Kurume, Japan
Kurume, Japan

Kurume University is a private university, established in 1946. Kurume University is located in Kurume , Fukuoka prefecture , Japan. Wikipedia.


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Patent
Kurume University and Hamamatsu Photonics K K | Date: 2016-11-30

In the estimation method, MRI indexes (such as ADC and FA) are estimated based on a scattering coefficient _(s) of a measurement site B or a parameter having a correlation with the scattering coefficient _(s), the scattering coefficient _(s) being obtained by a near-infrared spectroscopy based on a detection result of near-infrared light made incident on the measurement site B and propagated inside the measurement site B. The method allows acquisition of MRI index of a measurement site more simply as compared with MRI.


Yamagishi S.-I.,Kurume University
Experimental Gerontology | Year: 2011

A non-enzymatic reaction between ketones or aldehydes and the amino groups of proteins, lipids and nucleic acids contributes to the aging of macromolecules and to the development and progression of various age-related disorders such as vascular complications of diabetes, Alzheimer's disease, cancer growth and metastasis, insulin resistance and degenerative bone disease. Under hyperglycemic and/or oxidative stress conditions, this process begins with the conversion of reversible Schiff base adducts, and then to more stable, covalently-bound Amadori rearrangement products. Over a course of days to weeks, these early glycation products undergo further reactions and rearrangements to become irreversibly crossed-linked, fluorescent protein derivatives termed advanced glycation end products (AGEs). There is a growing body of evidence that AGE and their receptor RAGE (receptor for AGEs) interaction elicits oxidative stress, inflammatory reactions and thrombosis, thereby being involved in vascular aging and damage. These observations suggest that the AGE-RAGE system is a novel therapeutic target for preventing diabetic vascular complications. In this paper, we review the pathophysiological role of the AGE-RAGE-oxidative stress system and its therapeutic intervention in vascular damage in diabetes. We also discuss here the potential utility of the restriction of food-derived AGEs in diabetic vascular complications. © 2010 Elsevier Inc.


The present invention provides a method for producing a circular DNA molecule having a specific structure that enables to distinguish circular DNA formed from a single DNA molecule (single-molecule circular DNA), from circular DNA formed from multiple DNA molecules (multiple-molecule circular DNA) and also from single-molecule circular DNA derived from the circular DNA formed from multiple DNA molecules. According to the present invention, only single-molecule circular DNA that is not derived from multiple-molecule circular DNA can be selected in the production of circular DNA.


The present invention provides an embedding resin composition for electron microscopy having satisfactory performance as an embedding medium, including embedding performance and sectioning quality, and exhibiting excellent antistatic performance; and a method for observing a sample with an electron microscope using the composition. The embedding resin composition for electron microscopy of the present invention having antistatic performance comprises an ionic liquid and an embedding medium comprising an epoxy-based resin, a methacrylate resin or an unsaturated polyester resin. Preferably, the ionic liquid comprisinga quaternary ammonium compound based on the formula (I):an anion selected from the group consisting of BF_(4)^(-), PF_(6)^(-), (CF_(3)SO_(2))_(2)N^(-), a halide ion, a conjugate base of carboxylic acid, a conjugate base of sulfonic acid and a conjugate base of an inorganic acid.


Patent
K. N. Medical. Co. and Kurume University | Date: 2014-04-09

An osteosynthesis device is provided, which, while being a single device, is wide in a range of fixing positions or fixing methods that can be selected in a repositioning operation, enables firm fixation of an affected portion, and alleviates feeling of discomfort felt at the affected portion after the operation. An osteosynthesis device D1 is a device used, in case of fracture of an olecranon side of an ulna, to fix and reposition respective bone fragments and includes an intramedullary nail 1 inserted into the ulna 3, an end plate 2a mounted on an outer surface of the ulna at the olecranon 31 side, and a threaded screw N1 arranged to screw on the end plate to the intramedullary nail. Screws S are used in combination with the osteosynthesis device D1 to fix, etc., the inserted intramedullary nail 1 onto the ulna 3. The intramedullary nail 1, which is a round rod body having a tapering tip end portion and has a thickness enabling entry into the marrow of the ulna and a predetermined length, includes a threaded hole 111 formed in a base end surface 101, long holes 114 and 115 formed at a base end side with respect to a central portion of a circumferential surface 102, and circular holes 112, 113, 116, 117, and 118 formed at predetermined parts between a tip portion side and the base end side of the circumferential surface 102.


