Kosuyolu Education and Research Hospital

İstanbul, Turkey

Kosuyolu Education and Research Hospital

İstanbul, Turkey

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Karadayi S.,Baskent University | Sen M.,Cumhuriyet University | Karadayi K.,Cumhuriyet University | Polat Z.,Cumhuriyet University | And 2 more authors.
Journal of B.U.ON. | Year: 2013

Purpose: There has been a long-standing interest in the identification of medicinal plants and derived natural products for developing anticancer agents. This work aimed at investigating the antiprolipherative properties of Origanum acutidens (OA) on breast cancer. Methods: OA water extracts were studied for cytotoxicity against the breast cancer cell lines MCF-7, MDA-MB-468 and MDA-MB-231. In vitro apoptosis studies of these cancer cell lines were performed by annexin V staining in flow cytometry analyses. Immunohistochemistry studies for Ki-67 and caspase-7 of tumor tissue sections of dimethylbenzanthracene (DMBA) -induced mammary cancer in rats were also performed. TUNEL assay was used to detect apoptotic cells of tumor tissue. In vivo anticancer activity testing was carried out by inhibiting the growth of DMBA-induced mammary cancer in rats. Results: OA showed cytotoxicity on all 3 cancer cell lines. Annexin-positive cells level in OA-treated cell lines were significantly higher compared with untreated control cells (p=0.002). The expressions of caspase-7 protein and TUNEL-positive cells were much higher for the rats treated by OA, compared with the untreated control group (p<0.05). The expressions of the Ki-67 decreased in the treated groups compared with the control group (p<0.05). In vivo studies showed that the mean tumor volume inhibition ratio in OA-treated group was 41% compared with the untreated rats (p<0.05). Conclusion: These results indicate that OA has antitumor activity against breast cancer cell lines.


PubMed | Samsun Education and Research Hospital, Ege University, Mersin University, Frat University and 4 more.
Type: Journal Article | Journal: Anatolian journal of cardiology | Year: 2016

The awareness, time in therapeutic range (TTR), and safety of warfarin therapy were investigated in the adult Turkish population.This multicenter prospective study includes 4987 patients using warfarin and involved regular international normalized ratio (INR) monitoring between January 1, 2014 and December 31, 2014. TTR was calculated according to F.R. Roosendaals algorithm. Awareness was evaluated based on the patients knowledge of warfarins affect and food-drug interactions.The mean TTR of patients was 49.5222.93%. The patients with hypertension (55.3%), coronary artery disease (23.2%), congestive heart failure (24.5%), or smoking habit (20.8%) had significantly lower TTR levels than the others. Of the total number of patients, 42.6% had a mechanical valve, 38.4% had non-valvular atrial fibrillation (AF), and 19% had other indications for warfarin. Patients with other indications had lower TTR levels than those with mechanical valve and non-valvular AF (p=0.018). Warfarin awareness decreased in higher age groups. The knowledge of warfarins food-drug interactions was 55%. People with higher warfarin awareness had higher TTR levels. Patients with 8 INR monitoring/year had lower TTR levels (46.425.3 vs. 51.121.3, respectively, p<0.001) and lower awareness (44.6% vs. 60.6%, p<0.001) than patients with 8 INR monitoring/year. In this study, 20.1% of the patients had a bleeding event (major bleeding 15.8%, minor bleeding 84.2%) within a year.Both the mean TTR ratios and awareness of the Turkish population on warfarin therapy were found to be low. It was thought that low TTR levels of the Turkish population may be caused by the low awareness of warfarin, warfarins food-drug interactions, and high rates of concomitant diseases.


Tepe B.,Cumhuriyet University | Tuncer E.,Cumhuriyet University | Saraydan S.U.,Cumhuriyet University | Ozer H.,Cumhuriyet University | And 9 more authors.
Molecular Biology Reports | Year: 2013

This work aims to investigate the antiproliferative properties of Allium sivasicum (AS) on breast cancer. AS extracts were studied for cytotoxicity against the breast cancer cell lines. In vitro apoptosis studies of breast cancer cells were performed by annexin V staining in flow cytometry analyses. AS showed cytotoxicity to three cancer cell lines. Annexin-positive cells level in AS treated cell lines were higher than the untreated control cells. The expressions of caspase-7 protein and TUNEL positive cells were much higher for the rats treated by AS, compared with the untreated control group. The expressions of the Ki-67 decreased in treatment groups compared with the control group. In vivo studies showed that mean tumor volume inhibition ratio in AS treated group was 38% compared with the untreated rats. These results indicate that A. sivasicum has antitumoral potential against breast cancer. © 2012 Springer Science+Business Media Dordrecht.


