Kuwait University | Date: 2016-08-02
The green tea extract composition for hepatic fibrosis includes green tea extract encapsulated in chitosan nanoparticles. In order to treat a patient suffering from hepatic fibrosis, the patient is administered a therapeutically effective dose of the green tea extract composition for hepatic fibrosis. The treatment is preferably administered orally. In order to make the green tea extract treatment, chitosan and green tea extract (prepared from Camellia sinensis) are mixed in de-ionized water to form a first solution, which is then stirred. Pentasodium triphosphate is added to the first solution to foam a second solution, which is then sonicated to form nanoparticles of green tea extract encapsulated in chitosan. Preferably, the second solution is further stirred for approximately two hours following the sonication.
Kuwait University | Date: 2015-11-24
The multistage aeration system includes a water jet tank system having a closed water tank that holds a pool of water and seals in air above the pool of water. A nozzle in the top portion includes air bleeder passages to allow an ambient air to flow through the nozzle and into the closed water tank. A water flow meter and a water pump circulate water from the closed water tank to outside the tank through the water flow meter and then through the nozzle. The nozzle entrains air through the bleeder passages into the water as the water passes through the nozzle, and forms a jet spray into the pool of water. An air flow meter valve and a closed water tank air outlet pipe extend from the closed water tank and connect the water jet tank system to a diffused aeration tank system with a series tank system.
News Article | May 29, 2017
Global molecular diagnostics company Omixon, headquartered in Budapest with US offices in Cambridge, MA, announce today that Holotype HLA™ and other Omixon products will be featured in 12 poster presentations produced by Holotype customers at the annual meeting of the European Federation for Immunogenetics (EFI) in Mannheim, Germany. Additionally, Omixon’s Lunch Symposium on Wednesday will focus on Automated HLA Typing by NGS and feature three presentations from current Holotype HLA users from the EMEA region. Among the customer presentations the most common theme is the superiority of NGS compared with legacy methods, in which rare alleles created by rare crossing over events (P118, Thomas Binder et al.) or novel alleles (P119 & P123, Xavier Lafarge et al.) can be easily determined by Holotype HLA and remain a challenge for SBT. Another popular theme is the comparison of various NGS technologies (P115, Amalia Dinou et al. and Petra Neukirchen et al.) in which the strengths of Holotype HLA are showcased against those of other vendors. Additional examples of these themes are captured in a poster presented by Omixon’s Dr. Libor Kolesar (P110), who will focus on the “Super Powers” of NGS compared to legacy technologies and highlight unique capabilities of Holotype HLA. Omixon’s Lunch Symposium on May 31 will have three customer experience stories featuring Dr. Alexandre Walencik from the Etablissement Français du Sang (EFS), Nantes who will present their experience with Holotype HLA. “One year after, does NGS really change the world in a HLA laboratory?” Dr Walencik will their share good experiences, obstacles and their solutions with a focus on technical and organizational ways and means to encourage more labs adopt NGS for HLA such as Holotype HLA. Dr. Reem Ameen from Kuwait University will focus on describing the validation process for introducing Holotype HLA in clinical setting and her project to extend the known HLA haplotypes in several families of Kuwaiti descent. Dr. Ameen identified haplotypes that were not among the 200 most common HLA haplotypes in any of the 5 major US populations and included 199 (17%) unique alleles, 26 rare alleles, 6 very rare alleles and 2 novels. Kuwaiti individuals carry unique HLA haplotypes that are not shared by any of the majority of subjects historically reported to the US National Marrow Donor Program (NMDP) registry - a fascinating population with tremendous potential for ongoing HLA research. Dr. Mette Christiansen from the Aarhus University Hospital, Denmark will share their experiences on Automation of the Holotype HLA on the Beckman Biomek 4000. NGS has ushered in an era of increased capacity for HLA genotyping in terms of pooling more loci and processing larger numbers of samples thus placing ever more importance on repeatability and reproducibility. Handling of multiple samples at multiple loci simultaneously and eventually combining these into a single tube requires tightly controlled procedures, which may be achieved by automation. She will focus on the obstacles encountered and the benefits achieved