Dong X.-H.,Hospital Kunming Medical College
Journal of Clinical Rehabilitative Tissue Engineering Research | Year: 2010
BACKGROUND: Vascular endothelial progenitor cells can accumulate the vascularization in ischemic region. OBJECTIVE: To analyze how to accelerate tissue engineered skin vascularization by endothelial progenitor cells. METHODS: A computer-based online search was conducted in China Academic Journals Database and PubMed with the key words of "endothelial progenitor cell (EPC), tissue engineered skin, vascularization" in both English and Chinese from September 1999 to September 2009. Inclusion criteria: Articles were highly correlated with endothelial progenitor cells and tissue engineered skin development, including biological characteristics, stimulating methods, and mechanism of promoting vascular production of endothelial progenitor cells; current situation of tissue engineered skin; current situation of endothelial progenitor cells for tissue engineered skin construction. RESULTS AND CONCLUSION: The endothelial progenitor cells belonged to a crowd of cells which specifically homed on vascular cambium, as well as differentiated and proliferated into mature endothelial cells. Nowadays, a lot of animal tests proved that it could accelerate the vascularization in ischemic region by transplanting the in vitro cultured endothelial progenitor cells into the ischemic region. The clinical application would be true when auto-endothelial progenitor cells have been successfully used to treat myocardial infarction. However, the tissue engineered skin was in defect of vessel, which seriously influenced the cell survival of human skin and the functional achievement. Therefore, how to construct artificial skin which was rich in vessels and how to accelerate the human skin substitution vascularization have attracted more attention. It is of significance for endothelial progenitor cells to promote tissue engineered skin vascularization so as to increase the survival rate.