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Ōsaka, Japan

Morisawa Y.,Kwansei Gakuin University | Ikehata A.,Japan National Agriculture and Food Research Organization | Higashi N.,Kurabo Industries Ltd. | Ozaki Y.,Kwansei Gakuin University
Journal of Physical Chemistry A | Year: 2011

Far-ultraviolet (FUV) spectra in the 8.55-6.20 eV (145-200 nm) region were measured for several kinds of ketones in the liquid phase to investigate low-n Rydberg transitions using a uniquely developed technique of attenuated total reflection (ATR) FUV spectrometry. Assignments of the transitions are attempted for absorptions in this region by comparing the spectra for the liquid phase with those for the gas phase and ab initio calculations at the equation-of-motion coupled cluster theory with single and double substitutions at the aug-cc-pVDZ level. The transition from a nonbonding electron (n) to the 3s Rydberg orbital was found at around 6.7 eV for all investigated liquid ketones. Another intense band also appeared in the higher-energy region (ca. 8.5 eV) for all the ketones. A significant shoulder was found at around 7.4 eV for branched ketones. This shoulder band near 7.4 eV was assigned to the n-3p Rydberg transition. Band broadening and higher energy shifts were observed in the spectra of the liquid phase ketones in comparison with those of the gas phase ketones. © 2011 American Chemical Society. Source


Ozaki Y.,Kwansei Gakuin University | Morisawa Y.,Kwansei Gakuin University | Ikehata A.,Japan National Agriculture and Food Research Organization | Higashi N.,Kurabo Industries Ltd.
Applied Spectroscopy | Year: 2012

Ultraviolet (UV) spectroscopy has long been used together with visible (Vis) spectroscopy to investigate electronic transitions of a molecule. Most studies of the electronic structure of molecules using UV spectroscopy have been carried out in the 190-380 nm region because commercial UV-Vis spectrometers are available only for that region. The wavelength region shorter than 190 nm is also very rich in information about the electronic states and structure of a molecule, but the absorptivity is very high in this region, and thus, this region has been employed to investigate mainly the electronic states and structure of gas molecules. Because condensed-phase materials with high molecular density do not transmit much light in the shorter wavelength region of the UV, reflection spectroscopy has been used to observe spectra of solid samples in the wavelength region shorter than 190 nm. However, for liquid samples one cannot generally use either absorption spectroscopy or specular reflection spectroscopy. Accordingly, UV spectroscopy in this region for liquid samples has been a relatively undeveloped research area. To solve the above difficulties of UV spectroscopy in the wavelength region shorter than 190 nm we have recently developed a totally new UV spectrometer based on attenuated total reflection (ATR) that enables us to measure spectra of liquid and solid samples in the 140-280 nm region.We will show that spectroscopy in the wavelength region shorter than 190 nm holds considerable promise not only in basic science but also in applications such as qualitative and quantitative analysis, on-line monitoring, environmental geochemical analysis, and surface analysis. The purpose of the present review paper is to report recent progress in UV spectroscopy of solid and liquid phases in the 140-280 nm region. In this review, we refer to the 120-200 nm region to as the far-UV (FUV) region. The term "vacuum UV region" is no longer appropriate for the 120-200 nm region because most recent spectrometers used in this region are not evacuated but instead incorporate a nitrogen purge. This review consists of eight parts: (1) introduction to FUV spectroscopy, (2) brief history of FUV spectroscopy, (3) development of new FUV spectrometers, (4) FUV studies of liquid water and aqueous solutions, (5) FUV spectra of organic molecules in the liquid states, (6) band assignments by quantum chemical calculations, (7) potential applications of FUV spectroscopy in liquid and solid states; and (8) future prospects of FUV spectroscopy. © 2012 Society for Applied Spectroscopy. Source


Naitoh H.,Shiga University of Medical Science | Yamamoto H.,Shiga University of Medical Science | Murata S.,Shiga University of Medical Science | Kobayashi H.,Kurabo Industries Ltd. | And 2 more authors.
Gastric Cancer | Year: 2014

