Kuakini Medical Center

Honolulu, HI, United States

Kuakini Medical Center

Honolulu, HI, United States
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Imperatore G.,Centers for Disease Control and Prevention | Boyle J.P.,Centers for Disease Control and Prevention | Thompson T.J.,Centers for Disease Control and Prevention | Dabelea D.,University of Colorado at Denver | And 8 more authors.
Diabetes Care | Year: 2012

OBJECTIVE - To forecast the number of U.S. individuals aged <20 years with type 1 diabetes mellitus (T1DM) or type 2 diabetes mellitus (T2DM) through 2050, accounting for changing demography and diabetes incidence. RESEARCH DESIGN AND METHODS - We used Markov modeling framework to generate yearly forecasts of the number of individuals in each of three states (diabetes, no diabetes, and death). We used 2001 prevalence and 2002 incidence of T1DM and T2DM from the SEARCH for Diabetes in Youth study and U.S. Census Bureau population demographic projections. Two scenarios were considered for T1DM and T2DM incidence: 1) constant incidence over time; 2) for T1DMyearly percentage increases of 3.5, 2.2, 1.8, and 2.1%by age-groups 0-4years,5-9years,10-14 years, and 15-19 years, respectively, and for T2DM a yearly 2.3% increase across all ages. RESULTS-Under scenario 1, the projected number of youth with T1DM rises from 166,018 to 203,382 and with T2DM from 20,203 to 30,111, respectively, in 2010 and 2050. Under scenario 2, the number of youth with T1DM nearly triples from 179,388 in 2010 to 587,488 in 2050 (prevalence 2.13/1,000 and 5.20/1,000 [+144% increase]), with the greatest increase in youth of minority racial/ethnic groups. The number of youth with T2DM almost quadruples from 22,820 in 2010 to 84,131 in 2050; prevalence increases from 0.27/1,000 to 0.75/1,000 (+178% increase). CONCLUSIONS - A linear increase in diabetes incidence could result in a substantial increase in the number of youth with T1DM and T2DM over the next 40 years, especially those ofminority race/ethnicity. © 2012 by the American Diabetes Association.

Berg D.,German Center for Neurodegenerative Diseases | Marek K.,Institute for Neurodegenerative Disorders | Ross G.W.,VA Pacific Islands Health Care System | Ross G.W.,Kuakini Medical Center | Poewe W.,University of Innsbruck
Movement Disorders | Year: 2012

It is currently widely acknowledged that the natural history of PD includes a preclinical phase, and there are increasing efforts to identify markers that would allow the identification of individuals at risk for PD. Here, we discuss the issues related to defining at-risk populations for PD and review findings of current population-based cohorts that have reported potential biomarkers for PD, such as the Honolulu-Asia Aging Study (HAAS) and the PRIPS (Prospective Validation of Risk factors for the development of Parkinson Syndromes) study. We also discuss enriched risk cohorts designed to evaluate specificity and predictive value of markers exemplified by the PARS (Parkinson Associated Risk Study) and the TREND (Tübinger evaluation of Risk factors for the Early detection of NeuroDegeneration) study. Although there is still a long way to go, studies designed according to these concepts might eventually provide sufficient data to form the basis for future screening programs for PD risk to be applied at a population level. © 2012 Movement Disorder Society.

