Deralakatte, India
Deralakatte, India

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Tukka V.N.,Navodaya Medical College | Bhalki N.,Navodaya Medical College | Sreekantha,Navodaya Medical College | Avinash S.S.,FMMC | Remya,KSHEMA
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2014

Upper gastrointestinal bleeding or haemorrhage[UGIB/UGIH} constitutes about 0.5% of all the cases of surgical and medical indoor admissions in the hospitals all over the world. The incidence is highest between the age group of 31 to 70 years with male preponderance in all the age groups. This study was undertaken to study in detail focussing the etipathogenesis, pathology, complications, investigation, treatment and complications of UGIB. Mortality in emergency surgical intervention is quite high, a careful alert and effective conservative management go along with in giving relief to majority of the cases of upper gastrointestinal bleeding. Prompt and efficient investigation and conservative treatment greatly reduce the morbidity and mortality of these patients.


Sreekantha,KMC CBS Bejai | Vinodchandran,KMC CBS Bejai | Rangaswamy R.,KMC CBS Bejai | Amareshwara M.,KSHEMA | And 2 more authors.
Biomedicine | Year: 2010

Multiple sclerosis is the most common demyelinating disorder of CNS. It derives its name from the multiple scarred areas visible on macroscopic examination of the brain; lesions are termed as plaques, which are demarcated grey or pink areas. It has a progressive course and a pathologic triad of CNS inflammation, demyelination and gliosis (scarring). Complications from multiple sclerosis affect multiple body system and hence early laboratory diagnosis and treatment is recommended to optimize clinical care.


Savitha S.,KVG Dental College | Sharma S.M.,AB Shetty Dental College | Veena S.,KSHEMA | Rekha R.,KVG Medical College
Indian Journal of Plastic Surgery | Year: 2015

Background: The bone morphogenetic protein (BMP) signalling pathway is crucial in a number of developmental processes and is critical in the formation of variety of craniofacial elements including cranial neural crest, facial primordium, tooth, lip and palate. It is an important mediator in regulation of lip and palate fusion, cartilage and bone formation. Aim: To study the role of mutation of BMP4 genes in the aetiology of non-syndromic cleft lip with or without palate (NSCL ± P) and identify it directly from human analyses. Materials and Methods: A case-control study was done to evaluate whether BMP4T538C polymorphism, resulting in an amino acid change of Val=Ala (V152A) in the polypeptide, is associated with NSCL ± P in an Indian paediatric population. Genotypes of 100 patients with NSCL ± P and 100 controls (in whom absence of CL ± P was confirmed in three generations) were detected using a polymerase chain reaction-restriction fragment length polymorphism strategy. Logistic regression was performed to evaluate allele and genotype association with NSCLP. Results: Results showed significant association between homozygous CC genotype with CL ± P (odds ratio [OR]-5.59 and 95% confidence interval [CI] = 2.85-10.99). The 538C allele carriers showed an increased risk of NSCL ± P as compared with 538 T allele (OR-4.2% CI = 2.75-6.41). Conclusion: This study suggests an association between SNP of BMP4 gene among carriers of the C allele and increased risk for NSCLP in an Indian Population. Further studies on this aspect can scale large heights in preventive strategies for NSCLP that may soon become a reality. © 2015 Indian Journal of Plastic Surgery.


Hegde M.N.,NITTE University | Shetty S.S.,NITTE University | Shabin S.,NITTE University | Hegde N.D.,NITTE University | And 2 more authors.
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2014

