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Kumamoto-shi, Japan

Tazume H.,Kumamoto University | Miyata K.,Kumamoto University | Tian Z.,Kumamoto University | Endo M.,Kumamoto University | And 19 more authors.
Arteriosclerosis, Thrombosis, and Vascular Biology | Year: 2012

Objective-Recently, we reported that angiopoietin-like protein 2 (Angptl2) functions in various chronic inflammatory diseases. In the present study, we asked whether Angptl2 and its associated chronic inflammation contribute to abdominal aortic aneurysm (AAA). Methods and Results-Immunohistochemistry revealed that Angptl2 is abundantly expressed in infiltrating macrophages within the vessel wall of patients with AAA and in a CaCl2-induced AAA mouse model. When Angptl2-deficient mice were used in the mouse model, they showed decreased AAA development compared with wild-type mice, as evidenced by reduction in aneurysmal size, less severe destruction of vessel structure, and lower expression of proinflammatory cytokines and matrix metalloproteinase-9. However, no difference in the number of infiltrating macrophages within the aortic aneurysmal vessel wall was observed between genotypes. AAA development was also significantly suppressed in wild-type mice that underwent Angptl2-deficient bone marrow transplantation. Expression levels of proinflammatory cytokines and metalloproteinase-9 in Angptl2-deficient macrophages were significantly decreased, and those decreases were rescued by treatment of Angptl2 deficient macrophages with exogenous Angptl2. Conclusion-Macrophage-derived Angptl2 contributes to AAA development by inducing inflammation and degradation of extracellular matrix in the vessel wall, suggesting that targeting the Angptl2-induced inflammatory axis in macrophages could represent a new strategy for AAA therapy. © 2012 American Heart Association, Inc. Source


Inaba T.,Kumamoto Rosai Hospital
Otolaryngology - Head and Neck Surgery (Tokyo) | Year: 2010

A 91-year-old woman with adenoid cystic carcinoma of the base of the tongue was reported. She presented with a large painless mass in the throat, and computed tomography revealed a well-defined tabulated tumor measuring 48 mm in diameter arising from the base of the tongue. The tumor was successfully resected via transoral approach using an ultrasonic scalpel. Because the tumor invasion of the surrounding tissue was limited, the surgical defect was relatively small and no reconstructive procedure was performed. The tumor was histopathologically diagnosed as adenoid cystic carcinoma of the minor salivary gland. Her postoperative clinical course was uneventful. No aspiration or difficulty upon deglutition was recognized when she started transoral ingestion on the fourth postoperative day. The patient was currently free from disease 14 months after surgery. Source


Kadokawa Y.,Kumamoto Rosai Hospital
Otolaryngology - Head and Neck Surgery (Tokyo) | Year: 2010

We report two cases of mucosa-associated lymphoid tissue (MALT) lymphoma of the head and neck. The first case was a 21-year-old woman with Sjögren's syndrome who developed left-sided parotid MALT lymphoma. She underwent resection of the tumor with preservation of the facial nerve followed by 3 courses of chemotherapy consisting of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone. The second case was a 48-year-old man with epipharyngeal MALT lymphoma. He underwent resection of the tumor followed by 4 courses of rituximab administration and radiotherapy of 30 Gy. Complete remission was achieved in both patients, and no evidence of recurrence was observed in 20- and 12-month follow-up periods, respectively. The clinical characteristics, pathology and treatment of MALT lymphoma of the head and neck were bibliographically reviewed. Source


Hashimoto M.,Kumamoto Rosai Hospital | Sakaguchi H.,Red Cross | Sadanaga M.,Red Cross
Japanese Journal of Anesthesiology | Year: 2015

A 19-year-old male patient with transplanted heart received endoscopic sinus surgery. He was with X-linked dilated cardiomyopathy, and was one year after the transplantation. Preanesthetic study showed lactate dehydrogenase elevation estimated to have derived from striated muscle. Heart function was normal, and other abnormal findings were not revealed. Total intravenous anesthesia was performed with propofol target controlled infusion and remifentanil. Rocuronium was administered only for oro-tracheal intubation. After the operation, train-of-four ratio was 95%, and he awoke from anesthesia smoothly. We did not use atropine, neostigmine or sugammadex to reverse neuromuscular blockade. No inotropic agent was administered. He was discharged from the hospital 5 days after the operation without any complications. We used usual anesthetic management but we had to be careful about both denervated heart and myopathy. Source


Nakajima M.,Kumamoto Rosai Hospital | Hirano T.,Kumamoto University | Terasaki T.,Red Cross | Uchino M.,Kumamoto University
Internal Medicine | Year: 2010

Diffusion-weighted imaging can depict secondary signal changes of the substantia nigra in patients with ipsilateral striatal infarction. We report four patients who demonstrated obvious signal changes of the substantia nigra in the subacute phase of stroke. Embolic stroke was diagnosed in all of the cases, and none of the patients presented clinical deterioration in their course. Embolic mechanism might be more closely related to the secondary change of the substantia nigra than thrombosis. The relationship between secondary nigral degeneration and stroke etiology or between the nigral lesions and recanalization of the middle cerebral artery remains unclear. © 2010 The Japanese Society of Internal Medicine. Source

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