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Sardar A.,SVS Medical College | Basireddy S.R.,Kurnool Medical College | Navaz A.,SVS Medical College | Singh M.,SVS Medical College | Kabra V.,SVS Medical College
Journal of Clinical and Diagnostic Research | Year: 2017

Introduction: Fosfomycin is a broad spectrum anti-microbial agent with activity against various bacterial agents. It is a bactericidal antibiotic which interferes with cell wall synthesis. Fosfomycin is rapidly absorbed orally and majority of the drug is excreted unchanged in urine with very high concentration levels achieved in urine after a single oral dose. Urine levels remain high for prolonged period which makes it a suitable drug in the treatment of Urinary Tract Infections (UTI). E.coli is the most common organism causing the UTI. With the inappropriate and inadvertent use of higher antibiotics, these bacterial isolates have acquired multidrug resistance for which treatment options are limited. Aim: To evaluate the in-vitro activity of fosfomycin against uropathogenic E.coli and to compare its activity with the other anti-microbial agents Materials and Methods: This study was a prospective study done in the Department of Microbiology SVS Medical College, Mahbubnagar from Jan 2016 to Mar 2016. A total of 564 urine samples from suspected UTI cases were processed during the study period out of which 170 E.coli were isolated. Identification of the organisms were done by routine biochemical testing and anti-biotic sensitivity testing was done by Kirby-Bauer disc diffusion testing according to the CLSI guidelines (M100-S23) Results: A total of 170 E.coli isolates were tested for anti-biotic susceptibility. Out of 170 isolates 60 (35.30%) were isolated from males and 110 (64.70%) from females with male to female ratio of 1:1.83. Majority of the isolates were obtained from the age group of 21-30 years (25.8%). Antibiotics like fosfomycin, imipenem and methenamine mandelate showed the highest sensitivity with all the isolates (100%) being susceptible to these drugs. Whereas, least sensitivity was observed for amoxyclav (15.2%) followed by cefixime (16.4%) and norfloxacin (21%). Fosfomycin has shown very good in-vitro activity against all the tested isolates when compared with many other anti-biotics. Conclusion: In view of emergence of multidrug resistant pathogens, testing for old and forgotten antibiotics like fosfomycin is gaining importance. Because of its unique mechanism of action and low incidence of resistance it can be a potential therapeutic alternative in the treatment of UTI. © 2017, Journal of Clinical and Diagnostic Research. All rights reserved.


Rao V.M.M.,Kurnool Medical College | Rameswarudu M.,SVS Medical College
National Journal of Physiology, Pharmacy and Pharmacology | Year: 2017

Background: Peak expiratory flow rate (PEFR) assesses the overall functional status of the respiratory system. Aims and Objectives: The aim of this study was to observe the PEFR in school going healthy children, in a town located in the southern part of India. To illustrate the relation among the age, height, weight, and PEFR in the school going children. Materials and Methods: 119 school going healthy boys were selected randomly, aged between 5 and 16 years. Anthropometric parameters, namely, height and weight of the subjects were measured to the nearest reading with minimal clothes on and without footwear using stadiometer and weighing machine, respectively. Subjects were divided into five groups: Group I with a height range of 101-120 cm, Group II with 121-130 cm; Group III with 131-140 cm; Group IV with 141-150 cm; and Group V with 151-160 cm. PEFR was measured using the pocket flow meter and wrights flow meter. Results: Mean PEFR values with standard deviation in the five groups with pocket flow meter and with wrights flow meter are Group I: 159 ± 18.3 and 118 ± 22.5, Group II: 227 ± 31.0 and 204 ± 31.8, Group III: 253 ± 52.0 and 234 ± 51.2, Group IV: 309 ± 43 and 296 ± 40.9, and Group V: 368 ± 51.0 and 343 ± 47.7. Correlation coefficient was also calculated between the height and PEFR, measured with pocket flow meter in all the five groups; 0.64, 0.68, 0.25, 0.47, and 0.69 from Groups I to V. Conclusion: PEFR is increased with the increasing in height of the subjects. © 2016 Veera Mohan Rao M and Rameswarudu M.


