Wu B.,Chinese Academy of Fishery Sciences |
Xia S.,Tianjin Fisheries Research Institute |
Rahman M.M.,International Islamic University Malaysia |
Rajkumar M.,Kulliyyah of Science |
And 3 more authors.
Aquaculture | Year: 2015
A 60-day experiment was conducted to develop a practical diet for sea cucumber (Apostichopus japonicus) substituting seaweed with corn leaf. Five experimental diets were constructed with each containing a 70% sea mud. The other 30% is composed of (A) 30% Sargassum thunbergii (seaweed) only, (B) 22.5% seaweed and 7.5% corn (Zea mays) leaves, (C) 15% seaweed and 15% corn leaves, (D) 7.5% seaweed and 22.5% corn leaves and (E) 30% corn leaves only. The experiment was conducted in 15 plastic aquaria containing seawater, each of which stocked with 20 sea cucumbers. Three replicate groups of sea cucumber were fed one of the five experimental diets. The results revealed that the apparent digestibility coefficients for dry matter (ADMD) and crude protein (ACPD) of the test diets decreased with increasing corn leaf content in diets. Corn leaf content in the sea cucumber diet did not affect the body composition of sea cucumber. 22.5% seaweed can be replaced with powdered corn leaf in the sea cucumber diet without any negative effects on weight gain and specific growth rate (SGR) of sea cucumber. Diet containing higher than 15% corn leaf significantly increased the feed conversion ratio (FCR) of sea cucumber. However, the growth performance and FCR of sea cucumber fed the mixed diet of 15% corn leaf plus 15% seaweed were better than the growth performance and FCR of sea cucumber fed other experimental diets. The regression analysis of dietary corn leaf inclusion level versus SGR revealed that the optimal corn leaf inclusion level was 11.2% for the best growth rate of sea cucumber. Therefore, under the present experimental design and condition, a diet with 70% sea mud plus 18.8% seaweed plus 11.2% corn leaf can be recommended for the best growth performance of sea cucumber. The findings of this study will encourage feed manufacturers and sea cucumber culturists to utilize corn leaf in producing low-cost aqua-feed. © 2015 Elsevier B.V.
Abdullaev F.K.,Kulliyyah of Science |
Brazhnyi V.A.,University of Porto |
Salerno M.,University of Salerno
Nonlinear Photonics, NP 2014 | Year: 2014
The resonant scattering of gap solitons of the periodic NLS equation with a PT-symmetric defect is investigated. For suitable parameters of the defect potential the resonant transmission of soliton through the defect becomes possible. © 2014 OSA.
Norlelawati A.T.,International Islamic University Malaysia |
Rusmawati I.,Hospital Tengku Ampuan Afzan Hospital |
Nur Nadia O.,International Islamic University Malaysia |
Naznin M.,International Islamic University Malaysia |
And 2 more authors.
Medical Journal of Malaysia | Year: 2014
Objective: Inherited anti-thrombin deficiency is an autosomal dominant disorder which is associated with increased risk for venous thromboembolism (VTE). This condition is very rare in Malaysia and there has been no documented report. Thus, the aim of the present study is to investigate the type of an inherited anti-thrombin deficiency mutation in a 25-year-old Malay woman who presented with deep vein thrombosis in her first pregnancy. Methods: DNA was extracted from the patient's blood sample and buccal mucosal swabs from family members. Polymerase chain reaction(PCR) assays were designed to cover all seven exons of the serpin peptidase inhibitor, clade C (antithrombin), member 1 (SERPINC1) gene; and the products were subjected to DNA sequencing. Sequences were referred to NCBI Reference Sequence: NG_012462.1. Results: A heterozygous substitution mutation at nucleotide position 13267 (CCT->ACT) was identified in the patient and two other family members, giving a possible change of codon 439 (Pro→Thr) also known as anti-thrombin Budapest 5. The genotype was absent in 90 healthy controls. Conclusion: The study revealed a heterozygous antithrombin Budapest 5 mutation in SERPINC 1 giving rise to a possible anti-thrombin deficiency in a Malay-Malaysian family.