Background: We conducted a multicenter phase II trial to assess the suitability of three types of chemotherapy (docetaxel plus S-1, irinotecan plus S-1, or S-1 alone) for patients with advanced gastric cancer by means of the collagen gel droplet embedded culture-drug sensitivity test (CD-DST). To our knowledge, this is the first multicenter clinical trial that has employed CD-DST to choose anticancer agents for the treatment of advanced gastric cancer.Methods: Subjects (n = 64) were patients with advanced or recurrent gastric cancer. Patients were allocated to one of the treatment regimens on the basis of CD-DST results. Outcome of the patients was compared between the groups deemed chemosensitive or chemoresistant by the CD-DST.Results: Thirty-three patients showed high sensitivity (T/C ratio <60 %) to at least one type of anticancer agent (sensitive group), and 31 showed low sensitivity (T/C ratio ≥60 %) to all agents (resistant group). Specifically, the 1-year survival rate was significantly higher in the sensitive group (78.5 %; 95 % CI, 67.2–94.7 %) than in the resistant group (54.7 %; 95 % CI, 38.7–74.3 %; P = 0.019), whereas time to progression (TTP) was significantly longer in the sensitive group (59.8 %; 95 % CI, 48.2–81.7 %) than in the resistant group (30.0 %; 95 % CI 13.6–46.4 %; P = 0.023). Median survival time was also significantly longer in the sensitive group (15.5 months; 95 % CI, 12.8–18.2) than in the resistant group (12.5 months; 95 % CI, 10.2–14.9; P = 0.038).Conclusions: CD-DST predicts the outcome of patients undergoing chemotherapy for advanced gastric cancer, presumably through evaluating chemosensitivity. © 2013, The Author(s). Source


Horimoto W.,Kurabo Industries Ltd. | Miyazato S.,Kanazawa Institute of Technology
Zairyo/Journal of the Society of Materials Science, Japan | Year: 2013

The multiaxial fiber sheet is one of the continuous fiber sheets, and it has features to arrange the continuous fiber in parallel with angling variously. The purpose of this study is to clear the mechanical properties of the multiaxial carbon fiber sheet. Secondly, as the basic study on reinforcement for concrete member with this sheet, compressive test using cylinder specimen are performed. As a result, 1) the mechanical properties of this sheet can be controlled by designed of knitting conditions, 2) the compressive strengthening is evaluated from the mechanical properties of the sheet. Source


Goto T.,Japan National Agriculture and Food Research Organization | Ikehata A.,Japan National Agriculture and Food Research Organization | Morisawa Y.,Kwansei Gakuin University | Higashi N.,Kurabo Industries Ltd. | Ozaki Y.,Kwansei Gakuin University
Physical Chemistry Chemical Physics | Year: 2012

The first electronic transition (à ← X) of liquid water was studied from the perspective of the hydration of cations by analyzing the attenuated total reflection far-ultraviolet (ATR-FUV) spectra of the Group I, II, and XIII metal nitrate electrolyte solutions. The à ← X transition energies of 1 M electrolyte solutions are higher (Li +: 8.024 eV and Cs +: 8.013 eV) than that of pure water (8.010 eV) and linearly correlate with the Gibbs energies of hydration of the cations. The increases in the à ← X transition energies are mostly attributable to the hydrogen bond formation energies of water molecules in the ground state induced by the presence of the cations. The deviation from the linear relation was observed for the high charge density cations, H +, Li +, and Be 2+, which reflects that the electronic energies in the excited states are also perturbed. Quantum chemical calculations show that the à ← X transition energies of the water-cation complexes depend on the hydration structures of the cations. The calculated à ← X transition energies of the water molecules hydrating high charge density cations spread more widely than those of the low charge density cations. The calculated transition energy spreads of the water-cation complexes directly correlate with the widths of the à ← X transition bands measured by ATR-FUV spectroscopy. © 2012 the Owner Societies. Source

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