Deralakatte, India
Deralakatte, India

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John B.,University of Bahrain | Bellipady S.S.,KS Hegde Medical Academy | Bhat S.U.,Kshegde Medical Academy
International Journal of Mental Health Promotion | Year: 2017

Study objectives: The present study evaluated the efficacy of sleep promotion program (SPP) on sleep hygiene practices, sleep quality, daytime sleepiness, and present functioning among adolescents. Methods: A two-arm, parallel, cluster randomized controlled trial was adopted. Participants were 660 adolescents aged 11–17(330 each in the intervention and control group). A socio-demographic questionnaire with sleep and activity items along with standardized questionnaires was used. Results: Significant improvements were observed in the experimental group after the intervention in the sleep hygiene practices, overall sleep quality and its sub-components like subjective sleep quality, sleep latency, and sleep efficiency at 2 weeks, and daytime sleepiness at 6 weeks. Other sleep quality components such as sleep duration, sleep disturbance, daytime dysfunction, and the present functioning compared did not statistically differ from the control group. Statistically significant positive correlations were observed between the target sleep variables. Sleep hygiene tends to deteriorate with higher grade level of adolescents, whereas sleep quality, sleep duration, and daytime sleepiness became worse with higher age and grade level. Conclusions: SPP holds a promise for improving healthy adolescents sleep behaviors. Interventions to improve emotional health could be explored in the future. © 2017 The Clifford Beers Foundation


Aroor A.R.,Kshegde Medical Academy | Rama Prakasha S.,JIPMER | Seshadri S.,Kasturba Medical College | Teerthanath S.,Kshegde Medical Academy | Raghuraj U.,Kshegde Medical Academy
Journal of Clinical and Diagnostic Research | Year: 2014

Background: Mediastinal tumours are uncommon lesions encountered in clinical practice. There has been a significant increase in the incidence of malignant mediastinal tumours over the past four decades. The presentation varies from asymptomatic lesions detected incidentally on imaging to severe life threatening presentations. Aim and Objectives: The study was conducted to assess the clinical characteristics, types, treatment modalities and outcome of mediastinal masses. Materials and Methods: In this two year prospective study, a total of 35 cases with or without symptoms of mediastinal mass, confirmed by Computed Tomography (CT) imaging were included. The results were expressed as percentages or proportions. Results: Maximum numbers of patients (25.71%) were seen in the 3rd decade and majority (94.3%) was symptomatic at presentation. Malignant lesions (68.57%) were more common than benign (31.43%) and lymphoma was the commonest malignant tumour (50%). Mediastinal widening on chest X-ray was seen in 27 cases (77.14%), pleural effusion and lung mass in 5 cases each (14.29%). On CT imaging and sub-classification, anterior mediastinum was the commonest compartment involved (42.86%). Conclusion: Mediastinal masses are usually symptomatic at presentation. Majority of the masses were malignant lesions and the symptoms of mediastinal obstruction was significantly higher in malignant lesions and anterior mediastinal masses. Lymphoma was the most frequent primary mediastinal mass and thymoma constituted the commonest benign anterior mediastinal tumour.


Sumangala V.,Mangalore University | Sumangala V.,SeQuent Scientific | Poojary B.,Mangalore University | Chidananda N.,Mangalore University | And 3 more authors.
Archives of Pharmacal Research | Year: 2010

A new series of substituted 1,2,3-triazoles (4a-n) were synthesized from 4-azido-2,8-bistrifluoromethylquinoline 2. The 1,3-dipolar cycloaddition reaction of 2 with ethyl acetoacetate afforded 1-(2,8- Bistrifluoromethylquinolin-4-yl)-5-methyl-1,2,3-triazole-4-carboxylic acid 3, which was then converted into its corresponding acid hydrazide 3a. Condensation of this hydrazide with different aromatic aldehydes resulted in the formation of Schiff's bases, N-[1-Arylmethylene]-1-[2,8-bistrifluoromethylquinoline-4-yl]-5- methyl-1H-1,2,3-triazole-4-carbohydrazides (4a-n). These newly synthesized 1,2,3-triazole derivatives were characterized by analytical and spectral data. All the synthesized compounds were evaluated in vitro for their antibacterial and antifungal activity. A brief investigation of the structure activity relationships revealed that the nature of the substituent on position 4 of the triazole ring influences the antimicrobial activity. Among the newly synthesized compounds, the most active compound was 4n, which contained the 3-methylthien-2-yl moiety and showed a broad spectrum of antimicrobial activity against all the strains used for testing. Compounds 4b, 4c, 4e, 4f, 4h and 4l showed significant antimicrobial activity at the concentration of 6.25 μg/mL. © 2010 The Pharmaceutical Society of Korea and Springer Netherlands.