News Article | December 7, 2016
Site: www.prweb.com

The Honolulu cosmetic and medical dermatology practice Kitagawa Dermatology is proud to announce that its fully redesigned website, which launched October 17, 2016, features comprehensive information regarding a wide range of dermatologic conditions, as well as a sleek responsive design and easy-to-navigate layout. Visitors and patients can discover the latest clinical dermatology treatments for medical skin concerns as well as advanced skin care and cosmetic procedures. “Our revamped website serves as a great resource for individuals to learn about potential treatment options for both medical and cosmetic skin issues,” said Dr. Kory Kitagawa. “The website is also an easily accessible format for current and potential patients to explore our services and learn about who we are as a practice, which I believe the new design perfectly captures.” The responsive design enables visitors to easily and conveniently navigate the website from any device, be it a desktop computer, a laptop, a tablet, or a smartphone. The clean layout, drop-down menus, and beautiful images frame in-depth content about everything from medical skin conditions, such as eczema or skin cancer, to effective face and body treatments, including Botox and laser skin care. The website also provides answers to the most frequently asked questions regarding the practice’s most popular services. “Most importantly, the new website makes it easier for new and returning patients to get in touch with us right away,” added Dr. Kitagawa. “With just a few clicks, patients can set up an appointment or contact our office with any questions almost any time of day. Our social media sites are also just a click away, which helps us communicate and interact with our patients about weekly updates or insight into the newest procedures and treatments.” Kory Kitagawa M.D. is a renowned board-certified medical and cosmetic dermatologist practicing in Honolulu, Hawaii. Dr. Kitagawa and his exceptional team have the expert training and skills to treat or manage your skin condition using the latest products and cutting-edge technology available. They provide top-quality medical and cosmetic dermatological services for effective relief from painful or stress-inducing skin conditions anywhere on your body. Dr. Kitagawa and his staff pride themselves on providing friendly and compassionate service and care. His wife is the chief of marketing and business development while Rocco Laudadio, Jr., is a skilled board-certified physician’s assistant. Together, they form an amazing team dedicated to providing the best dermatological care in Hawaii. For either a medical or cosmetic skin care issue, such as skin cancer or wart removal, Honolulu patients will receive the best care and treatment from dermatology specialist Dr. Kitagawa, a current fellow of the American Academy of Dermatology (AAD) and dermatological consultant at Kuakini Medical Center. For more information, please visit our website at https://KitagawaDermatology.com/

Dabelea D.,University of Colorado at Denver | Pihoker C.,University of Washington | Talton J.W.,Wake forest University | D'Agostino Jr. R.B.,Wake forest University | And 8 more authors.
Diabetes Care | Year: 2011

OBJECTIVE - To describe an etiologic approach to classification of diabetes types in youth based on the 1997 American Diabetes Association (ADA) framework, using data from the SEARCH for Diabetes in Youth Study. RESEARCH DESIGN AND METHODS - SEARCH conducted a comprehensive assessment of 2,291 subjects aged <20 years with recently diagnosed diabetes. Using autoimmunity (at least one of two diabetes autoantibodies) and insulin sensitivity (equation validated against hyperinsulinemic-euglycemic clamps) as the main etiologic markers, we described four categories along a bidimensional spectrum: autoimmune plus insulin-sensitive (IS), autoimmune plus insulin-resistant (IR), nonautoimmune plus IS, and nonautoimmune plus IR.We then explored how characteristics, including genetic susceptibility to autoimmunity (HLA genotypes), insulin deficiency, and clinical factors varied across these four categories. RESULTS - Most subjects fell into either the autoimmune plus IS (54.5%) or nonautoimmune plus IR categories (15.9%) and had characteristics that align with traditional descriptions of type 1 or type 2 diabetes. The group classified as autoimmune plus IR (19.5%) had similar prevalence and titers of diabetes autoantibodies and similar distribution of HLA risk genotypes to those in the autoimmune plus IS group, suggesting that it includes individuals with type 1 diabetes who are obese. The group classified as nonautoimmune plus IS (10.1%) likely includes individuals with undetected autoimmunity but may also include those with monogenic diabetes and thus requires further testing. CONCLUSIONS - The SEARCH study offers researchers and clinicians a practical application for the etiologic classification of diabetes type and at the same time identifies a group of youths who would benefit from further testing. © 2011 by the American Diabetes Association.