in the automation process. Marcello Scala, Director of Sales, EMEA at Omixon says, “The explosion in labs adopting Holotype HLA throughout Europe and Middle East has been truly astonishing. Even more impressive is the affection customers have for the technology due to its unrivaled ability to resolve the genotypes of complex samples for the benefit of patients and the transplant community as a whole.” Omixon at EFI 2017 May 30 - June 02 | Omixon will be exhibiting at Booth #18 throughout the conference May 30, 9.30am - 11am | Resolving Laboratory NGS Assay Challenges with HLA Twin May 30, 11.30am-1pm | Resolving Complex Cases of NGS-based HLA Typing with HLA Twin May 31, 1.30pm-2.30pm | High-throughput Automation of Holotype HLA in Clinical Routine Omixon featured in posters P108 | E. Bauer et al. (2017) - Full-length sequencing of a novel MICA allele variant P110 | L. Kolesar et al. (2017) - Superpowers of NGS P111 | J. Diegel et al. (2017) - HLA-E genotyping – the sooner the better P115 | A. Dinou et al. (2017) - Evaluation of a commercially available HLA typing kit for NGS P117 | T. Binder et al. (2017) - Complete human leukocyte antigen gene sequence determination combining long range polymerase chain reaction and next generation sequencing P118 |T. Binder et al. (2017) - Whole gene sequence determination of a rare human leukocyte antigen DRB1 allele by combining long range polymerase chain reaction and next generation sequencing. P119 | X. Lafarge et al. (2017) - Exon phasing permits identification of new alleles by NGS not detectable by Sanger sequence-based typing P121 | P. Neukirchen et al. (2017) - NGS based HLA typing: comparison of four protocols and corresponding software P123 | X. Lafarge et al. (2017) Validation and routine setting of HLA typing by Next Generation Sequencing using the HOLOTYPE HLA (OMIXON) kits : a multicentric experience P127 | A. Hansen et al. (2017) - Implementing ABO genotyping into HLA sequencing workflow P129 | L. Krammes et al. (2017) - What’s new genotyping KIR2DL5? P145 | M. Dorak et al. (2017) - HLA-A, -B, -C typing by next generation sequencing in a sample of Turkish population About Omixon Omixon is a global molecular diagnostics company, headquartered in Budapest, Hungary, with US offices in Cambridge, MA that commercializes disruptive technologies for clinical and research laboratories. Omixon’s flagship product, Holotype HLA™, is the world’s leading NGS-based HLA genotyping product that delivers the most accurate high-resolution HLA genotyping available, and is used in more than 35 hospitals worldwide. Omixon’s research software, HLA Explore™ analyzes data from any sequencing technology and determines HLA genotypes from Whole Exome/Genome Sequencing experiments. Omixon maintains an active grant-funded research program with a product pipeline focused on pre- and post-transplantation, and HLA genotyping applications beyond transplantation.
Kuwait University | Date: 2016-01-19
The drive system for wind turbine with contra-rotating generator includes various embodiments of belt drive pulley systems for a direct drive contra-rotating wind generator. The generator has a magnetic rotor and an armature mounted on a shaft configured to rotate in the opposite direction from the magnetic rotor. In some embodiments, a belt extends across two pairs of coaxially mounted idler pulleys between a pulley on the magnetic rotor shaft and a pulley on the armature shaft. In other embodiments, the pulleys on the magnetic rotor and armature shafts are double sheave pulleys, and a first belt extends across one or two coaxial pair(s) of idler pulleys between an inner and outer sheave, and a second belt extends across one or two coaxial pair(s) of idler pulleys between an inner and outer sheave. Either the magnetic rotor or the armature shaft or both are coupled to a wind turbine rotor.
Kuwait University | Date: 2016-02-01
The odd/even invert coding for phase change memory with thermal crosstalk devises a cost model that captures Phase Change Memory (PCM) SET/RESET write asymmetries, as well as write disturbs caused by thermal crosstalk. The cost is computed by counting the different types of transitions between the old and the new data to be written to PCM. An Odd/Even Invert data encoding/decoding algorithm makes intelligent decisions based on a cost model by taking into account the number of bit flips, write asymmetry, as well as write disturbs. The data encoding algorithm recodes the data on the fly based on selective inverting (even, odd, or full invert) to search for a minimum cost solution with aim at reducing write activities and extending the PCM lifetime. A hardware architecture for the present encoding/decoding algorithm is presented that requires only two bits storage overhead for coding, regardless of the width of data.