Hariprasad P.,Kasturba Medical College | Hariprasad S.,Raja Rajeswari Medical College | Srinivas T.,Kshegde Medical Academy | Jayrama Shetty K.,Ks Hegde Medical Academy
Journal of Clinical and Diagnostic Research | Year: 2013

Primary fallopian tube carcinoma is an extremely uncommon neo- plasm of the female genital tract. Primary Fallopian Tube Carcinoma (PFTC) has a clinical and a histological resemblance to Epithelial Ovarian Cancer (EOC). We are reporting a case of PFTC in a 55 year old tubectomized, postmenopausal woman with the non-spe- cific complaints of a watery vaginal discharge and lower abdomi- nal pain. The clinical and radiological findings suggested a bilateral tubo-ovarian abscess. On laprotomy, a bilateral fallopian tube tu- mour was seen, with a focal extension to the surface of the right ovary from the right fallopian tube. Total abdominal hysterectomy, bilateral adnexectomy andomentectomy, along with excision of the draining lymph nodes, was done. The histopathological examina- tion revealed a bilateral papillary serous carcinoma of the fallopian tube. The patient was treated with adjuvant chemotherapy with Paclitaxel. There was no evidence of any recurrence, after 2 years of regular follow up. The clinical signs and symptoms of fallopian tube neoplasms are usually non-specific. The primary treatment remains a surgical resection, followed by adjuvant chemotherapy or radiation. The prognosis is poor, although long-term survivors have been reported.


Hariprasad S.,Raja Rajeswari Medical College | Hariprasad P.,Kasturba Medical College | Srinivas T.,Kshegde Medical Academy
Journal of Clinical and Diagnostic Research | Year: 2013

Carcinoma of the male breast is a relatively rare disease that accounts for less than 1% of all the cases of cancer in men. Intracystic Papillary Carcinoma (IPC) is an extremely rare disease of the male breast, with a few case reports. The prognosis is excellent for the patients who are diagnosed with IPC, regardless of whether the tumour is in-situ or of an invasive type. We are reporting the case of a 50 year old man who presented with a painless cystic lump in the left breast. Ultrasonography revealed an intracystic tumour. Fine needle aspiration suggested a papillary tumour. The patient underwent simple mastectomy without a sentinel lymph node biopsy. The final pathologic examination revealed an intracystic papillary carcinoma of a low nuclear grade without an invasion.


PubMed | Consultant Orthopaedic Surgeon, Aware Global Hospitals and Kshegde Medical Academy
Type: Journal Article | Journal: Journal of clinical and diagnostic research : JCDR | Year: 2017

Bone tunnel enlargement after Anterior Cruciate Ligament Reconstruction (ACL-R) is a well-accepted phenomenon but there are very few published data comparing the extent of tunnel widening by various methods of fixation after ACL-R.To compare the femoral and tibial tunnel widening following ACL-R with different methods of fixation using CT scan.This one year prospective study included all patients with chronic Anterior Cruciate Ligament (ACL) injury who underwent primary arthroscopic ACL-R using tripled hamstring tendon autograft. The graft was fixed to the tibial tunnel by Interference Screw (IFS) or Suture Disc (SD) and to the femoral tunnel by IFS, SD, Cross-Pin (CP) or Endo-button CL (Smith & Nephew). The widening of the tibial and femoral tunnels in different methods of fixation was assessed by Computed Tomography (CT) at 12 months follow-up; and was compared using paired sample test.A total of 63 patients were included in the study of which 58 (92%) were males and 5 (8%) were females, with a mean age of 29.1 5.9 years. The tibial tunnel widening at one year follow-up was 1.680 1.08794 (19.37%) and 1.517 0.94834 mm (17.39%) by IFS and SD methods respectively. Femoral tunnel widening at one year follow-up was 1.294 0.231, 1.809 0.912, 1.320 0.238, 1.779 0.889 mm by IFS, SD, EB, and CP methods respectively. Femoral tunnel widening following suture disc method of fixation was very highly significant (p<0.001) in comparison with other methods.Femoral tunnel and tibial tunnel widening varies with different methods of fixation and was maximum with suture disc method compared to others at one year follow-up after ACL-R.


