Kawasaki H.,Keio University |
Nagao K.,Keio University |
Kubo A.,Keio University |
Hata T.,Keio University |
And 5 more authors.
Journal of Allergy and Clinical Immunology | Year: 2012
Background: Loss-of-function mutations in filaggrin are major predisposing factors for atopic dermatitis. Although various reports suggest a critical role for filaggrin in stratum corneum (SC) barrier formation, the lack of filaggrin-null (Flg-/-) mice has hampered detailed in vivo analysis of filaggrin's functions. Objective: We sought to generate Flg-/- mice and to assess the effect of filaggrin loss on SC barrier function and percutaneous immune responses. Methods: We generated Flg-/- mice using gene targeting and assessed the morphology, hydration, mechanical strength, and antigen permeability of their SC. Percutaneous immune responses were evaluated through irritant- and hapten-induced contact hypersensitivity studies and by measuring humoral responses to epicutaneous sensitization with protein antigen. Results: Newborn Flg-/- mice exhibited dry scaly skin. Despite marked decreases in natural moisturizing factor levels, which are filaggrin degradation products, SC hydration and transepidermal water loss were normal. Microscopic analyses suggested premature shedding of SC layers, and indeed, increased desquamation under mechanical stress was demonstrated. Loss of keratin patterns, which are critical for corneocyte stabilization, is likely attributable to fragility in the Flg-/- SC. Antigens penetrated the Flg-/- SC more efficiently, leading to enhanced responses in hapten-induced contact hypersensitivity and higher serum levels of anti-ovalbumin IgG1 and IgE. Conclusion: Complete filaggrin deficiency led to altered barrier integrity and enhanced sensitization, which are important factors in early-phase atopic dermatitis. Flg-/- mice should provide a valuable tool to further explore additional factors the dysfunction of which leads to uncontrolled inflammation in patients with atopic diseases. © 2012 American Academy of Allergy, Asthma & Immunology.
Kose Corporation and CHIBA FLOUR MILLING Co. | Date: 2011-02-16
An object of the present invention is to provide novel dextrin fatty acid ester that is excellent in tackiness and useful as a base for cosmetics and the like. The novel dextrin fatty acid ester is prepared by esterification between dextrin and fatty acids, wherein the dextrin has an average degree of glucose polymerization of 3 to 150; the fatty acids comprise more than 50 mol % and 100 mol % or less, based on the total amount of the fatty acids, of one or more saturated branched fatty acids having 4 to 26 carbon atoms, and 0 mol % or more and less than 50 mol %, based on the total amount of the fatty acids, of one or more fatty acids selected from the group consisting of saturated linear fatty acids having 2 to 22 carbon atoms, unsaturated linear or branched fatty acids having 6 to 30 carbon atoms, and saturated or unsaturated cyclic fatty acids having 6 to 30 carbon atoms; and the degree of substitution by the fatty acids is 1.0 to 3.0 per glucose unit.
KOSE Corporation | Date: 2013-03-28
It is an object of the present invention to provide a hair cosmetic achieving a hair-setting property without causing flaking and further having an excellent hair-rearranging property and non-stickiness. The hair cosmetic of the present invention includes the following components (A) to (D):
Kose Corporation | Date: 2015-03-19
KOSE Corporation | Date: 2012-12-14
A stick-type cosmetic holder is formed in a cylindrical shape opened at upper and lower ends. On an inner peripheral surface, an inner diameter is gradually decreased from an upper opening downward to provide an upper tapered surface, and the inner diameter is gradually decreased from a lower opening upward to provide a lower tapered surface. A single annular step portion forming a step such that the lower tapered surface side is higher than the upper tapered surface side is provided at a boundary between the upper tapered surface and the lower tapered surface. The step portion is formed with an inclination in relation to the axial center as viewed from the lateral side. Moreover, taper angles of the upper and lower tapered surfaces are 1 to 10, and the height of the step portion is 0.1 to 2.0 mm.