Kursk State Medical University

www.kurskmed.com
Marks, Russia

Kursk State Medical University is a Russia Government University of higher professional education and ministry on health and social medicine. Kursk State Medical University also known as Kursk State Medical Institute; KSMU; KurskGMU; KurskSMU; Kursk State Government Medical University. The university is listed in the WHO list of world medical schools and also in the International Medical education directory provided by FAIMER . Wikipedia.

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Donnez J.,Catholic University of Leuven | Tatarchuk T.F.,Kiev City Clinical Hospital No 16 | Bouchard P.,University Paris - Sud | Puscasiu L.,Spitalul Clinic Judetean de Urgenta | And 9 more authors.
New England Journal of Medicine | Year: 2012

BACKGROUND: The efficacy and safety of oral ulipristal acetate for the treatment of symptomatic uterine fibroids before surgery are uncertain. METHODS:We randomly assigned women with symptomatic fibroids, excessive uterine bleeding (a score of >100 on the pictorial blood-loss assessment chart [PBAC, an objective assessment of blood loss, in which monthly scores range from 0 to >500, with higher numbers indicating more bleeding]) and anemia (hemoglobin level of ≤10.2 g per deciliter) to receive treatment for up to 13 weeks with oral ulipristal acetate at a dose of 5 mg per day (96 women) or 10 mg per day (98 women) or to receive placebo (48 women). All patients received iron supplementation. The coprimary efficacy end points were control of uterine bleeding (PBAC score of <75) and reduction of fibroid volume at week 13, after which patients could undergo surgery. RESULTS: At 13 weeks, uterine bleeding was controlled in 91% of the women receiving 5 mg of ulipristal acetate, 92% of those receiving 10 mg of ulipristal acetate, and 19% of those receiving placebo (P<0.001 for the comparison of each dose of ulipristal acetate with placebo). The rates of amenorrhea were 73%, 82%, and 6%, respectively, with amenorrhea occurring within 10 days in the majority of patients receiving ulipristal acetate. The median changes in total fibroid volume were -21%, -12%, and +3% (P = 0.002 for the comparison of 5 mg of ulipristal acetate with placebo, and P = 0.006 for the comparison of 10 mg of ulipristal acetate with placebo). Ulipristal acetate induced benign histologic endometrial changes that had resolved by 6 months after the end of therapy. Serious adverse events occurred in one patient during treatment with 10 mg of ulipristal acetate (uterine hemorrhage) and in one patient during receipt of placebo (fibroid protruding through the cervix). Headache and breast tenderness were the most common adverse events associated with ulipristal acetate but did not occur significantly more frequently than with placebo. CONCLUSIONS: Treatment with ulipristal acetate for 13 weeks effectively controlled excessive bleeding due to uterine fibroids and reduced the size of the fibroids. (Funded by PregLem; ClinicalTrials.gov number, NCT00755755.) Copyright © 2012 Massachusetts Medical Society.


Solin A.V.,Kursk State Medical University
Bulletin of experimental biology and medicine | Year: 2012

Administration of opioid peptides dynorphin A (1-13) and DSLET was followed by a decrease in the stress-induced activation of LPO and increase in SOD activity in the liver tissue of rats. DAGO produced a similar, but less pronounced effect. The observed changes can be related to a specific distribution of opioid receptors in the liver tissue and stress-limiting influence of these peptides in the whole body.


Serikov V.S.,Kursk State Medical University | Lyashev Y.D.,Kursk State Medical University
Bulletin of Experimental Biology and Medicine | Year: 2015

Effects of melatonin on changes in the liver structures were studied in stress-resistant and stress-sensitive rats exposed to chronic stress. It was found that the number of degenerative cells increased and intralobular sinusoidal capillary enlarged in the liver of animals of both groups. These parameters were significantly higher in stress-sensitive rats. Melatonin (1 mg/kg) reduced the severity of degenerative changes and stimulated the development of reparative processes in the liver tissue. The effects of the hormone was more pronounced in rats sensitive to stress and was noted after melatonin administration in a dose of 0.2 mg/kg. © 2015, Springer Science+Business Media New York.


Bereznikov A.I.,Kursk State Medical University
Biomedical Engineering | Year: 2015

Techniques of catheterization of the retrobulbar space, direct electrical stimulation of the optic nerve using the Amplipulse device, and sub-Tenon’s implantation of collagen sponge were developed at the Department of Ophthalmology of Kursk State Medical University. These techniques are simple, safe, and highly effective in the treatment of patients with traumatic neuropathy and posttraumatic optic atrophy; they are widely used in hospitals in the city of Kursk. © 2015 Springer Science+Business Media New York


Mikhin V.P.,Kursk State Medical University
Kardiologiya | Year: 2015

Currently, pharmacotherapy of coronary heart disease, based on antianginal drugs directly improve coronary blood flow, antiplatelet, and lipid-lowering drugs, includes a new class of drugs - cardiocytoprotectors. Recent ischemic cardiomyocytes improve security in the ATP, by optimizing the energy metabolism by reducing the need for oxygen cardiomyocytes and has an antioxidant effect, protecting cellular structures and enzymes from oxidative stress accompanying hypoxia.