Faudzi F.,Kulliyyah of Science |
Kamaruzzamanyunus,Kulliyyah of Science |
Kamaruzzamanyunus,Institute of Oceanography and Maritime Studies INOCEM |
Miskon M.,Kulliyyah of Science |
Rahman M.,International Islamic University Malaysia
Oriental Journal of Chemistry | Year: 2014
The concentrations of toxic metals were determined in estuary and freshwater zones from Kuantan River basin. Water samples were collected from the surface and bottom layers of nine sampling stations, from the downstream of the estuary towards the upstream along the mainstream drainage channel, traversing past the city center and industries of Kuantan city. The general physico-chemical parameters (salinity, temperature, pH and dissolved oxygen) and concentration of total dissolved metals, Cadmium (Cd), Chromium (Cr) and Lead (Pb)were measured during dry season (May and June 2012) and wet season (September and October 2012). Metal concentration was determined using Inductively Coupled Plasma Mass Spectrometry (ICP-MS).Metal concentrations ranged from 0.299 - 1.815μg/Lfor Cr, undetectable to 0.034μg/L for Cd and 4.697 - 16.017μg/L for Pb, respectively. The present measurements can be used as a baseline data for any future monitoring and comparison of trace metals distribution in the Kuantan River.
Norlelawati A.T.,International Islamic University Malaysia |
Mohd Danial G.,Kulliyyah of Science |
Nora H.,Hospital Tengku Ampuan Afzan Hospital |
Nadia O.,International Islamic University Malaysia |
And 3 more authors.
Malaysian Journal of Pathology | Year: 2016
Background: Synovial sarcoma (SS) is a rare cancer and accounts for 5-10% of adult soft tissue sarcomas. Making an accurate diagnosis is difficult due to the overlapping histological features of SS with other types of sarcomas and the non-specific immunohistochemistry profile findings. Molecular testing is thus considered necessary to confirm the diagnosis since more than 90% of SS cases carry the transcript of t(X;18)(p11.2;q11.2). The purpose of this study is to diagnose SS at molecular level by testing for t(X;18) fusion-transcript expression through One-step reverse transcriptase real-time Polymerase Chain Reaction (PCR). Method: Formalin-fixed paraffin-embedded tissue blocks of 23 cases of soft tissue sarcomas, which included 5 and 8 cases reported as SS as the primary diagnosis and differential diagnosis respectively, were retrieved from the Department of Pathology, Tengku Ampuan Afzan Hospital, Kuantan, Pahang. RNA was purified from the tissue block sections and then subjected to One-step reverse transcriptase real-time PCR using sequence specific hydrolysis probes for simultaneous detection of either SYT-SSX1 or SYT-SSX2 fusion transcript. Results: Of the 23 cases, 4 cases were found to be positive for SYT-SSX fusion transcript in which 2 were diagnosed as SS whereas in the 2 other cases, SS was the differential diagnosis. Three cases were excluded due to failure of both amplification assays SYT-SSX and control β-2-microglobulin. The remaining 16 cases were negative for the fusion transcript. Conclusion: This study has shown that the application of One-Step reverse transcriptase real time PCR for the detection SYT-SSX transcript is feasible as an aid in confirming the diagnosis of synovial sarcoma. © 2006, Malaysian Society of Pathologists. All rights reserved.
Zaleha K.,University of Malaysia, Terengganu |
Ibrahim B.,University of Malaysia, Terengganu |
Akbar John B.,Kulliyyah of Science |
Kamaruzzaman B.Y.,Kulliyyah of Science |
Kamaruzzaman B.Y.,International Islamic University Malaysia
Journal of Biological Sciences | Year: 2012
Recent investigations on harpacticoid copepods have demonstrated their higher nutritional values compared to Artemia and rotifer. Nevertheless, studies on the potential use of tropical harpacticoid copepods as live feed in aquaculture are still limited. The present study was carried out to compare the generation time between selected harpacticoid species cultured in laboratory condition as an early step to choose a potential live feed for aquaculture practices. Some estuarine species of harpacticoids were isolated from Merchang river mouth, an estuary of the South China Sea in Terengganu and undergone trial culture procedure. Three species (Paradactylopodia oculata, Schizopera knabeni and Robertsonia knoxi) were successfully adapted to the laboratory condition thus their generation time were recorded. Copepod samples were cultured under controlled laboratory condition at temperature 25±1°C and salinity 27±1 ppt for 40 days and fed with 0.1 mL of baker's yeast (0.02 g/L/day). The mean generation time (day) was different for each species where P. oculata showed the long generation time (17.19±4.74 days) followed by S. knabeni (10.19±3.51 days) andR. knoxi (8.93±1.00 days). The species with short generation times could be a better choice for fish larval rearing and hatchery activity due to the early time of nauplii production and hence we suggest the R. knoxi could be used as a potential live feed (on the basis of their generation time) in aquaculture practices. © 2012 Asian Network for Scientific Information.
