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Deralakatte, India

Tukka V.N.,Navodaya Medical College | Bhalki N.,Navodaya Medical College | Sreekantha,Navodaya Medical College | Avinash S.S.,FMMC | Remya,KSHEMA
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2014

Upper gastrointestinal bleeding or haemorrhage[UGIB/UGIH} constitutes about 0.5% of all the cases of surgical and medical indoor admissions in the hospitals all over the world. The incidence is highest between the age group of 31 to 70 years with male preponderance in all the age groups. This study was undertaken to study in detail focussing the etipathogenesis, pathology, complications, investigation, treatment and complications of UGIB. Mortality in emergency surgical intervention is quite high, a careful alert and effective conservative management go along with in giving relief to majority of the cases of upper gastrointestinal bleeding. Prompt and efficient investigation and conservative treatment greatly reduce the morbidity and mortality of these patients.

Hegde M.N.,NITTE University | Shetty S.S.,NITTE University | Shabin S.,NITTE University | Hegde N.D.,NITTE University | And 2 more authors.
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2014

The aim of this study was to examine the genotoxic potential of glass ionomer cement type IX available commercially before and after electron beam irradiation. The dental material used in the study was type IX Glass ionomer cement commercially available as GC Type IX (3M ESPE). The study was divided into two groups-Non radiated and radiated groups. The set material was placed in polypropylene vials and exposed to 10KGy of electron beam irradiation. Lymphocyte was separated and used for genotoxicity study. The alkaline comet assay was performed as described by Tice et al. 1991. DNA diffusion assay was performed as described by Singh et.al. 2004. Statistical analysis was performed using student't' test. The irradiation of Glass ionomer cement type IX with 10KGy dose of electron beam irradiation showed increase in the frequency of DNA damage when compared to that of the non-radiated group. Statistically significance was observed in olive moment (p=0.0203) and tail length (P<0.0001) between radiated and non-irradiated groups. Apoptotic DNA diffusion index did not show much difference between non-radiated and radiated groups. However DNA diffusion was higher in radiated group and was statistically significant (P<0.0001). From the study it can be concluded that the increase in the frequency of DNA damage after electron beam irradiation may be due to the release of unbound acids because of chain breakage and due to the release of fluoride ions. Further studies are required to study the exact mechanism involved in genotoxicity .

Savitha S.,KVG Dental College | Sharma S.M.,AB Shetty Dental College | Veena S.,KSHEMA | Rekha R.,Kvg Medical College
Indian Journal of Plastic Surgery | Year: 2015

Background: The bone morphogenetic protein (BMP) signalling pathway is crucial in a number of developmental processes and is critical in the formation of variety of craniofacial elements including cranial neural crest, facial primordium, tooth, lip and palate. It is an important mediator in regulation of lip and palate fusion, cartilage and bone formation. Aim: To study the role of mutation of BMP4 genes in the aetiology of non-syndromic cleft lip with or without palate (NSCL ± P) and identify it directly from human analyses. Materials and Methods: A case-control study was done to evaluate whether BMP4T538C polymorphism, resulting in an amino acid change of Val=Ala (V152A) in the polypeptide, is associated with NSCL ± P in an Indian paediatric population. Genotypes of 100 patients with NSCL ± P and 100 controls (in whom absence of CL ± P was confirmed in three generations) were detected using a polymerase chain reaction-restriction fragment length polymorphism strategy. Logistic regression was performed to evaluate allele and genotype association with NSCLP. Results: Results showed significant association between homozygous CC genotype with CL ± P (odds ratio [OR]-5.59 and 95% confidence interval [CI] = 2.85-10.99). The 538C allele carriers showed an increased risk of NSCL ± P as compared with 538 T allele (OR-4.2% CI = 2.75-6.41). Conclusion: This study suggests an association between SNP of BMP4 gene among carriers of the C allele and increased risk for NSCLP in an Indian Population. Further studies on this aspect can scale large heights in preventive strategies for NSCLP that may soon become a reality. © 2015 Indian Journal of Plastic Surgery.

Sreekantha,Manipal University India | Manjunatha Goud B.K.,Manipal University India | Avinash S.S.,Father Muller Medical College | Amareshwara M.,KSHEMA | And 2 more authors.
International Journal of Pharma and Bio Sciences | Year: 2010

Psoriasis is regarded as a multifactorial disease in which interaction between genetic and environmental factors seem to play a causative role. Evidence is now accumulating that there is an association between Vitamin C, Vitamin E, Calcium, Phosphorus and psoriasis but the detailed mechanisms are not yet known. In the present study we estimated vitamin E, Vitamin C, Calcium and Phosphorus in 25 psoriatic patients and 25 age matched controls. We observed a very highly significant decrease in Vitamin E, Vitamin C and Calcium (p<0.001). It could be concluded from our study that decrease in above parameters are the probable causative agents for the pathogenesis of psoriasis.

Patil R.S.,MRMC | Nimbal N.V.,BIMS | Pratima S.,MRMC | Patil S.R.,MRMC | And 2 more authors.
International Journal of Pharma and Bio Sciences | Year: 2013

Thyroid gland disorders of various types; congenital, infectious, autoimmune, benign and malignant lesions. In the present study we have focused on all the disorders with special reference to age, sex, etiology, etiopathogenesis, complication and pathological diagnostic part of thyroid lesions. This study helps in the detection of thyroid lesions in the early diagnosis, treatment and assessment of prognosis of thyroid gland disorders.

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