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Hatta S.,Kirin Holdings Company | Hitomi Y.,Kirin Holdings Company | Yotsumoto Y.,Kirin Beverage Co. | Wakabayashi H.,Kirin Beverage Co. | And 2 more authors.
Japanese Pharmacology and Therapeutics | Year: 2012

Objectives: It is shown that some of dietary polyphenols inhibit the absorption of dietary iron. A placebo-controlled, parallel-group trial was carried out to investigate whether iron deficit would be caused by the inhibition of iron absorption when healthy volunteers consume the newly developed black tea polyphenols (BTP) - enriched black tea beverage (BTP beverage) daily with meal for 12 weeks. Methods: 80 healthy volunteers were divided into four groups who consumed either three bottles of BTP beverage, one bottle of BTP beverage, one bottle of regular black tea beverage or one bottle of placebo everyday for 12 weeks. Each bottle contained 350 mL of each beverage. The subjects who consumed three bottles of BTP beverage (BTP3 group) consumed a bottle of the beverage at every meal (three times per day) and the subjects in the other groups consumed a bottle of each beverage daily at dinner. Blood samples were collected every four weeks. Results: Although serum ferritin increased 4 weeks after the termination of the consumption of the BTP beverage in the BTP3 group, blood hemoglobin concentration was increased and no adverse changes were observed in iron metabolism or in parameters for general health during the consumption period. These results indicated that possible inhibition of iron absorption by the consumption of three bottles of BTP beverage does not cause iron deficit in a healthy population. Conclusion: The long-term consumption of three bottles of BTP beverage per day with meals did not cause iron deficit in healthy volunteers. Source


Kishimoto Y.,Matsutani Chemical Industry Co. | Tachibe M.,Matsutani Chemical Industry Co. | Kitagawa M.,Matsutani Chemical Industry Co. | Nishibata T.,Matsutani Chemical Industry Co. | And 2 more authors.
Japanese Pharmacology and Therapeutics | Year: 2014

Methods: Fifty four healthy female subjects with constipation tendency were recruited for a randomized and placebo-controlled study. After 2-week observation period (Pre-Period), all subjects received 28 g of placebo biscuits (without HXLS) for 2 weeks (Period I). Following Period I, subjects received placebo, low-dose (3.5 g of dietary fiber from HXLS), or highdose (7 g of dietary fiber from HXLS) biscuits for 2 weeks (Period II). During 6-week test period, subjects were requested to record symptoms such as stool frequency, stool volume.Results: Compared to Pre-Period, no significant effect was observed in low-dose group, whereas high-dose group showed significantly higher frequency of defecation during Period II.Conclusion: The investigation revealed that defecation frequency depends on dietary fiber intake and effective amount of dietary fiber from HXLS is 7 g.Objectives: We investigated the efficacy and dose-dependent effect of highly cross-linked starch (HXLS) from tapioca on defecation. Source


Suzuki M.,Kirin Beverage Co. | Wakabayashi H.,Kirin Beverage Co. | Yoshida A.,Kirin Beverage Co. | Deuchi K.,Kirin Beverage Co. | And 2 more authors.
Japanese Pharmacology and Therapeutics | Year: 2010

Objectives: To evaluate the effect of carbonated beverage containing indigestible dextrin on elevation of postprandial serum triglyceride, a double-blinded crossover study was performed. Methods: The subjects were 90 healthy volunteers (serum triglyceride 120-200 mg/dL). The subjects ingested the test drink containing 5 g (as dietary fiber) of indigestible dextrin or the control drink without indigestible dextrin, together with the fat-rich diet. Blood samples were drawn before and 2, 3, 4 and 6 hours after the ingestion, and their serum triglyceride levels were measured. Results: Intake of the test drink containing indigestible dextrin significantly suppressed the elevation of postprandial serum triglyceride levels at 2, 3 and 4 hours as compared with those of the control drink (p < 0.05). Conclusions: These results demonstrated that carbonated beverage containing indigestible dextrin given with meal had inhibitory effect on the elevation of postprandial serum triglyceride. Source


Takamizawa N.,Waseda University | Shioya N.,KSO Corporation | Nagaoka H.,Kunwakai Medical Corporation | Uchino T.,Everlife Co.
Japanese Pharmacology and Therapeutics | Year: 2016

Objectives: The aim of this study was to evaluate the effect and safety of a dietary supplement (Kojun premium®) containing hyaluronic acid derived from chicken combs on knee pain, stiffness and discomfort. Methods: We conducted a randomized, double-blind, placebo-controlled, parallel-group comparison study. The subjects, 80 adults whose Kellgren-Lawrence classification of osteoarthritis of the knee corresponded to 0-II and who were not suffering from the disease, were randomly divided into two groups: the test product (chicken comb extract-containing supplement) group and the control product (placebo) group. Knee pain and discomfort were evaluated using a visual analogue scale (VAS). The subjects were given each product for 12 weeks. Blood and urine samples were tested to evaluate the safety of the test product. Results: Significant positive results demonstrating the effectiveness of the chicken comb extract-containing supplement appeared 4-12 weeks after the intake as demonstrated by the VAS scores. The blood test results did not indicate any health hazard from the use of these supplements. Conclusion: These results indicate that an intake of hyaluronic acid-containing supplements derived from chicken combs is safe and effective in managing knee pain, stiffness and discomfort. Source


Takahashi T.,Asahi Breweries Ltd. | Fujiwara K.,Asahi Breweries Ltd. | Nozato N.,Asahi Breweries Ltd. | Shimizu J.,Asahi Breweries Ltd. | And 5 more authors.
Japanese Pharmacology and Therapeutics | Year: 2013

Objective The effect of carbonated beverage containing resistant maltodextrin on the postprandial serum triglyceride was evaluated by a randomized double-blind crossover study. Method The subjects were 90 healthy volunteers (fasting serum triglyceride: 120-200 mg/dL) and randomly divided into two groups. They ingested the test beverage containing 5 g (as fiber) of resistant maltodextrin or the placebo beverage containing none of resistant maltodextrin with a high fat diet. Serum triglyceride was measured before and 2, 3, 4 and 6 h after ingestion. Result In comparison with the placebo beverage, the test beverage significantly lowered the postprandial serum triglyceride at 2, 3 and 4 h after ingestion. In addition, postprandial serum remnant-like particle cholesterol was significantly lowered at 2, 3 and 4 h after ingestion of the test beverage. Conclusion These results suggest that the elevation of postprandial serum triglyceride is suppressed by the carbonated beverage containing resistant maltodextrin. Source

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