The aim of this study was to examine the genotoxic potential of glass ionomer cement type IX available commercially before and after electron beam irradiation. The dental material used in the study was type IX Glass ionomer cement commercially available as GC Type IX (3M ESPE). The study was divided into two groups-Non radiated and radiated groups. The set material was placed in polypropylene vials and exposed to 10KGy of electron beam irradiation. Lymphocyte was separated and used for genotoxicity study. The alkaline comet assay was performed as described by Tice et al. 1991. DNA diffusion assay was performed as described by Singh et.al. 2004. Statistical analysis was performed using student't' test. The irradiation of Glass ionomer cement type IX with 10KGy dose of electron beam irradiation showed increase in the frequency of DNA damage when compared to that of the non-radiated group. Statistically significance was observed in olive moment (p=0.0203) and tail length (P<0.0001) between radiated and non-irradiated groups. Apoptotic DNA diffusion index did not show much difference between non-radiated and radiated groups. However DNA diffusion was higher in radiated group and was statistically significant (P<0.0001). From the study it can be concluded that the increase in the frequency of DNA damage after electron beam irradiation may be due to the release of unbound acids because of chain breakage and due to the release of fluoride ions. Further studies are required to study the exact mechanism involved in genotoxicity .


Sreekantha,Navodaya Medical College | Kowsalya R.,Institute of Nephrourology | Avinash S.S.,Father Muller Medical College | Chandran V.,Kasturba Medical College | And 2 more authors.
Biomedicine | Year: 2011

Objectives: Proteins modified under oxidative stress seem to play a pivotal role in pathogenesis of several diseases. The present study was undertaken to know the relation between protein carbonylation and antioxidants in the form of glutathione and albumin in rheumatoid arthritis patients. Methods: Protein carbonylation & glutathione levels were measured in plasma in all the 30 patients and 25 controls using spectrophotometric methods along with total protein and albumin. Results: There was significant increase in protein carbonylation content (P<0.001) associated with a significant decrease in glutathione and albumin levels (P<0.001) in patients compared to healthy controls. A significant negative correlation of protein carbonylation with glutathione and albumin was also noted. Conclusion: Thus our study suggests a possible role for oxidatively modified proteins in form of protein carbonyls in mediation of inflammation in rheumatoid arthritis leading to increased consumption of available antioxidants in the body.


Sreekantha,Manipal University India | Manjunatha Goud B.K.,Manipal University India | Avinash S.S.,Father Muller Medical College | Amareshwara M.,KSHEMA | And 2 more authors.
International Journal of Pharma and Bio Sciences | Year: 2010

Psoriasis is regarded as a multifactorial disease in which interaction between genetic and environmental factors seem to play a causative role. Evidence is now accumulating that there is an association between Vitamin C, Vitamin E, Calcium, Phosphorus and psoriasis but the detailed mechanisms are not yet known. In the present study we estimated vitamin E, Vitamin C, Calcium and Phosphorus in 25 psoriatic patients and 25 age matched controls. We observed a very highly significant decrease in Vitamin E, Vitamin C and Calcium (p<0.001). It could be concluded from our study that decrease in above parameters are the probable causative agents for the pathogenesis of psoriasis.


Patil R.S.,MRMC | Nimbal N.V.,BIMS | Pratima S.,MRMC | Patil S.R.,MRMC | And 2 more authors.
International Journal of Pharma and Bio Sciences | Year: 2013

Thyroid gland disorders of various types; congenital, infectious, autoimmune, benign and malignant lesions. In the present study we have focused on all the disorders with special reference to age, sex, etiology, etiopathogenesis, complication and pathological diagnostic part of thyroid lesions. This study helps in the detection of thyroid lesions in the early diagnosis, treatment and assessment of prognosis of thyroid gland disorders.


Ganesh Kumar S.,Jawaharlal Institute of Postgraduate Medical Education & Research | Subba S.H.,Manipal University India | Unnikrishnan B.,Manipal University India | Jain A.,Manipal University India | Badiger S.,KSHEMA
Kathmandu University Medical Journal | Year: 2011

Background Smoking among health care personnel such as medical students is an important public health issue. More effective measures to reduce tobacco smoking among medical students are needed worldwide. Very few studies had been conducted in past in India and other developing countries to understand the magnitude of problem. Objectives To determine the prevalence and associated factors of current smoking among medical students. Methods Cross sectional study was conducted during January and February 2009 among 333 study subjects selected randomly from four batches of a teaching institution. Subjects were administered a self administered pre tested questionnaire and smoking status was assessed as per the criteria laid down by WHO. Proportion, chi square test and multiple logistic regression analysis were used for statistical analysis. Results The prevalence of current smoking was found to be 22.4% (67). There were widespread deficiencies in knowledge of smoking among students of different classes, as an important causal factor in many diseases like gastro intestinal malignancy, heart problems, asthma, and emphysema. It was found that only half of them were willing to quit smoking (33). Fourth year students (OR=2.54) and presence of peer pressure (OR=21.91) had independent significant association with current smoking. Conclusion Prevalence of smoking among medical students is high that warrants adoption of comprehensive smoking control interventions among them.