The article examines the morphometric parameters (the area of neuronal pericarya and their nuclei, as well as the nucleocytoplasmic ratio) describing the metabolic activity of the nucleus basalis of Meynert (NBM), tuberomamillary (TMN) nucleus, and medial mammillary (MMN) nucleus of the human hypothalamus in four age groups. A reliable enlargement has been found in the size of neurons and their nuclei in elderly people. Increases in the metabolic activity of neurons in the NBM begin earlier than in the TMN and MMN and are morphologically manifested in middle-aged persons. The age-related metabolic activation of neurons in the studied human brain structures, which participate in the regulation of memory and other cognitive functions, can be attributed to defensive and adaptive and/or compensatory mechanisms in aging that target prevention of the development of Alzheimer’s disease. © 2015, Pleiades Publishing, Ltd.


Berdnikov D.V.,Kursk State Medical University
Human Ecology | Year: 2012

We have studied the electrophysiological mechanisms of providing optimal manifestation of non-specific characteristics and self-regulation properties of the functional comprehension systems and measuring the length of a sound signal and spatio-temporal parameters reflecting the processes occurring in the action result acceptors. It has been established that various self-regulation properties of the same functional system differed greatly in the links with EEG-rhythms, the peculiarities of the dynamic connection between various parts of the brain and the necessary nonspecific activation of CNS connected with the activating influences of the dominating motivation. It has been shown that with the similar character of dependence of the same self-regulation properties of different functional systems on EEG-rhythms and changes in their spatio-temporal synchronization, they were provided by different levels of the CNS generalized activation.


Polonikov A.V.,Kursk State Medical University | Ivanov V.P.,Kursk State Medical University | Solodilova M.A.,Kursk State Medical University
Bulletin of Experimental Biology and Medicine | Year: 2013

We studied the association between of cytochrome P450 2E1 (CYP2E1) gene polymorphism and risk of essential hypertension development depending on alcohol drinking habit in unrelated men in Russian population (patients with essential hypertension and healthy volunteers). All participants were genotyped for four CYP2E1 gene polymorphisms -1293G>C (rs3813867), -1053C>T (rs2031920), 7632T>A (rs6413432), and 9896C>G (rs2070676) by PCR and restriction analysis. We found statistically significant associations between -1293C allele (OR=5.04, 95% CI=1.23-20.70, p=0.03) and -1293GC genotype (OR=5.36, 95% CI=1.28-22.50, p=0.03) with increased risk of essential hypertension in men. Stratified analysis on alcohol drinking habit showed that the presence of -1293C allele (OR=6.82, 95% CI=1.12-41.70, p=0.04) and -1293GC genotype (OR=7.61, 95% CI=1.2-48.4, p=0.03) in men with alcohol abuse increases the risk of essential hypertension. The obtained data suggest that excessive alcohol consumption and increased induction of cytochrome in the carriers of -1293C allele of CYP2E1 gene lead to generation of highly reactive free radical oxidation products. These processes induced oxidative stress and endothelial induction, which served as the pathogenetic basis for essential hypertension. © 2013 Springer Science+Business Media New York.


Ishunina T.A.,Institute of the Royal Netherlands Academy of Arts and science | Ishunina T.A.,Kursk State Medical University | Swaab D.F.,Institute of the Royal Netherlands Academy of Arts and science
Neurobiology of Aging | Year: 2012

In this study we identified 62 estrogen receptor alpha (ERα) mRNA splice variants in different human brain areas of Alzheimer's disease (AD) and control cases and classified them into 12 groups. Forty-eight of these splice forms were identified for the first time. The distribution of alternatively spliced ERα mRNAs was brain area- and case-specific. The dominant negative deletion (del.) 7 isoform appeared to be the major splice variant. The average number of ERα splice forms per brain area was lower in AD cases compared with controls, although the incidence of large deletions with alternative usage of 5' and 3' splice sites inside exons was more frequent in AD female cases. Relative transcription levels of del 7 and del 2 (missing exon 2) variants were decreased in the temporal cortex of AD patients, whereas the expression of the wild type ERα mRNA did not change. Our data show that alternative splicing of ERα mRNA is diminished in the AD brain and more prominently in AD female cases. © 2012 Elsevier Inc.


Gorshunova N.K.,Kursk State Medical University
Experimental and Clinical Cardiology | Year: 2014

The aim of the study is estimation of the inflammatory and apoptotic processes activation, oxidative and nitrosative stress in the endothelial dysfunction pathogenesis due to essential hypertension. Study group included 66 elderly hypertensive patients (mean age 66,1 ± 0,5 years), control group - 22 practically healthy humans. The degree of endothelial dysfunction examined by Doppler of brachial artery, lipid metabolism and homeostasis peroxidation, endotheliocytemia level was estimated by the Hladovec and Rossmann method, nitric oxide in the Griess reaction, C-reactive protein, apoptosis markers - by the immune enzyme method. Found that key role in endothelial dysfunction pathogenesis in elderly hypertensive patients belongs to intensity of nitrosative stress and oxidative reactions due to lower effectiveness of antioxidant enzyme system that induces subclinical inflammation, the outcome of which is the activation of apoptosis and increased endothelial desquamation.

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