Indore, India
Indore, India

Krishna University was established in Machilipatnam Krishna district Andhra Pradesh, India, in 2008. It was established by the state of Andhra Pradesh. Facilities include laboratories, internet, reading room, guest house, and extra-curricular activities. Wikipedia.

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Phatak R.S.,Krishna University
Journal of Pharmaceutical Negative Results | Year: 2016

Objective: The main objective was to explore the anthelmintic capacity of Kalanchoe pinnata (K. pinnata). Materials and Methods: Petroleum ether and methanolic extracts of K. pinnata were extracted by maceration methods. Both the extracts were investigated for their anthelmintic activity against Pheretima posthuma. Different concentrations of 25 mg/mL, 50 mg/mL, 100 mg/mL, and 200 mg/mL of both extracts were studied by determining time of paralysis (PT) and time of death (DT) of the earthworms. Results: Both the extracts have exhibited no anthelmintic activity even at the highest concentration of 200 mg/mL. A concentration of 15 mg/mL of albendazole was used as standard reference or positive control while normal saline was used as negative control. Conclusion: This study has revealed that in vitro anthelmintic activity of K. pinnata leaves lacks anthelmintic property. Both the extracts of this plant have displayed no vermicide activity against the earthworms used in the study. © 2016 Journal of Pharmaceutical Negative Results | Published by Wolters Kluwer - Medknow.


In this study, we report a fast and eco-friendly method employing the use of sun dried leaves extract of Kalanchoe pinnata (SDKP) for sunlight induced phyto-synthesis of silver nanoparticles. Aqueous extract of SDKP was produced and subjected to phytochemical investigations for determination of alkaloids, phenolics, flavonoids, steroids, glycosides and saponin. Sunlight induced green synthesis of silver nanoparticles was performed by treating the aqueous extract with silver nitrate in different ratios. The reaction was optimized by varying reaction time, temperature. The silver nanoparticles produced were subjected to physicochemical characterization in terms of UVVis Spectroscopic studies, Fourier Transform Infra Red spectroscopy (FTIR), Scanning electron microscope, Energy Dispersive Spectroscopy (SEM-EDX), Differential Scanning Calorimetry (DSC), Thermogravimetric Analysis (TGA) and Differential Thermal Analysis (DTA), Particle Size Analysis (PS), X-Ray Diffractometer (XRD), X-Ray Diffractometer (XRD), Atomic Absorption Spectroscopy (AAS) and photocatalytic degradation of methylene blue dye. Silver nitrate solution (6 mM) and aqueous extract of SDKP (4% w/v) produced silver nanoparticles of desired properties. The rate of reduction was accelerated within 10 min when the mixture was irradiated with sunlight. This green synthesis was performed at normal pH and room temperature. Silver nanoparticles bear the desired physicochemical properties in terms of optical, structural, thermal and photocatalytic properties. The study provides herein a green approach utilizing sunlight for development of silver nanoparticles using bioactive SKDP plant extract envisages potentiating of therapeutic efficiency of silver nanoparticles. The green approach for development of silver nanoparticles as discussed herein suggests it's applicability for synthesis of other metallic particles.


Phatak R.S.,Krishna University | Hendre A.S.,Krishna University
International Journal of PharmTech Research | Year: 2015

Aim and Objectives: In the present study, we have been successively extracted from methanolic extract of Kalanchoe pinnata into three successive different fractions like flavonoid rich fraction, saponin rich fraction and phenolics rich fraction to evaluate in-vitro models of antioxidant and anti-radical activities. Till date the correlation analysis between various parameters of Kalanchoe pinnata has been not reported. To our knowledge it may be first reported in the current research work. Material and Methods: Different fractions of Kalanchoe pinnata were extracted successively and were evaluated for their total phenolic and flavonoid contents. Antioxidative abilities of these fractions individually were analyzed by Phosphomolybdenum Assay (PMA), Cupric ions Reducing Antioxidant Capacity (CUPRAC) and Ferric ions Reducing Ability Power (FRAP) methods. The free radical scavenging activities such as hydroxyl, DPPH, and anti-peroxidation like Thiobarbituric Acid Reactive Substance (TBARS), Metal Chelation Capacity (MCC) were assayed through in-vitro models. Results: Antioxidant and antiradical effects of different fractions of Kalanchoe pinnata were ascertained through different in-vitro models. Results of individual tests demonstrated good correlation among themselves. In the correlation analysis, total flavonoids content has found to be negative correlation with all assays. Apart from total flavonoid contents, TBARS and DPPH assays have well correlated positively with other assays. Conclusion: Methanolic extract of Kalanchoe pinnata and its successive fractions were performed at various concentrations using in vitro models of antioxidant assays studied. From these results, revealed Kalanchoe pinnata exhibited significant antioxidant activity and free radical-scavenging activity. However, further evaluation of their isolated bioactive compounds, antioxidant activities should be investigated. © 2015, Sphinx Knowledge House. All right reserved.