Prakasha S.R.,KSHEMA | Suresh G.,KSHEMA | D'Sa I.P.,KSHEMA | Shetty S.S.,KSHEMA | Kumar S.G.,JIPMER
Journal of Global Infectious Diseases | Year: 2013

Background and Objectives: There has been a rapid expansion of the directly observed treatment short-term (DOTS) under the revised national tuberculosis control program throughout India in the last decade. Few reports exist detailing individual DOTS centers' experiences with regard to extrapulmonary tuberculosis (EPTB) in a medical college hospital setting. Materials and Methods: This is a retrospective, record-based study of patients with the diagnosis of EPTB, in all age groups. Data on all consecutive EPTB cases diagnosed at the K. S. Hegde Medical College and Hospital, Deralakatte, Mangalore from 1 January 2005 to 31 December 2011 at the DOTS centre attached to this hospital were collected, analyzed by Mantel-Haenszel Chi square for linear trend and described in proportion or percentages. Results: Among 1267 cases registered for treatment of all forms of tuberculosis, 528 (41.67%) had EPTB. Around half of the cases of EPTB (269, 51%) were among adult age groups and the majority of cases (342, 64.77%) received Category-I treatment. Pleural TB was the commonest type of EPTB (n = 148, 28.03%), followed by lymph node TB (n = 131, 24.81%). Involvement of lymph nodes was the commonest manifestation among the less than 14 years' age group (27, 58.7%), while involvement of pleura was more common among > 65 years' age group (23, 45.1%). The difference in the occurrence of EPTB by site between males and females is statistically significant with a P value of <0.005. There is a significant increase in the number of cases of tuberculosis affecting bones and joints, and other forms of tuberculosis over the years. Conclusion: The burden of EPTB is more among the productive age group. Increase in the trend of bone and joint tuberculosis, and other rare forms of EPTB is a point of concern highlighting the importance of strengthening the services towards this group.


PubMed | AB Shetty Dental College, KSHEMA, KVG Medical College and KVG Dental College
Type: Journal Article | Journal: Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India | Year: 2015

The bone morphogenetic protein (BMP) signalling pathway is crucial in a number of developmental processes and is critical in the formation of variety of craniofacial elements including cranial neural crest, facial primordium, tooth, lip and palate. It is an important mediator in regulation of lip and palate fusion, cartilage and bone formation.To study the role of mutation of BMP4 genes in the aetiology of non-syndromic cleft lip with or without palate (NSCL P) and identify it directly from human analyses.A case-control study was done to evaluate whether BMP4T538C polymorphism, resulting in an amino acid change of Val=Ala (V152A) in the polypeptide, is associated with NSCL P in an Indian paediatric population. Genotypes of 100 patients with NSCL P and 100 controls (in whom absence of CL P was confirmed in three generations) were detected using a polymerase chain reaction-restriction fragment length polymorphism strategy. Logistic regression was performed to evaluate allele and genotype association with NSCLP.Results showed significant association between homozygous CC genotype with CL P (odds ratio [OR]-5.59 and 95% confidence interval [CI] = 2.85-10.99). The 538C allele carriers showed an increased risk of NSCL P as compared with 538 T allele (OR - 4.2% CI = 2.75-6.41).This study suggests an association between SNP of BMP4 gene among carriers of the C allele and increased risk for NSCLP in an Indian Population. Further studies on this aspect can scale large heights in preventive strategies for NSCLP that may soon become a reality.

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