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Liu Q.G.,Kunming General Hospital of Chengdu Military Command
Zhonghua wai ke za zhi [Chinese journal of surgery]

To evaluate the safety, effectiveness, and outcomes of holmium laser enucleation of the prostate (HoLEP) for patients with symptomatic enlarged prostate after 11 years of experience. The 3162 evaluable patients treated with holmium laser enucleation of the prostate at our institution between August 2001 and August 2011 were retrospectively analyzed. Study variables included International Prostate Symptom Score, quality of life, maximum urinary flow rate, and incidence of complications. HoLEP were performed successfully completed, not patients which occurs as electric cutting syndrome. The operation time was (60.8 ± 18.4) minutes; average resection of prostate quality was (45.4 ± 24.4) g. The hemoglobin reduce though surgery was (1.81 ± 0.93) g/L; percentage of red blood cell change was 1.24% ± 0.43%, and sodium blood drop was (1.14 ± 0.35) mmol/L. Postoperative patients of hospital stay (3.1 ± 1.1) days, average time of indwelling catheter time was (2.3 ± 0.8) days. Patients were followed up for 6-131 months time, an average of 32.4 months. Postoperative patients with international prostate symptom score progressive declined. The quality of life score was 2.2 ± 1.7, and it less than preoperative (5.7 ± 3.3, t = 2.447, P < 0.01). The time of follow-up droped further, and postoperative comparative differences have statistical significance (t = 2.179, 2.228, 2.306 and 2.365, P < 0.05). The maximum urinary flow rate also improved (P < 0.05). Postoperative complications included bladder neck contracture (4 cases), urinary tract infection (107 cases), urethral stricture (11 cases) and urinary incontinence (11 cases). The 11 patients reoperation. HoLEP treatment of benign prostatic hyperplasia could achieve the advantages of open surgery the same effect. It had fewer damage, faster recovery, fewer complications, and is a good treatment option. Source

Chen J.,Shanghai University | Yang C.,Shanghai University | Ran B.,Shanghai University | Wang Y.,Kunming General Hospital of Chengdu Military Command | And 4 more authors.

Study Design.: A single-center, retrospective study of 39 consecutive patients with Lenke 5 adolescent idiopathic scoliosis (AIS), all operated by a single surgeon using identical surgical technique and type of instrumentation (pedicle screws). Objective.: The objective of this study is to evaluate the effect of implant density on coronal and sagittal correction in the treatment of Lenke 5 AIS. Summary of Background Data.: There is an increasing trend in the use of pedicle screws in spinal corrective surgery. It is reported that decreased numbers of pedicle screws (low screw density) have no effects on the clinical outcomes for patients with Lenke 1 AIS. However, no previous studies have investigated the effects of reduced density of screw implantation on coronal correction and sagittal lumbar lordosis in patients with Lenke 5 AIS. Methods.: Thirty-nine consecutive patients with Lenke 5 AIS underwent single-stage posterior correction and instrumented spinal fusion with pedicle screw fixation between 2006 and 2010. The radiographs were analyzed before surgery, immediately after surgery, and at the 2-year follow-up. General information of patients was recorded. Pearson correlation analysis was used to analyze the correlation between implant density, coronal Cobb angle correction, and correction index (postoperative correction/preoperative curve flexibility). The relations between implant density and magnitude of coronal and sagittal curve correction were also investigated. Results.: The mean patient age at the time of operation was 14.5 years. The mean preoperative lumbar curve of 48.5 ± 9.2 was corrected to 13.7 ± 7.2 (72% correction) at a 2-year follow-up. There was a significant correlation between implant density and curve correction (r = 0.43, P < 0.05). No correlation was detected between implant density and correction index (r =-0.21, P = 0.20), and there was also no correlation between implant density and magnitude of sagittal curve correction (r = 0.065, P = 0.693). Conclusion.: Without curve flexibility taken into consideration, implant density is positively correlated with thoracolumbar or lumbar coronal Cobb curve correction. No significant correlation is found between screw density and correction index, if the effect of the flexibility was eliminated. There was no association between implant density and magnitude of sagittal curve correction before and after surgery. Copyright © 2013 Lippincott Williams & Wilkins. Source

