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Tanaka Y.,Hiroshima International University | Tanaka Y.,Hiroshima University | Inkyo M.,Kotobuki Industries Co. | Yumoto R.,Hiroshima University | And 3 more authors.
Drug Development and Industrial Pharmacy | Year: 2012

To improve the dissolution and oral absorption properties of probucol, a novel wet-milling process using the ULTRA APEX MILL was investigated. The particle size of bulk probucol powder was 17.1 m. However, after wet-milling with dispersing agents such as Gelucire 44/14, Gelucire 50/13, vitamin E-TPGS, and Pluronic F-108, the probucol particle sizes decreased to about 77176nm. Scanning electron microscopy (SEM) analysis also suggested that the probucol particles were successfully milled into the nanometer range. An in vitro dissolution study showed that the dissolution rates of all nanopowders were several folds higher than those of the corresponding mixed powders. When orally administered to rats, the AUC values of probucol nanopowders treated with Gelucire 44/14 and 50/13, and vitamin E-TPGS were about 3.063.54-folds greater than that of the bulk powder. Therefore, through this study, we have developed a new pharmaceutical technique to improve the dissolution rate and oral absorption of probucol using the ULTRA APEX MILL by wet-milling with various dispersing agents. © 2012 Informa Healthcare USA, Inc.


Tahara T.,Kotobuki Industries Co. | Tahara T.,Hiroshima University | Imajyo Y.,Kotobuki Industries Co. | Nandiyanto A.B.D.,Hiroshima University | And 4 more authors.
Advanced Powder Technology | Year: 2014

The low-energy dispersion of nanomaterials in the bead-milling process is examined. The effect of milling parameters including bead size, rotation speed, and milling time on the dispersibility of fragile rod-type titanium dioxide nanoparticles is investigated. From experimental data obtained for the morphological, optical, and crystalline properties of dispersed nanoparticles, an unbroken primary particle dispersion in colloidal suspension was obtained only by conducting the bead-milling process using the optimum milling parameters. Deviation from the optimum conditions (i.e., higher rotation speed and larger bead size) causes re-agglomeration phenomena, produces smaller and ellipsoidal particles, and worsens crystallinity and physicochemical properties, especially the refractive index, of the dispersed nanoparticles. We also found that decreases in refractive index induced by the milling process are related to collisions forming broken particles and the amorphous phase on the surface of the particles. In addition, the present low-energy dispersion method is prospective for industrial applications, confirming almost no impurity (from breakage of the beads) was apparent in the final product. © 2014 The Society of Powder Technology Japan. Published by Elsevier B.V. and The Society of Powder Technology Japan. All rights reserved.


Tahara T.,Kotobuki Industries Co. | Inkyo M.,Kotobuki Industries Co. | Imajou Y.,Kotobuki Industries Co. | Ogi T.,Hiroshima University | Okuyama K.,Hiroshima University
Kagaku Kogaku Ronbunshu | Year: 2013

Titania nanoparticles were dispersed with a dual axis beads mill that enables nanoparticles to be dispersed with much lower energy than usual, and their dispersion characteristics were examined. In a recent study, titania nanoparti-cles were found to disperse to a primary nanoparticle size by evaluating the size and crystallinity of dispersed particles. In this study, the dispersed titania nanoparticles were further characterized by examining TEM, small angle X-ray scattering, ζ-potential, specifc surface area and optical properties. TEM revealed that the dispersion of titania nanopar-ticles at low energy gave the primary particle size without crushing the crystals, while dispersion at higher energy gave rise to coagulation of crushed titania nanoparticles of around 10 nm in size. Te large agglomerated nanoparticles were re-dispersed to around 10 nm by adding dispersant under the appropriate conditions to give a transparent titania slurry. © 2013 The Society of Chemical Engineers, Japan.


Inkyo M.,Kotobuki Industries Co. | Hagarty T.,Kotobuki Industries Co. | Arai T.,Marubeni Techno Systems America Inc.
Nanotechnology 2010: Advanced Materials, CNTs, Particles, Films and Composites - Technical Proceedings of the 2010 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2010 | Year: 2010

Kotobuki Industries has developed a new type of beads mill which has successfully solved many problems related to nanoparticle dispersion such as reaglomeration and damage to the crystal structure of nanoparticles. The Ultra Apex Mill uses centrifugation technology which enables the use of ultra small beads with a diameter of less than 0.05mm for the first time in the world. Now 0.015mm beads are available. This technology has pioneered practical applications for nanoparticles in various areas, such as composition materials for LCDs, ink-jet printing, ceramic condensers and cosmetics.


Inkyo M.,Kotobuki Industries Co. | Tahara T.,Kotobuki Industries Co. | Imajyo Y.,Kotobuki Industries Co.
IOP Conference Series: Materials Science and Engineering | Year: 2011

Two of the major problems related to nanoparticle dispersion with a conventional beads mill are re-agglomeration and damage to the crystalline structure of the particles. The Ultra Apex Mill was developed to solve these problems by enabling the use of ultra-small beads with a diameter of less than 0.1mm. The core of this breakthrough development is centrifugation technology which allows the use of beads as small as 0.015mm. When dispersing agglomerated nanoparticles the impulse of the small beads is very low which means there is little influence on the particles. The surface energy of the nanoparticles remains low so the properties are not likely to change. As a result, stable nanoparticle dispersions can be achieved without re-cohesion. The Ultra Apex Mill is superior to conventional beads mills that are limited to much larger bead sizes. The technology of the Ultra Apex Mill has pioneered practical applications for nanoparticles in various fields: composition materials for LCD screens, ink-jet printing, ceramic condensers and cosmetics. © 2011 Ceramic Society of Japan.


Patent
Kotobuki Industries Co. | Date: 2014-01-01

A straight-drum centrifugal dehydration device, wherein extraction of moisture from heavy phase built up in a bowl is facilitated to improve the dehydration effect, and compression efficiency is improved to achieve a reduced load. The straight-drum centrifugal dehydration device, wherein an outer peripheral surface of a rotary drum (21) of a screw conveyor (20) comprises a straight section (24) and a tapered section (25) that spreads outward and away from the straight section, the straight-drum centrifugal dehydration device having an inorganic flocculant feed path for feeding an inorganic flocculant to an inner peripheral surface of the straight section (24) of the rotary drum, and the straight section being provided with an inorganic flocculant addition nozzle (109) communicating with the inorganic flocculant feed path and projecting into an annular space of the bowl and an orifice (108) for adding the inorganic flocculant.


Patent
Kotobuki Industries Co. | Date: 2012-02-17

A straight-drum centrifugal dehydration device, wherein extraction of moisture from heavy phase built up in a bowl is facilitated to improve the dehydration effect, and compression efficiency is improved to achieve a reduced load. The straight-drum centrifugal dehydration device, wherein an outer peripheral surface of a rotary drum (21) of a screw conveyor (20) comprises a straight section (24) and a tapered section (25) that spreads outward and away from the straight section, the straight-drum centrifugal dehydration device having an inorganic flocculant feed path for feeding an inorganic flocculant to an inner peripheral surface of the straight section (24) of the rotary drum, and the straight section being provided with an inorganic flocculant addition nozzle (109) communicating with the inorganic flocculant feed path and projecting into an annular space of the bowl and an orifice (108) for adding the inorganic flocculant.

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