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Jyothi B.,Krishna Teja Pharmacy College
Asian Journal of Pharmaceutical and Clinical Research | Year: 2013

Objectives: The present study was undertaken for investigating the protective effect of ethanolic extract of Mirabilis Jalapa Linn leaves on anti-tubercular drugs induced hepatotoxicity. Methods: Anti-tubercular drugs were used to induce hepatotoxicity in rats. Silymarin was used as standard drug (100 mg/kg p.o.). Ethanolic extract of leaves of Mirabilis Jalapa Linn (250 & 500 mg/kg p.o.) was administered along with one hour prior administration of anti-tubercular drugs once daily for 35 days. Results: Liver biomarkers such as SGOT, SGPT, ALP, TB, total cholesterol were elevated and total HDL were reduced on anti-tubercular drugs administration. The treatment of ethanolic extract of Mirabilis Jalapa Linn leaves 250 mg/kg and 500 mg/kg with anti-tubercular drugs were significantly reduced liver biomarker enzymes. Antioxidant parameters such as SOD, CAT, GSH, GPx and GRx were suppressed and increased TBARs levels in anti-tubercular drugs administration but restored these antioxidant levels in the treatment of ethanolic extract of Mirabilis Jalapa Linn leaves at a dose of 250 mg/kg and 500 mg/kg. Conclusion: The result of the present study was indicated that Mirabilis Jalapa Linn leaves showed protective effect on hepatotoxicity induced by anti-tubercular drugs. Source


Sekhar M.C.,Gurram Balanarasaiah Institute of Pharmacy | Sekhar M.C.,Jawaharlal Nehru Technological University | Jaya Chandra Reddy P.,Krishna Teja Pharmacy College
Molecular and Cellular Biochemistry | Year: 2012

Dyslipidemia is common in patients with type 2 diabetes. Statins are used as the first choice in treatment of diabetic dyslipidemia. Atorvastatin represents a first-line treatment option, alongside other hydroxyl methylglutaryl coenzyme A reductase inhibitors. Repaglinide is a short-acting, oral, insulin secretagogue that is used in the treatment of type 2 diabetes mellitus. Both the category of drugs undergo extensive metabolism with cytochrome enzyme system. This may lead to drug-drug interaction problems with altered repaglinide activity which is cautious. Repaglinide/atorvastatin/ atorvastatin + repaglinide were administered orally to normal, diabetic rats, and to normal rabbits. Blood samples were collected at different time intervals and were analyzed for blood glucose by GOD-POD method using commercial glucose kits and repaglinide estimation in plasma by HPLC method. Diabetes was induced by alloxan 100 mg/kg body weight administered by I.P route. In the presence of atorvastatin, repaglinide activity was increased and maintained for longer period in diabetic rats compared with repaglinide matching control. The present study concludes co-administration of atorvastatin was found to improve repaglinide responses significantly in diabetic rats and improved glucose metabolism of atorvastatin played an important role and increased repaglinide levels by competitive CYP 3A4 enzyme inhibition by atorvastatin could be added advantage for anti hyperglycemic activity. © Springer Science+Business Media, LLC. 2011. Source


Mohan Krishna L.,Krishna Teja Pharmacy College | Jayachandra Reddy P.,Krishna Teja Pharmacy College | Jaya Sankar Reddy V.,Krishna Teja Pharmacy College | Prasada Rao K.V.S.,Rahul Institute of Pharmaceutical science
Rasayan Journal of Chemistry | Year: 2011

Three simple and sensitive visible spectrophotometric methods (M 1, M2, and M3) have been described for the estimation of Ceftazidime (CTZ). The methods that are based on the formation of radical anion with the involvement of basic nitrogen in CTZ (donor) and quinones [2,3-dichloro-5,6-dicyano-p-benzoquinone(DDQ), chloranilic acid (DHQ), 2,3,5,6-tetrachloro-p-benzoquinone (TQ)] (acceptor). The variable parameters in all these methods have been optimized and the chemical reactions involved are presented. The results obtained in the three methods are statistically validated and recoveries range from 99.7 to 101.3%. Common excipients used in additives in pharmaceutical preparations do not interfere in die proposed methods. © 2011 RASAYAN. All rights reserved. Source


Krishna L.M.,Krishna Teja Pharmacy College | Reddy P.J.,Krishna Teja Pharmacy College | Rao K.V.S.P.,Rahul Institute of Pharmaceutical science
Asian Journal of Chemistry | Year: 2011

Simple spectrophotometric methods (A-C) for the assay of aripiprazole (APZ) based on the formation of its complex with alkaloidal precipitants are described. Aripiprazole under quantitative precipitation in the form of molecular complexes with iodine (method A), ammonium molybdate (method B) or phosphomolybdic acid (method C) when used in excess. In addition to precipitation reactions, colour reactions have also been combined to estimate aripiprazole. They are based on the colour formation with either unreacted precipitant of the filtrate (I2) or released precipitant from the molecular complex (method B or C) with chromogenic reagent such as P-N-methyl amino phenol sulphate-sulphanilic acid (method A), potassium thiocyanate (method B), cobalt nitrate Co(II)-disodium salt of ethylene diamine tetra acetic acid complex (method C). Source


Shaik S.,Krishna Teja Pharmacy College | Rajendra Y.,Krishna Teja Pharmacy College | Jaya Chandra Reddy P.,Krishna Teja Pharmacy College
International Journal of Pharmacy and Technology | Year: 2012

Mirabilis Jalapa L. is a perennial herbal medicinal plant, has a long traditional uses. Various constituents are found in different parts of the plants. The active chemical constituents reported from this plant are alkaloids, flavonoids, phenols, glycosides, tannins, saponins, lignins, carbohydrates. In conventional medicine, the plant is used in treatment of skin diseases, carminative, cathartic, purgative, stomachic, tonic and vermifuge properties, anti-dysenteric, anti-parasitic, wound healer, digestive stimulant. Its various extracts reported number of pharmacological activities such as anti-diabetic, anti-inflammatory, anti-oxidative, antibacterial, anti-microbial, anti-fungal, anti-spasmodic, antinociceptive, anti-viral, diuretic, anthelmentic and urinary tract disorder. The present review is therefore an effort to give a detailed survey of the literature on its pharmacognosy, phytochemical and its traditional uses along with special emphasis given on pharmacological activities. Source

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