Messikh A.,Kulliyah of Information and Communication Technology |
Umarov B.,Kulliyyah of Science
Journal of Physics: Conference Series | Year: 2013
We use homoclinic orbits to find solutions of a dynamical system of the dipolar Bose Einstein Condensate (BEC) in a deep optical lattice. The equation of motion is transformed to a two-dimensional map and its homoclinic orbits are computed numerically. Each homoclinic orbit leads to a different solution. These different solutions lead to different types of solitons. We also analyse the stability of the solutions. © Published under licence by IOP Publishing Ltd.
Ahmed F.,Indian Institute of Crop Processing Technology |
Ghalib R.,Kulliyyah of Science |
Sasikala P.,Indian Institute of Crop Processing Technology |
Mueen Ahmed K.,King Faisal University
Pharmacognosy Reviews | Year: 2013
Alzheimer′s disease (AD) is a progressive neurodegenerative disease, wherein a progressive loss of cholinergic synapses occurs in hippocampus and neocortex. Decreased concentration of The neurotransmitter, acetylcholine (ACh), appears To be critical element in The development of dementia, and The most appropriate Therapeutic approach To Treat AD and other form of dementia is To restore acetylcholine levels by inhibiting both major form of cholinesterase: Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Consequently, researches have focused Their attention Towards finding cholinesterase inhibitors from natural products. A large number of such inhibitors have been isolated from medicinal plants. This review presents a comprehensive account of The advances in field of cholinesterase inhibitor phytoconstituents. The structures of some important phytoconstituents (collected Through www.Chemspider.com) are also presented and The scope for future research is discussed.
PubMed | Indian Institute of Crop Processing Technology, Kulliyyah of Science and King Faisal University
Type: Journal Article | Journal: Pharmacognosy reviews | Year: 2013
Alzheimers disease (AD) is a progressive neurodegenerative disease, wherein a progressive loss of cholinergic synapses occurs in hippocampus and neocortex. Decreased concentration of the neurotransmitter, acetylcholine (ACh), appears to be critical element in the development of dementia, and the most appropriate therapeutic approach to treat AD and other form of dementia is to restore acetylcholine levels by inhibiting both major form of cholinesterase: Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Consequently, researches have focused their attention towards finding cholinesterase inhibitors from natural products. A large number of such inhibitors have been isolated from medicinal plants. This review presents a comprehensive account of the advances in field of cholinesterase inhibitor phytoconstituents. The structures of some important phytoconstituents (collected through www.Chemspider.com) are also presented and the scope for future research is discussed.
PubMed | Kulliyyah of Science
Type: Journal Article | Journal: Journal of basic microbiology | Year: 2015
The non-stereospecific -haloalkanoic acid dehalogenase DehE from Rhizobium sp. RC1 catalyzes the removal of the halide from -haloalkanoic acid D,L-stereoisomers and, by doing so, converts them into hydroxyalkanoic acid L,D-stereoisomers, respectively. DehE has been extensively studied to determine its potential to act as a bioremediation agent, but its structure/function relationship has not been characterized. For this study, we explored the functional relevance of several putative active-site amino acids by site-specific mutagenesis. Ten active-site residues were mutated individually, and the dehalogenase activity of each of the 10 resulting mutants in soluble cell lysates against D- and L-2-chloropropionic acid was assessed. Interestingly, the mutants W34A,F37A, and S188A had diminished activity, suggesting that these residues are functionally relevant. Notably, the D189N mutant had no activity, which strongly implies that it is a catalytically important residue. Given our data, we propose a dehalogenation mechanism for DehE, which is the same as that suggested for other non-stereospecific -haloalkanoic acid dehalogenases. To the best of our knowledge, this is the first report detailing a functional aspect for DehE, and our results could help pave the way for the bioengineering of haloalkanoic acid dehalogenases with improved catalytic properties.