Patent
Tokyo Metropolitan Geriatric Hospital And Institute Of Gerontology and Kurume University | Date: 2015-01-14

To obtain data associated with a mitochondrial disease, a method includes measuring the level of at least one protein selected from the group consisting of GDF15 (growth differentiation factor 15), HGF (hepatocyte growth factor), MIG (gamma interferon induction monokine), SCF (stem cell factor) and SCGF- (stem cell growth factor beta) in a biological sample collected from a subject. The measured protein level is compared to that of control subjects and then it is checked whether or not there is difference between the protein level of the subject and that of control subjects.


Patent
Kurume University and Nhk Spring Co. | Date: 2015-03-25

Provided is a vascular anastomosis device for favorably anastomosing two blood vessels with different diameters. T he vascular anastomosis device comprises two rings with pins 21 made of a flexible material and an openable ring holder 2 2, which is made of a pair of components and detachably hold s the rings with pins 21, the ring holder 22 has a means for deforming the rings with pins, the end portion of the large-diameter blood vessel is inserted through a ring 21 and the vascular wall is extended outward 90 degrees and impaled on the pins, the end portion of the small-diameter blood vessel is inserted through the other ring 21, an incision is made i n a longitudinal direction from the end surface of the small -diameter blood vessel, the two rings 21 are elliptically de formed into a same elliptical shape by the means for deformi ng the rings so that the minor axis agrees with the diameter of the small-diameter blood vessel, the small-diameter blood vessel is elliptically opened and the vascular wall is exte nded outward 90 degrees and impaled on the pins, and the two rings 21 are joined together by allowing the pins provided o n the ring in one component to stick into the ring in the oth er component.


Patent
Kurume University | Date: 2015-01-12

There is provided a method for producing a circular DNA which consists of a circular DNA formed from a single-molecule DNA and which does not comprise circular DNA formed from multiple-molecule DNA. According to the method of the present invention, a circular DNA molecule formed only from a single-molecule DNA can be reliably produced.


Patent
Shino Test Corporation, Saga University and Kurume University | Date: 2014-07-16

The present invention provides a method and a reagent for measuring periostin contained in a sample with improved accuracy, a method for improving accuracy in measurement of periostin, and a method of testing for pulmonary fibrosis or interstitial pneumonia with improved accuracy. The antibody of the present invention binds to at least one region selected from the group consisting of an EMI region, an R1 region, an R2 region, and an R3 region of periostin or a cleavage product thereof. The method and the reagent for measuring periostin and the method for improving accuracy in periostin measurement of the present invention is characterized by detecting at least one region selected from the group consisting of an EMI region, an R1 region, an R2 region, and an R3 region of periostin. The method of testing for pulmonary fibrosis or interstitial pneumonia of the present invention includes the steps of a) measuring the amount or concentration of periostin in a sample derived from a subject, which measuring includes detecting at least one region selected from the group consisting of an EMI region, an R1 region, an R2 region, and an R3 region of periostin and b) comparing the amount or concentration of the periostin in the sample derived from the subject with an amount or concentration of periostin in a sample derived from a living body not suffering from pulmonary fibrosis and interstitial pneumonia.


Patent
Shino Test Corporation, Saga University and Kurume University | Date: 2016-04-29

The present invention provides a method and a reagent for measuring periostin contained in a sample with improved accuracy, a method for improving accuracy in measurement of periostin, and a method of testing for pulmonary fibrosis or interstitial pneumonia with improved accuracy. The antibody of the present invention binds to at least one region selected from the group consisting of an EMI region, an R1 region, an R2 region, and an R3 region of periostin or a cleavage product thereof. The method and the reagent for measuring periostin and the method for improving accuracy in periostin measurement of the present invention is characterized by detecting at least one region selected from the group consisting of an EMI region, an R1 region, an R2 region, and an R3 region of periostin. The method of testing for pulmonary fibrosis or interstitial pneumonia of the present invention includes the steps of a) measuring the amount or concentration of periostin in a sample derived from a subject, which measuring includes detecting at least one region selected from the group consisting of an EMI region, an R1 region, an R2 region, and an R3 region of periostin and b) comparing the amount or concentration of the periostin in the sample derived from the subject with an amount or concentration of periostin in a sample derived from a living body not suffering from pulmonary fibrosis and interstitial pneumonia.

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