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PubMed | Smt Kashibai Navale Medical College, Kurnool Medical College and Viswa Bharathi Medical College
Type: Journal Article | Journal: International journal of yoga | Year: 2014

The Pulmonary Function Tests are important for measuring the fitness of an individual from a physiological point of view. Lung function parameters tend to have a relationship with lifestyle such as regular yoga, an ancient system of Indian Philosophy. Yoga is probably the best lifestyle ever devised in the history of mankind. Hence the present analytical study was undertaken to assess the effects of yoga on respiratory system when compared with sedentary subjects.To compare the pulmonary function test among the yogic and sedentary groups.The present study was conducted on 50 subjects practicing yoga and 50 sedentary subjects in the age group of 20-40 years. They were assessed for pulmonary function test in which sedentary group acted as controls. The tests which were recorded as per standard procedure using Medspiror as determinants of pulmonary function were FVC, FEV1, FEV3, PEFR and FVC/FEV1 ratio.Pulmonary Functions were compared between the yoga practitioners and sedentary group. Yoga exercise significantly increased chest wall expansion as observed by higher values of pulmonary functions compared with sedentary controls. The study group were having higher mean of percentage value of FVC 109.1 18.2%, FEV1 of 116.3 15.9%, FEV3 of 105.7 14.9 %, PEFR of 109.2 21.3% and FEV1/FVC ratio of 111.3 6.9% as compared to sedentary group.Regular Yoga practice increases the vital capacity, timed vital capacity, maximum voluntary ventilation, breath holding time and maximal inspiratory and expiratory pressures.


Reddy B.V.,Ms Ramaiah Hospital | Sivakanth A.,Kurnool Medical College | Swamyvelu K.,Kidwai Memorial Institute of Oncology | Goud Y.G.B.,Kidwai Memorial Institute of Oncology | And 2 more authors.
ecancermedicalscience | Year: 2014

A germ-cell tumour (GCT) of the testis is a chemosensitive tumour with high cure rates even in advanced disease. Radical inguinal orchiectomy is the initial procedure used to diagnose it which helps to risk-stratify these patients. However, in patients with life-threatening metastases, primary chemotherapy was attempted in a few studies, followed by delayed orchiectomy. The aim of this review is to study the histopathological findings of delayed orchiectomy and the retroperitoneal lymph node dissection (RPLND) specimens, to assess difference and concordance in response rates in histological types of GCTs in pathological specimens. Overall, 352 patients received initial chemotherapy followed by orchiectomy, and 235 of them had undergone RPLND. Delayed orchiectomy specimens had viable tumour in 74 (21%) patients, scarring/necrosis in 171 patients (48.5%), and teratoma in 107 (30.3%) patients. RPLND specimens had residual disease in 36 (15.3%) patients, scarring/necrosis in 100 patients (42.5%), and teratoma in 99 patients (42.3%). Patients with seminoma who underwent delayed orchiectomy had complete disappearance of tumour in 81.3% of cases, and in non-seminomatous GCT, it was 43.4%. These results raise the question of the existence of a blood-testis barrier in patients with advanced GCT and argue against the testis as a sanctuary site. © the authors; licensee ecancermedicalscience.


PubMed | University of Leicester, Kurnool Medical College, Lincoln County Hospital and King's College
Type: Journal Article | Journal: The Indian journal of radiology & imaging | Year: 2016

The OUTBACK() catheter is a reentry device that enables reentry into a vessel lumen from the subintimal space during subintimal angioplasty. It is reserved for cases where reentry has not been possible using conventional wire and catheter techniques. We report a two-center experience in recanalization of the chronic total occlusions of the common iliac (CIA) and the superficial femoral artery (SFA) using the OUTBACK() catheter in cases where other techniques were unsuccessful.All cases where recanalization was performed using the OUTBACK() reentry catheter between January 2010 to January 2015 were retrospectively identified and included in this study. 21 patients were identified. The indication for intervention in these cases included claudication and critical leg ischemia. In all cases, conventional recanalization could not be successfully achieved.The OUTBACK() catheter was used to recanalize 10 SFA occlusion and 9 CIA occlusions. In 19 patients (90%), reentry into true arterial lumen was successfully achieved. 17 patients had their recanalization through the transfemoral approach whereas 2 patients had a transpopliteal artery approach. In 2 patients, reentry into the true lumen could not be achieved using the OUTBACK() catheter due to patients intolerability for the procedure and severe atherosclerotic calcified plaques. There was 100% patency of the vessel intervened on Duplex ultrasound at 24 months of follow up. 16 patients (84%) remained asymptomatic and 2 patients (10.5%) reported worsening of their symptoms due to the development of new lesions within the arterial system.The OUTBACK() catheter is an effective and safe technique for reentry into the vessel lumen when conventional techniques fail.


