more authors.
Thyroid | Year: 2015
Background: Mouse thyroid side population (SP) cells consist of a minor population of mouse thyroid cells that may have multipotent thyroid stem cell characteristics. However the nature of thyroid SP cells remains elusive, particularly in relation to thyroid cancer. Stanniocalcin (STC) 1 and 2 are secreted glycoproteins known to regulate serum calcium and phosphate homeostasis. In recent years, the relationship of STC1/2 expression to cancer has been described in various tissues. Method: Microarray analysis was carried out to determine genes up- and down-regulated in thyroid SP cells as compared with non-SP cells. Among genes up-regulated, stanniocalcin 1 (STC1) was chosen for study because of its expression in various thyroid cells by Western blotting and immunohistochemistry. Results: Gene expression analysis revealed that genes known to be highly expressed in cancer cells and/or involved in cancer invasion/metastasis were markedly up-regulated in SP cells from both intact as well as partial thyroidectomized thyroids. Among these genes, expression of STC1 was found in five human thyroid carcinoma-derived cell lines as revealed by analysis of mRNA and protein, and its expression was inversely correlated with the differentiation status of the cells. Immunohistochemical analysis demonstrated higher expression of STC1 in the thyroid tumor cell line and thyroid tumor tissues from humans and mice. Conclusion: These results suggest that SP cells contain a population of cells that express genes also highly expressed in cancer cells including Stc1, which warrants further study on the role of SP cells and/or STC1 expression in thyroid cancer. © 2015 Mary Ann Liebert, Inc.
Ito T.,Kuwana East Medical Center |
Ito T.,Mie University |
Ishikawa E.,Mie University |
Fujimoto N.,Mie University |
And 6 more authors.
Clinical and Experimental Hypertension | Year: 2014
Background: A direct renin inhibitor (DRI), aliskiren, may be effective for blood pressure (BP) control in hemodialysis patients. However, it is unclear whether aliskiren has a greater beneficial effect on BP and humoral factors than angiotensin II receptor antagonists (ARBs) in hypertensive patients on hemodialysis. Methods: Eighteen hemodialysis patients (58±14 years) on the recommended dose of an ARB were prospectively randomized into two groups: ARB and DRI groups. Patients in the ARB group continued taking their previous ARB, whereas those in the DRI group switched to aliskiren (150mg/day) for 12 weeks. Baseline measurements of BP and humoral factors such as plasma renin activity (PRA), plasma aldosterone concentration (PAC) and brain natriuretic peptide (BNP) were performed. Measurements were repeated every 4 weeks. Results: At baseline, no differences were observed in age, gender or BP between the two groups. Systolic BP was unaffected by treatment in either groups (group effect, p=0.26; time effect, p=0.38; group×time effect, p=0.24). PRA decreased in DRI (pâ‰'0.02, group effect, p=0.65; time effect, p=0.13; group×time effect, p=0.048), but not in ARB (pâ‰§0.94). PAC increased only in DRI (pâ‰'0.03), whereas BNP was unaffected in either group. Conclusion: Aliskiren at a dose of 150mg/day had a similar effect on BP compared with ARBs, but significantly lowered PRA. © 2014 Informa Healthcare USA, Inc.
PubMed | Kuwana East Medical Center
Type: Case Reports | Journal: Hinyokika kiyo. Acta urologica Japonica | Year: 2013
A 78-year-old female patient with fever and general malaise was referred to our hospital. Laboratory examination showed the marked elevation of leukocyte and serum granulocyte-colony stimulating factor (GCSF) concentration without any infectious sign. A computed tomography scan demonstrated irregular enhanced mass of the right kidney with liver metastasis. The pathological findings of the needle biopsy was high-grade urothelial cancer with positive staining for G-CSF antibody. Systemic chemotherapy with gemcitabine and cisplatin was administered. The patient showed a partial response and the serum G-CSF level was normalized after 1 course of chemotherapy. After four courses of chemotherapy, the extent of liver metastasis increased and the G-CSF concentration became elevated. Although combined chemotherapy with paclitaxel and gemcitabine was administered, the patient died 7 months after her first visit.
PubMed | Kuwana East Medical Center
Type: Journal Article | Journal: Journal of rural medicine : JRM | Year: 2016
Liver metastases from colorectal carcinoma commonly form nodular lesions in the liver parenchyma. We report a case of liver metastasis from rectal adenocarcinoma that extended predominantly into the bile duct. A 62-year-old Japanese man underwent low anterior resection for rectal adenocarcinoma 9 years ago. Approximately 3 years later, he underwent radiofrequency ablation therapy for a metastatic liver tumor. Nine years after surgery, a tumor in liver segment III exhibiting intrabiliary extension was discovered; it was unclear if this was a metastatic liver tumor or intrahepatic cholangiocarcinoma. Accordingly, we performed a left hepatectomy with lymph node dissection. The tumor was negative for cytokeratins 7 and 20, and was histologically similar to the primary rectal adenocarcinoma; it was diagnosed as rectal carcinoma metastasis. The patient has survived for 3 years after the hepatic surgery, for 9 years after radiofrequency ablation therapy, and for 12 years after the primary surgery. This case shows that liver metastasis from colorectal carcinoma can present as a predominantly intrabiliary growth that mimics intrahepatic cholangiocarcinoma on imaging. Moreover, our case provides evidence for the superiority of anatomical hepatectomy over partial hepatectomy for metastatic liver tumors with intrabiliary growth arising from rectal adenocarcinomas.