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Kuwait City, Kuwait

Zamecnikova A.,Kuwait Cancer Control Center
Expert Review of Hematology | Year: 2010

Many biological and clinical features of chronic myeloid leukemia make it as a paradigm of rational drug design in human cancer. Chronic myeloid leukemia was the first malignancy to be linked to a clear genetic anomaly, the Philadelphia chromosome and, at present, it is probably the best understood of all human malignancies. Studies of the disease pathology revealed that the molecular consequence of the Philadelphia translocation is a BCR-ABL chimeric gene, which encodes a constitutively active tyrosine kinase with wholesale range of biological activities. Animal models have validated the direct role of the BCR-ABL protein in malignant transformation and subsequent research confirmed that its enhanced tyrosine kinase activity is essential and sufficient for the leukemogenesis. The very existence of a single genetic abnormality, presented in essentially all patients with the disease, made it an effective target for molecularly designed therapeutic approaches for the disease. The advent of tyrosine kinase inhibitors, designed specifically to inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein, represents one of the major innovations in cancer therapy and may serve as a model for, how discoveries of disease pathogenesis may be translated into the development of successful targeted therapies in cancer medicine. © 2010 Expert Reviews Ltd. Source


Mohammed E.M.A.,Kuwait Cancer Control Center
Pathogenesis | Year: 2016

Introduction: Multiple sclerosis (MS) is an autoimmune disease that attacks the central nervous system, causing the appearance of focal areas of inflammation and demyelination. A detailed study of MS would offer a better understanding of the causes of increased number of MS cases in the Arab Gulf countries. Materials and Methods: A comprehensive literature search was performed to extract data regarding MS in general and MS in Arabian Gulf countries in specific. Only peer-reviewed, full-text articles published in English were included. Results: Data have shown a noticeable increase in cases of MS in the Arab Gulf countries. Although the underlying causes still remain elusive, many factors have been proposed to influence MS. This review will discuss the factors influencing MS, correlate their effects with disease pathology, their interaction in the context of disease development, and try to explain the increased number of MS in Arabian Gulf countries. Conclusion: Understanding MS development could open new doors for the treatment of MS, as well as initiate novel target therapies for citizens of Arab Gulf countries. © 2016 The Author. Source


Mittal R.,Kuwait Cancer Control Center
The Gulf journal of oncology | Year: 2012

Adrenocortical tumors (ACT) are rare tumors of childhood. The majority of these tumors is hormone-producing and cause virilization and Cushing syndrome or feminization. The authors describe 6 cases of adrenal cortical tumors treated at the Kuwait Cancer Center which were presented over a period of 20 years (1989-2009). The mean age was 5.5 years (range 15 months - 12 years). All had signs of virilization. One child had hypertension, while 2 had a metastatic disease at presentation. The diagnosis was made by clinical signs and symptoms, high levels of relevant adrenal hormones and imaging. Two children were not fit for surgery; one was too sick for any treatment and died shortly after diagnosis, while the other died after receiving one cycle of palliative chemotherapy. Four patients underwent complete surgical resection and achieved complete remission, three of whom later had recurrence (distant in one and local in two patients) and succumbed due to progressive disease. Mitotane was used in two children. Only one patient is currently surviving and well nearly 13 years after her surgery. In our series, the long-term outcome of children with adrenocortical tumors was very poor. Virilization is an important clue to the diagnosis of ACT. Early diagnosis and complete surgical resection are important for survival. Metastasis at presentation or as recurrence carries very dismal prognosis. Source


Usmani S.,Kuwait Cancer Control Center
Clinical Nuclear Medicine | Year: 2015

ABSTRACT: Sinus tarsi syndrome is a pain in the lateral side of the hind foot that is responsive to injection of local anesthetic agents. We report a case of a 42-year-old man who presented with pain over the lateral aspect of the right foot. Laboratory investigations and x-ray were normal. Bone scintigraphy showed hyperemia and increase tracer uptake in right hind foot. SPECT-CT localizes this uptake at the inferior aspect of the talus and superior aspects of the calcaneus. Diagnosis of sinus tarsi syndrome was made on the basis of history, clinical examination, and bone scintigraphy findings. Local conservative therapy was initiated. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. Source


Bastaki J.M.,Kuwait Cancer Control Center
Ear, Nose and Throat Journal | Year: 2015

Tonsillitis and pharyngitis are among the most common infections in the head and neck. Viral tonsillitis is usually caused by enterovirus, influenza, parainfluenza, adenovirus, rhinovirus and Epstein-Barr virus (causing infectious mononucleosis). Acute bacterial tonsillitis is most commonly caused by group A beta-hemolytic streptococci. On the other hand, pseudomembranous and necrotizing tonsillitis are usually caused by fusiform bacilli and spirochetes. Here we report what is, to our knowledge, the first case of necrotizing tonsillitis caused by group C beta-hemolytic streptococci. © 2015 Vendome Group. Source

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