Rajesh P.,Kurnool Medical College
Asian Journal of Pharmaceutical and Clinical Research | Year: 2016

Objective: The antihypertensive drugs (beta-blockers - carvedilol, calcium channel blocker - amlodipine, and angiotensin-converting enzyme inhibitor - enalapril) were investigated for its hepatoprotective effect by antioxidant property against carbon tetrachloride (CCl4)-induced acute liver damage on albino rats. Methods: In this study the liver was damaged by giving Carbon tetra chloride (CCl4)-1 ml/kg-p.o. After giving CCl4 (1 ml/kg), it significantly elevated the serum levels of biochemical markers such as serum glutamate-pyruvate transaminase, serum glutamic oxaloacetic transaminase, alkaline phosphatase, total bilirubin, protein, and depleted antioxidant enzymes glutathione. After treatment with carvedilol (10 mg/kg), enalapril (0.5 mg/kg), and amlodipine (10 mg/kg) for 2 weeks, these drugs were significantly reduces the elevated levels of biochemical markers mentioned above. Conclusion: These results suggest that these antihypertensive drugs may have the potential therapeutic value in the treatment of CCl4-induced hepatic damage and some liver diseases. Hepatoprotective activity of these drugs may be attributed to the antioxidant principles in it. © 2016, Innovare Academics Sciences Pvt. Ltd. All rights reserved.


Bhanu Murthy R.,Kurnool Medical College | Srihari V.,Kurnool Medical College | Lakshmi Narayana M.,Kurnool Medical College
Indian Journal of Otolaryngology and Head and Neck Surgery | Year: 2014

Primary hyperparathyroidism is due to parathyroid adenoma (80-85%), hyperplasia (10-15%), carcinoma (2-3%) of cases. The most common presentation is asymptomatic hypercalcemia. Multiple pathological fractures, nephrocalcinosis as a presenting feature of primary hyperparathyroidism due to parathyroid adenoma is extremely rare at the age of 19 years. A case of parathyroid adenoma with multiple fractures of left femur, renal calculi, nephrocalcinosis, weight loss, constipation, dyspepsia abdominal pain was presented. The case was investigated completely with biochemical investigations, X-ray of forearm bones and femur, ultrasonography of neck and abdomen, CT scan of neck and abdomen, MRI scan, Scintigraphy of the neck. Right inferior parathyroid adenoma was diagnosed and confirmed by histopathological examination after excision. The post operative serum calcium levels became normal. © 2012 Association of Otolaryngologists of India.


Mekapogu N.P.,Kurnool Medical College | Gundela S.,Kurnool Medical College | Avula R.D.,Kurnool Medical College
Journal of Clinical and Diagnostic Research | Year: 2016

Introduction: Diabetes is a known risk factor for asymptomatic bacteriuria (ASB). However, the influence of diabetes on antenatal ASB was previously not addressed. Aim: The prevalence of ASB, effect of risk factors and type of isolates and susceptibility patterns were studied in diabetic pregnancy. Materials and Methods: A total of 311 pregnant women were recruited for this study of which 103 were diabetic and 208 non-diabetic. A clean catch midstream urine samples were collected and cultured. The isolates were identified and antibiotic sensitivity was studied. The data was analysed by Chi-square test. Results: The prevalence of ASB in diabetic pregnancy was 38.83% (40/103; 95% CI: 23.73 - 53.94) and in non-diabetic pregnancy was 37.98% (79/208; CI: 27.28- 48.68). The odds ratio was not significant 1.0225 (95% CU: 0.65 – 1.599; p=0.922) and associated factors such as age and gestational period had no effect. The major isolates were Escherichia coli (25.0%), Staphylococcus aureus (22.5%), Coagulase negative staphylococci (CONS) (20.00%), and Klebsiella pneumonia (20.00%) in diabetic pregnancy and CONS (31.7%), E.coli (24.0%) and K.pneumonia (16.5%) in non-diabetic pregnancy. The isolates of diabetic pregnancy showed highest susceptibility to nitrofurantoin (56.4%), gentamicin (38.5%) and cotrimoxazole (38.5%) whereas that of non-diabetic pregnancy to gentamicin (43.0%), azithromycin (32.9%) and norfloxacin (30.4). There was no significant (p<0.05) difference in the type and susceptibly of the isolates between diabetic and non-diabetic pregnancy. Conclusion: Diabetes has no significant influence on the prevalence of ASB in diabetic pregnancy both in terms of isolates and antibiotic susceptibility pattern. © 2016, Journal of Clinical and Diagnostic Research. All Rights Reserved.


Ahmed S.M.,Kurnool Medical College | Kumar M.M.,Kurnool Medical College
Journal of Nepal Paediatric Society | Year: 2015

A seven years old child presented with multiple pebble stones in the gastro intestinal tract. Clinical examination did not reveal any abnormality except mild dehydration. Serial clinical examination for period of three days and regular radiographic follow up was done. Spontaneous expulsion of all the pebbles per rectum without any complication occurred in three days. In the absence of emergency surgical situation observation and watchful follow up of the patients will suffice the management. © 2015, Nepal Paediatric Society (NEPAS). All rights reserved.


