KSO Corporation

Japan

KSO Corporation

Japan
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Toda T.,FUJICCO Co. | Nanba F.,FUJICCO Co. | Arai K.,FUJICCO Co. | Takamizawa N.,Waseda University | And 2 more authors.
Japanese Pharmacology and Therapeutics | Year: 2017

Objectives The aim of this study was to evaluate the effect of Lactococcus lactis subsp. cremoris FC on fecal properties and fecal microflora in healthy subjects prone to constipation. Methods In total, 50 volunteers (seven men and 43 women) were randomized into two groups and given 100 mg of L. lactis subsp. cremoris FC (test) or dextrin (placebo) daily for 2 weeks in a double-blind, placebo-controlled, cross-over study. The fecal microflora was analyzed using the DNA extracted from feces and a real-time polymerase chain reaction. Results Compared with the ingestion of placebo, the defecation frequency significantly increased (days/week, P<0.05; times/week, P< 0.001) with the ingestion of L. lactis subsp. cremoris FC. The total bacterial count (log) and Lactobacillus sp. bacterial count (log) significantly (P<0.05) increased 2 weeks after the ingestion of test. Conclusion These results suggest that the continuous ingestion of L. lactis subsp. cremoris FC caused changes in intestinal microflora, improving defecation status and fecal characteristics in healthy subjects prone to constipation.


Hatta S.,Kirin Holdings Co. | Hitomi Y.,Kirin Holdings Co. | Yotsumoto Y.,Kirin Beverage Co. | Wakabayashi H.,Kirin Beverage Co. | And 2 more authors.
Japanese Pharmacology and Therapeutics | Year: 2012

Objectives: It is shown that some of dietary polyphenols inhibit the absorption of dietary iron. A placebo-controlled, parallel-group trial was carried out to investigate whether iron deficit would be caused by the inhibition of iron absorption when healthy volunteers consume the newly developed black tea polyphenols (BTP) - enriched black tea beverage (BTP beverage) daily with meal for 12 weeks. Methods: 80 healthy volunteers were divided into four groups who consumed either three bottles of BTP beverage, one bottle of BTP beverage, one bottle of regular black tea beverage or one bottle of placebo everyday for 12 weeks. Each bottle contained 350 mL of each beverage. The subjects who consumed three bottles of BTP beverage (BTP3 group) consumed a bottle of the beverage at every meal (three times per day) and the subjects in the other groups consumed a bottle of each beverage daily at dinner. Blood samples were collected every four weeks. Results: Although serum ferritin increased 4 weeks after the termination of the consumption of the BTP beverage in the BTP3 group, blood hemoglobin concentration was increased and no adverse changes were observed in iron metabolism or in parameters for general health during the consumption period. These results indicated that possible inhibition of iron absorption by the consumption of three bottles of BTP beverage does not cause iron deficit in a healthy population. Conclusion: The long-term consumption of three bottles of BTP beverage per day with meals did not cause iron deficit in healthy volunteers.


Uno T.,Asahi Soft Drinks Co. | Shinoda Y.,Asahi Soft Drinks Co. | Okamoto T.,Asahi Soft Drinks Co. | Kametani N.,Asahi Group Holdings Ltd. | And 3 more authors.
Japanese Pharmacology and Therapeutics | Year: 2015

Objectives It's well recognized that Resistant maltodextrin (RMD) is applied to many Foods for Specified Health Use for maintaining healthy intestinal regularity, blood glucose levels, and serum lipids. We studied the efficacy of a carbonated soft drink (CSD) containing RMD for suppressing the elevation of postprandial blood glucose level as for preventing the prediabetes development. Methods A randomized double-blinded crossover trial was conducted. The 42 subjects who were judged as prediabetes because of their impaired glucose tolerance, impaired fasting glucose, and/or impaired casual blood glucose level were divided into two groups; the subjects in one group ingested the CSDs with 5 g (as dietary fiber) RMD together with test meals, the subjects in another group did placebo CSDs as the same. After one week interval, the subjects in each group ingested opposite CSDs. The levels of blood glucose and insulin were measured drawn at 0 (before), 30, 60, 90, and 120 minutes after ingesting, and were compared between CSDs with and without RMD. Results Intake of CSD with RMD significantly suppressed the elevation of postprandial blood glucose levels at 60 and 90 minutes and its AUC, compared with placebo CSD. Conclusions These results indicated that the CSD supplemented with RMD suppresses the elevation of the postprandial blood glucose level.


