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Sancheti S.,Kongju National University | Um B.-H.,Korea Institute of Science and Technology | Seo S.-Y.,Kongju National University | Seo S.-Y.,Korean Collection of Herbal Extract Inc.
South African Journal of Botany | Year: 2010

The search for a novel pharmacotherapy from medicinal plants for neurodegenerative disorders has significantly advanced. Therefore, the present study was performed to evaluate the anticholinesterase activities of one hundred medicinal plants in Korea, where Terminalia chebula (T. chebula) fruits showed significant acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitions. Further bioassay monitored phytochemical exploration led to the isolation of 1,2,3,4,6-penta-O-galloyl-β-d-glucose (compound 1), which showed significant AChE and BChE inhibitory effects with IC50 values of 29.9 ± 0.3 μM and 27.6 ± 0.2 μM, respectively. The inhibitory effect of compound 1 towards acetylcholinesterase was also evaluated using TLC and compared with tacrine as the positive control; the positive effect was confirmed. Furthermore, compound 1 also displayed strong antioxidant activity by the FRAP assay (IC50 = 4.6 ± 0.2 μM). In conclusion, compound 1 may prove to be a potential natural anti-Alzheimer source based on noteworthy AChE and BChE inhibitions, and strong antioxidant activity. © 2009 Elsevier B.V. All rights reserved. Source


Sancheti S.,Kongju National University | Bafna M.,Kongju National University | Seo S.-Y.,Kongju National University | Seo S.-Y.,Korean Collection of Herbal Extract Inc.
Medicinal Chemistry Research | Year: 2011

Five distinct organic compounds with protected and unprotected phenolic hydroxyl groups were screened for their a-glucosidase inhibitory potential. Of these compounds, 2,4,6-trihydroxybenzaldehyde (THB) showed the strongest noncompetitive a-glucosidase inhibition (IC50 = 4.60 lM) and the most powerful antioxidant activity (DPPH assay) (IC50 = 71.4 lM) in vitro. In in vivo studies, THB significantly reduced blood glucose levels in normal and diabetic rats after glucose load compared to maltose load. © Springer Science+Business Media, LLC 2010. Source


Sancheti S.,Kongju National University | Seo S.-Y.,Kongju National University | Seo S.-Y.,Korean Collection of Herbal Extract Inc.
Drug and Chemical Toxicology | Year: 2013

The available conventional remedies for the treatment of drug-induced liver diseases are highly inadequate and possess serious adverse effects; therefore, the development of new, effective drugs is considered necessary. This article explores the hepatoprotective and antioxidant potential of 7-methylcoumarin (MC) and 7-methoxycoumarin (MOC) in CCl4-induced hepatotoxicity in rats. MC and MOC individually, at doses of 50 and 100 mg/kg body weight, were administered orally once-daily for 7 days. The hepatoprotective activity was assessed using various biochemical parameters, such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), serum bilirubin (TB), total protein (TP), and albumin (TA). Serum antioxidant enzyme [e.g., superoxide dismutase (SOD) and catalase (CAT)] levels were determined. Also, thiobarbituric-acid-related substances (TBARS) levels, along with histopathological studies of liver tissue, were scrutinized. Pretreatment with MC and MOC significantly decreased ALT, AST, and TB in the serum of CCl4-induced liver damaged rats in a dose-dependent manner. TA and TP levels in the serum were also restored significantly in all presupplemented MC and MOC groups. In addition, oxidative stress induced by CCl4 was prevented significantly; thereby, increasing SOD and CAT levels and decreasing TBARS levels in liver homogenates. Histopathological studies revealed the ameliorative natures of both the compounds. This study demonstrates the strong hepatoprotective activity of MC and MOC, which could be attributed to their potent antioxidant effects. © 2013 Informa Healthcare USA, Inc. Source


Sancheti S.,Kongju National University | Seo S.-Y.,Kongju National University | Seo S.-Y.,Korean Collection of Herbal Extract Inc.
Experimental and Toxicologic Pathology | Year: 2013

The present study was intended to examine the effects of the supplementation of active α-glucosidase, α-amylase and lipase inhibitory ethyl acetate (CSE) fraction from the fruits of Chaenomeles sinensis (Thouin) Koehne on blood glucose (BG), triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), alanine aminotransferase (ALT), aspartate aminotransaminase (AST), acetylcholinesterase (AChE) and antioxidant levels. The diabetic rats were treated orally with CSE at the doses of 50 and 100. mg/kg bw for 14 days. BG, TC, TG, HDL-C, ALT, AST and AChE levels were significantly reduced; on the other hand antioxidant levels were significantly increased in the treated groups. These observations suggest protective effects of CSE against STZ-induced diabetic dementia model. © 2011 Elsevier GmbH. Source


Sancheti S.,Kongju National University | Bafna M.,Kongju National University | Lee S.-H.,Kongju National University | Seo S.-Y.,Kongju National University | Seo S.-Y.,Korean Collection of Herbal Extract Inc.
Journal of Medicinal Plants Research | Year: 2011

This research aims to investigate the α-glucosidase (baker's yeast and rat intestinal acetone powder) inhibitory potential of Diospyros kaki Thunb. (Ebenaceae) leaf extract (DKLE) along with its antioxidant activity against metal-catalysed protein oxidation by pro-oxidant model (Fe 2+/ascorbate) in rat liver homogenates, in vitro. DKLE evidenced the outstanding inhibitory effect with IC 50 values of 1.22 and 32 μg/ml for baker's yeast and rat intestinal α-glucosidase enzymes. The inhibition mode of this extract was determined by measuring enzyme activity in different concentrations of substrate for Lineweaver- Burk plot analysis. Its inhibition was found to be noncompetitive. The addition of Fe2+/scorbate to the liver homogenate significantly increased the extent of lipid peroxidation which was significantly lowered with the extract treatment. Furthermore, DKLE ability to alleviate postprandial hyperglycemia in normal and streptozotocin (STZ)-induced diabetic rats was scrutinized. Oral administration of this leaf extract (250 to 1000 mg/kg body wt.) considerably decreased blood glucose in normal and diabetic rats after glucose and maltose loading in a dose-dependent manner. These results propose that DKLE might show an anti-diabetic effect by suppressing carbohydrate and glucose absorption from the intestine and can reduce the postprandial blood glucose rise. © 2011 Academic Journals. Source

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