Vedala S.,Kurnool Medical College | Paul N.,Navodaya Medical College | Mane A.B.,Navodaya Medical College
National Journal of Physiology, Pharmacy and Pharmacology | Year: 2013

Background: Pulmonary function assessment has achieved a lot of importance nowadays owing to a steep rise in air pollution. Lung function parameters tend to have a relationship with lifestyle such as regular exercise and non-exercise. Hence the present study was under taken to assess the effects of exercise in athletes on respiratory system and compared with sedentary group. Aims & Objective: To compare the differences in pulmonary function test among the athletes and sedentary group. Materials and Methods: A total of 152 subjects comprising athletes and sedentary were assessed for pulmonary function test. The parameters used as determinants of lung function were FVC, FEV1, FEV3, PEFR and FVC/FEV1 ratio were recorded as per standard procedure using Medspiror. Results: Pulmonary Function Profile was analyzed and compared between the study groups. In our study the athletic group were having higher mean of percentage value of FVC 88.0 ± 12.8%, FEV1 of 86.8 ± 22.0%, FEV3 of 86.5 ± 13.7 %, PEFR of 93.0 ± 12.8% and FEV1/ FVC ratio of 92.1 ± 4.4% as compared to sedentary group. Conclusion: The FVC, FEV1, FEV3, PEFR and FEV1/FVC ratio were higher in athletes than in the normal sedentary control individuals. This study suggests that regular exercise has an important role in determining and improving lung functions.


PubMed | Kurnool Medical College
Type: Journal Article | Journal: Neurochemical research | Year: 2013

The effect of intramuscular administration of hydrocortisone (10 mg/day per animal) for 5 days has been studied on the content of the amino acids belonging to the glutamate family, in the different regions of the mouse brain, along with the activities of glutamine synthetase, glutamate dehydrogenase, and aspartate, alanine, tyrosine, and ornithine aminotransferases. Further, since proline too is related to glutamate metabolism, the activity of proline oxidase was also studied in these regions. As hydrocortisone is known to influence the ionic fluxes in different tissues and the nitrogen metabolism, the activities of Na(+),K(+)-ATPase together with the content of RNA and protein have also been estimated. A fall in the amino acids of the glutamate family in all three regions was observed with an increase in glutamate dehydrogenase activity in cerebral cortex. A significant fall in the protein content was also observed, mainly in the brain stem. A universal increase in Na(+),K(+)-ATPase activity was observed in all three regions, with the highest in the cerebral cortex. The results indicate that hydrocortisone triggers increased utilization of glutamate in brain as an alternative to glucose, thereby shifting the nitrogen metabolism toward catabolism. The increased activity of Na(+),K(+)-ATPase under these conditions would further aggravate the same and may lead to membrane stabilization.


PubMed | Kurnool Medical College
Type: Journal Article | Journal: Journal of clinical and diagnostic research : JCDR | Year: 2016

Diabetes is a known risk factor for asymptomatic bacteriuria (ASB). However, the influence of diabetes on antenatal ASB was previously not addressed.The prevalence of ASB, effect of risk factors and type of isolates and susceptibility patterns were studied in diabetic pregnancy.A total of 311 pregnant women were recruited for this study of which 103 were diabetic and 208 non-diabetic. A clean catch midstream urine samples were collected and cultured. The isolates were identified and antibiotic sensitivity was studied. The data was analysed by Chi-square test.The prevalence of ASB in diabetic pregnancy was 38.83% (40/10(3); 95% CI: 23.73 - 53.94) and in non-diabetic pregnancy was 37.98% (79/208; CI: 27.28- 48.68). The odds ratio was not significant 1.0225 (95% CU: 0.65 - 1.599; p=0.922) and associated factors such as age and gestational period had no effect. The major isolates were Escherichia coli (25.0%), Staphylococcus aureus (22.5%), Coagulase negative staphylococci (CONS) (20.00%), and Klebsiella pneumonia (20.00%) in diabetic pregnancy and CONS (31.7%), E.coli (24.0%) and K.pneumonia (16.5%) in non-diabetic pregnancy. The isolates of diabetic pregnancy showed highest susceptibility to nitrofurantoin (56.4%), gentamicin (38.5%) and cotrimoxazole (38.5%) whereas that of non-diabetic pregnancy to gentamicin (43.0%), azithromycin (32.9%) and norfloxacin (30.4). There was no significant (p<0.05) difference in the type and susceptibly of the isolates between diabetic and non-diabetic pregnancy.Diabetes has no significant influence on the prevalence of ASB in diabetic pregnancy both in terms of isolates and antibiotic susceptibility pattern.

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