Shinoda Y.,Asahi Soft Drinks Co. | Kametani N.,Asahi Soft Drinks Co. | Uno T.,Asahi Soft Drinks Co. | Okamoto T.,Asahi Soft Drinks Co. | And 3 more authors.
Japanese Pharmacology and Therapeutics | Year: 2015

Objectives We carried out a randomized double-blind crossover study to investigate the effect of carbonated beverage containing resistant maltodextrin (RMD) on the postprandial serum triglyceride. Methods The subjects were 90 healthy volunteers (fasting serum triglyceride: 120-200 mg/dL) and randomly divided into two groups. They ingested the test beverage containing RMD (5 g) or the beverage without RMD (placebo) together with a fat-rich meal (lipid: 41.0 g). Blood samples were drawn before and 2, 3, 4 and 6 hours after ingestion, and the serum triglyceride was measured. Results In comparison with the placebo beverage, the test beverage significantly lowered the postprandial serum triglyceride at 2, 3, 4 and 6 hours after ingestion of the test beverage (2 and 3 hours: P<0.05, 4 and 6 hours: P<0.01). Postprandial RLP-cholesterol elevation also significantly suppressed at 2, 3, 4 and 6 hours after food ingestion as compared with that of the placebo (2, 3 and 6 hours: P<0.05, 4 hours: P<0.01). Conclusions These results indicated that the carbonated beverage containing RMD has inhibitory effect on the elevation of postprandial serum triglyceride.


Shinoda Y.,Asahi Soft Drinks Co. | Kametani N.,Asahi Soft Drinks Co. | Uno T.,Asahi Soft Drinks Co. | Okamoto T.,Asahi Soft Drinks Co. | And 4 more authors.
Japanese Pharmacology and Therapeutics | Year: 2014

Objectives: We developed carbonated beverage containing resistant maltodextrin (RMD). A randomized, double-blind crossover study was carried out to investigate whether the beverage would suppress the postprandial elevation of the serum triglyceride (TG) levels, remnant like lipoprotein particle (RLP)-cholesterol levels. Also, two randomized double-blind placebo-controlled studies were carried out to assess the safety of excessive or long-term intake of the beverage. Methods: The subjects were 90 healthy volunteers (serum TG : 120-200 mg/dL). The subjects ingested a test beverage containing RMD (5 g) or beverage without RMD (placebo) together with fat-rich meal (lipid : 42.1 g). Blood samples were drawn before and 2, 3, 4 and 6 hours after ingestion, and the serum triglyceride levels were measured. The subject for safety evaluation of long-term intake was 30 healthy volunteers, including 10 volunteers whose serum TG levels were 150-200 mg/dL. They consumed one bottle of test beverage (485 mL/bottle) containing RMD (5 g) at a meal per day for 12 weeks. The subject for safety evaluation of excessive intake was 30 healthy volunteers, including 10 volunteers whose serum TG levels were 150-200 mg/dL. They consumed one bottle of test beverage containing RMD (15 g) at a meal per day for 4 weeks. Results: Intake of RMD beverage significantly suppressed the level of serum TG observed at 2, 3 and 4 hours after food ingestion as compared with that of the placebo (P< 0.05). Postprandial RLP-cholesterol elevation also significantly suppressed at 3, 4 and 6 hours after food ingestion as compared with that of the placebo (P<0.05). Also, there were no clinical problems in the blood examinations and physical examinations. No adverse reactions were observed. Conclusions: These results indicated that intake of the RMD supplemented beverage suppresses postprandial serum triglyceride levels without any safety problem.


Suzuki M.,Kirin Beverage Company | Wakabayashi H.,Kirin Beverage Company | Yoshida A.,Kirin Beverage Company | Deuchi K.,Kirin Beverage Company | And 2 more authors.
Japanese Pharmacology and Therapeutics | Year: 2010

Objectives: To evaluate the effect of carbonated beverage containing indigestible dextrin on elevation of postprandial serum triglyceride, a double-blinded crossover study was performed. Methods: The subjects were 90 healthy volunteers (serum triglyceride 120-200 mg/dL). The subjects ingested the test drink containing 5 g (as dietary fiber) of indigestible dextrin or the control drink without indigestible dextrin, together with the fat-rich diet. Blood samples were drawn before and 2, 3, 4 and 6 hours after the ingestion, and their serum triglyceride levels were measured. Results: Intake of the test drink containing indigestible dextrin significantly suppressed the elevation of postprandial serum triglyceride levels at 2, 3 and 4 hours as compared with those of the control drink (p < 0.05). Conclusions: These results demonstrated that carbonated beverage containing indigestible dextrin given with meal had inhibitory effect on the elevation of postprandial serum triglyceride.