Saraydin S.U.,Cumhuriyet University | Tuncer E.,Cumhuriyet University | Tepe B.,Cumhuriyet University | Karadayi S.,Cumhuriyet University | And 8 more authors.
Asian Pacific Journal of Cancer Prevention | Year: 2012

Background: There is a long standing interest in the identification of medicinal plants and derived natural products for developing cancer therapeutics. Here we investigated the antiproliferative properties of Melissa officinalis (MO) from Turkey on breast cancer. Methods: MO extracts were studied for cytotoxicity against breast cancer cell lines (MCF-7, MDA-MB-468 and MDA-MB-231). In vitro apoptosis studies were performed by annexin V staining and flow cytometry analyses. Immunohistochemistry for Ki-67 and caspase 7 in the tumoral tissue sections of DMBA-induced mammary tumors in rats was also performed, along with TUNEL assays to detect apoptotic cells. In vivo anticancer activity testing was carried out with reference to inhibition of growth of DMBA induced mammary tumors in rats. Results: MO showed cytotoxicity against three cancer cell lines, inducing increase in Annexin-positive cells. Expression of caspase-7 protein and TUNEL positive cells were much higher in rats treated by MO, compared with the untreated control group, while expression of Ki-67 was decreased. Furthermore, in vivo studies showed that mean tumor volume inhibition ratio in MO treated group was 40% compared with the untreated rats. Conclusion: These results indicated that MO extrcts have antitumoral potential against breast cancer.


Tasar M.,Ankara University | Kalender M.,Konya Education and Research Hospital | Karaca O.G.,Duzce University | Ecevit A.N.,Konya Education and Research Hospital | And 3 more authors.
Heart Surgery Forum | Year: 2015

Background: Carotid artery disease is not rare in cardiac patients. Patients with cardiac risk factors and carotid stenosis are prone to neurological and cardiovascular complications. With cardiac risk factors, carotid endarterectomy operation becomes challenging. Regional anesthesia is an alternative option, so we aimed to investigate the operative results of carotid endarterectomy operations under regional anesthesia in patients with cardiac risk factors. Methods: We aimed to analyze and compare outcomes of carotid endarterectomy under regional anesthesia with cardiovascular risk groups retrospectively. Between 2006 and 2014, we applied 129 carotid endarterectomy ± patch plasty to 126 patients under combined cervical plexus block anesthesia. Patients were divided into three groups (high, moderate, low) according to their cardiovascular risks. Neurological and cardiovascular events after carotid endarterectomy were compared. Results: Cerebrovascular accident was seen in 7 patients (5.55%) but there was no significant difference between groups (P > .05). Mortality rate was 4.76% (n = 6); it was higher in the high risk group and was not statistically significant (P = .180). Four patients required revision for bleeding (3.17%). We did not observe any postoperative surgical infection. Conclusion: Carotid endarterectomy can be safely performed with regional cervical anesthesia in all cardiovascular risk groups. Comprehensive studies comparing general anesthesia and regional anesthesia are needed. © 2015 Forum Multimedia Publishing, LLC.


PubMed | Konya Education and Research Hospital, Afyon Kocatepe University, Ankara University, Kosuyolu Education and Research Hospital and 2 more.
Type: Journal Article | Journal: The heart surgery forum | Year: 2015

Carotid artery disease is not rare in cardiac patients. Patients with cardiac risk factors and carotid stenosis are prone to neurological and cardiovascular complications. With cardiac risk factors, carotid endarterectomy operation becomes challenging. Regional anesthesia is an alternative option, so we aimed to investigate the operative results of carotid endarterectomy operations under regional anesthesia in patients with cardiac risk factors.We aimed to analyze and compare outcomes of carotid endarterectomy under regional anesthesia with cardiovascular risk groups retrospectively. Between 2006 and 2014, we applied 129 carotid endarterectomy patch plasty to 126 patients under combined cervical plexus block anesthesia. Patients were divided into three groups (high, moderate, low) according to their cardiovascular risks. Neurological and cardiovascular events after carotid endarterectomy were compared.Cerebrovascular accident was seen in 7 patients (5.55%) but there was no significant difference between groups (P > .05). Mortality rate was 4.76% (n = 6); it was higher in the high risk group and was not statistically significant (P = .180). Four patients required revision for bleeding (3.17%). We did not observe any postoperative surgical infection.Carotid endarterectomy can be safely performed with regional cervical anesthesia in all cardiovascular risk groups. Comprehensive studies comparing general anesthesia and regional anesthesia are needed.


Ustaalioglu B.B.O.,Dr Lutfi Kirdar Kartal Education And Research Hospital | Seker M.,Dr Lutfi Kirdar Kartal Education And Research Hospital | Bilici A.,Dr Lutfi Kirdar Kartal Education And Research Hospital | Canpolat N.,Kosuyolu Education and Research Hospital | And 7 more authors.
Medical Oncology | Year: 2011

Thymic hyperplasia is a common phenomenon in both children and young adults after chemotherapy and may explain the finding of a mediastinal mass in patients with malignant lymphoma after complete remission. In the present study, we report 5 cases with malignant lymphoma presenting with a mediastinal mass on CT scan after completion of chemotherapy diagnosed as thymic hyperplasia by PET-CT imaging. We retrospectively analyzed 5 patients who presented with anterior mediastinal masses a median of 4 months (range 3-6) after achieving complete remission following successful treatment for malignant lymphoma. Three patients were diagnosed with Hodgkin's lymphoma (HL) and the others with non-Hodgkin's lymphoma (NHL). The median age of the patients was 23 (range of 18-47). PET-CT was performed on these patients to determine the characteristics of a mass which had been detected on CT. PET-CT was performed for all patients, and the thymic masses demonstrated only mild FDG uptake considered to be consistent with thymic hyperplasia. During a median of 24 months of follow-up, all patients were recurrence-free with a median survival of 15 months (range 10-26 months). It is important to be aware of the possibility of thymic hyperplasia after chemotherapy to avoid misdiagnosis or over-staging of disease, as well as unnecessary biopsies, especially when the presenting anterior mediastinal mass was originally located near the thymus on CT scan. Mild FDG PET uptake was sufficient for the diagnosis of benign disease in the cases in this study. © 2010 Springer Science+Business Media, LLC.