Girisha B.S.,Kshegde Medical Academy
Kathmandu University Medical Journal | Year: 2013

Incontinentia pigmenti is an X-linked dominant condition characterized by cutaneous lesions associated with developmental defects of the eye, skeletal system and central nervous system. We report a case of incontinentia pigmenti in a 30 day old female infant who presented to us with skin eruptions over bilateral upper limbs, lower limbs and trunk since birth. She had linear verrucous plaques and vesicles distributed along the Blaschko's lines in addition to macular hyperpigmentation in a linear and whorled pattern involving the concerned areas. On ophthalmological examination, proliferative retinopathy in the right eye was noted.


Asha Pai K.B.,Kshegde Medical Academy | Rai R.,Kshegde Medical Academy | Sanjeev H.,Kshegde Medical Academy | Karnaker V.K.,Kshegde Medical Academy | Krishna Prasad M.S.,Kshegde Medical Academy
Journal of Clinical and Diagnostic Research | Year: 2011

Introduction: Escherichia coli have been implicated as the commonest organism causing uncomplicated cystitis. The frequent irrational use of antibiotics has led to an increased prevalence of resistance to commonly used antibiotics like cotrimoxazole, Fluoroquinolones and β-lactams. Alternative antibiotic compounds are needed to treat such infections. This study was conducted to assess the prevalence of antimicrobial resistance among Escherichia coli causing cystitis and evaluate the sensitivitity of these strains to nitrofurantoin. Material and methods: Three hundred and thirty two strains of Escherichia coli obtained from 2293 fresh midstream urine samples were included in the study. Antibiotic sensitivity testing was done by Kirby Bauer disc diffusion method according to CLSI guidelines Results: Seven hundred and thirty six (32.09%) cases showed significant bacteriuria. A significant number of Escherichia coli isolates were found to be resistant to ciprofloxacin (72.59%), Norfloxacin (73.49%) and cotrimoxazole (71.38%). Over 90% of the strains were sensitive to nitrofurantoin. Two hundred and seventeen isolates (65.36%) were found to be ESBL producers by phenotypic confirmatory test. The ESBL producing isolates showed a high rate of sensitivity to ertapenem (96.77%), nitrofurantoin (88.94%) and amikacin (83.41%). Conclusion: We consider that nitrofurantoin is a good alternative antibiotic to treat uncomplicated cystitis caused by antibiotic resistant Escherichia coli.


PubMed | Kshegde Medical Academy
Type: Case Reports | Journal: Kathmandu University medical journal (KUMJ) | Year: 2013

Incontinentia pigmenti is an X- linked dominant condition characterized by cutaneous lesions associated with developmental defects of the eye, skeletal system and central nervous system. We report a case of incontinentia pigmenti in a 30 day old female infant who presented to us with skin eruptions over bilateral upper limbs, lower limbs and trunk since birth. She had linear verrucous plaques and vesicles distributed along the Blaschkos lines in addition to macular hyperpigmentation in a linear and whorled pattern involving the concerned areas. On ophthalmological examination, proliferative retinopathy in the right eye was noted.


PubMed | Kshegde Medical Academy
Type: Journal Article | Journal: Journal of clinical and diagnostic research : JCDR | Year: 2014

A 39-year-old nulliparous female was admitted with massive splenomegaly. Computed tomography of abdomen revealed multiple aneurysms in the distal half of the splenic artery. Splenic artery aneurysms are rare in nulliparous women and most cases are reported in females with a past history of pregnancy. Splenic artery aneurysms, though very rare are clinically significant as they have a high propensity for fatal rupture. Here, we report a patient with multiple splenic artery aneurysms presenting as extrahepatic portal hypertension and massive splenomegaly.

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