PubMed | Smt Kashibai Navale Medical College, Kurnool Medical College and Viswa Bharathi Medical College
Type: Journal Article | Journal: International journal of yoga | Year: 2014

The Pulmonary Function Tests are important for measuring the fitness of an individual from a physiological point of view. Lung function parameters tend to have a relationship with lifestyle such as regular yoga, an ancient system of Indian Philosophy. Yoga is probably the best lifestyle ever devised in the history of mankind. Hence the present analytical study was undertaken to assess the effects of yoga on respiratory system when compared with sedentary subjects.To compare the pulmonary function test among the yogic and sedentary groups.The present study was conducted on 50 subjects practicing yoga and 50 sedentary subjects in the age group of 20-40 years. They were assessed for pulmonary function test in which sedentary group acted as controls. The tests which were recorded as per standard procedure using Medspiror as determinants of pulmonary function were FVC, FEV1, FEV3, PEFR and FVC/FEV1 ratio.Pulmonary Functions were compared between the yoga practitioners and sedentary group. Yoga exercise significantly increased chest wall expansion as observed by higher values of pulmonary functions compared with sedentary controls. The study group were having higher mean of percentage value of FVC 109.1 18.2%, FEV1 of 116.3 15.9%, FEV3 of 105.7 14.9 %, PEFR of 109.2 21.3% and FEV1/FVC ratio of 111.3 6.9% as compared to sedentary group.Regular Yoga practice increases the vital capacity, timed vital capacity, maximum voluntary ventilation, breath holding time and maximal inspiratory and expiratory pressures.


Reddy B.V.,Ms Ramaiah Hospital | Sivakanth A.,Kurnool Medical College | Swamyvelu K.,Kidwai Memorial Institute of Oncology | Goud Y.G.B.,Kidwai Memorial Institute of Oncology | And 2 more authors.
ecancermedicalscience | Year: 2014

A germ-cell tumour (GCT) of the testis is a chemosensitive tumour with high cure rates even in advanced disease. Radical inguinal orchiectomy is the initial procedure used to diagnose it which helps to risk-stratify these patients. However, in patients with life-threatening metastases, primary chemotherapy was attempted in a few studies, followed by delayed orchiectomy. The aim of this review is to study the histopathological findings of delayed orchiectomy and the retroperitoneal lymph node dissection (RPLND) specimens, to assess difference and concordance in response rates in histological types of GCTs in pathological specimens. Overall, 352 patients received initial chemotherapy followed by orchiectomy, and 235 of them had undergone RPLND. Delayed orchiectomy specimens had viable tumour in 74 (21%) patients, scarring/necrosis in 171 patients (48.5%), and teratoma in 107 (30.3%) patients. RPLND specimens had residual disease in 36 (15.3%) patients, scarring/necrosis in 100 patients (42.5%), and teratoma in 99 patients (42.3%). Patients with seminoma who underwent delayed orchiectomy had complete disappearance of tumour in 81.3% of cases, and in non-seminomatous GCT, it was 43.4%. These results raise the question of the existence of a blood-testis barrier in patients with advanced GCT and argue against the testis as a sanctuary site. © the authors; licensee ecancermedicalscience.


PubMed | University of Leicester, Kurnool Medical College, Lincoln County Hospital and King's College
Type: Journal Article | Journal: The Indian journal of radiology & imaging | Year: 2016