Kojima G.,University of Hawaii at Manoa | Bell C.,University of Hawaii at Manoa | Bell C.,Kuakini Medical Center | Abbott R.D.,University of Virginia | And 8 more authors.
Stroke | Year: 2012

BACKGROUND AND PURPOSE-: Vitamin D deficiency has been reported to contribute to the risk of cardiovascular disease, especially stroke. We examined the relationship between dietary vitamin D intake and 34-year incident stroke. METHODS-: The Honolulu Heart Program is a prospective population-based cohort study of 8006 Japanese-American men in Hawaii who were 45 to 68 years old at the baseline examination in 1965 to 1968. Dietary vitamin D intake was calculated using the Nutritionist IV Version 3 software from a 24-hour dietary recall. Subjects with prevalent stroke were excluded, leaving 7385 men followed through 1999 for incident stroke. Subjects were divided into quartiles of dietary vitamin D for analyses. RESULTS-: During 34 years of follow-up, 960 subjects developed stroke. Age-adjusted rates of incident stroke were significantly higher in the lowest dietary vitamin D quartile compared with the highest (all stroke: 6.38 versus 5.14 per 1000 person-years follow-up, P=0.030; thromboembolic stroke: 4.36 versus 3.30, P=0.033). Using Cox regression, adjusting for age, total kilocalories, body mass index, hypertension, diabetes mellitus, pack-years smoking, physical activity index, serum cholesterol, and alcohol intake, those in the lowest quartile had a significantly increased risk of incident stroke (all stroke hazard ratio, 1.22; 95% CI, 1.01-1.47; P=0.038; thromboembolic stroke hazard ratio, 1.27; 95% CI, 1.01-1.59; P=0.044) with the highest as the reference. We found no significant associations between dietary vitamin D and hemorrhagic stroke. CONCLUSIONS-: Low dietary vitamin D intake was an independent risk factor for 34-year incidence of all stroke and thromboembolic stroke in Japanese-American men. Additional research is needed on vitamin D supplementation to prevent stroke. © 2012 American Heart Association, Inc.

Feleppa E.J.,Riverside Research Institute | Mamou J.,Riverside Research Institute | Porter C.R.,Virginia Mason Medical Center | MacHi J.,Kuakini Medical Center
Seminars in Oncology | Year: 2011

Ultrasound is a relatively inexpensive, portable, and versatile imaging modality that has a broad range of clinical uses. It incorporates many imaging modes, such as conventional gray-scale "B-mode" imaging to display echo amplitude in a scanned plane; M-mode imaging to track motion at a given fixed location over time; duplex, color, and power Doppler imaging to display motion in a scanned plane; harmonic imaging to display nonlinear responses to incident ultrasound; elastographic imaging to display relative tissue stiffness; and contrast-agent imaging with simple contrast agents to display blood-filled spaces or with targeted agents to display specific agent-binding tissue types. These imaging modes have been well described in the scientific, engineering, and clinical literature. A less well-known ultrasonic imaging technology is based on quantitative ultrasound (QUS), which analyzes the distribution of power as a function of frequency in the original received echo signals from tissue and exploits the resulting spectral parameters to characterize and distinguish among tissues. This article discusses the attributes of QUS-based methods for imaging cancers and providing improved means of detecting and assessing tumors. The discussion will include applications to imaging primary prostate cancer and metastatic cancer in lymph nodes to illustrate the methods. © 2011 Elsevier Inc. All rights reserved.

Willcox B.J.,University of Hawaii at Manoa | Willcox B.J.,Kuakini Medical Center | Willcox D.C.,University of Hawaii at Manoa | Willcox D.C.,Kuakini Medical Center | Willcox D.C.,Okinawa International University
Current Opinion in Clinical Nutrition and Metabolic Care | Year: 2014

