Juneja M.,Krishna Dental College
Microscopy Research and Technique | Year: 2012
Background: The early detection of neoplasia is the prime aim of a diagnostician. Altered chromatin distribution is the earliest microscopic change observed in malignant transformation making it a valuable morphometric parameter. This study was aimed to assess and correlate the progressive changes in chromatin texture from normal to varying grades of premalignancies to malignancy of the oral cavity. Methods: Thirty-four archival tissue specimens categorized as normal buccal mucosa (5), low-grade epithelial dysplasia (11), high-grade epithelial dysplasia (7), and squamous cell carcinoma (11) were stained with Feulgen reaction. Pixel optical densitometry histograms were obtained from analysis of an average of 300 cells/case using ImageJ software. Nine histogram curve characteristics (including area under the curve, area integer percentage, center, centroid) were then analyzed statistically for differences between the four groups. Results: Area integer percentage (P = 0.002), center (P = 0.038), and centroid (P = 0.021) were statistically significant within the four groups The parameters showed a dip in their value from normal to low-grade dysplasia but showed a steady increase in high-grade dysplasia and carcinoma. Conclusion: The optical density characteristics had the ability to differentiate the progression of neoplastic changes by extracting information of the chromatin distribution not quantifiable by routine microscopy. The early clumping of chromatin in the periphery in low-grade dysplasia followed by progressively increasing chromatin aggregates in high-grade dysplasia and carcinoma correlated well with the shift observed in the histogram center and centroid. The novel pixel optical densitometry technique efficiently predicted malignant transformation. © 2012 Wiley Periodicals, Inc.
Pathak S.,Sri Ram Murti Medical College |
Vashisth S.,Kalka Dental College |
Mishra S.,District Hospital Moradabad |
Singh S.P.,Krishna Dental College |
Sharma S.,Sri Sai Dental Clinic
Journal of Clinical and Diagnostic Research | Year: 2014
Background: Extraction of mandibular third molars are somewhat a matter of interest because of its malpositioning, curved roots, proximity to vital structures due to this the procedure is often associated with post operative complications like pain and trismus. The extraction of third molar was classified in four grads according to the difficulty of the procedure. Aims: The purpose of this paper is to find any significant relationship between grading of extraction and post operative complications like pain and trismus. Materials and Methods: A total number of 180 patients need to go for extraction of third molar was included in the study. The variables taken into account were grading of extraction, pain six hour post operatively trismus one day after extraction, and trismus five day after extraction. The four grades of extractions as described by Parent in 1974 were statistically analyzed by computing pearson product moment correlation coefficient with post operative pain and trismus first and fifth day to find any co relation between them. Results: The grading of extraction was found significantly correlated with post operative pain, trismus one day after and fifth day of surgery.
Dudeja P.G.,ESIC Dental College and Hospital |
Grover S.,ESIC Dental College and Hospital |
Srivastava D.,ESIC Dental College and Hospital |
Dudeja K.K.,Krishna Dental College |
Sharma V.,ESIC Dental College and Hospital
Journal of Clinical and Diagnostic Research | Year: 2015
Pulpal regeneration after tooth injury is not easy to accomplish. In teeth with immature apices and exposed vital pulp tissue, partial or complete pulpotomy is indicated to preserve pulpal function and allow continued root development. In many cases, injury causes loss of pulp vitality and arrested root development leading to a tooth with poor crown root ratio, a root with very thin walls, an open blunderbuss apex and development of apical pathosis. The ideal treatment in such cases would be to obtain further root development and thickening of dentinal walls by stimulating the regeneration of a functional pulp dentin complex. This outcome has been observed after reimplantation in avulsed immature permanent teeth but has been thought impossible in a necrotic infected tooth. This case series evaluates the efficacy of revascularization procedure in immature, non vital permanent teeth. Pulp regeneration was attempted in four patients at Department of Conservative Dentistry, ESIC Dental College, New Delhi using blood clotting approach. The cases were treated and followed up regularly at regular intervals ranging from 6 months to 3 years to assess the treatment response clinically and radiographically. The patients remained clinically asymptomatic with three out of four patients even responding positively to pulp responsiveness tests. Radiographic examination also revealed increased root formation and thickening of dentinal walls. It was concluded that the triad of a disinfected canal, a matrix (blood clot) in to which new tissue could grow and an effective coronal seal produced the desirable environment for successful revascularization. © 2015, Journal of Clinical and Diagnostic Research. All Rights Reserved.