The OUTBACK() catheter is a reentry device that enables reentry into a vessel lumen from the subintimal space during subintimal angioplasty. It is reserved for cases where reentry has not been possible using conventional wire and catheter techniques. We report a two-center experience in recanalization of the chronic total occlusions of the common iliac (CIA) and the superficial femoral artery (SFA) using the OUTBACK() catheter in cases where other techniques were unsuccessful.All cases where recanalization was performed using the OUTBACK() reentry catheter between January 2010 to January 2015 were retrospectively identified and included in this study. 21 patients were identified. The indication for intervention in these cases included claudication and critical leg ischemia. In all cases, conventional recanalization could not be successfully achieved.The OUTBACK() catheter was used to recanalize 10 SFA occlusion and 9 CIA occlusions. In 19 patients (90%), reentry into true arterial lumen was successfully achieved. 17 patients had their recanalization through the transfemoral approach whereas 2 patients had a transpopliteal artery approach. In 2 patients, reentry into the true lumen could not be achieved using the OUTBACK() catheter due to patients intolerability for the procedure and severe atherosclerotic calcified plaques. There was 100% patency of the vessel intervened on Duplex ultrasound at 24 months of follow up. 16 patients (84%) remained asymptomatic and 2 patients (10.5%) reported worsening of their symptoms due to the development of new lesions within the arterial system.The OUTBACK() catheter is an effective and safe technique for reentry into the vessel lumen when conventional techniques fail.


Rajesh P.,Kurnool Medical College
Asian Journal of Pharmaceutical and Clinical Research | Year: 2016

Objective: The antihypertensive drugs (beta-blockers - carvedilol, calcium channel blocker - amlodipine, and angiotensin-converting enzyme inhibitor - enalapril) were investigated for its hepatoprotective effect by antioxidant property against carbon tetrachloride (CCl4)-induced acute liver damage on albino rats. Methods: In this study the liver was damaged by giving Carbon tetra chloride (CCl4)-1 ml/kg-p.o. After giving CCl4 (1 ml/kg), it significantly elevated the serum levels of biochemical markers such as serum glutamate-pyruvate transaminase, serum glutamic oxaloacetic transaminase, alkaline phosphatase, total bilirubin, protein, and depleted antioxidant enzymes glutathione. After treatment with carvedilol (10 mg/kg), enalapril (0.5 mg/kg), and amlodipine (10 mg/kg) for 2 weeks, these drugs were significantly reduces the elevated levels of biochemical markers mentioned above. Conclusion: These results suggest that these antihypertensive drugs may have the potential therapeutic value in the treatment of CCl4-induced hepatic damage and some liver diseases. Hepatoprotective activity of these drugs may be attributed to the antioxidant principles in it. © 2016, Innovare Academics Sciences Pvt. Ltd. All rights reserved.


Mekapogu N.P.,Kurnool Medical College | Gundela S.,Kurnool Medical College | Avula R.D.,Kurnool Medical College
Journal of Clinical and Diagnostic Research | Year: 2016

Introduction: Diabetes is a known risk factor for asymptomatic bacteriuria (ASB). However, the influence of diabetes on antenatal ASB was previously not addressed. Aim: The prevalence of ASB, effect of risk factors and type of isolates and susceptibility patterns were studied in diabetic pregnancy. Materials and Methods: A total of 311 pregnant women were recruited for this study of which 103 were diabetic and 208 non-diabetic. A clean catch midstream urine samples were collected and cultured. The isolates were identified and antibiotic sensitivity was studied. The data was analysed by Chi-square test. Results: The prevalence of ASB in diabetic pregnancy was 38.83% (40/103; 95% CI: 23.73 - 53.94) and in non-diabetic pregnancy was 37.98% (79/208; CI: 27.28- 48.68). The odds ratio was not significant 1.0225 (95% CU: 0.65 – 1.599; p=0.922) and associated factors such as age and gestational period had no effect. The major isolates were Escherichia coli (25.0%), Staphylococcus aureus (22.5%), Coagulase negative staphylococci (CONS) (20.00%), and Klebsiella pneumonia (20.00%) in diabetic pregnancy and CONS (31.7%), E.coli (24.0%) and K.pneumonia (16.5%) in non-diabetic pregnancy. The isolates of diabetic pregnancy showed highest susceptibility to nitrofurantoin (56.4%), gentamicin (38.5%) and cotrimoxazole (38.5%) whereas that of non-diabetic pregnancy to gentamicin (43.0%), azithromycin (32.9%) and norfloxacin (30.4). There was no significant (p<0.05) difference in the type and susceptibly of the isolates between diabetic and non-diabetic pregnancy. Conclusion: Diabetes has no significant influence on the prevalence of ASB in diabetic pregnancy both in terms of isolates and antibiotic susceptibility pattern. © 2016, Journal of Clinical and Diagnostic Research. All Rights Reserved.