Nishizuka T.,Asahi Breweries LTD. | Itagaki H.,Asahi Breweries LTD. | Noda A.,Asahi Breweries LTD. | Fujiwara K.,Asahi Breweries LTD. | And 4 more authors.
Japanese Pharmacology and Therapeutics | Year: 2015

Objectives The effect of carbonated beverage containing resistant maltodextrin on the postprandial elevation of blood glucose level was evaluated by a randomized, double-blind, crossover study. Methods A randomized, double-blinded, crossover trial was performed. The subjects were 50 healthy volunteers whose fasting blood glucose levels are from 110 mg/dL to 125 mg/dL or whose blood glucose levels after 2 hours by OGTT are from 140 mg/dL to 199 mg/dL. They were randomly divided into two groups and ingested the test beverage containing 5 g (as fiber) of resistant maltodextrin or the placebo beverage with the test meal. Blood glucose levels and blood insulin levels were measured before and 30, 60, 90, 120 minutes after ingestion. Results In comparison with the placebo beverage, the test beverage significantly lowered the postprandial blood glucose levels at 30 minutes (test beverage: 152.2±26.8 mg/dL, placebo beverage: 155.9±22.9 mg/dL, P<0.05) and at 60 minutes (test beverage: 169.1 ±44.3 mg/ dL, placebo beverage: 174.1 ±44.8 mg/dL, P<0.05). Conclusions The data obtained through the trial indicated that the carbonated beverage containing resistant maltodextrin suppresses the elevation of the postprandial blood glucose levels.


Takamizawa N.,Waseda University | Shioya N.,KSO Corporation | Nagaoka H.,Kunwakai Medical Corporation | Uchino T.,Everlife Co.
Japanese Pharmacology and Therapeutics | Year: 2016

Objectives: The aim of this study was to evaluate the effect and safety of a dietary supplement (Kojun premium®) containing hyaluronic acid derived from chicken combs on knee pain, stiffness and discomfort. Methods: We conducted a randomized, double-blind, placebo-controlled, parallel-group comparison study. The subjects, 80 adults whose Kellgren-Lawrence classification of osteoarthritis of the knee corresponded to 0-II and who were not suffering from the disease, were randomly divided into two groups: the test product (chicken comb extract-containing supplement) group and the control product (placebo) group. Knee pain and discomfort were evaluated using a visual analogue scale (VAS). The subjects were given each product for 12 weeks. Blood and urine samples were tested to evaluate the safety of the test product. Results: Significant positive results demonstrating the effectiveness of the chicken comb extract-containing supplement appeared 4-12 weeks after the intake as demonstrated by the VAS scores. The blood test results did not indicate any health hazard from the use of these supplements. Conclusion: These results indicate that an intake of hyaluronic acid-containing supplements derived from chicken combs is safe and effective in managing knee pain, stiffness and discomfort.


Takahashi T.,Asahi Breweries Ltd. | Fujiwara K.,Asahi Breweries Ltd. | Nozato N.,Asahi Breweries Ltd. | Shimizu J.,Asahi Breweries Ltd. | And 5 more authors.
Japanese Pharmacology and Therapeutics | Year: 2014

Objectives: We carried out two double-blind, placebo-controlled, parallel group studies to evaluate the safety of long-term intake and excessive intake of the carbonated beverage containing resistant maltodextrin. Methods: The subjects for the safety evaluation of long-term intake were 30 healthy volunteers and randomly divided into two groups. In the long-term intake study, they ingested one bottle (350 mL) of the test beverage containing 5 g (as fiber) of resistant maltodextrin or the placebo beverage containing none of resistant maltodextrin per day for 12 weeks. The subjects for the safety evaluation of excessive intake were 30 healthy volunteers and randomly divided into two groups. In the excessive intake study, they ingested 3 bottles of the test beverage or the placebo beverage per day for 4 weeks. Results: No unusual changes caused by the test beverage ingestion were observed in physical, blood and urinary examination and medical interview. Conclusions: These results suggest that the carbonated beverage containing resistant maltodextrin was safe for long-term and excessive intake.


Kishimoto Y.,Matsutani Chemical Industry Co. | Tachibe M.,Matsutani Chemical Industry Co. | Kitagawa M.,Matsutani Chemical Industry Co. | Nishibata T.,Matsutani Chemical Industry Co. | And 2 more authors.
Japanese Pharmacology and Therapeutics | Year: 2014

Methods: Fifty four healthy female subjects with constipation tendency were recruited for a randomized and placebo-controlled study. After 2-week observation period (Pre-Period), all subjects received 28 g of placebo biscuits (without HXLS) for 2 weeks (Period I). Following Period I, subjects received placebo, low-dose (3.5 g of dietary fiber from HXLS), or highdose (7 g of dietary fiber from HXLS) biscuits for 2 weeks (Period II). During 6-week test period, subjects were requested to record symptoms such as stool frequency, stool volume.Results: Compared to Pre-Period, no significant effect was observed in low-dose group, whereas high-dose group showed significantly higher frequency of defecation during Period II.Conclusion: The investigation revealed that defecation frequency depends on dietary fiber intake and effective amount of dietary fiber from HXLS is 7 g.Objectives: We investigated the efficacy and dose-dependent effect of highly cross-linked starch (HXLS) from tapioca on defecation.

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