Ahmed Kaid N.A.,International Islamic University Malaysia |
Norbaiyah M.B.,International Islamic University Malaysia |
Imad M.A.,International Islamic University Malaysia |
Norazian M.H.,Kulliyyah of Pharmacy
International Medical Journal Malaysia | Year: 2016
Introduction: This study aims to build a standardization method for preparation of effective powder from FSA and to quantify diosgenin in FSA. Methodology: One kg of FS were used in this study. Setting: BMS, KOM and KOP, IIUM Kuantan campus. FS were washed with distilled water to exclude any foreign matter, and were then air dried. FS-powder were put in distilled water in a ratio of 1 g of powder in 20 ml of distilled water and were shaken at room temperature for 24 hours. Ten mg of hydrolyzed extract sample was diluted in 10 ml volumetric flask with methanol for 15 minutes. Chromatographic estimation was performed using an equilibrated reverse phase Eclipse XDB-C18 column (particle size 5 μg, 4.6 mm x 150 mm). Results: One gram of FSA extract was hydrolyzed to produce sapogenins and 46.6% was recovered. A calibration curve that was constructed based on five dilutions of diosgenin standard at concentrations of 2, 5, 10, 20, 30 and 50 ppm produced a linear graft (r = 0.999). The concentration of diosgenin in FSA extract as calculated using the regression analysis was found to be 29.66 μg/ml, 13.81 % w/w on dried weight basis. Conclusion: Preparation and standardization of effective powder from FSA are the corner stone of many scientific researches in IIUM and Malaysia. Diosgenin is available in the FSA in adequate concentration. The adequate amount of diosgenin in the FSA will guide us to do further study in the way of preparation of a natural product that can be used in the field of reversible anti-fertility therapy.
Aefan Q.,Kulliyyah of Pharmacy |
Ibrahim M.I.M.,Kulliyyah of Pharmacy |
Razak T.A.,Kulliyyah of Pharmacy |
Ayub A.,Kulliyyah of Pharmacy
Journal of Clinical and Diagnostic Research | Year: 2010
Aim: Since many Malaysians with hypertension have poor control rates of blood pressure, this study wasconducted to determine the impact of uncontrolled hypertension on the utilization of ambulatory care resources. Setting: The study took place at the Jaya Gading Polyclinic in Kuantan city, Pahang, Malaysia. Methods: This was a1year follow-up of 600 hypertensive patients who were classified into groups, based on average blood pressure. The monthly direct and indirect costs and the differences in costs were determined. Main outcome measure: Data analysis using the Mann-Whitney test was performed to compare the direct costswhich were associated with controlled and uncontrolled blood pressure. Results: The direct costs were significantly higher in the uncontrolled blood pressure groups as compared to the controlled blood pressure groups. Medication costs represented the major portion of the total direct costs in both the controlled and the uncontrolled blood pressure groups. Conclusion: Poor control of uncomplicated hypertension is associated with the higher utilization of the ambulatory care resources in Malaysia. Aggressive strategies are needed to control hypertension and to reduce the utilization of the ambulatory care resources.