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Mangalore, India

Raveendra U.S.,KS Hegde Medical Academy
Indian Journal of Anaesthesia

Fibreoptic-guided endotracheal intubation skill is a strongly desirable attribute of an anaesthesiologist, essential to deal with difficult airway situations. Facilities for formal training in this crucial area are limited. Various aspects of the available and desirable training in fibreoptic endoscopic skills are discussed. © 2011. Source

Fernandes M.S.,KS Hegde Medical Academy | Bhat R.M.,Fr Muller Medical College
International Journal of STD and AIDS

In this study, 100 HIV-positive cases (63 men, 37 women) with skin findings were included. The mean CD4 T cell count was 253 cells/mm3. A total of 235 dermatological manifestations were seen. The common infectious dermatoses were candidiasis (21%), Staphylococcal skin infections (20%), dermatophytoses (14%) and herpes zoster (6%). Among the non-infectious dermatoses were papular pruritic eruptions (20%), xerosis/ichthyosis (20%) and seborrhoeic dermatitis (16%). Statistically significant association (p < 0.05) with CD4 T cell count was seen in pyodermas, dermatophytoses and papular pruritic eruptions. Adverse drug reactions, diffuse hair loss, straightening of hairs and pigmentary changes were also noted. Although there was an absence of Kaposi’s sarcoma in our study, a case of verrucous carcinoma of penis was noted. © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav Source

Sathyanarayana Rao K.N.,KS Hegde Medical Academy | Subbalakshmi N.K.,Kasturba Medical College
Singapore Medical Journal

Introduction: The need for the rational development of newer and adjuvant drugs to treat epilepsy has prompted this study of the potential anticonvulsant effect of amlodipine. Methods: The acute effect was studied in mice in single doses of 1 mg/kg, 2 mg/kg and 4 mg/kg of amlodipine and the chronic effect was studied in doses of 1 mg/kg and 4 mg/kg (administered daily for 21 days) using the maximal electroshock seizure and pentylenetetrazole-induced seizure models of epilepsy. Sodium valproate and normal saline were used as the standard and control, respectively. Results: For the acute study, in the maximal electroshock seizure model, the administration of 1 mg/kg of amlodipine resulted in the complete abolition of seizures in 33 percent of the mice, and this was increased to 67 percent with the administration of 4 mg/kg. In the pentylenetetrazole-induced seizure model, the administration of 1 mg/kg and 2 mg/kg amlodipine protected 33 percent of the animals from mortality, and 67 percent were protected with the administration of 4 mg/kg. For the chronic study, in the maximal electroshock seizure model, the administration of 1 mg/kg amlodipine resulted in the complete abolition of seizures in 40 percent of the mice and in 60 percent, with the administration of 4 mg/kg. In the pentylenetetrazole-induced seizure model, 50 percent of the mice were protected from mortality with 1 mg/kg amlodipine and 60 percent, with 4 mg/kg amlodipine. Conclusion: These f indings indicate that amlodipine may be a good candidate as an add-on therapy for epilepsy. Source

Puttige K.,KS Hegde Medical Academy | Nooralabettu K.P.,P.A. College
Food Science and Biotechnology

Hepatopancreatic tissues of shrimps were homogenized at various pestle speed and time intervals at a constant jerk of 15 passes/min on a narrow space using 0. 1 M Tris-HCl buffer of pH 8. 4 at 4°C. Release of proteins and alkaline phosphatase were determined by estimating the quantity of protein and alkaline phosphatase activity in each homogenate at the end of the experiments. Optimum condition for the homogenization of the hepatopancreatic cells was achieved at operating speeds of 3,000 rpm for 10 min in the homogenizer. Increase in pestle speed beyond 3,000 rpm for 10 min have no effect on the release of protein. Increasing the disruption speed above 3,000 rpm decreases the specific activity of alkaline phosphatase release, while extending the time of homogenization beyond 10 min at 3,000 rpm or the speed of pestle beyond 3,000 rpm for 10 min caused shear damage to the enzyme. © 2012 The Korean Society of Food Science and Technology and Springer Netherlands. Source

Jain A.,Manipal University India | Vinod Bhat H.,Manipal University India | Acharya D.,KS Hegde Medical Academy
Indian Journal of Pediatrics

Objective: To determine the prevalence and to study the socio-demographic correlates of bronchial asthma among children aged 6-15 yr. Methods: This is a cross-sectional community based study conducted by interview of parents of randomly selected 559 children using an International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire. Results: The prevalence of bronchial asthma was found to be 10.3%. The prevalence of asthma was higher among boys (12.1%). There was a significant inverse linear trend with increasing age. A statistically significant association of bronchial asthma with family history of asthma was also observed. Conclusion: There is a high prevalence of bronchial asthma among children with a higher prevalence among boys than girls. There were significant inverse linear association with increasing age and also with family history of asthma. Efforts should be directed towards screening and early detection among the children, especially those of parents with history of asthma to enable treatment and reduce morbidity. © 2010 Dr. K C Chaudhuri Foundation. Source

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