ABSTRACT: Severe motorcycle spoke injuries of the heel lead to Achilles tendon defects, calcaneal tubercle exposure or loss, and overlying soft tissue defects, which are challenging to treat. Given the special physiological and developmental characteristics of children, severe spoke injuries of the heel in children are especially troublesome.We report details of 31 cases of severe motorcycle spoke injuries of the heel in children. The reconstruction timing depended on the time since injury, systematic conditions, and concurrent injuries. Eighteen cases were reconstructed at the time of emergency surgery, and 13 cases underwent delayed reconstruction. Appropriate flap transfer and Achilles tendon repair were conducted based on the defect size of the Achilles tendon, the main location of the soft tissue defect, and the distal residues of the Achilles tendon.Of the 31 cases, 16 cases were reconstructed with sliding gastrocnemius musculocutaneous flaps, 7 cases had saphenous neurocutaneous flaps, 4 cases had posterior tibial perforator flaps, 3 cases had sural neurocutaneous flaps, and 1 case was repaired with a peroneal artery perforator flap. All flaps healed uneventfully except for 3 cases of flap partial necrosis and 1 case of local infection of the Achilles tendon. During 6 months to 4 years of follow-up, dorsiflexion of the ankle was obviously limited at first but gradually recovered and enabled normal walking. However, due to the possibilities of calcaneal defects, epiphyseal injuries, and Achilles tendon problems, long-term follow-up is indicated. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. Source

Guo L.,Chongqing Medical University | Li S.-Y.,Kunming General Hospital of Chengdu Military Command | Ji F.-Y.,Chongqing Medical University | Zhao Y.-F.,Pudong New Area Gongli Hospital | And 4 more authors.
Inflammation Research

Background: Angptl4 is a secreted protein involved in the regulation of vascular permeability, angiogenesis, and inflammatory responses in different kinds of tissues. Increases of vascular permeability and abnormality changes in angiogenesis contribute to the pathogenesis of tumor metastasis, ischemic-reperfusion injury. Inflammatory response associated with Angptl4 also leads to minimal change glomerulonephritis, wound healing. However, the role of Angptl4 in vascular permeability, angiogenesis, and inflammation is controversy. Hence, an underlying mechanism of Angptl4 in different kind of tissues needs to be further clarified. Methods: Keywords such as angptl4, vascular permeability, angiogenesis, inflammation, and endothelial cells were used in search tool of PUBMED, and then the literatures associated with Angptl4 were founded and read. Results: Data have established Angptl4 as the key modulator of both vascular permeability and angiogenesis; furthermore, it may also be related to the progression of metastatic tumors, cardiovascular events, and inflammatory diseases. This view focuses on the recent advances in our understanding of the role of Angptl4 in vascular permeability, angiogenesis, inflammatory signaling and the link between Angptl4 and multiple diseases such as cancer, cardiovascular diseases, diabetic retinopathy, and kidney diseases. Conclusions: Taken together, Angptl4 modulates vascular permeability, angiogenesis, inflammatory signaling, and associated diseases. The use of Angptl4-modulating agents such as certain drugs, food constituents (such as fatty acids), nuclear factor (such as PPARα), and bacteria may treat associated diseases such as tumor metastasis, ischemic-reperfusion injury, inflammation, and chronic low-grade inflammation. However, the diverse physiological functions of Angptl4 in different tissues can lead to potentially deleterious side effects when used as a therapeutic target. In this regard, a better understanding of the underlying mechanisms for Angptl4 in different tissues is necessary. © 2013 Springer Basel. Source

Dou K.,Kunming General Hospital of Chengdu Military Command | Xu Q.,Tianjin Medical University | Han X.,The First Peoples Hospital of Kunming City
Diagnostic Pathology

Background: Numerous epidemiological studies have been conducted to explore the association between the Lys939Gln polymorphism of Xeroderma pigmentosum group C (XPC) gene and urinary bladder cancer susceptibility. However, the results remain inconclusive. In order to derive a more precise estimation of this relationship, a large and update meta-analysis was performed in this study.Methods: A comprehensive search was conducted through researching MEDLINE, EMBASE, PubMed, Web of Science, China Biomedical Literature database (CBM) and China National Knowledge Infrastructure (CNKI) databases before June 2013. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to estimate the strength of the association.Results: A total of 12 studies with 4828 cases and 4890 controls for evaluating the XPC Lys939Gln polymorphism and urinary bladder cancer were included. Overall, there was significant associations between the XPC Lys939Gln polymorphism and urinary bladder cancer risk were found for homozygous model (OR = 1.352, 95% CL = 1.088-1.681), heterozygous model (OR = 1.354, 95% CL = 1.085-1.688), and allele comparison (OR = 1.109, 95% CL = 1.013-1.214). In subgroup analysis by ethnicity and source of controls, there were still significant associations detected in some genetic models.Conclusion: Our meta-analysis suggested that the XPC Lys939Gln polymorphism contributed to the risk of urinary bladder cancer.Virtual slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1001118393101798. © 2013 Dou et al.; licensee BioMed Central Ltd. Source

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