Alawadhi E.M.,Kuwait University
Energy and Buildings | Year: 2012
A significant amount of the solar heat gain in buildings comes through the windows, and the most effective way to reduce it is to install exterior shading devices, such as window shutters. The window shutters are typically made of foam filled aluminum rolling shutter slat. In this research, a technique of solar heat gain reduction in building through windows using phase change material (PCM) in the shutter instead of foam is investigated using finite element method. The objective of using PCM in the shutters is to utilize its high latent heat of fusion to reduce the heat gain by absorbing the heat gain before it reaches the indoor space. The thermal effectiveness of the proposed PCM shutter system is evaluated by comparing the gain at the indoor space to the heat gain of foam shutter during typical working hours. A parametric study is conducted to assess the effect of different design parameters, such as PCM's type and quantity in the shutter. The result indicates that PCM with the highest examined melting temperature shows the best thermal performance, and the heat gain through windows can be reduced as high as 23.29%. © 2012 Elsevier B.V. All rights reserved.
Abraham A.,Kuwait University
Frontiers in Human Neuroscience | Year: 2014
Creativity is primarily investigated within the neuroscientific perspective as a unitary construct. While such an approach is beneficial when trying to infer the general picture regarding creativity and brain function, it is insufficient if the objective is to uncover the information processing brain mechanisms by which creativity occurs. As creative thinking emerges through the dynamic interplay between several cognitive processes, assessing the neural correlates of these operations would enable the development and characterization of an information processing framework from which to better understand this complex ability. This article focuses on two aspects of creative cognition that are central to generating original ideas. "Conceptual expansion" refers to the ability to widen one's conceptual structures to include unusual or novel associations, while "overcoming knowledge constraints" refers to our ability to override the constraining influence imposed by salient or pertinent knowledge when trying to be creative. Neuroimaging and neuropsychological evidence is presented to illustrate how semantic processing and cognitive control networks in the brain differentially modulate these critical facets of creative cognition. © 2014 Abraham.
Aladwani A.M.,Kuwait University
Computers in Human Behavior | Year: 2014
In its current state, the Facebook literature speaks very little about metrics developed specifically for this important social networking service. This study tries to fill part of this gap by conceptualizing, developing and validating a new Facebook use construct, "Gravitating towards Facebook" (GoToFB). Unlike traditional Facebook usage views that have focused on lean usage measures, the one presented in the current study offers a broader conceptualization of the same by taking into account the interaction among three elements: the user, Facebook features, and task. This investigation has put extensive efforts to validate the new Facebook instrument using a series of exploratory and confirmatory scale development techniques and found that it exhibits adequate measurement properties. The resultant scale consists of eight dimensions: connecting, sharing, relaxing, organizing, branding, monitoring, expressing, and learning. The instrument would be useful for businesses looking for deeply understanding how potential customers use Facebook and for researchers seeking to develop and test Facebook success models. © 2014 Elsevier Ltd. All rights reserved.
Yahyaoui H.,Kuwait University
Knowledge-Based Systems | Year: 2012
We present in this paper a trust-based game theoretical model for Web services collaboration. Each collaboration is modeled as a game. In each round of the game, a collaborating Web service submits a cost for achieving a specific task. The task-owner Web service computes the so-called trust-based cost, which is the product between the submitted cost and the inverse of the trust value of the bidding Web service. The game winner is the Web service which has the minimal trust-based cost. The trust is derived from the quality attribute values of a Web service. These values are computed during a collaboration evaluation period. They are updated after each game round based on a demotion or promotion decision. We also show how the proposed model is convenient for modeling Web services composition and assessing the trust of composite Web services. Furthermore, we provide a metric for the assessment of the collaboration trust. The application of this metric shows that the use of the trust allows a safer collaboration with respect to a game where there is no consideration of the trust as a criteria for allocating tasks. © 2011 Elsevier B.V. All rights reserved.
Kuwait University | Date: 2015-05-07
The system and method for determining the feedback capacity of information distributed in a complex network determines feedback capacity as information is received and diffused throughout the network. Traditionally, real networks, such as computer networks, were used in determining network feedback. However, current complex networks typically incorporate graphing models for network analysis. The system and method provide a process to determine the quality of a complex network with respect to feedback capacity, such as can be determined by a corresponding Belief Propagation algorithm and a corresponding entropy equation. The system and method can also determine the cyclic entropy per penetration in a to complex network, the depth penetration for nodes in the complex network and a plurality of cycle counts per node in the complex network based on a source node.