Kumamoto, Japan
Kumamoto, Japan

Kumamoto University , abbreviated to Kumadai , is a Japanese public university located in Kumamoto, Kumamoto prefecture in the Kyushu region of Japan. It was established on May 31, 1949, at which time the following institutions were subsumed into it; Kumamoto Teachers College , Kumamoto Pharmaceutical College , the Fifth High School , Kumamoto Medical College , and Kumamoto Technical College . Currently, the university has seven faculties and eight graduate schools with a total of around 10,000 Japanese students and 400 international students from Asia, North America, South America, Europe, Africa, and Oceania. Wikipedia.

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Patent
Kumamoto University and Nihon Shokuhin Kako Co. | Date: 2014-12-03

Provided is a pharmaceutical composition for the treatment of disorders such as Niemann-Pick disease and GM1 gangliosidosis which are caused by the storage of cholesterol, such as lysosomal storage disease. Also provided is a method for screening for said pharmaceutical compositions that uses iPS cell strains that phenocopy phentotypes of these disorders. Provided is a pharmaceutical composition for the treatment and/or prevention of lysosomal storage disease, characterized by containing hydroxypropyl--cyclodextrin as an active ingredient. Also provided are an iPS cell strain derived from patients suffering from intractable disorders and prepared using a new temperature-sensitive Sendai virus vector, and a screening method for pharmaceuticals using said iPS cell strain.


Patent
Thee Dyne Co. and Kumamoto University | Date: 2015-09-10

Provided is a needle removal operation cover with which a user can safely perform an injection needle removal operation even when a needle tip is directly inserted into the needle removal operation cover, and with which the user can remove the injection needle without requiring a wrist twisting motion. In a needle removal operation cover which is configured such that an injection needle which is detachably and threadedly mounted on a distal end of an injection cylinder is threadedly removed by rotating the injection needle, the needle removal operation cover is formed in a cylindrical shape such that a needle tube of the injection needle including a needle tip is accommodated in the needle removal operation cover and integral mounting of a needle hub in the needle removal operation cover is allowed, a flange body for a rotating operation is formed on a cylindrical outer peripheral surface in a projecting manner, an outer periphery of the flange body is formed of a plurality of continuous mountain-like ridge portions, and among the mountain-like ridge portions, the mountain-like ridge portions which correspond to a rotational direction along which the injection needle is released from the injection cylinder are formed into a shape which allows easy engagement of a finger for an operation with the ridge portions.


The purpose of the present invention is to provide pluripotent cells that are highly safe in applications for regenerative medicine, and a method for producing the same. Another purpose of the present invention is in particular to provide pluripotent cells that pose fewer problems with respect to malignant transformation of cells and that arouse less concern about safety regarding the presence of bacteria inside cells, and a method for producing the same. The present invention provides a method for producing pluripotent cells from somatic cells. This method includes a step for inducing reprogramming of cells by bringing a ribosome fraction of biological origin into contact with somatic cells. The present invention also provides a composition for inducing cell reprogramming, the composition including a ribosome fraction of biological origin.


Patent
Mitsui Mining, Smelting Co. and Kumamoto University | Date: 2017-03-08

The invention relates to a catalyst carrier for exhaust gas purification catalyst which contains a metal phosphate containing Zr, and it provides a new catalyst carrier which exhibits excellent NOx purification performance in a high temperature region. The invention proposes a carrier for exhaust gas purification catalyst containing a metal phosphate which has a NASICON type structure and contains Zr.


Patent
Transgenic Inc., Kumamoto University and Gunma University | Date: 2014-07-31

The present invention provides a method for detection of an inflammatory reaction, which comprises using a transformant or transgenic non-human animal transfected with a vector comprising a promoter for a gene encoding an inflammatory cytokine, a gene encoding a reporter protein, a gene encoding the inflammatory cytokine, and a gene encoding a proteolytic signal sequence to thereby detect an inflammatory reaction induced upon inflammatory stimulation in the transformant or in the transgenic non-human animal.


Patent
Transgenic Inc., Kumamoto University and Gunma University | Date: 2017-07-26

The present invention provides a method for detection of an inflammatory reaction, which comprises using a transformant or transgenic non-human animal transfected with a vector comprising a promoter for a gene encoding an inflammatory cytokine, a gene encoding a reporter protein, a gene encoding the inflammatory cytokine, and a gene encoding a proteolytic signal sequence to thereby detect an inflammatory reaction induced upon inflammatory stimulation in the transformant or in the transgenic non-human animal.


Provided are a method for preparing a mammalian ovum or embryo in which zona pellucida has been thinned or eliminated, and a method for fertilization using the mammalian ovum prepared by the aforementioned method. The resulting mammalian ovum or embryo is capable of realizing an improved fertilization rate and development rate when used for in vitro fertilization, transplantation of a fertilized ovum, or for preparation of an embryo in the early stages of development used in the production of a genetically modified animal.


Patent
Alnylam Pharmaceuticals and Kumamoto University | Date: 2016-07-06

The invention relates to a method of treating ocular amyloidosis by reducing TTR expression in a subject by administering a double-stranded ribonucleic acid (dsRNA) that targets a TTR gene to the retinal pigment epithelium of the subject.


Patent
Sekisui Chemical Co. and Kumamoto University | Date: 2017-10-11

There is provided a thermally conductive sheet having excellent thermal conductivity in the thickness direction of the sheet. A thermally conductive sheet comprising expanded graphite; and orientation-controlling particles, wherein at least part of the expanded graphite is oriented in a direction different from a plane direction of the sheet by the orientation-controlling particles.


Indo Y.,Kumamoto University
European Journal of Neuroscience | Year: 2014

Although nerve growth factor (NGF) is a well-known neurotrophic factor, it also acts as a mediator of pain, itch and inflammation. Congenital insensitivity to pain with anhidrosis (CIPA) is an autosomal recessive genetic disorder caused by loss-of-function mutations in NTRK1, the gene encoding a receptor tyrosine kinase for NGF, TrkA. Mutations in NTRK1 cause the selective loss of NGF-dependent neurons in otherwise intact systems. NGF-dependent primary afferents are thinly myelinated Aδ or unmyelinated C-fibers that are dependent on the NGF-TrkA system during development. In CIPA, the lack of pain and the presence of anhidrosis (inability to sweat) are due to the absence of both NGF-dependent primary afferents and sympathetic postganglionic neurons, respectively. These peripheral neurons form an interface between the nervous system and the 'body-proper' and play essential roles in the interoception and sympathetic regulation of various tissues or organs. Patients with CIPA also show mental retardation and characteristic behaviors and are probably neuron-deficient within the brain. However, the functions of NGF-dependent neurons in the brain are controversial, both in animal and in human studies. This review focuses on various brain regions that express TrkA mRNA, based on data from the Allen Human Brain Atlas, and discusses putative neuronal networks related to these brain regions in humans. A better understanding the distribution of NGF-dependent neurons in the brain will provide a framework for further studies to investigate pain, interoception and emotional responses. Furthermore, strategies targeting the molecular mechanisms through which the NGF-TrkA system functions may provide hope for the development of novel analgesics. © 2014 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.

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