Bilici A.,Dr Lutfi Kirdar Kartal Education And Research Hospital | Bilici A.,Aire Inc | Ustaalioglu B.B.O.,Dr Lutfi Kirdar Kartal Education And Research Hospital | Seker M.,Dr Lutfi Kirdar Kartal Education And Research Hospital | And 2 more authors.
Clinical Nuclear Medicine | Year: 2010

We report a case of recurrent mantle cell lymphoma (MCL) with cauda equina involvement imaged with F-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT). A 75-years-old man presented with bilateral lower extremity muscle weakness who had received treatment for MCL. The involvement of L3-S1 nerve roots with disease were diagnosed based on the findings on electromyography. An FDG PET/CT scan was performed to rule out lymphoma recurrence. PET revealed intense focal uptake in the cauda equina in the midline and at the level of the right neuroforamen on the L2-L5 vertebrae, which showed lymphoma involvement. He was treated with radiotherapy and his neurologic symptoms improved. We conclude that it is useful to use FDG PET/CT in the work-up of possible cauda equina involvement of recurrent MCL. © 2010 by Lippincott Williams & Wilkins.


Oven Ustaalioglu B.B.,Dr Lutfi Kirdar Kartal Education And Research Hospital | Gumus M.,Dr Lutfi Kirdar Kartal Education And Research Hospital | Bilici A.,Dr Lutfi Kirdar Kartal Education And Research Hospital | Seker M.,Dr Lutfi Kirdar Kartal Education And Research Hospital | And 6 more authors.
Journal of B.U.ON. | Year: 2010

Purpose: Positron emission tomography (PET) is an important imaging techniquefor the diagnosis and staging of patients with non-small cell lung cancer (NSCLC). In this study, we evaluated the standardized uptake values (SUV) of PET in NSCLC patients to determine whether there was a cut-off value for predicting response to treatment and survival. Methods: We retrospectively analyzed 149 patients with locally advanced NSCLC. All the patients were staged by PET-computerized tomography (CT) after diagnosis. 18fluoro-2- deoxyribose (FDG) was used as the PET tracer. Univariate and multivariate analyses were performed to detect whether any prognostic factors were related to response to treatment. Results: The median patient age was 60 years and the median follow-up time 10.3 months. One-year progression-free survival (PFS) and overall survival (OS) rates were 31% and 58.7%, respectively. The median OS was 15.4 months. Stage, sex and response to treatment were important factors for OS and PFS. We defined a cut-off value for SUVmax (the highest standardized uptake value for all cross sectional areas) as 10.8 by using ROC analysis. Multivariate analysis identified response to treatment as the most significant (p<0.05) prognostic factor for OS. Logistic regression analysis showed that SUVmax and weight loss were important for response to treatment. Conclusion: Multivariate analysis indicated that whilst response to treatment was an important factor for predicting survival, the SUVmax was also significant for determining response to therapy and a cut-off value for SUVmax was defined as 10.8. © 2010 Zerbinis Medical Publications.


Bilici A.,Dr Lutfi Kirdar Kartal Education And Research Hospital | Seker M.,Dr Lutfi Kirdar Kartal Education And Research Hospital | Ustaalioglu B.B.O.,Dr Lutfi Kirdar Kartal Education And Research Hospital | Canpolat N.,Kosuyolu Education and Research Hospital | And 2 more authors.
Journal of Korean Medical Science | Year: 2011

Extra marginal-zone lymphomas of the lung is a very rare tumor and it originates from bronchial-associated lymphoid tissue. A 68-yr-old woman presented with productive cough and dyspnea. A thorax computed tomography scan showed a 9 × 10 cm in size mass in the left lung and pleural effusion in the lower lobe of left lung. Positron emission tomography/computed tomography (PET/CT) revealed intense uptake foci at the upper and middle sites of left lung and slight uptake foci at the mediastinal lymph nodes which showed malignant involvement. After bronchoscopic biopsy, the diagnosis of pulmonary bronchial-associated lymphoid tissue (BALT) lymphoma was confirmed. At the end of the eight cycles weekly rituximab treatment, complete response was obtained by PET/CT findings. It is concluded that extended rituximab schedule is more effective and it would be beneficial to investigate the use of PET/CT in the diagnosis and evaluating of the treatment response of pulmonary BALT lymphoma. © 2011 The Korean Academy of Medical Sciences.

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