Prasad C.J.,Krishna University | Aryasri A.R.,Jawaharlal Nehru Technological University
International Journal of Retail and Distribution Management | Year: 2011

Purpose: Retailing in India is an unchartered territory. Food and grocery is the most promising area for setting up retail business in India. An understanding of shopper retail format choice behaviour will enable retailers to segment their market and target specific consumer groups with strategies premeditated to meet their retail needs. The purpose of this paper is to make a detailed study on the effect of shoppers' demographic, geographic and psychographic dimensions in terms of format choice behaviour in the fast growing Indian food and grocery retailing. Design/methodology/approach: Descriptive research design is adopted applying mall intercept survey method using structured questionnaire for data collection. Both descriptive (mean and standard deviation) and inferential statistical tools like χ2, factor analysis and multivariate analysis are used to analyse the data collected from 1,040 food and grocery retail customers from upgraded neighbourhood kirana stores, convenience stores, supermarkets and hypermarkets in conjoint cities of Secunderabad and Hyderabad in Andhra Pradesh in India. Findings: The findings suggest that shoppers' age, gender, occupation, education, monthly household income, family size and distance travelled to store have significant association with retail format choice decisions. The choice decisions are also varied among shoppers' demographic attributes. The findings from shoppers' psychographic dimensions like values, lifestyle factors and shopping orientations resulted in segmentation of food and grocery retail consumers into hedonic, utilitarian, autonomous, conventional and socialization type. Practical implications: The study has practical implications for food and grocery retailers for better understanding the shopper behaviour in the context of changing consumer demographic and psychographic characteristics in an emerging Indian retail market. The findings may help the retailers to segment and target the food and grocery retail consumers and, as a consequence, to undertake more effective retail marketing strategies for competitive advantage. Originality/value: Given the absence of published academic literature and empirical findings relating to store format choice behaviour in food and grocery retailing in India, this study may serve as a departure point for future studies in this area of concern. The research is also relevant to retail marketers in terms of format development and reorientation of marketing strategies in the fastest growing Indian retail market. © Emerald Group Publishing Limited.


Jayasankaraprasad C.,Krishna University
Journal of International Consumer Marketing | Year: 2014

The evolution of store formats and the resultant consumers' cross-shopping behavior has been the prevalent trends in Indian food and grocery retailing. More recently, however, the growing incidence of cross-format shopping-defined as consumers shopping regularly at each of two or more types of grocery retail outlets-has become a subject of research, as it is regarded as a necessary evil associated with concentric retail growth. The aim of the article is to identify factors influencing consumers' cross-format shopping in relation to four retail formats-kirana stores, convenience stores, supermarkets, and hypermarkets. Furthermore, it investigates the impact of identified factors on repatronage behavior relative to four types of retail outlets. The mall intercept survey method was used to collect data from 1,040 adult food and grocery consumers. Results from exploratory factor analysis and zero-order correlation matrix indicate that value for money, value for time, shopping situations, shopping motives, and store attributes are significant and positively correlated with cross-format shopping. The multiple discriminant analysis provides empirical support, suggesting that value for money, task definitions, value for time, shopping trip pattern, basket size, price-conscious and local shopping motives, price promotions, customer service, store environment, distance to store, and monthly household income are not only the significant predictors but also able to discriminate repatronage intentions toward four types of retail outlets in an emerging retail market. The present study provides useful information on consumers' intertype cross-shopping (e.g., crossing from kirana store type to supermarket type and vice versa) between four types of grocery retail outlets. © 2014 Copyright Taylor and Francis Group, LLC.


