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Takarazuka, Japan

Koshien University is a private university in Takarazuka, Hyōgo, Japan. The predecessor of the school was founded in 1941, and it was chartered as a university in 1967. Wikipedia.


Utsumi M.,Osaka University | Makimoto K.,Osaka University | Quroshi N.,Osaka University | Ashida N.,Koshien University
Age and Ageing | Year: 2010

Background: Infectious outbreaks in long-term care facilities (LTCFs) tend to have a significant impact on infection rates and mortality rates of the residents. 299 Objectives: this review aimed to update the information on pathogens identified in such outbreaks and to try to explore indicators that reflect the impact of outbreaks among residents and health care workers (HCWs). Methods: MEDLINE (1966-2008) was used to identify outbreaks using the following thesaurus terms: 'Cross-Infection', 'Disease Outbreaks', 'Urinary-Tract Infections' and 'Blood-Borne Pathogens'. Elderly care facilities were identified with the following thesaurus terms: 'Long-Term Care', 'Assisted-Living Facilities', 'Homes for the Aged' and 'Nursing Homes'. Age category was limited using 'Aged'. Results: thirty-seven pathogens were associated with 206 outbreaks. The largest number of reported outbreaks by a single pathogen involved the influenza virus, followed by noroviruses. Among residents, the highest median attack rate for respiratory infection outbreaks was caused by Chlamydia pneumoniae (46%), followed by respiratory syncytial virus (40%). In gastrointestinal tract infection outbreaks, high median attack rates were caused by Clostridium perfringens (48%) and noroviruses (45%). Outbreaks with high median case fatality rates were caused by Group A Streptococci (50%) and Streptococcus pneumoniae (44%). High median attack rates for HCWs were caused by C. pneumoniae (41%), noroviruses (42%) and scabies (36%). Conclusion: a variety of infectious agents were identified as the cause of outbreaks in the elderly and HCWs in LTCFs. Attack rates and case fatality rates are useful indicators for setting priorities for education and prevention of the outbreaks. © The Author 2010. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org. Source


Nasu Y.,Koshien University
Telemedicine journal and e-health : the official journal of the American Telemedicine Association | Year: 2011

Although many studies have analyzed breathing sounds in the diagnosis of obstructive sleep apnea syndrome, the recording of snoring sounds at home is hampered by the various background noises of daily life. Recordings also frequently include talking during sleep, which may infringe the privacy of patients. A recording system used a bone conduction microphone to record snoring sounds. This microphone reduced background noise. A simple system transmitted recorded breathing sound data for screening at a hospital as envelope data instead of complete sound recordings, thereby decreasing data volume and protecting privacy. In periods in which blood oxygen levels (SpO 2) were drastically decreased, the probability of apnea as deduced from the envelope curve of breathing sounds was consistent with SpO 2 values. This method provides a basis for telemonitoring of sleep apnea syndrome. Source


Matsuo A.,Koshien University | Sato K.,Kyoto Prefectural University | Park E.Y.,Kyoto Prefectural University | Nakamura Y.,Kyoto Prefectural University | Ohtsuki K.,Kyoto Prefectural University
Journal of Functional Foods | Year: 2012

Direct addition of a food additive-grade Aspergillus niger phytase preparation to 30% brown rice flour-added bread ingredients reduced the bread myo-inositol hexaphosphate (IP 6) content. The phytase preparation had protease and amylase activities. Addition of the crude phytase preparation induced bread crust collapse. Protease-free high- and low-amylase phytase fractions were prepared using preparative ampholyte-free isoelectric focusing (autofocusing). Addition of the protease-free low-amylase phytase fraction did not significantly affect loaf volume and did not collapse the crust. Addition of the protease-free high-amylase phytase fraction significantly increased loaf volume approximately 1.5× in the presence of amylase at 193-1029U. However, addition of 1029 and 2058U of amylase induced partial and whole bread crust collapse, respectively. Therefore, removal of protease and control of amylase activities in the phytase preparation are crucial in the preparation of brown rice flour-added bread with a low myo-inositol phosphate (IP 6) and good swelling property. © 2012 Elsevier Ltd. Source


Omura K.,Koshien University
Synthesis | Year: 2010

The oxidation of 2,4,6-trialkylphenols with lead(IV) oxide and 70% perchloric acid in water-acetone or in alcohols gives p-quinols or p-quinol ethers, respectively. Some nonmetallic oxidants serve the same purpose. © Georg Thieme Verlag Stuttgart. Source


Prostaglandin (PG) F 2α is widely distributed in various organs and exhibits various biological functions, such as luteolysis, parturition, aqueous humor homeostasis, vasoconstriction, rennin secretion, pulmonary fibrosis and so on. The first enzyme reported to synthesize PGF 2 was referred to as PGF synthase belonging to the aldo-keto reductase (AKR) 1C family, and later PGF 2α synthases were isolated from protozoans and designated as members of the AKR5A family. In 2003, AKR1B5, which is highly expressed in bovine endometrium, was reported to have PGF 2α synthase activity, and recently, the paper entitled 'Prostaglandin F 2α synthase activities of AKR 1B1, 1B3 and 1B7' was reported by Kabututu et al. (J. Biochem.145, 161-168, 2009). Clones that had already been registered in a database as aldose reductases (AKR1B1, 1B3, and 1B7) were expressed in Escherichia coli, and these enzymes were found to have PGF 2α synthase activity. Moreover, in the above-cited article, the effects of inhibitors specific for aldose reductase on the PGF 2α synthase activity of AKR1B were discussed. Here, I present an overview of various PGF/PGF 2α synthases including those of AKR1B subfamily that have been reported until now. © 2011 The Authors. Source

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