PURPOSE OF REVIEW: To examine the role of two nutritional factors implicated in the healthy aging of the Okinawans: caloric restriction; and traditional foods with potential caloric restriction-mimetic properties. RECENT FINDINGS: Caloric restriction is a research priority for the US National Institute on Aging. However, little is known regarding health effects in humans. Some caloric restriction-related outcomes, such as cause-specific mortality and lifespan, are not practical for human clinical trials. Therefore, epidemiological data on older Okinawans, who experienced a caloric restriction-like diet for close to half their lives, are of special interest. The nutritional data support mild caloric restriction (10-15%) and high consumption of foods that may mimic the biological effects of caloric restriction, including sweet potatoes, marine-based carotenoid-rich foods, and turmeric. Phenotypic evidence is consistent with caloric restriction (including short stature, low body weight, and lean BMI), less age-related chronic disease (including cardiovascular diseases, cancer, and dementia), and longer lifespan (mean and maximum). SUMMARY: Both caloric restriction and traditional Okinawan functional foods with caloric restriction-mimetic properties likely had roles in the extended healthspan and lifespan of the Okinawans. More research is needed on health consequences of caloric restriction and foods with caloric restriction-mimetic properties to identify possible nutritional interventions for healthy aging. © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins.

Willcox D.C.,Okinawa International University | Willcox D.C.,University of Hawaii at Manoa | Willcox D.C.,Kuakini Medical Center | Scapagnini G.,University of Molise | And 2 more authors.
Mechanisms of Ageing and Development | Year: 2014

The traditional diet in Okinawa is anchored by root vegetables (principally sweet potatoes), green and yellow vegetables, soybean-based foods, and medicinal plants. Marine foods, lean meats, fruit, medicinal garnishes and spices, tea, alcohol are also moderately consumed. Many characteristics of the traditional Okinawan diet are shared with other healthy dietary patterns, including the traditional Mediterranean diet, DASH diet, and Portfolio diet. All these dietary patterns are associated with reduced risk for cardiovascular disease, among other age-associated diseases. Overall, the important shared features of these healthy dietary patterns include: high intake of unrefined carbohydrates, moderate protein intake with emphasis on vegetables/legumes, fish, and lean meats as sources, and a healthy fat profile (higher in mono/polyunsaturated fats, lower in saturated fat; rich in omega-3). The healthy fat intake is likely one mechanism for reducing inflammation, optimizing cholesterol, and other risk factors. Additionally, the lower caloric density of plant-rich diets results in lower caloric intake with concomitant high intake of phytonutrients and antioxidants. Other shared features include low glycemic load, less inflammation and oxidative stress, and potential modulation of aging-related biological pathways. This may reduce risk for chronic age-associated diseases and promote healthy aging and longevity. © 2014 Elsevier Ireland Ltd.

Carnes B.A.,The University of Oklahoma Health Sciences Center | Staats D.,The University of Oklahoma Health Sciences Center | Willcox B.J.,University of Hawaii at Manoa | Willcox B.J.,Kuakini Medical Center
Journals of Gerontology - Series A Biological Sciences and Medical Sciences | Year: 2014

Demographers predict human life expectancy will continue to increase over the coming century. These forecasts are based on two critical assumptions: advances in medical technology will continue apace and the environment that sustains us will remain unchanged. The consensus of the scientific community is that human activity contributes to global climate change. That change will degrade air and water quality, and global temperature could rise 11.5°F by 2100. If nothing is done to alter this climatic trajectory, humans will be confronted by a broad spectrum of radical environmental challenges. Historically, children and the elderly adults account for most of the death toll during times of severe environmental stress. This article makes an assessment from a geriatric viewpoint of the adverse health consequences that global climate change will bring to the older segments of future populations in the United States. © The Author 2013.

The invention provides methods and compositions relating to identification and use of genetic information from the FOXO3A gene that can be used for determining and increasing an individuals likelihood of longevity and of retaining physical and cognitive function during aging, and for determining and decreasing an individuals likelihood of developing a cardiovascular-, metabolic- or age-related disease, including coronary artery (heart) disease, stroke, cancer, chronic pulmonary disease, diabetes, Parkinsons disease and dementia.

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