Bodiga V.L.,Krishna University | Eda S.R.,Koneru Lakshmaiah College of Engineering | Bodiga S.,Koneru Lakshmaiah College of Engineering
Heart Failure Reviews | Year: 2014

Increasing evidence demonstrates that advanced glycation end products (AGEs) play a pivotal role in the development and progression of diabetic heart failure, although there are numerous other factors that mediate the disease response. AGEs are generated intra- and extracellularly as a result of chronic hyperglycemia. Then, following the interaction with receptors for advanced glycation end products (RAGEs), a series of events leading to vascular and myocardial damage are elicited and sustained, which include oxidative stress, increased inflammation, and enhanced extracellular matrix accumulation resulting in diastolic and systolic dysfunction. Whereas targeting glycemic control and treating additional risk factors, such as obesity, dyslipidemia, and hypertension, are mandatory to reduce chronic complications and prolong life expectancy in diabetic patients, drug therapy tailored to reducing the deleterious effects of the AGE-RAGE interactions is being actively investigated and showing signs of promise in treating diabetic cardiomyopathy and associated heart failure. This review shall discuss the formation of AGEs in diabetic heart tissue, potential targets of glycation in the myocardium, and underlying mechanisms that lead to diabetic cardiomyopathy and heart failure along with the use of AGE inhibitors and breakers in mitigating myocardial injury. © Springer Science+Business Media 2013.


Kshirsagar V.Y.,Krishna University
Acta medica academica | Year: 2012

Pycnodysostosis is a rare autosomal recessive disorder whose gene responsible for this phenotype (CTSK), mapped to human chromosome 1q21, code for the enzyme cathepsin K, a lysosomal cysteine protease; with an estimated incidence of 1.7 per 1 million births. This clinical entity includes micromelic dwarfism, increased radiological bone density, dysplasia of the skull, acro-osteolysis, straightening of the mandibular angle and in some cases, dysplasia of the acromial end of the clavicle. Oral and maxillo-facial manifestations of this disease are very clear. Herein we reported a case of pycnodysostosis, showing short stature with widening of the sutures, unfused anterior and posterior fontanelles, crowding of teeth with dental caries and typical radiological features associated with ichthyosis vulgaris and palmoplantar keratoderma. Copyright © 2012 by Academy of Sciences and Arts of Bosnia and Herzegovina.


Patent
Krishna University | Date: 2012-01-05

A set of color coded rings consisting of one subset of even numbers and other subset of odd numbers together is indicative of serially increasing cervical dilatation from 4 cm. to 9 cm. Vaginal examination with all aseptic precautions is to be carried out every 2 to 4 hours for each delivering woman. Size and color of the ring corresponding to actual cervical dilatation is to be identified. Next ring of the same color indicates expected cervical dilatation at the end of every 2 hours. If the expected cervical dilatation is not reached within the stipulated period of time, it indicates slow progress of labor and need for intervention/referral. It is an alternative for cervicograph which is easy to understand and use by clinical as well as para-clinical personnel during delivery.


A caliper to measure foot length and corresponding category of birth weight group by four colors used on the measuring scale namely. Green as normal, yellow as low, orange as very low and red as extremely low birth weight is devised for the first time to be used at the community level. A metal caliper with concavity to accommodate convexity of the heel and sliding device perpendicular to the scale to touch the longest toe fix the two extreme ends. Thus direct measurement is possible between two extreme ends of the foot.


Patent
Krishna University | Date: 2012-05-02

A simulating training device for assessment of cervical dilatation is provided. The device includes a supporting platform, a rotating plastic drum rigidly connected to a shaft and having a plurality of rubber-lined holes of varying diameters, a box which covers the rotating drum and has an opening, an indexing mechanism which has a spring-loaded lock and a slotted indexing wheel, a turn wheel which has an indication arrow, and a scale which identifies a diameter of each of the plurality of rubber-lined holes. Rotation of the turn wheel and the slotted indexing wheel causes one of the plurality of rubber-lined holes to be positioned in the center of the opening of the box one at a time. The turn wheel, the rotating drum and indexing mechanism are synchronized such that the indicating arrow of the turn wheel points to the diameter of the positioned hole on the scale.

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