Ahmed S.M.,Kurnool Medical College | Kumar M.M.,Kurnool Medical College
Journal of Nepal Paediatric Society | Year: 2015

A seven years old child presented with multiple pebble stones in the gastro intestinal tract. Clinical examination did not reveal any abnormality except mild dehydration. Serial clinical examination for period of three days and regular radiographic follow up was done. Spontaneous expulsion of all the pebbles per rectum without any complication occurred in three days. In the absence of emergency surgical situation observation and watchful follow up of the patients will suffice the management. © 2015, Nepal Paediatric Society (NEPAS). All rights reserved.


Vedala S.,Kurnool Medical College | Paul N.,Navodaya Medical College | Mane A.B.,Navodaya Medical College
National Journal of Physiology, Pharmacy and Pharmacology | Year: 2013

Background: Pulmonary function assessment has achieved a lot of importance nowadays owing to a steep rise in air pollution. Lung function parameters tend to have a relationship with lifestyle such as regular exercise and non-exercise. Hence the present study was under taken to assess the effects of exercise in athletes on respiratory system and compared with sedentary group. Aims & Objective: To compare the differences in pulmonary function test among the athletes and sedentary group. Materials and Methods: A total of 152 subjects comprising athletes and sedentary were assessed for pulmonary function test. The parameters used as determinants of lung function were FVC, FEV1, FEV3, PEFR and FVC/FEV1 ratio were recorded as per standard procedure using Medspiror. Results: Pulmonary Function Profile was analyzed and compared between the study groups. In our study the athletic group were having higher mean of percentage value of FVC 88.0 ± 12.8%, FEV1 of 86.8 ± 22.0%, FEV3 of 86.5 ± 13.7 %, PEFR of 93.0 ± 12.8% and FEV1/ FVC ratio of 92.1 ± 4.4% as compared to sedentary group. Conclusion: The FVC, FEV1, FEV3, PEFR and FEV1/FVC ratio were higher in athletes than in the normal sedentary control individuals. This study suggests that regular exercise has an important role in determining and improving lung functions.


PubMed | Kurnool Medical College
Type: Journal Article | Journal: Journal of clinical and diagnostic research : JCDR | Year: 2016

Diabetes is a known risk factor for asymptomatic bacteriuria (ASB). However, the influence of diabetes on antenatal ASB was previously not addressed.The prevalence of ASB, effect of risk factors and type of isolates and susceptibility patterns were studied in diabetic pregnancy.A total of 311 pregnant women were recruited for this study of which 103 were diabetic and 208 non-diabetic. A clean catch midstream urine samples were collected and cultured. The isolates were identified and antibiotic sensitivity was studied. The data was analysed by Chi-square test.The prevalence of ASB in diabetic pregnancy was 38.83% (40/10(3); 95% CI: 23.73 - 53.94) and in non-diabetic pregnancy was 37.98% (79/208; CI: 27.28- 48.68). The odds ratio was not significant 1.0225 (95% CU: 0.65 - 1.599; p=0.922) and associated factors such as age and gestational period had no effect. The major isolates were Escherichia coli (25.0%), Staphylococcus aureus (22.5%), Coagulase negative staphylococci (CONS) (20.00%), and Klebsiella pneumonia (20.00%) in diabetic pregnancy and CONS (31.7%), E.coli (24.0%) and K.pneumonia (16.5%) in non-diabetic pregnancy. The isolates of diabetic pregnancy showed highest susceptibility to nitrofurantoin (56.4%), gentamicin (38.5%) and cotrimoxazole (38.5%) whereas that of non-diabetic pregnancy to gentamicin (43.0%), azithromycin (32.9%) and norfloxacin (30.4). There was no significant (p<0.05) difference in the type and susceptibly of the isolates between diabetic and non-diabetic pregnancy.Diabetes has no significant influence on the prevalence of ASB in diabetic pregnancy both in terms of isolates and antibiotic susceptibility pattern.

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