PubMed | Krishna Dental College, ESIC Dental College and Hospital and Dean College
Type: Journal Article | Journal: Journal of clinical and diagnostic research : JCDR | Year: 2015
Pulpal regeneration after tooth injury is not easy to accomplish. In teeth with immature apices and exposed vital pulp tissue, partial or complete pulpotomy is indicated to preserve pulpal function and allow continued root development. In many cases, injury causes loss of pulp vitality and arrested root development leading to a tooth with poor crown root ratio, a root with very thin walls, an open blunderbuss apex and development of apical pathosis. The ideal treatment in such cases would be to obtain further root development and thickening of dentinal walls by stimulating the regeneration of a functional pulp dentin complex. This outcome has been observed after reimplantation in avulsed immature permanent teeth but has been thought impossible in a necrotic infected tooth. This case series evaluates the efficacy of revascularization procedure in immature, non vital permanent teeth. Pulp regeneration was attempted in four patients at Department of Conservative Dentistry, ESIC Dental College, New Delhi using blood clotting approach. The cases were treated and followed up regularly at regular intervals ranging from 6 months to 3 years to assess the treatment response clinically and radiographically. The patients remained clinically asymptomatic with three out of four patients even responding positively to pulp responsiveness tests. Radiographic examination also revealed increased root formation and thickening of dentinal walls. It was concluded that the triad of a disinfected canal, a matrix (blood clot) in to which new tissue could grow and an effective coronal seal produced the desirable environment for successful revascularization.
Garg A.,Krishna Dental College |
Pandey A.,SN Medical College |
Oza P.,SN Medical College |
Chaturvedi M.,SN Medical College
National Journal of Physiology, Pharmacy and Pharmacology | Year: 2013
Aspirin is a highly successful antiplatelet drug & still retains its status as the 'front-line' antiplatelet drug; however, increased understanding of platelet biology has led to the development of new antiplatelet drugs that are potentially more effective. Now, more researches in platelet biology has led to this fact that there are more than 90 other metabolic pathways leading to platelet aggregation that are independent of arachidonic acid and therefore not inhibited by aspirin, hence, several more drugs are being developed, aimed at controlling different phases of platelet function such as platelet aggregation & adhesion. The newer drugs now offer potentially greater and more specific control over platelet function. Definitely, these drugs are going to be significantly more expensive than aspirin, and their eventual role in the clinical arena will ultimately depend on both their efficacy and their cost-effectiveness. As we approach the next millennium, it is envisaged that our increased understanding of platelet function, coupled with advances in technology and drug manufacture, will result in even greater improvements in the therapeutic control of platelet thrombus.
PubMed | ESIC Dental College and Krishna Dental College
Type: Journal Article | Journal: Journal of oral and maxillofacial pathology : JOMFP | Year: 2016
There is no greater association between the basic science and the practice of endodontics than that of microbiology. One of the strongest factors contributing to the controversies often encountered in the endodontic field is the lack of understanding that the disease processes of the pulp and periradicular tissues generally have a microbiological etiology. The vast majority of diseases of dental pulp and periradicular tissues are associated with microorganisms. After the microbial invasion of these tissues, the host responds with both nonspecific inflammatory responses and with specific immunologic responses to encounter such infections. The aim of this study is to fill the gaps in our knowledge regarding the role of microorganisms in endodontics and to discuss in depth whether their presence in periradicular lesions is a myth or a reality. An electronic search was carried out on PubMed database (custom range of almost 50 years) and Google using specific keywords and phrases. Inclusion and exclusion criteria were specified and around 50 articles were found suitable for inclusion. Full text of all the articles was retrieved and studied. Appropriate data were extracted and pooled and finally synthesized. It is important to understand the close relationship between the presence of microorganisms and endodontic disease process to develop an effective rationale for treatment.
