Korean Collection of Herbal Extract Inc.

Kongju, South Korea

Korean Collection of Herbal Extract Inc.

Kongju, South Korea

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Sancheti S.,Kongju National University | Um B.-H.,Korea Institute of Science and Technology | Seo S.-Y.,Kongju National University | Seo S.-Y.,Korean Collection of Herbal Extract Inc.
South African Journal of Botany | Year: 2010

The search for a novel pharmacotherapy from medicinal plants for neurodegenerative disorders has significantly advanced. Therefore, the present study was performed to evaluate the anticholinesterase activities of one hundred medicinal plants in Korea, where Terminalia chebula (T. chebula) fruits showed significant acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitions. Further bioassay monitored phytochemical exploration led to the isolation of 1,2,3,4,6-penta-O-galloyl-β-d-glucose (compound 1), which showed significant AChE and BChE inhibitory effects with IC50 values of 29.9 ± 0.3 μM and 27.6 ± 0.2 μM, respectively. The inhibitory effect of compound 1 towards acetylcholinesterase was also evaluated using TLC and compared with tacrine as the positive control; the positive effect was confirmed. Furthermore, compound 1 also displayed strong antioxidant activity by the FRAP assay (IC50 = 4.6 ± 0.2 μM). In conclusion, compound 1 may prove to be a potential natural anti-Alzheimer source based on noteworthy AChE and BChE inhibitions, and strong antioxidant activity. © 2009 Elsevier B.V. All rights reserved.


Sancheti S.,Kongju National University | Seo S.-Y.,Kongju National University | Seo S.-Y.,Korean Collection of Herbal Extract Inc.
Experimental and Toxicologic Pathology | Year: 2013

The present study was intended to examine the effects of the supplementation of active α-glucosidase, α-amylase and lipase inhibitory ethyl acetate (CSE) fraction from the fruits of Chaenomeles sinensis (Thouin) Koehne on blood glucose (BG), triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), alanine aminotransferase (ALT), aspartate aminotransaminase (AST), acetylcholinesterase (AChE) and antioxidant levels. The diabetic rats were treated orally with CSE at the doses of 50 and 100. mg/kg bw for 14 days. BG, TC, TG, HDL-C, ALT, AST and AChE levels were significantly reduced; on the other hand antioxidant levels were significantly increased in the treated groups. These observations suggest protective effects of CSE against STZ-induced diabetic dementia model. © 2011 Elsevier GmbH.


Sancheti S.,Kongju National University | Seo S.-Y.,Kongju National University | Seo S.-Y.,Korean Collection of Herbal Extract Inc.
Drug and Chemical Toxicology | Year: 2013

The available conventional remedies for the treatment of drug-induced liver diseases are highly inadequate and possess serious adverse effects; therefore, the development of new, effective drugs is considered necessary. This article explores the hepatoprotective and antioxidant potential of 7-methylcoumarin (MC) and 7-methoxycoumarin (MOC) in CCl4-induced hepatotoxicity in rats. MC and MOC individually, at doses of 50 and 100 mg/kg body weight, were administered orally once-daily for 7 days. The hepatoprotective activity was assessed using various biochemical parameters, such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), serum bilirubin (TB), total protein (TP), and albumin (TA). Serum antioxidant enzyme [e.g., superoxide dismutase (SOD) and catalase (CAT)] levels were determined. Also, thiobarbituric-acid-related substances (TBARS) levels, along with histopathological studies of liver tissue, were scrutinized. Pretreatment with MC and MOC significantly decreased ALT, AST, and TB in the serum of CCl4-induced liver damaged rats in a dose-dependent manner. TA and TP levels in the serum were also restored significantly in all presupplemented MC and MOC groups. In addition, oxidative stress induced by CCl4 was prevented significantly; thereby, increasing SOD and CAT levels and decreasing TBARS levels in liver homogenates. Histopathological studies revealed the ameliorative natures of both the compounds. This study demonstrates the strong hepatoprotective activity of MC and MOC, which could be attributed to their potent antioxidant effects. © 2013 Informa Healthcare USA, Inc.


Sancheti S.,Kongju National University | Bafna M.,Kongju National University | Seo S.-Y.,Kongju National University | Seo S.-Y.,Korean Collection of Herbal Extract Inc.
Medicinal Chemistry Research | Year: 2011

Five distinct organic compounds with protected and unprotected phenolic hydroxyl groups were screened for their a-glucosidase inhibitory potential. Of these compounds, 2,4,6-trihydroxybenzaldehyde (THB) showed the strongest noncompetitive a-glucosidase inhibition (IC50 = 4.60 lM) and the most powerful antioxidant activity (DPPH assay) (IC50 = 71.4 lM) in vitro. In in vivo studies, THB significantly reduced blood glucose levels in normal and diabetic rats after glucose load compared to maltose load. © Springer Science+Business Media, LLC 2010.


