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Kursk State Medical University is a Russia Government University of higher professional education and ministry on health and social medicine. Kursk State Medical University also known as Kursk State Medical Institute; KSMU; KurskGMU; KurskSMU; Kursk State Government Medical University. The university is listed in the WHO list of world medical schools and also in the International Medical education directory provided by FAIMER . Wikipedia.

Solin A.V.,Kursk State Medical University
Bulletin of experimental biology and medicine | Year: 2012

Administration of opioid peptides dynorphin A (1-13) and DSLET was followed by a decrease in the stress-induced activation of LPO and increase in SOD activity in the liver tissue of rats. DAGO produced a similar, but less pronounced effect. The observed changes can be related to a specific distribution of opioid receptors in the liver tissue and stress-limiting influence of these peptides in the whole body.

Donnez J.,Catholic University of Leuven | Tatarchuk T.F.,Kiev City Clinical Hospital No. 16 | Bouchard P.,University Paris - Sud | Puscasiu L.,Spitalul Clinic Judetean de Urgenta | And 9 more authors.
New England Journal of Medicine | Year: 2012

BACKGROUND: The efficacy and safety of oral ulipristal acetate for the treatment of symptomatic uterine fibroids before surgery are uncertain. METHODS:We randomly assigned women with symptomatic fibroids, excessive uterine bleeding (a score of >100 on the pictorial blood-loss assessment chart [PBAC, an objective assessment of blood loss, in which monthly scores range from 0 to >500, with higher numbers indicating more bleeding]) and anemia (hemoglobin level of ≤10.2 g per deciliter) to receive treatment for up to 13 weeks with oral ulipristal acetate at a dose of 5 mg per day (96 women) or 10 mg per day (98 women) or to receive placebo (48 women). All patients received iron supplementation. The coprimary efficacy end points were control of uterine bleeding (PBAC score of <75) and reduction of fibroid volume at week 13, after which patients could undergo surgery. RESULTS: At 13 weeks, uterine bleeding was controlled in 91% of the women receiving 5 mg of ulipristal acetate, 92% of those receiving 10 mg of ulipristal acetate, and 19% of those receiving placebo (P<0.001 for the comparison of each dose of ulipristal acetate with placebo). The rates of amenorrhea were 73%, 82%, and 6%, respectively, with amenorrhea occurring within 10 days in the majority of patients receiving ulipristal acetate. The median changes in total fibroid volume were -21%, -12%, and +3% (P = 0.002 for the comparison of 5 mg of ulipristal acetate with placebo, and P = 0.006 for the comparison of 10 mg of ulipristal acetate with placebo). Ulipristal acetate induced benign histologic endometrial changes that had resolved by 6 months after the end of therapy. Serious adverse events occurred in one patient during treatment with 10 mg of ulipristal acetate (uterine hemorrhage) and in one patient during receipt of placebo (fibroid protruding through the cervix). Headache and breast tenderness were the most common adverse events associated with ulipristal acetate but did not occur significantly more frequently than with placebo. CONCLUSIONS: Treatment with ulipristal acetate for 13 weeks effectively controlled excessive bleeding due to uterine fibroids and reduced the size of the fibroids. (Funded by PregLem; ClinicalTrials.gov number, NCT00755755.) Copyright © 2012 Massachusetts Medical Society.

Mikhin V.P.,Kursk State Medical University
Kardiologiya | Year: 2015

Currently, pharmacotherapy of coronary heart disease, based on antianginal drugs directly improve coronary blood flow, antiplatelet, and lipid-lowering drugs, includes a new class of drugs - cardiocytoprotectors. Recent ischemic cardiomyocytes improve security in the ATP, by optimizing the energy metabolism by reducing the need for oxygen cardiomyocytes and has an antioxidant effect, protecting cellular structures and enzymes from oxidative stress accompanying hypoxia.

Bereznikov A.I.,Kursk State Medical University
Biomedical Engineering | Year: 2015

Techniques of catheterization of the retrobulbar space, direct electrical stimulation of the optic nerve using the Amplipulse device, and sub-Tenon’s implantation of collagen sponge were developed at the Department of Ophthalmology of Kursk State Medical University. These techniques are simple, safe, and highly effective in the treatment of patients with traumatic neuropathy and posttraumatic optic atrophy; they are widely used in hospitals in the city of Kursk. © 2015 Springer Science+Business Media New York

The article examines the morphometric parameters (the area of neuronal pericarya and their nuclei, as well as the nucleocytoplasmic ratio) describing the metabolic activity of the nucleus basalis of Meynert (NBM), tuberomamillary (TMN) nucleus, and medial mammillary (MMN) nucleus of the human hypothalamus in four age groups. A reliable enlargement has been found in the size of neurons and their nuclei in elderly people. Increases in the metabolic activity of neurons in the NBM begin earlier than in the TMN and MMN and are morphologically manifested in middle-aged persons. The age-related metabolic activation of neurons in the studied human brain structures, which participate in the regulation of memory and other cognitive functions, can be attributed to defensive and adaptive and/or compensatory mechanisms in aging that target prevention of the development of Alzheimer’s disease. © 2015, Pleiades Publishing, Ltd.

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