Chhabra N.,Krishna Dental College
Minerva stomatologica | Year: 2012
Dental anxiety and fear pose a considerable challenge for the practice of clinical dentistry as these are problematic entities in the management of child patients and present a potential barrier to the utilization of oral health care services. The aim of this study was to estimate the prevalence of dental anxiety and fear among the 5-10 years aged Indian child population. A total of 523 children aged 5-10 years and their parents, visiting Krishna Dental College, Ghaziabad, India were finally recruited in this study. Dental Fear/anxiety distribution in the children was studied using the Indian parent's version of the Dental Subscale of the Children's Fear Survey Schedule (CFSS-DS). Total fear scores were calculated separately for boys and girls and at different age levels. The collected data was statistically analyzed using a SPSS statistical program. The estimated prevalence of dental anxiety among 5 to 10 year old children in the study population was 6.3%. The overall median CFSS-DS score was 23 and the overall mean value of CFSS-DS score was 24. The prevalence of dental anxiety in children aged 5 years was 7.9%, 7.1% for 6 years old, 6.6% in 7 years old, 6.5% in 8 years old, 6.3% for 9 year old children and 5.8% in children aged 10 years. No statistically significant gender differences were found in the dental anxiety scores. The most fear provoking situations were the sight of injections, the drilling procedures by the dentist, touch of a stranger and noise of drilling by the dentist. The results of this study indicate the need for preventive health education and intervention programmes in India to prevent and reduce dental anxiety/fear and to promote children's oral health.
Garg H.,Sharda University |
Bedi G.,Sharda University |
Garg A.,Krishna Dental College
Journal of Clinical and Diagnostic Research | Year: 2012
The aim of the present review was to elaborate on the surface modifications of biomaterials which are used in implant dentistry. The ongoing studies on the clinical and laboratory phases and on the biomaterial sciences have largely aimed at invoking a stronger bone response and an earlier and longer functional loading. Surgical grafting procedures to improve the bone bed are used to create an ideal environment for the implant functioning. The implant selection which is based on the available bone, is also an important determiner of the long term clinical success. The interfacial zone between the implant and the bone is composed of a relatively thin layer (<100um) which consists of heterogenous metallic oxide, proteins and connective tissue. The integrity of the implant - tissue interface is dependent on the material and on mechanical, chemical, surface, biological and local environmental factors, all of which change as a function of time in vivo. Because a stable interface must be developed before the loading, it is desirable that the tissue apposition may be accelerated to the implant surface. The material developments that have been implemented in the clinical practice include the use of surface roughened implants and bioactive ceramic coatings. Osseointegration occurs around the screw threaded implants through the tissue ongrowth or through a direct apposition between the tissue and the implant surface. The alternative methods of the implant-tissue attachments, based on the tissue ingrowth into roughened or three dimensional surface layers, yield a higher bone metal shear strength and decreased implant loosening. A positive effect of various surface modifications which are illustrated in this review, has been observed and suggested by many groups.
Chhabra N.,Krishna Dental College |
Chhabra A.,Safdarjang Hospital
Journal of Dentistry for Children | Year: 2014
Immature necrotic teeth after trauma pose both endodontic and restorative challenges because of incomplete closure of the apex, and thin and weakened dentinal walls that make them prone to fracture. The use of light-transmitting plastic posts, in combination with adhesive materials, enable intraradicular reinforcement of flared canals, helping to rehabilitate fractured immature teeth and maintain a functional unit within the dental arch. The purpose of this paper is to present the case of a nine-year-old patient who had a complicated fracture of an immature anterior tooth, which was endodontically treated with mineral trioxide aggregate in the apical third. The dentinal root walls were successfully reinforced with composite resin and a light-transmitting glass fiber post, followed by the placement of a glass fiber composite post and a metal ceramic crown.
Chhabra N.,Krishna Dental College |
Chhabra A.,Safdarjang Hospital
European Archives of Paediatric Dentistry | Year: 2012
Aim: Preschool children are dependent upon their parents for their dental care. The aim of this study was to assess the knowledge, attitude and beliefs of parents towards oral health and dental care of their children aged 1-4 years in an Indian population. METHODS: Parents of 620 preschool children, who visited Krishna Dental College and Hospital, Ghaziabad, India for dental treatment were recruited into this study and completed a selfadministered questionnaire. RESULTS: It was revealed that the lack of knowledge and awareness of importance of the primary teeth, dental fear of the parents and the myths associated with dental treatment, created barriers to early preventive dental care of preschool children. The oral hygiene and feeding practices were found to be disappointing and the knowledge about the essential role of fluoride and transmission of Streptococcus mutans bacteria was found to be limited. The elders in the family, especially grandparents, highly influenced the decisions of the parents regarding dental treatment of their children. CONCLUSIONS: Parents' knowledge, attitudes and beliefs about the importance of dental health need to be improved. Coordinated efforts by paediatricians, paediatric dentists and other health professionals are required to impart dental health education about oral hygiene, feeding practices, importance of the primary dentition and to promote preventive dental programmes.