Lee S.-H.,Kongju National University | Sancheti S.A.,Kongju National University | Bafna M.R.,Kongju National University | Sancheti S.S.,Kongju National University | And 2 more authors.
Journal of Medicinal Plants Research | Year: 2011

The aim of the present study was to evaluate the antiacetylcholinesterase and antioxidant potential of 80% methanolic extract of Rhododendron yedoense var. poukhanense bark (RYBE). The extract was rich in total phenolic content (160 mg gallic acid equivalent/g of dry extract) and possessed flavonoids (2.2 mg quercetin equivalent/g of dry extract). The acetylcholinesterase (AChE) inhibitory capacity of RYBE was determined against electric eel AChE enzyme. The extract exhibited substantial inhibitory activity with IC 50 value of 169.01 μg/ml. In addition, the extract revealed its strong antioxidant activity by various in vitro assay systems including 1,1-diphenyl-2-picrylhydrazyl, 2,2'-azinobis-(3- ethylbenzothiazoline-6-sulfonic acid), ferrous ion chelating and nitric oxide scavenging assays. The reducing power of RYBE was also determined by ferric reducing antioxidant power assay. Furthermore, this extract exhibited dose dependent inhibition of lipid peroxidation in rat liver homogenate. In conclusion, due to considerable AChE inhibitory and potent antioxidant nature of RYBE, further in vivo studies along with structural elucidation to find the active ingredient(s) will prove useful in searching an effective treatment for Alzheimer's disease. © 2011 Academic Journals.


Sancheti S.,Kongju National University | Bafna M.,Kongju National University | Lee S.-H.,Kongju National University | Seo S.-Y.,Kongju National University | Seo S.-Y.,Korean Collection of Herbal Extract Inc.
Journal of Medicinal Plants Research | Year: 2011

This research aims to investigate the α-glucosidase (baker's yeast and rat intestinal acetone powder) inhibitory potential of Diospyros kaki Thunb. (Ebenaceae) leaf extract (DKLE) along with its antioxidant activity against metal-catalysed protein oxidation by pro-oxidant model (Fe 2+/ascorbate) in rat liver homogenates, in vitro. DKLE evidenced the outstanding inhibitory effect with IC 50 values of 1.22 and 32 μg/ml for baker's yeast and rat intestinal α-glucosidase enzymes. The inhibition mode of this extract was determined by measuring enzyme activity in different concentrations of substrate for Lineweaver- Burk plot analysis. Its inhibition was found to be noncompetitive. The addition of Fe2+/scorbate to the liver homogenate significantly increased the extent of lipid peroxidation which was significantly lowered with the extract treatment. Furthermore, DKLE ability to alleviate postprandial hyperglycemia in normal and streptozotocin (STZ)-induced diabetic rats was scrutinized. Oral administration of this leaf extract (250 to 1000 mg/kg body wt.) considerably decreased blood glucose in normal and diabetic rats after glucose and maltose loading in a dose-dependent manner. These results propose that DKLE might show an anti-diabetic effect by suppressing carbohydrate and glucose absorption from the intestine and can reduce the postprandial blood glucose rise. © 2011 Academic Journals.


Sancheti S.,Kongju National University | Lee S.-H.,Kongju National University | Lee J.-E.,Kongju National University | Seo S.-Y.,Kongju National University | Seo S.-Y.,Korean Collection of Herbal Extract Inc.
Iranian Journal of Pharmaceutical Research | Year: 2011

Glycosidases are the enzymes involved in various biochemical processes related to metabolic disorders and diseases. Therefore, much effort has been focused on searching novel pharmacotherapy for the treatment of these ailments from medicinal plants due to higher safety margins. To pursue these efforts, the present study was performed to evaluate the et-glucosidase inhibitory activities of thirty Korean medicinal plant extracts. Among the plants studied, Euonymus sachalinensis, Rhododendron schlippenbachii, Astilbe chinensis and Juglans regia showed the strongest et-glucosidase inhibitory activity with IC50 values of 10, 20, 30 and 80 ug/ mL, respectively. In addition, Meliosma oldhamii and Symplocos chinensis showed moderate et-glucosidase inhibition with IC50 values of 150 and 220 ug/mL, respectively. Therefore, they might prove to be a potential natural source for the treatment of metabolic ailments such as, diabetes, and need further investigations. © 2011 by School of Pharmacy Shaheed Beheshti University of Medical Sciences and Health Services.


Sancheti S.,Kongju National University | Bafna M.,Kongju National University | Seo S.-Y.,Kongju National University | Seo S.-Y.,Korean Collection of Herbal Extract Inc.
European Food Research and Technology | Year: 2010

The rising incidence of diabetes mellitus (DM) is alarming and becoming a major health problem worldwide, which is mainly associated with hyperglycemia, abnormal lipid, and antioxidant profiles. Herbal medicines are being used by about 80% of the world population primarily in the developing countries for primary health care, including DM. Based on these facts, in this study, the antihyperglycemic, antihyperlipidemic, and antioxidant properties of Chaenomeles sinensis fruits extract (CSFE) were investigated in streptozotocin (STZ)-induced (55 mg/kg body weight) diabetic rats. CSFE was found to be rich in total phenolics and flavonoid contents. The following assays were performed: fasting blood glucose, hemoglobin (Hb), blood urea nitrogen (BUN), serum total cholesterol (TC), serum triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), serum glutamic pyruvic transaminase/alanine aminotransferase (SGPT/ALT), serum glutamic oxaloacetic transaminase/aspartate aminotransaminase (SGOT/AST), liver glycogen content and superoxide dismutase (SOD), reduced glutathione (GSH), and catalase (CAT) contents in liver and kidney. Oral administration of CSFE (500 mg/kg body weight) significantly decreased fasting blood glucose, BUN, and serum TC, TG, LDL-C, SGPT/ALT, and SGOT/AST, while it increased blood Hb content and HDL-C in diabetic rats. Furthermore, CSFE treatment significantly increased liver glycogen content, SOD, GSH, and CAT levels in diabetic rats. The results showed that CSFE significantly inhibited the progression of diabetes induced by STZ, and the inhibitory effect of CSFE on diabetes might be associated with its hypoglycemic effect, modulation of lipid metabolism, and its ability to scavenge free radicals. © 2010 Springer-Verlag.

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